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Liposomes

  • US 20040170560A1
  • Filed: 11/07/2003
  • Published: 09/02/2004
  • Est. Priority Date: 05/10/2001
  • Status: Abandoned Application
First Claim
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1. ) A liposome comprising:

  • i) a neutral phospholipid, ii) a negatively charged phospholipid, iii)a sterol, having a modifying compound entrapped in the internal phase of said liposome;

    wherein the modifying compound is a compound that is capable of irreversibly chemically modifying an internalisable material within said liposome following diffusion of said material across the phospholipid bilayer of said liposome, such that the irreversibly chemically modified material remains internalised within said liposome, and;

    wherein the neutral phospholipid is present at 60-90 mole percent of the total lipid content, the negatively charged phospholipid is present at 2-20 mole percent of the total lipid content and the sterol is present at 5-25 mole percent of the total lipid content.

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