N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives

• US 20040171881A1
• Filed: 11/08/2002
• Published: 09/02/2004
• Est. Priority Date: 11/08/2001
• Status: Active Grant

• Current Assignee: Elan Pharmaceuticals Incorporated (Perrigo Company PLC), Pharmacia & Upjohn Company (Pfizer Inc.)
• Original Assignee: Elan Pharmaceuticals Incorporated (Perrigo Company PLC)
• Inventors: Beck, James, Maillard, Michel, Jagodzinska, Barbara, Sealy, Jennifer, John, Varghese, TenBrink, Ruth, Gailunas, Andrea, Mickelson, John, Freskos, John, Samala, Lakshman, Fang, Lawrence, Hom, Roy
• Granted Patent: US 7,176,242 B2
• Time in Patent Office: Days
• US Class Current: 564/163
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07C 233/36 having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
• CPC Class Codes: C07C 233/40 having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
• CPC Class Codes: C07C 233/58 having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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• CPC Class Codes: C07C 235/74 of a saturated carbon skeleton
• CPC Class Codes: C07C 237/04 the carbon skeleton being acyclic and saturated
• CPC Class Codes: C07C 237/06 having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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• CPC Class Codes: C07C 2601/02 with a three-membered ring
• CPC Class Codes: C07C 2601/08 the ring being saturated
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• CPC Class Codes: C07C 311/17 : to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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• CPC Class Codes: C07C 317/46 : the carbon skeleton being further substituted by singly-bound oxygen atoms
• CPC Class Codes: C07C 317/50 : at least one of the nitrogen atoms being part of any of the groups , X being a hetero atom, Y being any atom
• CPC Class Codes: C07C 323/60 : with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
• CPC Class Codes: C07C 323/62 : having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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• CPC Class Codes: C07D 207/267 : with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
• CPC Class Codes: C07D 207/27 : with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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• CPC Class Codes: C07D 211/58 : attached in position 4
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• CPC Class Codes: C07D 211/96 : Sulfur atom
• CPC Class Codes: C07D 213/71 : to which a second hetero atom is attached
• CPC Class Codes: C07D 213/80 : in position 3
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• CPC Class Codes: C07D 213/85 : in position 3
• CPC Class Codes: C07D 215/36 : Sulfur atoms C07D215/24 takes precedence
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• CPC Class Codes: C07D 215/56 : with oxygen atoms in position 4
• CPC Class Codes: C07D 217/22 : with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
• CPC Class Codes: C07D 231/14 : with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
• CPC Class Codes: C07D 231/38 : Nitrogen atoms nitro radicals C07D231/16
• CPC Class Codes: C07D 233/84 : Sulfur atoms
• CPC Class Codes: C07D 233/90 : Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• CPC Class Codes: C07D 237/14 : Oxygen atoms
• CPC Class Codes: C07D 239/28 : with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
• CPC Class Codes: C07D 239/42 : One nitrogen atom nitro radicals C07D239/30
• CPC Class Codes: C07D 239/48 : Two nitrogen atoms
• CPC Class Codes: C07D 241/20 : Nitrogen atoms nitro radicals C07D241/16
• CPC Class Codes: C07D 241/24 : Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• CPC Class Codes: C07D 241/44 : with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
• CPC Class Codes: C07D 243/08 : not condensed with other rings
• CPC Class Codes: C07D 249/06 : with aryl radicals directly attached to ring atoms
• CPC Class Codes: C07D 249/10 : with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
• CPC Class Codes: C07D 251/46 : with oxygen or sulfur atoms attached to the two other ring carbon atoms
• CPC Class Codes: C07D 251/54 : Three nitrogen atoms
• CPC Class Codes: C07D 257/04 : Five-membered rings
• CPC Class Codes: C07D 257/06 : with nitrogen atoms directly attached to the ring carbon atom
• CPC Class Codes: C07D 261/08 : with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• CPC Class Codes: C07D 261/14 : Nitrogen atoms
• CPC Class Codes: C07D 261/18 : Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
• CPC Class Codes: C07D 263/32 : with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• CPC Class Codes: C07D 263/34 : with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
• CPC Class Codes: C07D 263/48 : Nitrogen atoms not forming part of a nitro radical
• CPC Class Codes: C07D 263/54 : Benzoxazoles; Hydrogenated benzoxazoles
• CPC Class Codes: C07D 263/58 : with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
• CPC Class Codes: C07D 265/36 : condensed with one six-membered ring
• CPC Class Codes: C07D 271/08 : 1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles
• CPC Class Codes: C07D 271/12 : condensed with carbocyclic rings or ring systems
• CPC Class Codes: C07D 275/06 : with hetero atoms directly attached to the ring sulfur atom
• CPC Class Codes: C07D 277/30 : Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• CPC Class Codes: C07D 277/36 : Sulfur atoms
• CPC Class Codes: C07D 277/56 : Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
• CPC Class Codes: C07D 277/68 : with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
• CPC Class Codes: C07D 277/82 : Nitrogen atoms
• CPC Class Codes: C07D 279/16 : condensed with one six-membered ring
• CPC Class Codes: C07D 285/06 : 1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
• CPC Class Codes: C07D 285/10 : 1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
• CPC Class Codes: C07D 285/135 : Nitrogen atoms
• CPC Class Codes: C07D 295/155 : with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
• CPC Class Codes: C07D 295/185 : from aliphatic carboxylic acids
• CPC Class Codes: C07D 295/192 : from aromatic carboxylic acids
• CPC Class Codes: C07D 295/26 : Sulfur atoms
• CPC Class Codes: C07D 307/20 : Oxygen atoms
• CPC Class Codes: C07D 307/46 : Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
• CPC Class Codes: C07D 307/68 : Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
• CPC Class Codes: C07D 307/84 : Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
• CPC Class Codes: C07D 307/86 : with an oxygen atom directly attached in position 7
• CPC Class Codes: C07D 307/91 : Dibenzofurans; Hydrogenated dibenzofurans
• CPC Class Codes: C07D 311/04 : Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
• CPC Class Codes: C07D 333/22 : Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
• CPC Class Codes: C07D 333/32 : Oxygen atoms
• CPC Class Codes: C07D 333/34 : Sulfur atoms
• CPC Class Codes: C07D 333/38 : Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• CPC Class Codes: C07D 333/62 : with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
• CPC Class Codes: C07D 333/68 : Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
• CPC Class Codes: C07D 335/06 : Benzothiopyrans; Hydrogenated benzothiopyrans
• CPC Class Codes: C07D 401/04 : directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 405/12 : linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 409/04 : directly linked by a ring-member-to-ring-member bond
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• CPC Class Codes: C07D 413/04 : directly linked by a ring-member-to-ring-member bond
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• CPC Class Codes: C07D 417/04 : directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 417/12 : linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 471/04 : Ortho-condensed systems
• CPC Class Codes: C07D 473/06 : with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
• CPC Class Codes: C07D 473/08 : with methyl radicals in positions 1 and 3, e.g. theophylline
• CPC Class Codes: C07D 473/16 : two nitrogen atoms
• CPC Class Codes: C07D 487/04 : Ortho-condensed systems
• CPC Class Codes: C07D 495/04 : Ortho-condensed systems

Abstract

Disclosed are compounds of the formula

wherein the variables R_N, R_C, R₁, R₂₅, R₂, and R₃ are as defined herein. These compounds have activity as inhibitors of beta-secretase and are therefore useful in treating a variety of discorders such as Alzheimer'"'"'s Disease.

Claims

1. A compound of the formula

2. A compound of the formula:

3. A compound of the formula

4. A compound according to claim 3 of the formula

5. A compound according to claim 4 wherein R₄₁ and R₄₂ are both hydrogen.

6. A compound according to claim 4 wherein

R₃₅ is phenyl, cyclohexyl, —

S-phenyl, benzodioxole, thienyl, C₃-C₆ alkyl, furanyl, each of which is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C₁-C₄ alkyl, C₁-C₄ alkoxy, OH, hydroxy C₁-C₆ alkyl, halogen, halo C₁-C₆ alkyl, halo C₁-C₆ alkoxy, —

O—

-(C₁-C₆ alkyl)-phenyl, —

CO₂—

(C₁-C₆ alkyl), —

(C₁-C₄ alkyl)-(C₅-C₆ cycloalkyl).

7. A compound according to claim 3 wherein

R₃₅ is phenyl, cyclohexyl, —

S-phenyl, benzodioxole, thienyl, C₃-C₆ alkyl, furanyl, each of which is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C₁-C₄ alkyl, C₁-C₄ alkoxy, OH, hydroxy C₁-C₆ alkyl, halogen, halo C₁-C₆ alkyl, halo C₁-C₆ alkoxy, —

O—

(C₁-C₆ alkyl) -phenyl, —

CO₂—

(C₁-C₆ alkyl), —

(C₁-C₄ alkyl)-(C₅-C₆ cycloalkyl);

R₄₀ is phenyl, -phenyl-pyridine, biphenyl, -phenyl-benzothienyl, -phenyl-thienyl, -phenyl-furanyl, -phenyl-pyrimidinyl, -phenyl-isooxazolyl, —

C(O)-pyridyl, —

(C₁-C₄ alkyl)-O—

C(O)NH-phenyl, —

(C₁-C₄ alkyl)-O—

C(O)N(C₁-C₆ alkyl)-phenyl, —

(C₁-C₄ alkyl)-phenyl, —

(C₁-C₄ alkyl)-SO₂NH₂, —

(C₁-C₄ alkyl)-SO₂NH(C₁-C₆ alkyl), —

(C₁-C₄ alkyl)-SO₂N(C₁-C₆ alkyl)(C₁-C₆ alkyl), CN, —

(CH₂)_0-4—

(C₃-C₈ cycloalkyl), —

(C₁-C₄ alkyl)-C(O)O-(C₁-C₄ alkyl), —

(C₁-C₄ alkyl)-R₃₃, C₁-C₈ alkyl, —

(C₁-C₄ alkyl)-NHC(O)—

(C₁-C₄ alkyl), —

(CH₂)_0-4-C(O)NH₂, —

(CH₂)_0-4—

C(O)NH(C₁-C₆ alkyl), —

(CH₂)_0-4—

C(O)N(C₁-C₆ alkyl)(C₁-C₆ alkyl), tetrahydronapthyl, dihydronaphthyl, wherein each of the above is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, halo (C₁-C₄ alkyl), —

O—

(C₁-C₄ alkyl)-phenyl wherein the phenyl is optionally substituted with 1 or 2 halogens, —

CHO, C₁-C₄ thioalkoxy, —

NHSO₂—

(C₁-C₄ alkyl), —

N(C₁-C₄ alkyl) SO₂—

(C₁-C₄ alkyl) wherein the alkyl groups are optionally substituted with 1, 2, or 3 halogens;

OH, SO₂R₃₃, R₃₃;

R₄₁ is H, cyclohexyl, phenyl, or C₁-C₆ alkyl optionally substituted with 1 or 2 groups that are phenyl, hydroxy, or C₁-C₄ thioalkoxy; and

R₄₂ is hydrogen or —

CH₂CN.

