Organ preservation apparatus and methods
First Claim
1. Apparatus comprising a perfusion fluid loop for maintaining an ex vivo organ in viable condition for transplantation, said perfusion fluid loop comprising:
- an organ container for receiving an organ to be transported, a bubble remover for removing gas bubbles from perfusion fluid disposed in said perfusion fluid loop, an oxygenator for supplying oxygen to and removing carbon dioxide from perfusion fluid disposed in said perfusion fluid loop, and a free radical scavenger located in said perfusion fluid loop and positioned to be in contact with a perfusion fluid in said perfusion fluid loop.
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Accused Products
Abstract
This invention is a transportable organ preservation system that substantially increases the time during which the organ can be maintained viable for successful implantation into a recipient. A chilled oxygenated nutrient solution can be pumped through the vascular bed of the organ after excision of the organ from the donor and during transport. The device of the present invention uses flexible permeable tubing to oxygenate the perfusion fluid while the CO2 produced by the organ diffuses out of the perfusion fluid. One pressurized two-liter “C” cylinder can supply oxygen for up to 34 hours of perfusion time. The device can use a simple electric pump driven by a storage battery to circulate the perfusion fluid through the organ being transported. The vessel containing the organ to be transported can be held at a suitable temperature by a chiller.
138 Citations
7 Claims
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1. Apparatus comprising a perfusion fluid loop for maintaining an ex vivo organ in viable condition for transplantation, said perfusion fluid loop comprising:
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an organ container for receiving an organ to be transported, a bubble remover for removing gas bubbles from perfusion fluid disposed in said perfusion fluid loop, an oxygenator for supplying oxygen to and removing carbon dioxide from perfusion fluid disposed in said perfusion fluid loop, and a free radical scavenger located in said perfusion fluid loop and positioned to be in contact with a perfusion fluid in said perfusion fluid loop. - View Dependent Claims (2, 3)
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- 4. A perfusion fluid comprising a free radical scavenger in an amount effective to increase the length of the period during which an ex vivo organ will remain viable in said perfusion fluid.
- 6. A composition comprising a free radical scavenger in time-release form adapted for releasing said scavenger into a perfusion fluid over a period of time.
Specification