Biopsy device with inner cutting member
First Claim
1. A tissue biopsy device for accessing and collecting a tissue specimen from a target site within a patient, comprising:
- a. an elongated probe member which has a longitudinal axis, which has a proximal end configured to be secured to a drive, which has an inner lumen extending therein, which has a penetrating distal tip and which has an aperture proximal to the penetrating distal tip configured to receive tissue from the target site; and
b. an elongated tissue cutting member which is disposed within the elongated probe member, which has at least one tissue cutting edge with a longitudinal orientation at an angle with respect to the longitudinal axis less than 90°
over a length thereof, which has an inner lumen extending therein, which is configured to be operably connected to at least one drive unit to move the tissue cutting member to cut a tissue specimen from tissue extending into the tissue receiving aperture of the elongated member.
1 Assignment
0 Petitions
Accused Products
Abstract
The invention is directed to devices and methods for separating and collecting a tissue specimen from a patient'"'"'s target site. The device includes a probe member with a penetrating distal tip and a tissue receiving aperture, and a tissue cutting member which is rotatable disposed within the probe member to cut a tissue specimen drawn into the interior of the device through the aperture. The longitudinal edges of the aperture are preferably sharpened to engage the cutting edges of the tissue cutting member. Vacuum may be provided in the inner lumen of the cutting member to transport tissue therethrough. Rotation, rotational oscillation and/or longitudinal reciprocation of the tissue cutting member is effective to separate a tissue specimen from surrounding tissue. An accessing cannula having an tissue receiving aperture may be concentrically disposed within the probe member and about the tissue cutting member. The tissue cutting edge of the tissue cutting member preferably is longitudinally oriented and may have a cutting angle less than 90° with respect to the longitudinal axis of the tissue cutting member.
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Citations
70 Claims
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1. A tissue biopsy device for accessing and collecting a tissue specimen from a target site within a patient, comprising:
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a. an elongated probe member which has a longitudinal axis, which has a proximal end configured to be secured to a drive, which has an inner lumen extending therein, which has a penetrating distal tip and which has an aperture proximal to the penetrating distal tip configured to receive tissue from the target site; and
b. an elongated tissue cutting member which is disposed within the elongated probe member, which has at least one tissue cutting edge with a longitudinal orientation at an angle with respect to the longitudinal axis less than 90°
over a length thereof, which has an inner lumen extending therein, which is configured to be operably connected to at least one drive unit to move the tissue cutting member to cut a tissue specimen from tissue extending into the tissue receiving aperture of the elongated member. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A tissue biopsy device for accessing and collecting a tissue specimen from a target site within a patient, comprising:
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a. a drive housing which has a plurality of drive units;
b. an outer member which is releasably secured to the drive housing, which has a proximal tubular portion, which has an inner lumen extending within the proximal tubular portion, which has a tissue penetrating distal tip, which has an open section proximal to the tissue penetrating distal tip and which has a supporting strut extending from the penetrating distal tip to the proximal tubular portion;
c. a tissue accessing cannula which is slidably disposed at least in part within the inner lumen of the proximal tubular portion of the outer member, which has an inner lumen extending therein, and which has a tissue receiving aperture spaced proximal to the distal end thereof in fluid communication with the inner lumen of the accessing cannula and which is operably secured to a drive unit in the drive housing to rotate the tissue receiving cannula to adjust the orientation of the tissue receiving aperture; and
d. an elongated tissue cutting member which is formed at least in part of a tubular member, which is slidably disposed within the inner lumen of the tissue accessing cannula, which has a tissue cutting edge, which has an inner lumen extending therein configured to receive a tissue specimen cut by the tissue cutting member, and which is connected to a drive unit to move the tissue cutting member within the inner lumen of the tissue accessing cannula. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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40. A probe for a tissue biopsy device for accessing and collecting a tissue specimen from a target site within a patient, comprising:
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a. an outer member which has a proximal tubular portion configured to be releasably secured to a drive housing, which has an inner lumen extending therein, which has a tissue penetrating distal tip, which has an open section proximal to the penetrating distal tip and a supporting strut extending from the penetrating distal tip to the proximal tubular portion;
b. a tissue accessing cannula which is slidably disposed at least in part within the inner lumen of the tubular portion of the outer member, which has an inner lumen extending therein, and which has a tissue receiving aperture spaced proximal to the distal end thereof in fluid communication with the inner lumen of the accessing cannula and which is configured to be operably secured to a drive unit in a drive housing to rotate the tissue receiving cannula to adjust the orientation of the tissue receiving aperture; and
c. an elongated tissue cutting member which is slidably disposed within the inner lumen of the tissue accessing cannula, which has at least one longitudinal tissue cutting edge, which defines at least in part an inner lumen for receiving tissue cut by the tissue cutting surface, and which is connected to a drive unit to move the tissue cutting member within the inner lumen of the tissue accessing cannula. - View Dependent Claims (41, 42, 43, 44, 45)
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46. A method of separating a biopsy tissue specimen from supporting tissue at a target site within a patient'"'"'s body, comprising:
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a. providing a biopsy device having a biopsy probe comprising;