8. A compound according to claim 6 wherein

R₃₅ is phenyl, C₃-C₈ cycloalkyl, —

S-phenyl, benzodioxole, thienyl, C₃-C₆ alkyl, furanyl, each of which is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C₁-C₄ alkyl, C₁-C₄ alkoxy, OH, hydroxy C₁-C₆ alkyl, halogen, CF₃, OCF₃, —

Obenzyl, —

CO₂—

(C₁-C₆ alkyl), —

(C₁-C₄ alkyl)-(C₅-C₆ cycloalkyl);

R₄₀ is phenyl, -phenyl-pyridine, biphenyl, -phenyl-benzothienyl, -phenyl-thienyl, -phenyl-furanyl, -phenyl-pyrimidinyl, -phenyl-isoxazolyl, —

C(O)-pyridyl, —

(C₁-C₄ alkyl)-O—

C(O)NH-phenyl, —

(C₁-C₄ alkyl)-O—

C(O)N(C₁-C₆ alkyl)-phenyl, —

(C₁-C₄ alkyl)-phenyl, —

(C₁-C₄ alkyl)-SO₂NH₂, —

(C₁-C₄ alkyl)-SO₂NH(C₁-C₆ alkyl), —

(C₁-C₄ alkyl)-SO₂N(C₁-C₆ alkyl)(C₁-C₆ alkyl), CN, —

(C₁-C₄ alkyl)-(C₃-C₆ cycloalkyl), —

(C₁-C₄ alkyl)-C(O)O—

(C₁-C₄ alkyl), —

(C₁-C₄ alkyl)-R₃₃, C₁-C₈ alkyl, —

(C₁-C₄ alkyl)-NHC(O)—

(C₁-C₄ alkyl), —

C(O)NH₂, wherein each of the above rings is unsubstituted or substituted with 1, 2, or 3 groups that are independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, CF₃, —

O—

(C₁-C₄ alkyl)-phenyl wherein the phenyl is optionally substituted with 1 or 2 halogens, —

CHO, —

NHSO₂—

(C₁-C₄ alkyl), —

N(C₁-C₄ alkyl)SO₂—

(C₁-C₄ alkyl) wherein the alkyl is optionally substituted with 1, 2, or 3 halogens,

R₄₁ is H, cyclohexyl, phenyl, or C₁-C₆ alkyl optionally substituted with 1 or 2 groups that are phenyl, hydroxy, or C₁-C₄ thioalkoxy; and

R₄₂ is hydrogen or —

CH₂CN;

R₅₁ at each occurrence is independently C₁-C₆ alkyl, C₁-C₆ alkoxy, —

NHSO₂—

(C₁-C₄ alkyl) wherein the alkyl group is optionally substituted with 1, 2, or 3 halogens, —

SO₂—

NH—

(C₁-C₆ alkyl)-NH₂, —

SO₂—

NH—

(C₁-C₆ alkyl)-NH(C₁-C₄ alkyl), —

SO₂—

NH—

(C₁-C₆ alkyl)-N(C₁-C₄ alkyl) (C₁-C₄ alkyl), [1,2,4]triazolidine-3,5-dione, —

NHC(O)NH₂, —

NHC(O)NH(C₁-C₆ alkyl), —

NHC(O)N(C₁-C₆ alkyl) (C₁-C₆ alkyl), —

N(C₁-C₆ alkyl)C(O)NH₂, —

N(C₁-C₆ alkyl)C(O)NH(C₁-C₆ alkyl), —

N(C₁-C₆ alkyl)C(O)N(C₁-C₆ alkyl) (C₁-C₆ alkyl), halogen, —

CF₃, OH, —

SO₂NR₃₁R₃₂, —

C(O)NR₃₁R₃₂, —

NR₃₁R₃₂, hydroxy C₁-C₁₀ alkyl optionally substituted with phenyl or 2-methylphenyl, —

O—

(C₁-C₄ alkyl)-phenyl, —

NHC(S)NH₂, —

NHC(S)NH(C₁-C₆ alkyl), —

NHC(S)N(C₁-C₆ alkyl) (C₁-C₆ alkyl), (C₁-C₄ alkyl)-O-phenyl, —

C(O)—

(C₁-C₆ alkyl) wherein the alkyl group is optionally substituted with NH₂, N(C₁-C₆ alkyl), or N(C₁-C₆ alkyl) (C₁-C₆ alkyl);

—

O—

C₃-C₆ cycloalkyl, oxazole optionally substituted with 1, or 2 groups that are independently C₁-C₄ alkyl or phenyl, hydroxy C₁-C₄ alkoxy, aminoalkoxy, NH(C₁-C₆alkyl) -alkoxy, N(C₁-C₆alkyl) (C₁-C₆alkyl) -alkoxy,

wherein R₃₁ and R₃₂ at each occurrence are independently selected from the group consisting of hydrogen, C₁-C₆ alkyl, hydroxy C₁-C₆ alkyl, —

(C₁-C₆ alkyl)-C(O)N(C₁-C₆ alkyl)(C₁-C₆ alkyl), —

(C₁-C₆ alkyl)-NH(C₁-C₆ alkyl), —

(C₁-C₆ alkyl)-N(C₁-C₆ alkyl) (C₁-C₆ alkyl), —

(C₁-C₆ alkyl)phenyl, —

(C₁-C₆ alkyl)pyridyl, —

C(O)furanyl, (C₁-C₆ alkyl)-tetrahydrofuran, wherein

the phenyl group is unsubstituted or substituted with 1, 2, or 3 groups that are independently C₁-C₄ alkoxy, or halogen,

wherein at each occurrence R₃₁, R₃₂ and the nitrogen to which they are attached independently form a pyrrolidinyl, piperazinyl, piperidinyl, or azepanyl, each of which is optionally fused to a benzene, pyridine or pyrimidine ring and each of which is optionally substituted with hydroxy, C₁-C₆ alkyl, hydroxy C₁-C₆ alkyl, C₁-C₄ alkoxy C₁-C₆ alkyl, —

C(O)NH₂, or —

C(O)NH-benzyl.

9. A compound according to claim 8 wherein

R₃₅ is phenyl;

halophenyl, dihalophenyl;

trihalophenyl;

tetrahalophenyl;

pentahalophenyl;

halo, benzyloxyphenyl;

halo, alkylphenyl;

benzyloxyphenyl;

cyclohexyl;

(C₁-C₄ alkoxy)carbonylphenyl;

(C₁-C₄ alkoxy)phenyl;

—

S-phenyl, or benzodioxole;

R₄₁ is H, cyclohexyl, phenyl, or C₁-C₆ alkyl optionally substituted with 1 or 2 groups that are phenyl, hydroxy, or C₁-C₄ thioalkoxy; and

R₄₂ is hydrogen or —

CH₂CN.

10. A compound according to claim 9 wherein

R₃₅ is 3,5-dihalophenyl;

R₄₀ is phenyl, -phenyl-pyridine, biphenyl, -phenyl-benzothienyl, -phenyl-thienyl, -phenyl-furanyl, -phenyl-pyrimidinyl, -phenyl-isoxazolyl, —

(C₁-C₄ alkyl)-O—

C(O)NH-phenyl, —

(C₁-C₄ alkyl)-O—

C(O)N(C₁-C₆ alkyl)-phenyl, —

(C₁-C₄ alkyl)-SO₂NH₂, CN, —

(C₁-C₄ alkyl)-(C₃-C₆ cycloalkyl), —

(C₁-C₄ alkyl)-C(O)O—

(C₁-C₄ alkyl), —

(C₁-C₄ alkyl)-R₃₃, or C₁-C₈ alkyl, wherein each of the above is unsubstituted or substituted with 1, 2, or 3 groups that are independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, CF₃, —

O—

(C₁-C₄ alkyl)-phenyl wherein the phenyl is optionally substituted with 1 or 2 halogens, —

CHO, or —

NHSO₂—

(C₁-C₄ alkyl).

11. A compound according to claim 10 wherein

R₃₅ is 3,5-difluorophenyl;

3,5-dichlorophenyl;

or 3-chloro, 5-fluorophenyl; and

R₄₀ is phenyl which is unsubstituted or substituted with 1, 2, or 3 groups that are independently fluoro, chloro, bromo, iodo, methyl, ethyl, methoxy, ethoxy, CF₃, or -Obenzyl wherein the phenyl is optionally substituted with 1 or 2 groups that are independently halogen, or —

NHSO₂CH₃.

12. A compound according to claim 11 wherein

R₅, at each occurrence is independently C₁-C₆ alkyl, C₁-C₆ alkoxy, —

NHSO₂CH₃, —

SO₂—

NH-(ethyl)-NH(CH₃), [1,2,4]triazolidine-3,5-dione, —

NHC(O)NH₂, —

CF₃, OH, —

SO₂NR₃₁R₃₂, —

C(O)NR₃₁R₃₂, hydroxyoctyl, —

CH(OH)-2-methylphenyl, —

Obenzyl, or —

NHC(S)NH(CH₃);

wherein R₃₁ and R₃₂ at each occurrence are independently selected from the group consisting of hydrogen;

C₁-C₆ alkyl;

hydroxy C₁-C₆ alkyl;

—

(CH₂)C(O)N(CH₃)₂;

—

CH₂CH₂N(CH₃)₂;

benzyl which is optionally substituted with 1 or 2 groups that are independently C₁-C₄ alkyl, C₁-C₄ alkoxy or halogen;

phenethyl;

—

CH₂CH₂pyridyl;

or —

C(O)furanyl;

or

at each occurrence R₃₁, R₃₂ and the nitrogen to which they are attached independently form a pyrrolidinyl, piperazinyl, piperidinyl, or azepanyl, each of which is optionally substituted with hydroxymethyl, hydroxyethyl, methoxymethyl, or —

C(O)NH₂.

13. A compound according to claim 12 wherein

R₄₀ is 3-ethylphenyl or 3-methoxyphenyl;

and

R₄₂ is hydrogen.

14. A compound according to claim 12 wherein

R₅₁ at each occurrence is independently H, —

SO₂NH-propyl-OH, —

SO₂NH-ethyl-OH, —

SO₂NH-ethyl-OCH₃, —

SO₂NH—

CH(CH₃)₂—

CH₂OH, —

SO₂NH—

(CH₂CH(OH)CH₃), —

SO₂NH-ethyl-NH(CH₃), —

SO₂NH(CH₂CH₂OH)₂, —

SO₂NHCH(CH₃)CH₂OH, —

SO₂N(CH₃)₂, —

SO₂NH(CH₂CH(OH)CH₃), —

SO₂-pyrrolidine, —

SO₂-(2,6-dimethylpiperidine), —

SO₂-(2-propylpiperidine), —

SO₂-(hydroxypropyl), —

C(O)-(2-methoxymethylpyrrolidine), —

C(O)-(2-methylpyrrolidine), —

C(O)-(2,6-dimethylpyrrolidine), —

C(O)-(2-hydroxymethylpyrrolidine), —

C(O)N(methyl)(ethyl), —

C(O)N(methyl)(propyl), —

C(O)N(methyl)(butyl), —

C(O)N(propyl)(butyl), —

C(O)N(allyl)(cyclopentyl), —

C(O)N(allyl)(cyclohexyl), —

C(O)N(methyl) (methyl), —

C(O)N(ethyl) (ethyl), —

C(O)N(butyl)(butyl), —

C(O)N(isopropyl)(isopropyl), —

C(O)N(propyl)(propyl), —

C(O)N(methyl)(cyclohexyl), —

C(O)N(ethyl)(cyclohexyl), —

C(O)NH(cyclobutyl), —

C(O)NH(cyclopentyl), —

C(O)N(CH₃)(cyclopentyl), —

C(O)NH(2-methylcyclohexyl), —

C(O)NH(pentyl), —

C(O)N(pentyl)(pentyl), —

C(O)NH(isopentyl), —

C(O)NH(ethoxyethyl), —

C(O)N(CH₃) (methoxyethyl), —

C(O)N(propyl)(methoxyethyl), —

C(O)N(methoxyethyl)(methoxyethyl), —

C(O)N(ethoxyethyl)(ethoxyethyl), —

C(O)N(ethyl)(methoxyethyl), —

C(O)N(propyl)(hydroxyethyl), —

C(O)N(hydroxyethyl)(ethyl), ethynyl, methyl, bromo, —

N(CH₃) SO₂ (CH₃), —

N(CH₃) SO₂-thienyl, —

N(hydroxypropyl)SO₂CH₃, —

CH₂)—

SO₂—

(CH₃), or —

C(O)—

CH(CH₃)CH₂CH₂CH₃.

15. A compound according to claim 14 wherein there are two R₅₁ groups.

16. A compound according to claim 15 wherein the R₅, groups are at the 3 and 5 positions of the phenyl group.

17. A compound according to claim 11 wherein

R₅₁ at each occurrence is independently C₁-C₆ alkyl, C₁-C₆ alkoxy, —

C(O)NR₃₁R₃₂, —

C(O)CH₂NH₂, cyclopentyloxy, —

NHC(O)NH(ethyl), oxazole optionally substituted with 1 or 2 groups that are independently C₁-C₄ alkyl or phenyl, hydroxyethoxy, diethylaminoethoxy,

wherein R₃₁ and R₃₂ at each occurrence are independently selected from the group consisting of hydrogen, C₁-C₆ alkyl, hydroxy C₁-C₆ alkyl, —

CH₂-tetrahydrofuran.

