Delivery of rizatriptan or zolmitriptan through an inhalation route
First Claim
1. A composition for delivery of rizatriptan consisting of a condensation aerosol a) formed by volatilizing a thin layer of rizatriptan on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of rizatriptan and condensing the heated vapor of rizatriptan to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% rizatriptan degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
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Abstract
The present invention relates to the delivery of compounds for the treatment of migraine and headache through an inhalation route. Specifically, it relates to aerosols containing rizatriptan or zolmitriptan that are used in inhalation therapy. In a method aspect of the present invention, rizatriptan or zolmitriptan is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of rizatriptan or zolmitriptan on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering rizatriptan or zolmitriptan through an inhalation route is provided which comprises: a) a thin coating of a rizatriptan or zolmitriptan composition; and, b) a device for dispending said thin coating as a condensation aerosol.
90 Citations
14 Claims
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1. A composition for delivery of rizatriptan consisting of a condensation aerosol
a) formed by volatilizing a thin layer of rizatriptan on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of rizatriptan and condensing the heated vapor of rizatriptan to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% rizatriptan degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
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5. A composition for delivery of zolmitriptan consisting of a condensation aerosol
a) formed by volatilizing a thin layer of zolmitriptan on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of zolmitriptan and condensing the heated vapor of zolmitriptan to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% zolmitriptan degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
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9. A method of producing rizatriptan in an aerosol form comprising:
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a. heating a thin layer of rizatriptan on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the rizatriptan to form a heated vapor of the rizatriptan, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the rizatriptan comprising less than 5% rizatriptan degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (10, 11)
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12. A method of producing zolmatriptan in an aerosol form comprising:
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a. heating a thin layer of zolmatriptan on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the zolmatriptan to form a heated vapor of the zolmatriptan, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the zolmatriptan comprising less than 5% zolmatriptan degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (13, 14)
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Specification