Systems and methods for global optimization of treatment planning for external beam radiation therapy
First Claim
1. A method for developing an optimal treatment plan for treatment of a target volume within a patient using an external beam radiation delivery unit, the method comprising:
- receiving information corresponding to at least one parameter related to intensity-modulated radiation therapy (IMRT) to be used in developing the optimal treatment plan;
receiving information corresponding to at least one clinical objective related to a target volume and a critical structure;
developing a treatment plan optimization model based on a plurality of variables corresponding to the at least one parameter related to IMRT and the at least one clinical objective which define a global system; and
developing a globally optimal treatment plan which optimizes the at least one clinical objective subject to the at least one parameter.
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Accused Products
Abstract
Systems and methods for providing an optimal treatment plan for delivering a prescribed radiation dose to a predefined target volume within a patient using an external beam radiation delivery unit are provided. One such method comprises: (1) receiving information related to the prescribed radiation dose, the predefined target volume, and parameters associated with the external beam delivery unit, (2) developing a treatment plan optimization model based on a plurality of variables corresponding to the information which define a global system, and (3) outputting an optimal treatment plan based on the treatment plan optimization model and the information.
112 Citations
26 Claims
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1. A method for developing an optimal treatment plan for treatment of a target volume within a patient using an external beam radiation delivery unit, the method comprising:
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receiving information corresponding to at least one parameter related to intensity-modulated radiation therapy (IMRT) to be used in developing the optimal treatment plan;
receiving information corresponding to at least one clinical objective related to a target volume and a critical structure;
developing a treatment plan optimization model based on a plurality of variables corresponding to the at least one parameter related to IMRT and the at least one clinical objective which define a global system; and
developing a globally optimal treatment plan which optimizes the at least one clinical objective subject to the at least one parameter. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 17, 18)
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11. A system for optimizing treatment planning in intensity-modulation radiation therapy (IMRT), the system comprising:
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a user interface for enabling a user to specify at least one parameter related to IMRT, at least one constraint, and at least one clinical objective;
a treatment plan modeling module configured to develop a treatment plan optimization model containing a plurality of variables corresponding to the at least one parameter related to IMRT, the at least one constraint, and the at least one clinical objective; and
a global optimization module configured to calculate a globally optimal treatment plan which optimizes the at least one clinical objective subject to the at least one parameter related to IMRT and the at least one constraint. - View Dependent Claims (12, 13, 14, 15, 16)
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19. A system for optimizing treatment planning in intensity-modulation radiation therapy (IMRT), the system comprising:
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means for interfacing with an I/O device to enable a user to specify at least one parameter related to IMRT, at least one constraint, and at least one clinical objective;
means for modeling a global system based on a plurality of variables corresponding to the at least one parameter related to IMRT, the at least one constraint, and the at least one clinical objective; and
means for calculating a globally optimal treatment plan which optimizes the at least one clinical objective subject to the at least one parameter related to IMRT and the at least one constraint.
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20. A computer program embodied in a computer-readable medium for optimizing treatment planning in intensity-modulation radiation therapy (IMRT), the computer program comprising:
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logic configured to interface with a user and enable the user to specify at least one parameter related to IMRT, at least one constraint, and at least one clinical objective;
logic configured to develop a treatment plan optimization model containing a plurality of variables corresponding to the at least one parameter related to IMRT, the at least one constraint, and the at least one clinical objective; and
logic configured to calculate a globally optimal treatment plan which optimizes the at least one clinical objective subject to the at least one parameter related to IMRT and the at least one constraint. - View Dependent Claims (21, 22, 23, 24, 25, 26)
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Specification