18. A compound according to claim 9 wherein

R₃₅ is cyclohexyl.

19. A compound according to claim 15 wherein

R₄₀ is phenyl, or C₁-C₈ alkyl, wherein each is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, halo (C₁-C₄ alkyl);

and

R₄₂ and R₄₁ are both hydrogen.

20. A compound according to claim 16 wherein

R₄₀ is phenyl, 3-methoxyphenyl, 4-methoxyphenyl, 3-ethoxyphenyl, 4-ethoxyphenyl, 3-trifluoromethylphenyl, 4-trifluoromethylphenyl, 2-methylphenyl, 3-methylphenyl, 2-ethylphenyl, 3-ethylphenyl, or C₃-C₆ alkyl;

and

R₅₁ at each occurrence is independently C₁-C₆ alkyl, C₁-C₆ alkoxy, or halogen,

wherein R₃₁ and R₃₂ at each occurrence are independently selected from the group consisting of hydrogen, C₁-C₆ alkyl, hydroxy C₁-C₆ alkyl, and —

(C₁-C₆ alkyl)phenyl wherein the phenyl group is unsubstituted or substituted with 1, 2, or 3 groups that are independently C₁-C₄ alkoxy, or halogen,

wherein at each occurrence R₃₁, R₃₂ and the nitrogen to which they are attached independently form a pyrrolidinyl, piperazinyl, piperidinyl, or azepanyl, each of which is optionally fused to a benzene, pyridine or pyrimidine ring and each of which is optionally substituted with hydroxy, hydroxy C₁-C₆ alkyl, C₁-C₄ alkoxy C₁-C₆ alkyl, —

C(O)NH₂, or —

C(O)NH-benzyl.

21. A compound according to claim 9 wherein

R₃₅ is 3-halo, 5-benzyloxyphenyl;

3-benzyloxyphenyl;

or 4-benzyloxyphenyl;

R₄₁ is H, cyclohexyl, phenyl, or C₁-C₆ alkyl optionally substituted with 1 or 2 groups that are phenyl, hydroxy, or C₁-C₄ thioalkoxy; and

R₄₂ is hydrogen or —

CH₂CN.

22. A compound according to claim 21 wherein

R₄₀ is phenyl, -phenyl-pyridine, biphenyl, —

(C₁-C₄ alkyl)-O—

C(O)NH-phenyl, —

(C₁-C₄ alkyl)-O—

C(O)N(C₁-C₆ alkyl)-phenyl, —

(C₁-C₄ alkyl)-SO₂NH₂, —

(C₁-C₄ alkyl)-(C₃-C₆ cycloalkyl), —

(C₁-C₄ alkyl)-C(O)O—

(C₁-C₄ alkyl), —

(C₁-C₄ alkyl)-R₃₃, or C₁-C₈ alkyl, wherein each of the above is unsubstituted or substituted with 1, 2, or 3 groups that are independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, CF₃, —

Obenzyl wherein the phenyl is optionally substituted with 1 or 2 halogens, —

CHO, or —

NHSO₂—

(C₁-C₄ alkyl).

23. A compound according to claim 22 wherein

R₄₀ is phenyl or C₁-C₈ alkyl, wherein each of the above is unsubstituted or substituted with 1, 2, or 3 groups that are independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, CF₃, -Obenzyl wherein the phenyl is optionally substituted with 1 or 2 halogens, —

CHO, or —

NHSO₂—

(C₁-C₄ alkyl); and

R₄₁ is hydrogen or C₁-C₆ alkyl optionally substituted with 1 or 2 groups that are phenyl, hydroxy, or C₁-C₄ thioalkoxy;

R₄₂ is hydrogen; and

R₅₁ at each occurrence is independently C₁-C₆ alkyl, C₁-C₆ alkoxy, —

NHSO₂—

(C₁-C₄ alkyl) wherein the alkyl group is optionally substituted with 1, 2, or 3 halogens, —

SO₂—

NH—

(C₁-C₆ alkyl)-NH₂, —

SO₂—

NH—

(C₁-C₆ alkyl)-NH(C₁-C₄ alkyl), —

SO₂—

NH—

(C₁-C₆ alkyl)-N(C₁-C₄ alkyl) (C₁-C₄ alkyl), —

NHC(O)NH₂, —

NHC(O)NH(C₁-C₆ alkyl), —

NHC(O)N(C₁-C₆ alkyl) (C₁-C₆ alkyl), —

N(C₁-C₆ alkyl)C(O)NH₂, —

N(C₁-C₆ alkyl)C(O)NH(C₁-C₆ alkyl), —

N(C₁-C₆ alkyl)C(O)N(C₁-C₆ alkyl) (C₁-C₆ alkyl), halogen, —

CF₃, OH, —

SO₂NR₃₁R₃₂, —

C(O)NR₃₁R₃₂, —

NR₃₁R₃₂, hydroxy C₁-C₁₀ alkyl, —

Obenzyl, —

NHC(S)NH₂, —

NHC(S)NH(C₁-C₆ alkyl), —

NHC(S)N(C₁-C₆ alkyl) (C₁-C₆ alkyl), (C₁-C₄ alkyl)-O-phenyl, —

C(O)—

(C₁-C₆ alkyl), —

O-cyclopentyl, —

O-cyclohexyl, hydroxy C₁-C₄ alkoxy, aminoalkoxy, NH(C₁-C₆alkyl)-alkoxy, N(C₁-C₆alkyl) (C₁-C₆alkyl)-alkoxy,

wherein R₃₁ and R₃₂ at each occurrence are independently selected from the group consisting of hydrogen, C₁-C₆ alkyl, hydroxy C₁-C₆ alkyl, —

(C₁-C₆ alkyl)-NH(C₁-C₆ alkyl), —

(C₁-C₆ alkyl)-N(C₁-C₆ alkyl) (C₁-C₆ alkyl), and benzyl wherein the phenyl group is unsubstituted or substituted with 1, or 2 groups that are independently C₁-C₄ alkoxy, or halogen,

wherein at each occurrence R₃₁, R₃₂ and the nitrogen to which they are attached independently form a pyrrolidinyl, piperazinyl, or piperidinyl, each of which is optionally substituted with hydroxy, hydroxy C₁-C₆ alkyl, C₁-C₄ alkoxy C₁-C₆ alkyl, —

C(O)NH₂, or —

C(O)NH-benzyl.

24. A compound according to claim 23 wherein

R₄₀ is phenyl or C₁-C₈ alkyl, wherein each of the above is unsubstituted or substituted with 1, 2, or 3 groups that are independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, or CF₃;

and

R₅₁ at each occurrence is independently C₁-C₆ alkyl, C₁-C₆ alkoxy, —

NHSO₂CH₃, —

NHSO₂CF₃, halogen, —

CF₃, OH, —

SO₂NR₃₁R₃₂, —

C(O)NR₃₁R₃₂, —

NR₃₁R₃₂, hydroxy C₁-C₁₀ alkyl, hydroxy C₁-C₄ alkoxy, aminoalkoxy, NH(C₁-C₆alkyl)-alkoxy, N(C₁-C₆alkyl) (C₁-C₆alkyl) -alkoxy,

wherein R₃₁ and R₃₂ at each occurrence are independently selected from the group consisting of hydrogen, C₁-C₆ alkyl, hydroxy C₁-C₆ alkyl, and benzyl wherein the phenyl group is unsubstituted or substituted with 1 or 2 groups that are independently methoxy, ethoxy, or halogen, or

wherein at each occurrence R₃₁, R₃₂ and the nitrogen to which they are attached independently form a pyrrolidinyl, piperazinyl, or piperidinyl ring each of which is optionally substituted with hydroxy, hydroxy C₁-C₆ alkyl, C₁-C₄ alkoxy C₁-C₆ alkyl, or —

C(O)NH₂.

25. A compound according to claim 24 wherein

R₃₅ is 3-fluoro, 5-benzyloxyphenyl or 3-chloro, 5-benzyloxyphenyl.

26. A compound according to claim 9 wherein

R₃₅ is —

S-phenyl, benzo[1,3]dioxole, furanyl, or thienyl;

R₄₁ is H, cyclohexyl, phenyl, or C₁-C₆ alkyl optionally substituted with 1 or 2 groups that are phenyl, hydroxy, or C₁-C₄ thioalkoxy; and

R₄₂ is hydrogen or —

CH₂CN.

27. A compound according to claim 26 wherein

R₄₀ is phenyl, -phenyl-pyridine, biphenyl, -phenyl-pyrimidinyl, —

(C₁-C₄ alkyl)-O—

C(O)NH-phenyl, —

(C₁-C₄ alkyl)-O—

C(O)N(C₁-C₆ alkyl)-phenyl, —

(C₁-C₄ alkyl)-SO₂NH₂, —

(C₁-C₄ alkyl)-(C₃-C₆ cycloalkyl), —

(C₁-C₄ alkyl)-C(O)O—

(C₁-C₄ alkyl), —

(C₁-C₄ alkyl)-R₃₃, or C₁-C₈ alkyl, wherein each of the above is unsubstituted or substituted with 1, 2, or 3 groups that are independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, CF₃, -Obenzyl wherein the phenyl is optionally substituted with 1 or 2 halogens, —

CHO, or —

NHSO₂—

(C₁-C₄ alkyl), —

NHSO₂CF₃.

28. A compound according to claim 27 wherein

R₅₁ at each occurrence is independently selected from the group consisting of

C₁-C₄ alkyl, —

C(O)N(C₁-C₆ alkyl)(C₁-C₆ alkyl), —

C(O)NH₂, —

C(O)N(C₂-C₆ alkenyl)(C₃-C₈ cycloalkyl), —

C(O)NH(C₃-C₈ cycloalkyl), —

C(O)NH(C₁-C₆ alkyl), C(O)-(pyrrolidine) optionally substituted with 1 or two groups that are independently alkoxyalkyl or hydroxy, halogen, —

C(O)N(C₁-C₆ hydroxyalkyl) (C₁-C₆ alkyl), —

C(O)NH(alkoxyalkyl), —

C(O)N(alkoxyalkyl)(alkoxyalkyl), —

C(O)N(C₁-C₆ alkyl) (alkoxyalkyl), —

C(O)N(C₁-C₆ hydroxyalkyl) (alkyl), —

NHSO₂CF₃, —

N(C₁-C₆ alkyl)-SO₂-thienyl, —

N(C₁-C₆ hydroxyalkyl)SO₂—

(C₁-C₆ alkyl), —

NHC(O)C₁-C₄ alkyl, oxazolyl optionally substituted with 1 or 2 methyl groups, thiazolyl optionally substituted with 1 or 2 methyl groups, pyrazolyl optionally substituted with 1 or 2 methyl groups, imidazolyl optionally substituted with 1 or 2 methyl groups, isoxazolyl optionally substituted with 1 or 2 methyl groups, pyrimidinyl optionally substituted with 1 or 2 methyl or halogen groups, —

NHSO₂CH₃, —

NHSO₂-imidazolyl wherein the imidazole ring is optionally substituted with 1 or 2 methyl groups, —

N(C₁-C₆ alkyl)SO₂(C₁-C₆ alkyl), —

SO₂NH—

C₁-C₆ hydroxyalkyl, —

SO₂NH—

C₁-C₆ alkyl-NH(C₁-C₄ alkyl), —

SO₂-piperazinyl optionally substituted with 1 or 2 methyl groups, —

SO₂-pyrrolidine optionally substituted with 1 or 2 methyl groups, —

SO₂-piperidine optionally substituted with 1 or 2 C₁-C₄ alkyl groups, —

SO₂N(C₁-C₄ hydroxyalkyl) (C₁-C₄ hydroxyalkyl), —

SO₂NH₂, —

SO₂N(C₁-C₆ alkyl) (C₁-C₆ alkyl), C₂-C₆ alkynyl, —

SO₂—

(C₁-C₆ hydroxyalkyl), —

SO₂NH(C₁-C₆ hydroxyalkyl), —

SO₂N(C₁-C₆ alkyl) (C₁-C₆ hydroxyalkyl), —

(C₁-C₄ alkyl)-SO₂—

(C₁-C₄ alkyl), or —

C(O)—

(C₁-C₁₀ alkyl).

