Liposomes
First Claim
1. ) A liposome comprising:
- i) a neutral phospholipid, ii) a negatively charged phospholipid, iii)a sterol, having a modifying compound entrapped in the internal phase of said liposome;
wherein the modifying compound is a compound that is capable of irreversibly chemically modifying an internalisable material within said liposome following diffusion of said material across the phospholipid bilayer of said liposome, such that the irreversibly chemically modified material remains internalised within said liposome, and;
wherein the neutral phospholipid is present at 60-90 mole percent of the total lipid content, the negatively charged phospholipid is present at 2-20 mole percent of the total lipid content and the sterol is present at 5-25 mole percent of the total lipid content.
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Accused Products
Abstract
Liposomes of a specific bilayer composition containing an entrapped modifying compound are claimed. The liposomes of the invention are suitable for the internalisation of a variety of materials, even following long-term storage. Suitable materials of the invention include radiometals, parmagnetic compounds, radioopaque compounds and prodrugs. Upon internalisation, the material reacts chemically with the entrapped modifying compound such that said material remains internalised within the liposomes of the invention. Also claimed in the present invention are the liposomes containing internalised material and kits for their preparation. Furthermore, the use of said liposomes containing internalised material for the imaging infection, inflammation or tumour in a human is claimed.
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Citations
30 Claims
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1. ) A liposome comprising:
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i) a neutral phospholipid, ii) a negatively charged phospholipid, iii)a sterol, having a modifying compound entrapped in the internal phase of said liposome;
wherein the modifying compound is a compound that is capable of irreversibly chemically modifying an internalisable material within said liposome following diffusion of said material across the phospholipid bilayer of said liposome, such that the irreversibly chemically modified material remains internalised within said liposome, and;
wherein the neutral phospholipid is present at 60-90 mole percent of the total lipid content, the negatively charged phospholipid is present at 2-20 mole percent of the total lipid content and the sterol is present at 5-25 mole percent of the total lipid content. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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Specification