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Standardized evaluation of therapeutic efficacy based on cellular biomarkers

  • US 20040171091A1
  • Filed: 02/27/2004
  • Published: 09/02/2004
  • Est. Priority Date: 02/27/2003
  • Status: Abandoned Application
First Claim
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1. A method of selecting a therapeutic agent for treatment of a disease state in a patient, comprising:

  • obtaining a cell sample from the patient, wherein the sample comprises cells characteristic of the disease state and the cells comprise one or more biomarkers;

    contacting the cells with a test compound that specifically binds to one or more biomarkers and comprises a fluorescent moiety;

    measuring the intensity of the fluorescence of the cells; and

    comparing the intensity of the fluorescence of the cells to a fluorescence intensity of a reference standard, wherein the ratio of the intensities correlates to the effectiveness of the therapeutic agent against the disease state.

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