29. A compound according to claim 28 wherein

R₅₁ at each occurrence is independently selected from the group consisting of —

SO₂NH-propyl-OH, —

SO₂NH-ethyl-OH, —

SO₂NH-ethyl-OCH₃, —

SO₂NH—

CH(CH₃)₂—

CH₂OH, —

SO₂NH—

(CH₂CH(OH)CH₃), —

SO₂NH-ethyl-NH(CH₃), —

SO₂NH (—

CH₂CH₂OH)₂, —

SO₂NHCH(CH₃)CH₂OH, —

SO₂N(CH₃)₂, —

SO₂NH(CH₂CH(OH)CH₃), —

SO₂-pyrrolidine, —

SO₂-(2,6-dimethylpiperidine), —

SO₂-(2-propylpiperidine), —

SO₂-(hydroxypropyl), —

C(O)-(2-methoxymethylpyrrolidine), —

C(O)-(2-methylpyrrolidine), —

C(O)-(2,6-dimethylpyrrolidine), —

C(O)-(2-hydroxymethylpyrrolidine), —

C(O)N(methyl)(ethyl), —

C(O)N(methyl)(propyl), —

C(O)N(methyl)(butyl), —

C(O)N(propyl)(butyl), —

C(O)N(allyl)(cyclopentyl), —

C(O)N(allyl)(cyclohexyl), —

C(O)N(methyl) (methyl), —

C(O)N(ethyl) (ethyl), —

C(O)N(butyl)(butyl), —

C(O)N(isopropyl)(isopropyl), —

C(O)N(propyl)(propyl), —

C(O)N(methyl)(cyclohexyl), —

C(O)N(ethyl)(cyclohexyl), —

C(O)NH(cyclobutyl), —

C(O)NH(cyclopentyl), —

C(O)N(CH₃)(cyclopentyl), —

C(O)NH(2-methylcyclohexyl), —

C(O)NH(pentyl), —

C(O)N(pentyl)(pentyl), —

C(O)NH(isopentyl), —

C(O)NH(ethoxyethyl), —

C(O)N(CH₃) (methoxyethyl), —

C(O)N(propyl)(methoxyethyl), —

C(O)N(methoxyethyl)(methoxyethyl), —

C(O)N(ethoxyethyl)(ethoxyethyl), —

C(O)N(ethyl)(methoxyethyl), —

C(O)N(propyl)(hydroxyethyl), —

C(O)N(hydroxyethyl)(ethyl), ethynyl, methyl, bromo, —

N(CH₃)SO₂(CH₃), —

N(CH₃)SO₂-thienyl, —

N(hydroxypropyl)SO₂CH₃, —

(CH₂)—

SO₂—

(CH₃), or —

C(O)—

CH(CH₃)CH₂CH₂CH₃.

30. A compound according to claim 27 wherein

R₄₀ is phenyl or C₁-C₈ alkyl, wherein each of the above is unsubstituted or substituted with 1, 2, or 3 groups that are independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, CF₃, —

Obenzyl wherein the phenyl is optionally substituted with 1 or 2 halogens, —

CHO, or —

NHSO₂—

(C₁-C₄ alkyl); and

R₄₁ is hydrogen or C₁-C₆ alkyl optionally substituted with 1 or 2 groups that are phenyl, hydroxy, or C₁-C₄ thioalkoxy; and

;

R₄₂ is hydrogen; and

R₅₁ at each occurrence is independently C₁-C₆ alkyl, C₁-C₆ alkoxy, —

NHSO₂—

(C₁-C₄ alkyl) wherein the alkyl group is optionally substituted with 1, 2, or 3 halogens, —

SO₂—

NH—

(C₁-C₆ alkyl)-NH₂, —

SO₂—

NH—

(C₁-C₆ alkyl)-NH(C₁-C₄ alkyl), —

SO₂—

NH—

(C₁-C₆ alkyl)-N(C₁-C₄ alkyl) (C₁-C₄ alkyl), —

NHC(O)NH₂, —

NHC(O)NH(C₁-C₆ alkyl), —

NHC(O)N(C₁-C₆ alkyl) (C₁-C₆ alkyl), —

N(C₁-C₆ alkyl)C(O)NH₂, —

N(C₁-C₆ alkyl)C(O)NH(C₁-C₆ alkyl), —

N(C₁-C₆ alkyl)C(O)N(C₁-C₆ alkyl) (C₁-C₆ alkyl), halogen, —

CF₃, OH, —

SO₂NR₃₁R₃₂, —

C(O)NR₃₁R₃₂, —

NR₃₁R₃₂, hydroxy C₁-C₁₀ alkyl, —

Obenzyl, —

NHC(S)NH₂, —

NHC(S)NH(C₁-C₆ alkyl), —

NHC(S)N(C₁-C₆ alkyl) (C₁-C₆ alkyl), (C₁-C₄ alkyl)-O-phenyl, —

C(O)—

(C₁-C₆ alkyl), —

O-cyclopentyl, —

O-cyclohexyl, hydroxy C₁-C₄ alkoxy, aminoalkoxy, NH(C₁-C₆ alkyl)-alkoxy, N(C₁-C₆ alkyl) (C₁-C₆ alkyl)-alkoxy,

wherein R₃₁ and R₃₂ at each occurrence are independently selected from the group consisting of hydrogen, C₁-C₆ alkyl, hydroxy C₁-C₆ alkyl, —

(C₁-C₆ alkyl)-NH(C₁-C₆ alkyl), —

(C₁-C₆ alkyl)-N(C₁-C₆ alkyl) (C₁-C₆ alkyl), and benzyl wherein the phenyl group is unsubstituted or substituted with 1, or 2 groups that are independently C₁-C₄ alkoxy, or halogen,

wherein at each occurrence R₃₁, R₃₂ and the nitrogen to which they are attached independently form a pyrrolidinyl, piperazinyl, or piperidinyl, each of which is optionally substituted with hydroxy, hydroxy C₁-C₆ alkyl, C₁-C₄ alkoxy C₁-C₆ alkyl, —

C(O)NH₂, or —

C(O)NH-benzyl.

31. A compound according to claim 30 wherein

R₄₀ is phenyl or C₁-C₈ alkyl, wherein each of the above is unsubstituted or substituted with 1, 2, or 3 groups that are independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, or CF₃;

and

R₅₁ at each occurrence is independently C₁-C₆ alkyl, C₁-C₆ alkoxy, —

NHSO₂CH₃, —

NHSO₂CF₃, halogen, —

CF₃, OH, —

SO₂NR₃₁R₃₂, —

C(O)NR₃₁R₃₂, —

NR₃₁R₃₂, hydroxy C₁-C₁₀ alkyl, hydroxy C₁-C₄ alkoxy, aminoalkoxy, NH(C₁-C₆alkyl)-alkoxy, N(C₁-C₆alkyl) (C₁-C₆alkyl) -alkoxy,

wherein R₃₁ and R₃₂ at each occurrence are independently selected from the group consisting of hydrogen, C₁-C₆ alkyl, hydroxy C₁-C₆ alkyl, and benzyl wherein the phenyl group is unsubstituted or substituted with 1 or 2 groups that are independently methoxy, ethoxy, or halogen, or

wherein at each occurrence R₃₁, R₃₂ and the nitrogen to which they are attached independently form a pyrrolidinyl, piperazinyl, or piperidinyl ring each of which is optionally substituted with hydroxy, hydroxy C₁-C₆ alkyl, C₁-C₄ alkoxy C₁-C₆ alkyl, or —

C(O)NH₂.

40. A compound according to claim 3 wherein

R₃₀ is pyridyl or pyrimidyl wherein each is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently selected from the group consisting of

C₁-C₁₀ alkyl optionally substituted with 1 phenyl or 1 CN;

OH, hydroxy C₁-C₁₀ alkyl optionally substituted with phenyl or (C₁-C₄ alkyl)phenyl, C₁-C₆ alkoxy optionally substituted with 1 or 2 groups that are independently hydroxy or phenyl;

haloalkyl, haloalkoxy, (CH₂)_0-4C(O)NR₃₁R₃₂, —

NR₃₁—

SO₂—

(C₁-C₆ alkyl) wherein the alkyl group is optionally substituted with 1, 2, or 3 groups that are independently halogen or R₃₃, —

SO₂—

NH(C₁-C₆ alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently halogen, OH, alkoxy, or R₃₃;

—

(C₁-C₆ alkyl)-SO₂—

(C₁-C₆ alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently halogen, OH, C₁-C₄ alkoxy, or R₃₃;

—

SO₂—

(C₁-C₆ alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently OH or C₁-C₄ alkoxy, —

SO₂—

N(C₁-C₆ alkyl) (C₁-C₆ alkyl) wherein each alkyl group is optionally substituted with 1 or 2 groups that are independently halogen, OH or R₃₃;

—

SO₂—

NH(C₁-C₆ alkyl)-phenyl wherein the phenyl is optionally substituted with 1 or 2 groups that are independently C₁-C₄ alkoxy or halogen, —

(C₁-C₆ alkyl)-O-phenyl, —

(C₁-C₆ alkyl)-O—

(C₁-C₆ alkyl)-phenyl, triazolidine-3,5-dione, halogen, —

NHC(O)NH₂, —

NHC(O)NH(C₁-C₆ alkyl), —

NHC(O)N(C₁-C₆ alkyl) (C₁-C₆ alkyl), —

N(C₁-C₆ alkyl)C(O)NH₂, —

N(C₁-C₆ alkyl)C(O)NH(C₁-C₆ alkyl), —

N(C₁-C₆ alkyl)C(O)N(C₁-C₆ alkyl) (C₁-C₆ alkyl), —

(C₁-C₆ alkyl) thienyl, —

(C₁-C₆ alkyl) furanyl, —

S—

(C₁-C₆ alkyl) phenyl, —

SO₂NR₃₁R₃₂, —

C(O)—

NR₃₁R₃₂, —

NR₃₁R₃₂, dithiane, —

NHC(S)NH₂, —

NHC(S)NH(C₁-C₆ alkyl), —

NHC(S)N(C₁-C₆ alkyl) (C₁-C₆ alkyl), —

CO₂(C₁-C₆ alkyl), tetrahydropyran, phenyl optionally substituted with 1 or 2 groups that are independently F, Cl or Br;

pyridine, —

C₂-C₄ alkynyl-phenyl, —

O—

C₃-C₈ cycloalkyl, —

O—

(C₁-C₆ alkyl)-R₃₃;

pyrrole optionally substituted with one or two methyl groups;

2,3-dihydro-benzofuran;

benzo[1,2,5]oxadiazole, —

C(O)—

(C₁-C₁₀ alkyl) wherein the alkyl group is optionally substituted with NH₂, N(C₁-C₆ alkyl), or N(C₁-C₆ alkyl) (C₁-C₆ alkyl);

—

C(O)NH-phenyl, —

C(O)N(C₁-C₆ alkyl)-phenyl, 4,4-dimethyl-4,5-dihydro-oxazole, —

(C₁-C₆ alkyl)-S-pyridine, —

(C₁-C₆ alkyl)-SO₂-pyridine, —

(C₁-C₆ thioalkoxy)-pyridine, thiazole optionally substituted with 1 or 2 methyl groups, pyrazole, —

S—

(C₁-C₆ alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently CN or OH;

indole, (C₁-C₆ thioalkoxy)-(C₁-C₆ alkyl), C₂-C₈ alkynyl, —

(CH₂)_0-4—

SO₂—

(C₁-C₁₀alkyl) wherein the alkyl group is optionally substituted with OH;

—

NHC(O)NH(C₃-C₈ cycloalkyl), —

N(C₁-C₆ alkyl)C(O)NH(C₃-C₈ cycloalkyl), —

N(C₁-C₆ alkyl)C(O)N(C₁-C₆ alkyl)(C₃-C₈ cycloalkyl), —

NHC(O)N(C₁-C₆ alkyl) (C₃-C₈ cycloalkyl), —

(C₁-C₆ alkoxy)-(C₁-C₆ thioalkoxy);

—

CO₂—

(C₁-C₆ alkyl) wherein the alkyl group is optionally substituted with phenyl;

—

C(O)-furan; and

imidazolyl;

wherein R₃₁ and R₃₂ at each occurrence are independently selected from the group consisting of hydrogen, C₁-C₈ alkyl, C₂-C₈ alkenyl, hydroxy C₁-C₆ alkyl, C₁-C₆ haloalkyl, C₁-C₆ alkoxy C₁-C₆ alkyl, —

