Sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
First Claim
1. A composition comprising a first oligomer and a second oligomer, wherein:
- at least a portion of said first oligomer is capable of hybridizing with at least a portion of said second oligomer, at least a portion of said first oligomer is complementary to and capable of hybridizing with a selected target nucleic acid, and at least one of said first or said second oligomers includes at least one sugar surrogate.
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Accused Products
Abstract
Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes a modification comprising a sugar surrogate. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleoside of the oligomer has a sugar surrogate modification.
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Citations
67 Claims
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1. A composition comprising a first oligomer and a second oligomer, wherein:
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at least a portion of said first oligomer is capable of hybridizing with at least a portion of said second oligomer, at least a portion of said first oligomer is complementary to and capable of hybridizing with a selected target nucleic acid, and at least one of said first or said second oligomers includes at least one sugar surrogate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 59, 62, 65)
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28. A composition comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein, said protein comprising at least a portion of a RNA-induced silencing complex (RISC), wherein:
said oligomer includes at least one nucleoside having a modification comprising a sugar surrogate. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 60, 63, 66)
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53. An oligomer having at least a first region and a second region, wherein:
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said first region of said oligomer complementary to and capable of hybridizing with said second region of said oligomer, at least a portion of said oligomer complementary to and capable of hybridizing to a selected target nucleic acid, said oligomer further including at least one nucleoside having a modification comprising a sugar surrogate. - View Dependent Claims (54, 55, 56, 57, 58, 61, 64, 67)
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Specification