i. an outer member which is releasably secured to a drive housing, which has an inner lumen extending therein, which has a tissue penetrating distal tip secured thereto, which has an open section proximal to the penetrating distal tip and a supporting strut extending from the penetrating distal tip, ii. a tissue accessing cannula which is slidably disposed at least in part within the inner lumen of the outer member, which has an inner lumen extending therein, and which has a tissue receiving aperture spaced proximal to the distal end thereof in fluid communication with the inner lumen of the accessing cannula and which is operably secured to a drive unit in the drive housing to rotate the tissue receiving cannula to adjust the orientation of the tissue receiving aperture, and iii. an elongated tissue cutting member which is formed at least in part of a tubular member, which is slidably disposed within the inner lumen of the tissue accessing cannula, which has at least one tissue cutting edge, which has an inner lumen extending therein for receiving a tissue specimen cut by the tissue cutting edge, and which is connected to a drive unit to move the tissue cutting member within the inner lumen of the tissue accessing cannula;
b. advancing the probe at least partially into or adjacent to tissue at the target site;
c. exposing the aperture of the accessing cannula to tissue at the tissue site;
d. applying a vacuum to the inner lumen of the tissue accessing cannula or the tissue cutting member to draw tissue from the tissue site into the inner lumen of the accessing cannula;
e. rotating the tissue cutting member to cut tissue extending into the inner lumen from supporting tissue at the tissue site by the cutting edge of the member; and
f. transporting a tissue specimen through the inner lumen of the tissue cutting member. - View Dependent Claims (47, 48, 49, 50)
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51. A tissue biopsy device for accessing and collecting a tissue specimen from a target site within a patient, comprising:
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a. an outer tubular member which has an inner lumen extending therein, which has a penetrating distal tip, and which has a tissue receiving aperture proximal to the penetrating distal tip in fluid communication with the inner lumen and having at least one longitudinally oriented, tissue cutting edge; and
b. an elongated tissue cutting member which is formed at least in part of a tubular member, which is rotatably disposed within the inner lumen of the outer tubular member, which has a longitudinal axis, which has a longitudinal tissue cutting edge oriented at an acute angle with respect to the longitudinal axis, which has an inner lumen extending therein for receiving tissue cut by the tissue cutting edge and which is configured for rotation within the inner lumen of the outer member to cut tissue extending into the inner lumen of the tissue cutting member.
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52. A tissue biopsy device for accessing and severing a tissue specimen from supporting tissue at a target site within a patient, comprising:
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a. an elongated probe member which has a longitudinal axis, which has an inner lumen extending therein, which has a tissue penetrating distal tip and which has a tissue receiving aperture proximal to the tissue penetrating distal tip and defined at least in part by one longitudinally oriented, tissue cutting edges; and
b. an elongated tissue cutting member which is disposed within the inner lumen of the elongated probe member and configured for cutting movements therein, which has a distal portion with a tissue cutting edge radially spaced from and is at least in part oriented at an acute cutting angle with respect to the at least one tissue cutting edge defining in part the aperture of the probe member and which is configured to be connected to at least one drive unit to move the tissue cutting member rotationally and longitudinally to sever from supporting tissue a tissue specimen tissue extending into the open tissue receiving section of the elongated member. - View Dependent Claims (53, 54, 55, 56, 57, 58, 59, 60, 61, 62)
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63. A device for accessing and collecting tissue from a target site within a patient, comprising:
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a. an elongated probe member which has a longitudinal axis, which has a proximal end configured to be secured to a drive, which has an inner lumen extending therein, which has a penetrating distal tip and which has an aperture proximal to the penetrating distal tip configured to receive tissue from the target site; and
b. an elongated tissue cutting member which is disposed within the elongated probe member, which has at least one tissue cutting edge with a longitudinal orientation at an angle with respect to the longitudinal axis less than 90°
over a length thereof, which has an inner lumen extending therein, which is configured to be operably connected to at least one drive unit to move the tissue cutting member to cut a tissue from tissue extending into the tissue receiving aperture of the elongated member.
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64. A device for accessing and collecting tissue from a target site within a patient, comprising:
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a. a drive housing which has a plurality of drive units;
b. an outer member which is releasably secured to the drive housing, which has a proximal tubular portion, which has an inner lumen extending within the proximal tubular portion, which has a tissue penetrating distal tip, which has an open section proximal to the tissue penetrating distal tip and which has a supporting strut extending from the penetrating distal tip to the proximal tubular portion;
c. a tissue accessing cannula which is slidably disposed at least in part within the inner lumen of the proximal tubular portion of the outer member, which has an inner lumen extending therein, and which has a tissue receiving aperture spaced proximal to the distal end thereof in fluid communication with the inner lumen of the accessing cannula and which is operably secured to a drive unit in the drive housing to rotate the tissue receiving cannula to adjust the orientation of the tissue receiving aperture; and
d. an elongated tissue cutting member which is formed at least in part of a tubular member, which is slidably disposed within the inner lumen of the tissue accessing cannula, which has a tissue cutting edge, which has an inner lumen extending therein configured to receive tissue cut by the tissue cutting member, and which is connected to a drive unit to move the tissue cutting member within the inner lumen of the tissue accessing cannula.