(CH₂)_0-4—

SO₂—

(C₁-C₆ alkyl) wherein the alkyl is optionally substituted with 1, 2, 3 or 4 independently selected halogen atoms;

—

(CH₂)_0-4—

SO₂-imidazolyl, —

(C₁-C₆ alkyl)-C(O)NH₂, —

(C₁-C₆ alkyl)-C(O)NH(C₁-C₆ alkyl), —

(C₁-C₆ alkyl)-C(O)N(C₁-C₆ alkyl) (C₁-C₆ alkyl), —

(C₁-C₆ alkyl)-NH₂₁—

(C₁-C₆ alkyl)-NH(C₁-C₆ alkyl), —

(C₁-C₆ alkyl)-N(C₁-C₆ alkyl) (C₁-C₆ alkyl), —

(C₁-C₆ alkyl)phenyl, —

(C₁-C₆ alkyl)pyridyl, —

C(O)furanyl, (C₁-C₆ alkyl)-tetrahydrofuran, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, —

CO₂—

(C₁-C₆ alkyl), —

(C₁-C₆ alkyl)-furanyl, —

(CH₂)_0-4—

SO₂-thienyl, -pyrrolidinyl-benzyl, —

(C₁-C₆ thioalkoxy)-(C₁-C₆ alkyl), —

C(O)—

(C₁-C₆ alkyl), (C₁-C₆ alkoxy), —

(C₂-C₆ alkenyloxy), —

(C₁-C₆ alkyl)-CO₂—

(C₁-C₆ alkyl), and —

C(O)-piperidinyl optionally substituted with C₁-C₆ alkyl;

wherein

the phenyl and pyridyl groups are unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C₁-C₄ alkyl, hydroxy, C₁-C₄ alkoxy, halogen, or

R₃₁, R₃₂ and the nitrogen to which they are attached form a 5, 6, or 7 membered heterocycloalkyl or a 6 membered heteroaryl ring, each of which is optionally fused to a benzene, pyridine or pyrimidine ring and each of which is optionally substituted with C₁-C₆ alkoxy, hydroxy, hydroxy C₁-C₆ alkyl, C₁-C₄ alkoxy C₁-C₆ alkyl, —

C(O)NH₂, —

C(O)NH—

(C₁-C₆ alkyl)-phenyl; and

R₃₃ at each occurrence is independently, H, NH₂, NH(C₁-C₆ alkyl), N(C₁-C₆ alkyl) (C₁-C₆ alkyl), N(C₁-C₆ alkyl) (phenyl), N(C₁-C₆ alkyl) (benzyl).

41. A compound according to claim 40 wherein

R₃₅ is phenyl;

halophenyl, dihalophenyl;

trihalophenyl;

tetrahalophenyl;

pentahalophenyl;

phenyl substituted with one halogen and one benzyloxy group;

phenyl substituted with one halogen and one alkyl group;

benzyloxyphenyl;

cyclohexyl;

(C₁-C₄ alkoxy) carbonylphenyl;

(C₁-C₄ alkoxy)phenyl;

—

S-phenyl, or benzodioxole.

42. A compound according to claim 41 wherein

R₄₀ is phenyl, -phenyl-pyridine, biphenyl, -phenyl-benzothienyl, -phenyl-thienyl, -phenyl-furanyl, -phenyl-pyrimidinyl, -phenyl-isoxazolyl, —

(C₁-C₄ alkyl)-O—

C(O)NH-phenyl, —

(C₁-C₄ alkyl)-O—

C(O)N(C₁-C₆ alkyl)-phenyl, —

(C₁-C₄ alkyl)-SO₂NH₂, CN, —

(C₁-C₄ alkyl)-(C₃-C₆ cycloalkyl), —

(C₁-C₄ alkyl)-C(O)O—

(C₁-C₄ alkyl), —

(C₁-C₄ alkyl)-R₃₃, C₁-C₈ alkyl, pyridyl, or pyrimidyl, wherein each of the above is unsubstituted or substituted with 1, 2, or 3 groups that are independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, CF₃, —

O—

(C₁-C₄ alkyl)-phenyl wherein the phenyl is optionally substituted with 1 or 2 halogens, —

CHO, or —

NHSO₂—

(C₁-C₄ alkyl).

43. A compound according to claim 42 wherein

R₃₀ is pyridyl or pyrimidyl wherein each of the above is unsubstituted or substituted with 1, 2, or 3 groups that are independently selected from the group consisting of —

SO₂NR₃₁R₃₂, —

C(O)—

NR₃₁R₃₂, —

NR₃₁R₃₂, C₁-C₄ alkyl, halogen, C₁-C₄ alkoxy,

C₆ alkyl), —

(C₁-C₆ alkyl)-NH₂, —

(C₁-C₆ alkyl)-NH(C₁-C₆ alkyl), —

(C₁-C₆ alkyl)-N(C₁-C₆ alkyl)(C₁-C₆ alkyl), —

(C₁-C₆ alkyl)phenyl, and —

(C₁-C₆ alkyl)pyridyl, wherein

R₃₁ and R₃₂ at each occurrence are independently selected from the group consisting of hydrogen, C₁-C₆ alkyl, C₂-C₆ alkenyl, hydroxy C₁-C₆ alkyl, C₁-C₆ haloalkyl, C₁-C₆ alkoxy C₁-C₆ alkyl, —

(CH₂)_0-4—

SO₂—

(C₁-C₆ alkyl)-, (C₁-C₆ alkyl)-C(O)NH₂, —

(C₁-C₆ alkyl)-C(O)NH(C₁-C₆ alkyl), —

(C₁-C₆ alkyl)-C(O)N(C₁-C₆ alkyl)(C₁-C₆ alkyl), -(C₁-C₆ alkyl)-NH₂, —

(C₁-C₆ alkyl)-NH(C₁-C₆ alkyl), —

(C₁-C₆ alkyl)-N(C₁-C₆ alkyl) (C₁-C₆ alkyl), —

(C₁-C₆ alkyl)phenyl, —

(C₁-C₆ alkyl)pyridyl, —

C(O)furanyl, (C₁-C₆ alkyl)-tetrahydrofuran, or

R₃₁, R₃₂ and the nitrogen to which they are attached form a pyrrolidinyl, piperidinyl, piperazinyl, pyridyl, or pyrimidyl ring each of which is optionally fused to a benzene, pyridine or pyrimidine ring and each of which is optionally substituted with C₁-C₆ alkoxy, hydroxy, hydroxy C₁-C₆ alkyl, C₁-C₄ alkoxy C₁-C₆ alkyl, —

C(O)NH₂, —

C(O)NH—

(C₁-C₆ alkyl)-phenyl.

44. A compound according to claim 43 wherein

R₄₀ is phenyl, pyridyl, or pyrimidyl, wherein each of the above is unsubstituted or substituted with 1, 2, or 3 groups that are independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, CF₃, —

O—

(C₁-C₄ alkyl)-phenyl wherein the phenyl is optionally substituted with 1 or 2 halogens, —

CHO, or —

NHSO₂—

(C₁-C₄ alkyl).

45. A compound according to claim 44 wherein

R₃₅ is phenyl;

halophenyl, or dihalophenyl.

46. A compound according to claim 45 wherein

R₃₀ is pyridyl which is unsubstituted or substituted with 1 or 2 groups that are independently selected from the group consisting of

C₁-C₄ alkyl, —

C(O)N(C₁-C₆ alkyl) (C₁-C₆ alkyl), —

C(O)NH₂, —

C(O)N(C₂-C₆ alkenyl) (C₃-C₈ cycloalkyl), —

C(O)NH(C₃-C₈ cycloalkyl), —

C(O)NH(C₁-C₆ alkyl), C(O)-(pyrrolidine) optionally substituted with 1 or two groups that are independently alkoxyalkyl or hydroxy, halogen, —

C(O)N(C₁-C₆ hydroxyalkyl) (C₁-C₆ alkyl), —

C(O)NH(alkoxyalkyl), —

C(O)N(alkoxyalkyl) (alkoxyalkyl), —

C(O)N(C₁-C₆ alkyl) (alkoxyalkyl), —

C(O)N(C₁-C₆ hydroxyalkyl) (alkyl), —

NHSO₂CF₃, —

N(C₁-C₆ alkyl)-SO₂-thienyl, —

N(C₁-C₆ hydroxyalkyl)SO₂—

(C₁-C₆ alkyl), —

NHC(O)C₁-C₄ alkyl, oxazolyl optionally substituted with 1 or 2 methyl groups, thiazolyl optionally substituted with 1 or 2 methyl groups, pyrazolyl optionally substituted with 1 or 2 methyl groups, imidazolyl optionally substituted with 1 or 2 methyl groups, isoxazolyl optionally substituted with 1 or 2 methyl groups, pyrimidinyl optionally substituted with 1 or 2 methyl or halogen groups, —

NHSO₂CH₃, —

NHSO₂-imidazolyl wherein the imidazole ring is optionally substituted with 1 or 2 methyl groups, —

N(C₁-C₆ alkyl)SO₂(C₁-C₆ alkyl), —

SO₂NH—

C₁-C₆ hydroxyalkyl, —

SO₂NH—

C₁-C₆ alkyl-NH(C₁-C₄ alkyl), —

SO₂-piperazinyl optionally substituted with 1 or 2 methyl groups, —

SO₂-pyrrolidine optionally substituted with 1 or 2 methyl groups, —

SO₂-piperidine optionally substituted with 1 or 2 C₁-C₄ alkyl groups, —

SO₂N(C₁-C₄ hydroxyalkyl) (C₁-C₄ hydroxyalkyl), —

SO₂NH₂, —

SO₂N(C₁-C₆ alkyl) (C₁-C₆ alkyl), C₂-C₆ alkynyl, —

SO₂—

(C₁-C₆ hydroxyalkyl), —

SO₂NH(C₁-C₆ hydroxyalkyl), —

SO₂N(C₁-C₆ alkyl) (C₁-C₆ hydroxyalkyl), —

(C₁-C₄ alkyl)-SO₂—

(C₁-C₄ alkyl), or —

C(O)-(C₁-C₁₀ alkyl).

47. A compound according to claim 46 wherein

R₃₀ is pyridyl which is unsubstituted or substituted with at least one group which is —

SO₂NH-propyl-OH, —

SO₂NH-ethyl-OH, —

SO₂NH-ethyl-OCH₃, —

SO₂NH—

CH(CH₃)₂—

CH₂OH, —

SO₂NH—

(CH₂CH(OH)CH₃), —

SO₂NH-ethyl-NH(CH₃), —

SO₂NH(—

CH₂CH₂OH)₂, —

SO₂NHCH(CH₃)CH₂OH, —

SO₂N(CH₃)₂, —

SO₂NH(CH₂CH(OH)CH₃), —

SO₂-pyrrolidine, —

SO₂-(2,6-dimethylpiperidine), —

SO₂-(2-propylpiperidine), —

SO₂-(hydroxypropyl), —

C(O)-(2-methoxymethylpyrrolidine), —

C(O)-(2-methylpyrrolidine), —

C(O)-(2,6-dimethylpyrrolidine), —

C(O)-(2-hydroxymethylpyrrolidine), —

C(O)N(methyl)(ethyl), —

C(O)N(methyl)(propyl), —

C(O)N(methyl)(butyl), —

C(O)N(propyl)(butyl), —

C(O)N(allyl)(cyclopentyl), —

C(O)N(allyl)(cyclohexyl), —

C(O)N(methyl)(methyl), —

C(O)N(ethyl)(ethyl), —

C(O)N(butyl)(butyl), —

C(O)N(isopropyl)(isopropyl), —

C(O)N(propyl)(propyl), —

C(O)N(methyl)(cyclohexyl), —

C(O)N(ethyl)(cyclohexyl), —

C(O)NH(cyclobutyl), —

C(O)NH(cyclopentyl), —

C(O)N(CH₃) (cyclopentyl), —

C(O)NH(2-methylcyclohexyl), —

C(O)NH(pentyl), —

C(O)N(pentyl)(pentyl), —

C(O)NH(isopentyl), —

C(O)NH(ethoxyethyl), —

C(O)N(CH₃) (methoxyethyl), —

C(O)N(propyl) (methoxyethyl), —

C(O)N(methoxyethyl)(methoxyethyl), —

C(O)N(ethoxyethyl)(ethoxyethyl), —

C(O)N(ethyl)(methoxyethyl), —

C(O)N(propyl)(hydroxyethyl), —

C(O)N(hydroxyethyl)(ethyl), ethynyl, methyl, bromo, —

N(CH₃)SO₂(CH₃), —

N(CH₃)SO₂-thienyl, —

N(hydroxypropyl)SO₂CH₃, —

(CH₂)—

SO₂—

(CH₃), or —

C(O)—

CH(CH₃)CH₂CH₂CH₃.

