Cytotherapeutics, cytotherapeutic units and methods for treatments using them
First Claim
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1. A cytotherapeutic unit comprising a plurality of potent cells;
- the content of said unit being known with respect to the identities and numbers at least some of said plurality;
the unit being assayed to ensure the accuracy of said identities and numbers.
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Abstract
The present invention provides cytotherapeutic units comprising predetermined numbers of selected types of potent cells. Assurance of the nature and identities of such cells is achieved through assay and certification of said numbers and identities. Therapeutic modalities are provided. Libraries of cell preparations with assayed and preferably certified populations are preferred and the preparation of cell preparations tailored to specific patients or disease states are provided.
218 Citations
53 Claims
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1. A cytotherapeutic unit comprising a plurality of potent cells;
- the content of said unit being known with respect to the identities and numbers at least some of said plurality;
the unit being assayed to ensure the accuracy of said identities and numbers. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
- the content of said unit being known with respect to the identities and numbers at least some of said plurality;
- 18. A cytotherapeutic unit comprising minimum numbers of preselected types of potent cells.
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26. A kit for treatment of a person suspected of having a disease state or condition comprising a cytotherapeutic unit comprising a plurality of potent cells;
- the content of said unit being known with respect to the identities and numbers at least some of said plurality;
the unit being assayed to ensure the accuracy of said identities and numbers; and
a certification of the accuracy of the assay. - View Dependent Claims (27)
- the content of said unit being known with respect to the identities and numbers at least some of said plurality;
- 28. A kit for treatment of a person suspected of having a disease state or condition comprising a cytotherapeutic unit having minimum numbers of identified potent cells and a certification of the potent cell composition of the unit.
- 31. A cytotherapeutic unit comprising cells derived from umbilical cord blood, placenta, or a mixture thereof, wherein at least one type of cell has been removed from the unit.
- 34. A cytotherapeutic unit comprising cells derived from umbilical cord blood, placenta, or a mixture thereof, said cells comprising a plurality of different types, at least some of the different types having been separated into components and recombined into said unit.
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39. A method of treating a disease in a mammal comprising:
- Administering to said mammal a therapeutically effective amount of a composition comprising;
a cytotherapeutic unit comprising a plurality of potent cells;
the content of said unit being known with respect to the identities and numbers of at least some of said plurality;
the unit being assayed to ensure the accuracy of said identities and numbers. - View Dependent Claims (40, 41, 42, 43, 44, 45, 46, 47, 48, 49)
- Administering to said mammal a therapeutically effective amount of a composition comprising;
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50. A library of cytotherapeutic units, each unit member of said library comprising a plurality of potent cells;
- the content of each of said units being known with respect to the identities and numbers at least some of the plurality of potent cells comprising said unit;
each of said units being assayed to ensure the accuracy of said identities and numbers.
- the content of each of said units being known with respect to the identities and numbers at least some of the plurality of potent cells comprising said unit;
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51. A method of treatment of a patient in need of cytotherapeutic treatment comprising selecting from a library of cytotherapeutic units at least two unit members of said library;
- combining aliquots from said unit members to form a treatment unit and administering said treatment unit to the patient.
- View Dependent Claims (52, 53)
Specification