Catheter based sensing for intraluminal procedures

• US 20040167385A1
• Filed: 12/17/2003
• Published: 08/26/2004
• Est. Priority Date: 12/18/2002
• Status: Abandoned Application

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Inventors: Bourne, George, Rioux, Robert F.
• Application Number:
  US10/739,584
• Publication Number:
  US 20040167385A1
• Time in Patent Office: Days
• US Class Current: 600/373
• CPC Class Codes: A61B 2017/00084 Temperature
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/02055 Simultaneously evaluating both cardiovascular condition and temperature
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61M 2025/0002 with a pressure sensor at the distal end
• CPC Class Codes: A61M 25/005 with embedded materials for reinforcement, e.g. wires, coils, braids
• CPC Class Codes: A61M 25/0053 having a variable stiffness along the longitudinal axis, e.g. by varying the pitch of the coil or braid

Abstract

A system for embolotherapy comprises a catheter with a lumen extending therethrough from a proximal opening to a distal opening through which an embolic agent may be dispensed to a treatment site and at least one sensor coupled proximate to the distal end of the catheter to generate signals relating to a physiological condition in an area of the lumen adjacent to the sensor in combination with a controller receiving and processing the signals to generate data indicative of the physiological condition. A method of performing embolotherapy comprises inserting a catheter including at least one sensor mounted thereon into a blood vessel supplying a target tissue mass, the at least one sensor generating signals corresponding to a selected physiological condition in an area of the blood vessel adjacent thereto and processing signals generated by the at least one sensor prior to treatment of the target tissue mass to determine an initial state of the selected physiological condition in combination with treating the target tissue mass by dispensing an embolic agent from a distal end of the catheter, processing, after initiation of the treatment of the target tissue mass, the signals generated by the at least one sensor to determine a current state of the selected physiological condition and comparing the initial and current states to determine whether a desired change in the current physiological condition has been achieved.

Claims

1. A catheter comprising:

an elongated body having a distal end adapted for insertion into a body lumen and a proximal end opposite the distal end with a working lumen extending therethrough;

at least one sensor disposed on the elongated body generating a signal corresponding to a physiological condition; and

a transmission element adapted to convey the signal between the at least one sensor and an external controller.

2. The catheter according to claim 1, wherein the at least one sensor is a low profile sensor.

3. The catheter according to claim 2, wherein the at least one sensor is a thin film pressure sensor.

4. The catheter according to claim 2, wherein the at least one sensor is a temperature sensor.

5. The catheter according to claim 1, wherein the at least one sensor is disposed near the distal end of the elongated body.

6. The catheter according to claim 1, wherein the at least one sensor is responsive to one of a pressure, temperature, flow rate, flow velocity, reflectivity, electrical activity, chemical characteristics and chemical content of a body lumen within which the catheter is inserted.

7. The catheter according to claim 1, wherein the transmission element comprises at least one conductive element.

8. The catheter according to claim 1, wherein the transmission element comprises a wireless signal transmitter.

9. The catheter according to claim 1, wherein the at least one sensor comprises first and second sensors and wherein the signal comprises a first signal component from the first sensor and a second signal component from the second sensor.

10. The catheter according to claim 9, wherein the first and second sensors are pressure sensors.

11. The catheter according to claim 10, wherein the signal is adapted for processing to determine a flow rate of a fluid surrounding the first and second sensors.

12. The catheter according to claim 1, further comprising a connector of the transmission element disposed near the proximal end, the connector being adapted to receive an external wire.

13. A system for embolotherapy comprising:

a catheter with a lumen extending therethrough from a proximal opening to a distal opening through which an embolic agent may be dispensed to a treatment site;

at least one sensor coupled proximate to the distal end of the catheter to generate signals relating to a physiological condition in an area of the lumen adjacent to the sensor; and

a controller receiving and processing the signals to generate data indicative of the physiological condition.

14. The embolotherapy system according to claim 13, further comprising a display visually depicting the data indicative of the physiological condition.

15. The embolotherapy system according to claim 13, wherein the controller includes one of software, hardware and firmware calculating a blood flow rate based on the signals.

16. The embolotherapy system according to claim 15, wherein the at least one sensor includes a first pressure sensor.

17. The embolotherapy system according to claim 16, wherein the at least one sensor further comprises a second pressure sensor and wherein the blood flow rate is calculated based on a first pressure signal generated by the first pressure sensor and a second pressure signal generated by the second pressure sensor.

18. The embolotherapy system according to claim 15, wherein the at least one sensor includes a first temperature sensor.

19. The embolotherapy system according to claim 18, wherein the at least one sensor further comprises a second temperature sensor and wherein the blood flow rate is calculated based on a first temperature signal generated by the first pressure temperature sensor and a second temperature signal generated by the second temperature sensor.

20. The embolotherapy system according to claim 17, wherein the blood flow rate is calculated using the equation:

Q=Δ

P/R

wherein Q is the blood flow rate, Δ

P is a difference between the first and second pressure signals, and R is a resistance to fluid flow.

21. The embolotherapy system according to claim 13, wherein the controller determines an initial state of the physiological condition and a current state of the physiological condition.

22. The embolotherapy system according to claim 21, further comprising a flow control element controlling the dispensing of embolic agent to the lumen, wherein the controller operates the flow control element to terminate dispensing of the embolic agent when the current state reaches a selected condition.

23. The embolotherapy system according to claim 13, wherein the controller comprises an indicator providing a first indication when a selected physiological condition has not been reached and a second indication when the selected physiological condition has been reached.

24. The embolotherapy system according to claim 23, wherein the selected physiological condition is reached when a flow of blood past the at least one sensor is interrupted.

25. The embolotherapy system according to claim 17, wherein the first and second pressure sensors are disposed near the distal end of the catheter.

26. The embolotherapy system according to claim 19, wherein the first and second temperature sensors are disposed near the distal end of the catheter.

27. A method of performing embolotherapy comprising:

inserting a catheter including at least one sensor mounted thereon into a blood vessel supplying a target tissue mass, the at least one sensor generating signals corresponding to a selected physiological condition in an area of the blood vessel adjacent thereto;

processing signals generated by the at least one sensor prior to treatment of the target tissue mass to determine an initial state of the selected physiological condition;

treating the target tissue mass by dispensing an embolic agent from a distal end of the catheter;

processing, after initiation of the treatment of the target tissue mass, the signals generated by the at least one sensor to determine a current state of the selected physiological condition; and

comparing the initial and current states to determine whether a desired change in the current physiological condition has been achieved.

28. The method according to claim 27, further comprising placing a distal end of the catheter at a mouth of the blood vessel supplying the target tissue.

29. The method according to claim 27, wherein the selected physiological condition is a blood flow rate through the blood vessel.

30. The method according to claim 27, wherein the at least one sensor includes first and second pressure sensors, the method further comprising processing first and second pressure signals received from the first and second pressure sensors, respectively, to generate data corresponding to a blood flow rate in the blood vessel.

31. The method according to claim 27, displaying an indication at least one of the initial and current state of the selected physiological condition.

32. The method according to claim 27, further comprising terminating dispensation of the embolic agent when the desired change in the selected physiological condition has been achieved.