32. A compound of the formula:

33. A compound according to claim 32 wherein

R₃₀ is selected from the group consisting of phenyl, pyrrolidinonyl, pyridyl, piperidinyl, furyl, cyclopropyl, and thienyl, wherein each of the above is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently selected from the group consisting of

C₁-C₁₀ alkyl, hydroxy, hydroxy C₁-C₁₀ alkyl C₁-C₆ alkoxy, —

NR₃₁—

SO₂—

(C₁-C₆ alkyl), —

SO₂—

NH(C₁-C₆ alkyl), —

SO₂—

N(C₁-C₆ alkyl) (C₁-C₆ alkyl), halogen, —

NHC(O)NH₂, —

N(C₁-C₆ alkyl)C(O)NH₂, —

N(C₁-C₆ alkyl)C(O)NH(C₁-C₆ alkyl), —

N(C₁-C₆ alkyl)C(O)N(C₁-C₆ alkyl)(C₁-C₆ alkyl), —

SO₂NR₃₁R₃₂, —

C(O)—

NR₃₁R₃₂, —

NR₃₁R₃₂, —

C₂-C₄ alkynyl-phenyl, —

O—

C₃-C₆ cycloalkyl, —

O—

(C₁-C₆ alkyl)-R₃₃, benzo[1,2,5]oxadiazole, —

C(O)—

(C₁-C₆ alkyl;

wherein R₃₁ and R₃₂ at each occurrence are independently selected from the group consisting of hydrogen, C₁-C₆ alkyl, hydroxy C₁-C₆ alkyl, C₁-C₆ haloalkyl, —

(C₁-C₆ alkyl)-C(O)NH₂, —

(C₁-C₆ alkyl)-C(O)NH(C₁-C₆ alkyl), —

(C₁-C₆ alkyl)-C(O)N(C₁-C₆ alkyl)(C₁-C₆ alkyl), —

(C₁-C₆ alkyl)-NH₂, —

(C₁-C₆ alkyl)-NH(C₁-C₆ alkyl), —

(C₁-C₆ alkyl)-N(C₁-C₆ alkyl) (C₁-C₆ alkyl), benzyl, and —

C(O)furanyl, wherein

the phenyl and pyridyl groups are unsubstituted or substituted with 1, 2, or 3, groups that are independently C₁-C₄ alkyl, hydroxy, C₁-C₄ alkoxy, or halogen, or

R₃₁, R₃₂ and the nitrogen to which they are attached form a 5, 6, or 7 membered heterocycloalkyl or a 6 membered heteroaryl ring, each of which is optionally substituted with C₁-C₆ alkoxy, hydroxy, hydroxy C₁-C₆ alkyl, C₁-C₄ alkoxy C₁-C₆ alkyl, or —

C(O)NH₂;

R₃₅ is phenyl, C₃-C₆ cycloalkyl, or —

S-phenyl, each of which is unsubstituted or substituted with 1, 2, or 3 groups that are independently C₁-C₄ alkyl, C₁-C₄ alkoxy, CF₃, OCF₃, halogen, —

Obenzyl, —

CO₂—

(C₁-C₆ alkyl), —

(C₁-C₄ alkyl)-(C₅-C₆ cycloalkyl);

R₄₂ is H, C₁-C₆ alkyl, benzyl, —

NHC(O)—

(C₁-C₆ alkyl), or —

NHC(O)-phenyl wherein the phenyl is optionally substituted with 1 or 2 alkyl groups,

R₅₅ is cyclohexyl;

azepanone;

phenyl;

piperidinyl;

—

SO₂-phenyl;

pyrrolidinyl;

or 4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine;

wherein each is optionally substituted with —

C(O)NH₂;

C₁-C₆ alkoxycarbonyl;

—

O—

(C₁-C₆ alkyl)-C(O)NR₃₁R₃₂;

—

(C₁-C₆ alkyl)-phenyl;

4,5-dihydro-2H-pyridazin-3-one;

cyclopentyl which is optionally substituted with one CN group, phenyloxy wherein the phenyl group is optionally substituted with —

NHC(O)C₁-C₆ alkyl, wherein

R₃₁, R₃₂ and the nitrogen to which they are attached form a pyrrolidine, piperidine, piperazine, or morpholine ring, wherein each ring is unsubstituted or substituted with 1, 2, or 3 groups that are independently OH, —

(C₁-C₆ alkyl)-imidazole wherein the imidazole is optionally substituted with 1 or 2 C₁-C₄ alkyl groups, or hydroxy (C₁-C₆ alkyl) wherein the alkyl group is optionally substituted with 1 phenyl ring, or

R₄₂, R₅₅ and the nitrogen to which they are attached form a tetrahydroisoquinolinyl, group which is optionally substituted by 1, 2, 3, or 4 groups that are independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, CN, OH, and phenyl, wherein the phenyl is optionally substituted with halogen, hydroxyl, C₁-C₄ alkoxy, and C₁-C₄ alkyl.

34. A compound according to claim 33 wherein

R₃₀ is selected from the group consisting of phenyl, pyridyl, or piperidinyl wherein each of the above is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently selected from the group consisting of

C₁-C₁₀ alkyl, hydroxy, hydroxy C₁-C₁₀ alkyl C₁-C₆ alkoxy, halogen, —

SO₂NR₃₁R₃₂, —

C(O)—

NR₃₁R₃₂, —

NR₃₁R₃₂, —

O—

C₃-C₆ cycloalkyl, —

C(O)—

(C₁-C₆ alkyl);

wherein R₃₁ and R₃₂ at each occurrence are independently selected from the group consisting of hydrogen, C₁-C₆ alkyl, hydroxy C₁-C₆ alkyl, —

(C₁-C₆ alkyl)-NH₂, —

(C₁-C₆ alkyl)-NH(C₁-C₆ alkyl), —

(C₁-C₆ alkyl)-N(C₁-C₆ alkyl)(C₁-C₆ alkyl), benzyl, and —

C(O)furanyl, wherein

the phenyl group is unsubstituted or substituted with 1, 2, or 3, groups that are independently C₁-C₄ alkyl, hydroxy, C₁-C₄ alkoxy, or halogen, or

R₃₁, R₃₂ and the nitrogen to which they are attached form a pyrrolidinyl, piperidinyl, morpholinyl, pyridinyl, or pyrimidinyl ring, each of which is optionally substituted with C₁-C₆ alkoxy, hydroxy, hydroxy C₁-C₆ alkyl, C₁-C₄ alkoxy C₁-C₆ alkyl, or —

C(O)NH₂;

R₃₅ is phenyl, cyclohexyl, cyclopentyl, or —

S-phenyl, each of which is unsubstituted or substituted with 1, 2, or 3 groups that are independently C₁-C₄ alkyl, C₁-C₄ alkoxy, CF₃, OCF₃, halogen, —

Obenzyl, —

CO₂—

(C₁-C₆ alkyl), —

(C₁-C₄ alkyl)-(C₅-C₆ cycloalkyl).

38. A compound according to claim 32 wherein R₃₅ is phenyl;

halophenyl, dihalophenyl;

trihalophenyl;

tetrahalophenyl;

pentahalophenyl;

phenyl substituted with one halogen and one benzyloxy group;

phenyl substituted with one halogen and one alkyl group;

benzyloxyphenyl;

cyclohexyl;

(C₁-C₄ alkoxy)carbonylphenyl;

(C₁-C₄ alkoxy)phenyl;

—

S-phenyl, or benzodioxole;

R₄₀ is phenyl, or —

(C₁-C₄ alkyl)-SO₂NH₂, wherein each of the above is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently halogen, methyl, ethyl, methoxy, ethoxy, or -Obenzyl wherein the phenyl is optionally substituted with 1 or 2 halogens,

R₄₂ is H.

39. A compound according to claim 38 wherein

R₃₅ is a halophenyl, dihalophenyl, trihalophenyl, phenyl substituted with one halogen and one benzyloxy group;

phenyl substituted with one halogen and one alkyl group;

benzyloxyphenyl, or (C₁-C₄ alkoxy)phenyl.

35. A compound of the formula

36. A compound according to claim 35 wherein

R₃₅ is phenyl, cyclohexyl, —

S-phenyl, or benzodioxole, each of which is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently methyl, ethyl, methoxy, ethoxy, OH, halogen, CF₃, OCF₃, —

Obenzyl, —

CO₂—

(C₁-C₆ alkyl), —

(C₁-C₄ alkyl)-(C₅-C₆ cycloalkyl);

R₄₀ is phenyl, -phenyl-pyridine, biphenyl, —

(C₁-C₄ alkyl)-SO₂NH₂, —

(C₁-C₄ alkyl)-SO₂NH(C₁-C₆ alkyl), —

(C₁-C₄ alkyl)-SO₂N(C₁-C₆ alkyl) (C₁-C₆ alkyl), —

(C₁-C₄ alkyl)-(cyclopentyl), —

(C₁-C₄ alkyl)-C(O)O—

(C₁-C₄ alkyl, C₁-C₈ alkyl, —

(C₁-C₄ alkyl)-NHC(O)—

(C₁-C₄ alkyl), —

C(O)NH₂, wherein each of the above rings is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, halo (C₁-C₄ alkyl), —

Obenzyl wherein the phenyl is optionally substituted with 1 or 2 halogens,

R₄₂ is H, C₁-C₆ alkyl, or benzyl;

R₅₂ is H, —

NHC(O)—

(C₁-C₆ alkyl)-(C₁-C₆ thioalkoxy), —

N(C₁-C₆ alkyl)C(O)—

(C₁-C₆ alkyl)-(C₁-C₆ thioalkoxy), OH, C₁-C₄ alkyl, and

R₆₀ is -L-V-R₆₅, C₁-C₈ alkyl, or hydroxy C₁-C₈ alkyl, wherein the alkyl or hydroxyalkyl groups are optionally substituted with 1 or 2 L-V-R₆₅ groups, wherein

L is absent, —

C(O)—

, —

CO₂—

, —

C(O)NH—

, —

C(O)N(C₁-C₆ alkyl)-, —

NHC(O)—

, —

N(C₁-C₆ alkyl)-C(O)—

, —

SO₂—

, —

(CH₂)_0-4—

O—

(CH₂)_0-4—

, —

(CH₂)_0-4—

S—

(CH₂)_0-4—

, —

NHC(O)NH—

, —

N(C₁-C₆ alkyl)C(O)NH—

, —

N(C₁-C₆ alkyl)C(O)N(C₁-C₆ alkyl)-, —

NHC(O)N(C₁-C₆ alkyl)-, —

NH—

, —

N(benzyl)-, —

(CH₂)_0-4—

NHSO₂—

(CH₂)_0-4—

, —

N(C₁-C₆ alkyl)SO₂—

, —

SO₂NH—

, —

SO₂N(C₁-C₆ alkyl)-, and

V is absent, —

C(O)NH—

, —

C(O)N(C₁-C₆ alkyl)-, cyclopropyl,

R₆₅ is cyclohexyl;

cyclopentyl;

phenyl;

—

(C₁-C₆ alkyl)-phenyl;

NH₂;

mono or di(C₁-C₆ alkyl)amino wherein the alkyl group or groups are optionally substituted with 1 or 2 groups that are independently cyclopropyl, phenyl or OH;

oxadiazolyl;

triazolopyrimidinyl;

triazolyl;

thiadiazolyl;

3H-quinazolin-2-onyl;

pyrimidinyl;

pyridyl;

pyridyl N-oxide;

—

(C₁-C₆ alkyl)-pyridyl;

piperazinyl;

phthalazinyl;

tetrahydro-thiophenyl 1,1-dioxide;

tetrazolyl;

