Delivering cooled fluid to sites inside the body

• US 20040167467A1
• Filed: 02/21/2003
• Published: 08/26/2004
• Est. Priority Date: 02/21/2003
• Status: Abandoned Application

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Inventors: Jenson, Mark L., Richardson, Leonard B., Drasler, William J., Kokate, Jaydeep Y., Harrison, Kent
• Application Number:
  US10/372,021
• Publication Number:
  US 20040167467A1
• Time in Patent Office: Days
• US Class Current: 604/113
• CPC Class Codes: A61B 5/028 by thermo-dilution
• CPC Class Codes: A61F 2007/126 for invasive application, e.g. for introducing into blood vessels
• CPC Class Codes: A61F 7/12 Devices for heating or cooling internal body cavities
• CPC Class Codes: A61M 2205/3368 Temperature

Abstract

Devices and methods to deliver cooled fluid to an internal site in the body are disclosed. A catheter includes an elongated member having a lumen longitudinally extending therethrough to a distal end of the elongated member. A temperature sensor senses the temperature of the fluid flowing through the lumen near the distal end. One method for treating an ischemic tissue region before reperfusion includes inserting a balloon catheter into a coronary vein that provides access to the ischemic tissue region. The balloon is inflated to occlude the coronary vein and cooled fluid is delivered from the balloon catheter and distal to the balloon. Another method involves inserting a catheter into a coronary artery where a lesion is obstructing blood flow through the artery. The distal end of the catheter is positioned at a location distal to the lesion and cooled fluid is provided from the distal end of the catheter to the ischemic tissue region.

Claims

1. A catheter comprising:

an elongated member having a lumen longitudinally extending therethrough to a distal end of the elongated member; and

a temperature sensor to sense the temperature of fluid flowing through the lumen near the distal end.

2. The catheter of claim 1 wherein the temperature sensor is located at a distal portion of the elongated member.

3. The catheter of claim 1 further comprising a balloon located at a distal portion of the elongated member.

4. The catheter of claim 3 wherein the temperature sensor is located distal of the balloon.

5. The catheter of claim 3 wherein the balloon is a dilation balloon.

6. The catheter of claim 3 wherein the balloon is a sealing balloon.

7. The catheter of claim 1 wherein the temperature sensor comprises a thermocouple.

8. The catheter of claim 7 wherein the thermocouple comprises two conductors of different material extending from a proximal end of the catheter and joined at a distal end to form a junction.

9. The catheter of claim 8 wherein the junction extends to an inside wall surrounding the lumen so that the fluid is in thermal communication with the junction as it flows through the lumen.

10. The catheter of claim 1 wherein the temperature sensor comprises a thermistor.

11. The catheter of claim 1 further comprising a temperature controller that receives feedback relating to the temperature of the fluid exiting the lumen from the temperature sensor.

12. The catheter of claim 11 wherein the temperature controller is adapted to adjust the temperature of the fluid in response to the feedback provided by the temperature sensor.

13. A method of treating an ischemic tissue region before reperfusion, the method comprising:

inserting a balloon catheter comprising a balloon into a coronary vein that provides access to the ischemic tissue region;

inflating the balloon to occlude the coronary vein; and

delivering a cooled fluid from the balloon catheter and distal to the balloon.

14. The method of claim 13 further comprising sensing the temperature of the fluid delivered to the ischemic tissue region.

15. The method of claim 14 wherein the sensing is performed in a distal portion of the balloon catheter.

16. The method of claim 13 further comprising positioning a distal end of a guide catheter into a coronary sinus before inserting the balloon catheter into the coronary vein.

17. The method of claim 16 wherein the balloon catheter is inserted into a coronary vein by inserting the balloon catheter into a lumen of the guide catheter and passing the balloon catheter through an opening at the distal end of the guide catheter.

18. The method of claim 17 further comprising cooling the fluid with the guide catheter while the fluid flows through a lumen in the balloon catheter.

19. The method of claim 13 wherein the cooled fluid comprises saline.

20. The method of claim 13 wherein the cooled fluid comprises blood.

21. The method of claim 13 wherein the cooled fluid comprises a blood substitute.

22. The method of claim 13 wherein the cooled fluid comprises a delta opioid ligand.

23. The method of claim 22 wherein the delta opioid ligand is D-Ala2-D-Leu5 enkephalin.

24. A method of treating an ischemic tissue region before reperfusion, the method comprising:

inserting a catheter into a coronary artery where a lesion is obstructing blood flow through the artery;

positioning a distal end of the catheter at a location distal to the lesion, and

providing a cooled fluid from the distal end of the catheter to the ischemic tissue region.

25. The method of claim 24 further comprising sensing the temperature of the fluid provided to the ischemic tissue region.

26. The method of claim 24 wherein the providing of the cooled fluid occurs during an angioplasty procedure that is performed using the catheter.

27. The method of claim 24 wherein the catheter is inserted into the coronary artery by inserting the catheter into a lumen of a guide catheter and passing the distal end of the catheter through an opening at a distal end of the guide catheter.

28. The method of claim 27 further comprising cooling the fluid with the guide catheter while the fluid flows through a lumen in the catheter.

29. The method of claim 24 wherein the cooled fluid comprises saline.

30. The method of claim 24 wherein the cooled fluid comprises blood.

31. The method of claim 24 wherein the cooled fluid comprises a blood substitute.

32. The method of claim 24 wherein the cooled fluid comprises a delta opioid ligand.

33. The method of claim 32 wherein the delta opioid ligand is D-Ala2-D-Leu5 enkephalin.