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65. A probe for accessing and collecting tissue from a target site within a patient, comprising:
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a. an outer member which has a proximal tubular portion configured to be releasably secured to a drive housing, which has an inner lumen extending therein, which has a tissue penetrating distal tip, which has an open section proximal to the penetrating distal tip and a supporting strut extending from the penetrating distal tip to the proximal tubular portion;
b. a tissue accessing cannula which is slidably disposed at least in part within the inner lumen of the tubular portion of the outer member, which has an inner lumen extending therein, and which has a tissue receiving aperture spaced proximal to the distal end thereof in fluid communication with the inner lumen of the accessing cannula and which is configured to be operably secured to a drive unit in a drive housing to rotate the tissue receiving cannula to adjust the orientation of the tissue receiving aperture; and
c. an elongated tissue cutting member which is slidably disposed within the inner lumen of the tissue accessing cannula, which has at least one longitudinal tissue cutting edge, which defines at least in part an inner lumen for receiving tissue cut by the tissue cutting surface, and which is connected to a drive unit to move the tissue cutting member within the inner lumen of the tissue accessing cannula.
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66. A method of separating tissue from supporting tissue at a target site within a patient'"'"'s body, comprising:
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a. providing a tissue removal device having an elongated probe comprising;
i. an outer member which is releasably secured to a drive housing, which has an inner lumen extending therein, which has a tissue penetrating distal tip secured thereto, which has an open section proximal to the penetrating distal tip and a supporting strut extending from the penetrating distal tip, ii. a tissue accessing cannula which is slidably disposed at least in part within the inner lumen of the outer member, which has an inner lumen extending therein, and which has a tissue receiving aperture spaced proximal to the distal end thereof in fluid communication with the inner lumen of the accessing cannula and which is operably secured to a drive unit in the drive housing to rotate the tissue receiving cannula to adjust the orientation of the tissue receiving aperture, and iii. an elongated tissue cutting member which is formed at least in part of a tubular member, which is slidably disposed within the inner lumen of the tissue accessing cannula, which has at least one tissue cutting edge, which has an inner lumen extending therein for receiving a tissue specimen cut by the tissue cutting edge, and which is connected to a drive unit to move the tissue cutting member within the inner lumen of the tissue accessing cannula;
b. advancing the probe at least partially into or adjacent to tissue at the target site;
c. exposing the aperture of the accessing cannula to tissue at the tissue site;
d. applying a vacuum to the inner lumen of the tissue accessing cannula or the tissue cutting member to draw tissue from the tissue site into the inner lumen of the accessing cannula; and
e. rotating the tissue cutting member to cut tissue extending into the inner lumen from supporting tissue at the tissue site by the cutting edge of the member. - View Dependent Claims (67, 68)
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69. A device for accessing and collecting tissue from a target site within a patient, comprising:
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a. an elongated probe means which has a longitudinal axis, which has a proximal end configured to be secured to a drive, which has an inner lumen extending therein, which has a penetrating means on the distal tip and which has an aperture proximal to the penetrating means on the distal tip configured to receive tissue from the target site; and
b. an elongated tissue cutting means which is disposed within the elongated probe member, which has at least one tissue cutting edge with a longitudinal orientation at an angle with respect to the longitudinal axis less than 90°
over a length thereof, which has an inner lumen extending therein, which is configured to be operably connected to at least one drive means to move the tissue cutting means to cut tissue from tissue extending into the tissue receiving aperture of the elongated probe means.
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70. A method of separating tissue from supporting tissue at a target site within a patient'"'"'s body, comprising the steps of:
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a. providing a tissue removal means having an elongated probe comprising;
i. an outer member which is releasably secured to a drive housing, which has an inner lumen extending therein, which has a tissue penetrating distal tip secured thereto, which has an open section proximal to the penetrating distal tip and a supporting strut extending from the penetrating distal tip, ii. a tissue accessing cannula which is slidably disposed at least in part within the inner lumen of the outer member, which has an inner lumen extending therein, and which has a tissue receiving aperture spaced proximal to the distal end thereof in fluid communication with the inner lumen of the accessing cannula and which is operably secured to a drive unit in the drive housing to rotate the tissue receiving cannula to adjust the orientation of the tissue receiving aperture, and iii. an elongated tissue cutting means which is formed at least in part of a tubular member, which is slidably disposed within the inner lumen of the tissue accessing cannula, which has at least one tissue cutting edge, which has an inner lumen extending therein for receiving a tissue specimen cut by the tissue cutting edge, and which is connected to a drive unit to move the tissue cutting member within the inner lumen of the tissue accessing cannula;
b. the step of advancing the probe at least partially into or adjacent to tissue at the target site;
c. the step of exposing the aperture of the accessing cannula to tissue at the tissue site;
d. the step of applying a vacuum to the inner lumen of the tissue accessing cannula or the tissue cutting member to draw tissue from the tissue site into the inner lumen of the accessing cannula; and
e. the step of rotating the tissue cutting member to cut tissue extending into the inner lumen from supporting tissue at the tissue site by the cutting edge of the member.
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Specification