C₃-C₆ cycloalkyl-C₁-C₆ alkyl;

—

(C₁-C₄ alkyl)-SO₂—

(C₁-C₄ alkyl)-;

benzothiazole;

hexahydro-isoindole-1,3-dionyl;

benzimidazolyl;

benzoxazolyl;

[1,2,4]triazolo[1,5-a]pyrimidinyl;

thiazolyl;

thiadiazolyl;

imidazo[1,2-a]pyridine;

C₁-C₆ alkyl;

3-aza-bicyclo[3.2.2]nonane;

pyrrolidinonyl;

diazepanyl;

benzo[1,2,5]thiadiazolyl;

—

NHSO₂-(4-methylphenyl);

[1,2,4]triazolo[4,3-b]pyridazinyl, benzopyrrolidinonyl;

thiomorpholinyl S-oxide;

2,3-dihydro-benzo[b]thiophene 1,1-dioxide;

pyrrolidinyl;

[1,2,4]oxadiazole;

C₁-C₁₀ alkyl;

isoxazolyl;

2,3-dihydro-1H-indolyl;

wherein each of the above is optionally substituted with 1, 2, 3, 4, or 5 groups that are independently

C₁-C₆ alkyl, CF₃, halogen, phenyl, —

(C₁-C₄ alkyl)-phenyl, —

C(O)phenyl, pyrrolidine-dione, C₁-C₆ alkoxy, —

C(O)-furan, —

C(O)NH₂, —

C(O)NH(C₁-C₆ alkyl), —

C(O)N(C₁-C₆ alkyl)(C₁-C₆ alkyl),cyclopropyl, benzoxazole, pyridine, —

NHC(O)—

(C₁-C₆ alkyl), —

N(C₁-C₆ alkyl)C(O)—

(C₁-C₆ alkyl), —

C(O)C₁-C₆ alkyl.

37. A compound according to claim 36 wherein

R₃₅ is phenyl, cyclohexyl, —

S-phenyl, benzodioxole, furanyl, or thienyl, each of which is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently methyl, ethyl, methoxy, ethoxy, OH, halogen, CF₃, OCF₃, —

Obenzyl, —

CO₂—

(C₁-C₄ alkyl), —

(C₁-C₂ alkyl)-(C₅-C₆ cycloalkyl);

R₄₀ is phenyl, —

(C₁-C₄ alkyl)-SO₂NH₂, —

(C₁-C₄ alkyl)-SO₂NH(C₁-C₆ alkyl), —

(C₁-C₄ alkyl)-SO₂N(C₁-C₆ alkyl)(C₁-C₆ alkyl), —

(C₁-C₄ alkyl)-(cyclopentyl), C₁-C₈ alkyl, —

(C₁-C₄ alkyl)-NHC(O)—

(C₁-C₄ alkyl), —

C(O)NH₂, wherein each of the above rings is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, halo (C₁-C₄ alkyl), —

Obenzyl wherein the phenyl is optionally substituted with 1 or 2 halogens,

R₄₂ is H, C₁-C₆ alkyl, or benzyl;

R₅₂ is H, —

NHC(O)—

(C₁-C₆ alkyl)-(C₁-C₆ thioalkoxy), —

N(C₁-C₆ alkyl)C(O)—

(C₁-C₆ alkyl)-(C₁-C₆ thioalkoxy), OH, C₁-C₄ alkyl, and

R₆₀ is -L-R₆₅, or C₁-C₆ alkyl optionally substituted with 1 or 2 L-R₆₅ groups, wherein

L is absent, —

C(O)—

, —

C(O)NH—

, —

C(O)N(C₁-C₆ alkyl)-, —

NHC(O)—

, —

N(C₁-C₆ alkyl)-C(O)—

, —

SO₂—

, —

(CH₂)_0-4—

O—

(CH₂)_0-4—

, —

S—

, —

NHC(O)NH—

, —

NH—

, —

N(benzyl)-, —

(CH₂)_0-4—

NHSO₂—

(CH₂)_0-4—

, —

N(C₁-C₆ alkyl)SO₂—

, —

SO₂NH—

, —

SO₂N(C₁-C₆ alkyl)-.

48. A compound of the formula wherein

49. A compound of the formula wherein

50. A compound of the formula

51. A compound according to claim 50 wherein

R₃₀ is selected from the group consisting of pyrazolopyrimidinyl, oxa-aza-benzoazulenyl, isoxazolyl, triazolopyridinyl, pyrrolidinonyl, tetrahydrothia-aza-fluorenyl, pyridyl, piperidinyl, thiazolyl, thiadiazolyl or thienyl, each of which is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently

C₁-C₄ alkyl, —

C(O)N(C₁-C₆ alkyl) (C₁-C₆ alkyl), —

C(O)NH₂, —

C(O)N(C₂-C₆ alkenyl) (C₃-C₈ cycloalkyl), —

C(O)NH(C₃-C₈ cycloalkyl), —

C(O)NH(C₁-C₆ alkyl), C(O)-(pyrrolidine) optionally substituted with 1 or two groups that are independently alkoxyalkyl or hydroxy, halogen, —

C(O)N(C₁-C₆ hydroxyalkyl) (C₁-C₆ alkyl), —

C(O)NH(alkoxyalkyl), —

C(O)N (alkoxyalkyl) (alkoxyalkyl), —

C(O)N(C₁-C₆ alkyl) (alkoxyalkyl), —

C(O)N(C₁-C₆ hydroxyalkyl) (alkyl), —

NHSO₂CF₃, —

N(C₁-C₆ alkyl)-SO₂-thienyl, —

N(C₁-C₆ hydroxyalkyl)SO₂—

(C₁-C₆ alkyl), —

NHC(O)C₁-C₄ alkyl, oxazolyl optionally substituted with 1 or 2 methyl groups, thiazolyl optionally substituted with 1 or 2 methyl groups, pyrazolyl optionally substituted with 1 or 2 methyl groups, imidazolyl optionally substituted with 1 or 2 methyl groups, isoxazolyl optionally substituted with 1 or 2 methyl groups, pyrimidinyl optionally substituted with 1 or 2 methyl or halogen groups, —

NHSO₂CH₃, —

NHSO₂-imidazolyl wherein the imidazole ring is optionally substituted with 1 or 2 methyl groups, —

N(C₁-C₆ alkyl)SO₂(C₁-C₆ alkyl), —

SO₂NH—

C₁-C₆ hydroxyalkyl, —

SO₂NH—

C₁-C₆ alkyl-NH(C₁-C₄ alkyl), —

SO₂-piperazinyl optionally substituted with 1 or 2 methyl groups, —

SO₂-pyrrolidine optionally substituted with 1 or 2 methyl groups, —

SO₂-piperidine optionally substituted with 1 or 2 C₁-C₄ alkyl groups, —

SO₂N(C₁-C₄ hydroxyalkyl)(C₁-C₄ hydroxyalkyl), —

SO₂NH₂, —

SO₂N(C₁-C₆ alkyl) (C₁-C₆ alkyl), C₂-C₆ alkynyl, —

SO₂—

(C₁-C₆ hydroxyalkyl), —

SO₂NH(C₁-C₆ hydroxyalkyl), —

SO₂N(C₁-C₆ alkyl) (C₁-C₆ hydroxyalkyl), —

(C₁-C₄ alkyl)-SO₂—

(C₁-C₄ alkyl), or —

C(O)—

(C₁-C₁₀ alkyl).

52. A compound according to claim 51 wherein

R₃₀ is pyridyl which is unsubstituted or substituted with at least one group which is —

SO₂NH-propyl-OH, —

SO₂NH-ethyl-OH, —

SO₂NH-ethyl-OCH₃, —

SO₂NH—

CH(CH₃)₂—

CH₂OH, —

SO₂NH—

(CH₂CH(OH)CH₃), —

SO₂NH-ethyl-NH(CH₃), —

SO₂NH(—

CH₂CH₂OH)₂, —

SO₂NHCH(CH₃)CH₂OH, —

SO₂N(CH₃)₂, —

SO₂NH(CH₂CH(OH)CH₃), —

SO₂-pyrrolidine, —

SO₂-(2,6-dimethylpiperidine), —

SO₂-(2-propylpiperidine), —

SO₂-(hydroxypropyl), —

C(O)-(2-methoxymethylpyrrolidine), —

C(O)-(2-methylpyrrolidine), —

C(O)-(2,6-dimethylpyrrolidine), —

C(O)-(2-hydroxymethylpyrrolidine), —

C(O)N(methyl)(ethyl), —

C(O)N(methyl)(propyl), —

C(O)N(methyl)(butyl), —

C(O)N(propyl)(butyl), —

C(O)N(allyl)(cyclopentyl), —

C(O)N(allyl)(cyclohexyl), —

C(O)N(methyl)(methyl), —

C(O)N(ethyl)(ethyl), —

C(O)N(butyl)(butyl), —

C(O)N(isopropyl)(isopropyl), —

C(O)N(propyl)(propyl), —

C(O)N(methyl)(cyclohexyl), —

C(O)N(ethyl)(cyclohexyl), —

C(O)NH(cyclobutyl), —

C(O)NH(cyclopentyl), —

C(O)N(CH₃) (cyclopentyl), —

C(O)NH(2-methylcyclohexyl), —

C(O)NH(pentyl), —

C(O)N(pentyl)(pentyl), —

C(O)NH(isopentyl), —

C(O)NH(ethoxyethyl), —

C(O)N(CH₃) (methoxyethyl), —

C(O)N(propyl) (methoxyethyl), —

C(O)N(methoxyethyl)(methoxyethyl), —

C(O)N(ethoxyethyl)(ethoxyethyl), —

C(O)N(ethyl)(methoxyethyl), —

C(O)N(propyl)(hydroxyethyl), —

C(O)N(hydroxyethyl)(ethyl), ethynyl, methyl, bromo, —

N(CH₃) SO₂ (CH₃), —

N(CH₃) SO₂-thienyl, —

N(hydroxypropyl)SO₂CH₃, —

(CH₂)—

SO₂—

(CH₃), or —

C(O)—

CH(CH₃)CH₂CH₂CH₃.

53. A compound of the formula

54. A compound of the formula

55. A compound of the formula

56. A compound according to claim 55, wherein q is 1.

57. A compound according to claim 56, wherein

two or three of R_z, R_z′

, R_z″

, and R_z′

″

is hydrogen, and

the other one or two of R_z, R_z′

, R_z″

, and R_z′

″

is hydroxy, nitro, halogen, —

CO₂H, cyano, or C₁-C₆ alkyl, where the alkyl is optionally substituted with one, two or three substituents independently selected from C₁-C₃ alkyl, halogen, —

OH, —

SH, —

CN, —

CF₃, C₁-C₆ alkoxy, amino, mono(C₁-C₆)alkylamino, and di(C₁-C₆)alkylamino.

58. A compound according to claim 57, wherein three of R_z, R_z′

, R_z″

, and R_z′

″

is hydrogen and the other is (C₁-C₆)alkyl, halogen, or (C₁-C₆)alkoxy.

59. A compound according to claim 58, wherein R₁₄₀ is phenyl substituted with 1, 2, or 3 groups independently selected from

C₁-C₆ alkyl, optionally substituted with one, two or three groups independently selected from C₁-C₃ alkyl, -halogen, hydroxy, —

SH, cyano, —

CF₃, C₁-C₃ alkoxy, amino, mono(C₁-C₆)alkylamino, and di(C₁-C₆)alkylamino,

hydroxy, nitro, halogen, —

CO₂H, cyano,

—

(CH₂)_0-4—

CO—

NR₁₄₂R₁₄₄ where R₁₄₂ and R₁₄₄ independently represent hydrogen, C₁-C₆ alkyl, hydroxy(C₁-C₆)alkyl, amino(C₁-C₆)alkyl, and C₃-C₇ cycloalkyl.

60. A compound according to claim 59, wherein R₁₄₀ is phenyl substituted with

one of hydroxy, nitro, halogen, —

CO₂H, cyano, or C₁-C₆ alkyl where the alkyl is optionally substituted with one, two or three groups independently selected from C₁-C₃ alkyl, -halogen, hydroxy, —

SH, cyano, —

CF₃, C₁-C₃ alkoxy, amino, mono(C₁-C₆)alkylamino, and di(C₁-C₆)alkylamino; and

one of —

(CH₂)_0-4—

CO—

NR₁₄₂R₁₄₄.

61. A compound according to claim 60, wherein R₁₄₀ is phenyl substituted with one of —

C(O)NR₁₄₂R₁₄₄ and R₁₄₂ and R₁₄₄ are independently hydrogen or C₁-C₆ alkyl.

62. A compound according to claim 61, wherein R₁₄₂ and R₁₄₄ are the same and are propyl.

63. A compound according to claim 60, wherein R₁₄₀ is phenyl substituted one (C₁-C₆)alkyl and with one —

C(O)NR₁₄₂R₁₄₄ where R₁₄₂ and R₁₄₄ are independently hydrogen or C₁-C₆ alkyl.

64. A compound according to claim 61, wherein R₁₄₂ and R₁₄₄ are the same and are propyl.

65. A compound according to claim 57, wherein R₃₅ is phenyl substituted with 1-5 halogen, or substituted with 1, 2, or 3 groups independently selected from (C₁-C₆) alkyl, hydroxy, halogen, (C₁-C₆)alkoxy, amino, mono(C₁-C₆)alkylamino, and di(C₁-C₆)alkylamino.

66. A compound according to claim 65, wherein R₃₅ is phenyl substituted with 2 halogens.

67. A compound according to claim 66, wherein R₃₅ is 3,5-difluorophenyl.

68. A compound according to claim 65, wherein R₁₄₀ is phenyl substituted with

one of hydroxy, nitro, halogen, —

CO₂H, cyano, or C₁-C₆ alkyl where the alkyl is optionally substituted with one, two or three groups independently selected from C₁-C₃ alkyl, -halogen, hydroxy, —

SH, cyano, —

CF₃, C₁-C₃ alkoxy, amino, mono(C₁-C₆)alkylamino, and di(C₁-C₆)alkylamino; and

one of —

(CH₂)_0-4—

CO—

NR₁₄₂R₁₄₄.

69. A compound according to claim 68, wherein R₁₄₀ is phenyl substituted with one of —

C(O)NR₁₄₂R₁₄₄ and R₁₄₂ and R₁₄₄ are independently hydrogen or C₁-C₆ alkyl.

70. A compound according to claim 69, wherein R₁₄₂ and R₁₄₄ are the same and are propyl.

71. A compound according to any of claims 55-70, wherein n is 1 and p is 0.

72. A compound according to claim 71, wherein the dashed lines all represent single bonds.

73. A compound according to claim 72, wherein R₁ is hydrogen and X is SO₂.

74. A compound according to claim 73, wherein Y is methylene.

75. A compound according to claim 74, wherein Z′

is 2-propyl.

76. A compound according to claim 74, wherein R₂ is hydrogen, hydroxy(C₁-C₃)alkyl, or (C₁-C₃)alkyl.

77. A compound according to claim 75, wherein R₂ is methyl.

78. A compound according to claim 72, wherein R₁ is hydrogen;

X is SO₂ and Y is NR₅, or X is NR₅ and Y is SO₂, where each R₅ is hydrogen, (C₁-C₆)alkyl, or hydroxy(C₁-C₆)alkyl.

79. A compound according to claim 72, wherein R₁ is hydrogen;

X is C(O) and Y is NR₅, or X is NR₅ and Y is C(O), where each R₅ is hydrogen, (C₁-C₆)alkyl, or hydroxy(C₁-C₆)alkyl.

80. A compound according to claim 55, which is represented by the formula

81. A compound according to claim 55, which is represented by the formula

82. A compound according to claim 69, which is represented by the formula

83. A compound according to claim 69, which is represented by the formula

84. A compound according to claim 82, wherein R₂ is (C₁-C₃) alkyl.

85. A compound according to claim 82, wherein R₂ is methyl.

86. A compound according to claim 82, wherein R₂ is hydroxy (C₁-C₃) alkyl.

87. A compound according to claim 83, wherein R₂ is (C₁-C₃)alkyl.

88. A compound according to claim 83, wherein R₂ is methyl.

89. A compound according to claim 83, wherein R₂ is hydroxy (C₁-C₃) alkyl.

90. A compound according to claim 55 which is

N′

-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(4S)-6-isopropyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;

N′

-((1S, 2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3R,4S)-3-(hydroxymethyl)-6-isopropyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;

N′

-((1S, 2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3R,4S)-6-isopropyl-3-methyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;

N′

-((1S, 2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3R,4S)-6-isopropyl-2,2-dioxido-3-propyl-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;

N′

-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3S,4R)-3-(hydroxymethyl)-6-isopropyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;

N′

-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3S,4R)-3-(2-hydroxyethyl)-6-isopropyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;

N′

-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3S,4S)-3-(2-hydroxyethyl)-6-isopropyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;

N′

-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3S,4S)-6-isopropyl-2,2-dioxido-3-propyl-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;

N′

-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3S,4S)-6-isopropyl-3-methyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]aminopropyl)-5-methyl-N,N-dipropylisophthalamide; and

N′

-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(4R)-6-isopropyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;

or a pharmaceutically acceptable salt thereof.

91. A compound of the formula:

92. A compound according to claim 91 wherein

R₁₀₀ is tertiary butoxy carbonyl.

93. A compound according to claim 91 wherein

R₁₁₀ is phenyl C₁-C₆ alkyl optionally substituted with 1, 2, 3, 4, or 5 groups that are independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, or phenyl C₁-C₆ alkoxy.

94. A compound according to claim 91 wherein

R₁₁₀ is monohalophenyl, dihalophenyl, or trihalophenyl.

95. A compound according to claim 91 wherein

R₁₁₀ is thienyl, or —

S-phenyl each of which is optionally substituted with 1, 2, 3, 4, or 5 groups that are independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, benzyloxy.

96. A compound according to claim 91 wherein

R₁₁₀ is furanyl, or benzodioxolyl each of which is optionally substituted with 1, 2, 3, 4, or 5 groups that are independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, benzyloxy.

97. A compound according to claim 91 wherein

R₁₂₀ is benzyl optionally substituted with 1, 2, or 3 groups that are independently C₁-C₆ alkyl, C₂-C₆ alkenyl, C₂-C₆ alkynyl, halogen, or C₁-C₆ alkoxy.

98. A compound according to claim 91 wherein

R₁₂₀ is cyclopropyl optionally substituted with C₁-C₆ alky or phenyl;

or cyclopropyl C₁-C₄ alkyl, wherein each of the above is optionally substituted with 1, 2, or 3 groups that are independently C₁-C₆ alkyl, C₂-C₆ alkenyl, C₂-C₆ alkynyl, halogen, or C₁-C₆ alkoxy.

99. A compound according to claim 92 wherein

R₁₁₀ is phenyl C₁-C₆ alkyl optionally substituted with 1, 2, 3, 4, or 5 groups that are independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, or phenyl C₁-C₆ alkoxy;

and

R₁₂₀ is H or benzyl optionally substituted with 1, 2, or 3 groups that are independently C₁-C₆ alkyl, C₂-C₆ alkenyl, C₂-C₆ alkynyl, halogen, or C₁-C₆ alkoxy.

100. A compound according to claim 92 wherein

R₁₁₀ is phenyl C₁-C₆ alkyl optionally substituted with 1, 2, 3, 4, or 5 groups that are independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, or phenyl C₁-C₆ alkoxy;

and

R₁₂₀ is cyclopropyl optionally substituted with C₁-C₆ alky or phenyl;

or cyclopropyl C₁-C₄ alkyl, wherein each of the above is optionally substituted with 1, 2, or 3 groups that are independently C₁-C₆ alkyl, C₂-C₆ alkenyl, C₂-C₆ alkynyl, halogen, or C₁-C₆ alkoxy.

101. A compound according to claim 92 wherein

R₁₁₀ is thienyl, or —

S-phenyl each of which is optionally substituted with 1, 2, 3, 4, or 5 groups that are independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, benzyloxy; and

R₁₂₀ is H or benzyl optionally substituted with 1, 2, or 3 groups that are independently C₁-C₆ alkyl, C₂-C₆ alkenyl, C₂-C₆ alkynyl, halogen, or C₁-C₆ alkoxy.

102. A compound according to claim 92 wherein

R₁₁₀ is thienyl, or —

S-phenyl each of which is optionally substituted with 1, 2, 3, 4, or 5 groups that are independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, benzyloxy; and

R₁₂₀ is cyclopropyl optionally substituted with C₁-C₆ alky or phenyl;

or cyclopropyl C₁-C₄ alkyl, wherein each of the above is optionally substituted with 1, 2, or 3 groups that are independently C₁-C₆ alkyl, C₂-C₆ alkenyl, C₂-C₆ alkynyl, halogen, or C₁-C₆ alkoxy.

103. A compound according to claim 92 wherein

R₁₁₀ is furanyl, or benzodioxolyl each of which is optionally substituted with 1, 2, 3, 4, or 5 groups that are independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, or benzyloxy.

R₁₂₀ is H or benzyl optionally substituted with 1, 2, or 3 groups that are independently C₁-C₆ alkyl, C₂-C₆ alkenyl, C₂-C₆ alkynyl, halogen, or C₁-C₆ alkoxy.

104. A compound according to claim 92 wherein

R₁₁₀ is furanyl, or benzodioxolyl each of which is optionally substituted with 1, 2, 3, 4, or 5 groups that are independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, or benzyloxy;

R₁₂₀ is cyclopropyl optionally substituted with C₁-C₆ alky or phenyl;

or cyclopropyl C₁-C₄ alkyl, wherein each of the above is optionally substituted with 1, 2, or 3 groups that are independently C₁-C₆ alkyl, C₂-C₆ alkenyl, C₂-C₆ alkynyl, halogen, or C₁-C₆ alkoxy.

105. A compound of the formula

106. A compound according to claim 105, wherein Z is CH.

107. A compound according to claim 106, wherein R₂ and R₃ are both H.

108. A compound according to claim 107 of the formula:

109. A compound according to claim 108 wherein,

R₁ is ethyl, ethynyl or CF₃;

and

R₄ is 2-oxazolyl optionally substituted with methyl, 2-thiazolyl, ethynyl, or methyl.

110. A compound according to claim 109, wherein R₅ is propyl;

and R₆ is propyl.

111. A compound according to claim 110, wherein

R₁ is ethyl;

R₄ is 2-oxazolyl optionally substituted with methyl; and

X and Y are both F.

112. A compound according to claim 109, wherein R₁ is ethyl, or CF₃;

and R₄ is 2-thiazolyl.

113. A compound according to claim 112, wherein

R₅ is propyl;

and R₆ is propyl;

or

R₅ is methyl; and

R₆ is propyl or butyl; and

X and Y are both F.

114. A compound according to claim 113, wherein R₁ is ethyl.

115. A compound according to claim 112, wherein R₁ is CF₃;

R₅ is propyl; and

R₆ is propyl.

116. A compound according to claim 109, wherein R₁ is ethynyl;

and R₄ is ethynyl, methyl, or 2-oxazolyl.

117. A compound according to claim 116, wherein R₅ is propyl;

and R₆ is propyl; and

X and Y are both F.

118. A compound according to claim 117, wherein R₄ is ethynyl or methyl.

119. A compound according to claim 106 of the formula:

120. A compound according to claim 119, wherein R₁ is ethyl or ethynyl;

R₄ is methyl or 2-oxazolyl.

121. A compound according to claim 120, wherein R₅ and R₆ are both propyl;

X and Y are both F.

122. A compound according to claim 121, wherein Z is N;

and R₄ is methyl.

123. A compound according to claim 121, wherein z is CH;

and R₄ is methyl or 2-oxazolyl.

124. A compound according to claim 105 wherein R₄ is 2-oxazolyl.

125. A compound of the formula

126. A compound of the formula

127. A compound according to claim 126, wherein R_s is N-[hydroxy(C₄-alkyl]-N-methylamino, —

N(C₁-C₃ hydroxyalkyl) (C₁-C₃ hydroxyalkyl), or —

NH(C₁-C₄ hydroxyalkyl).

128. A compound according to claim 127, wherein the hydroxyalkyl is 2-hydroxy-1,1-dimethylethyl;

2-hydroxyethyl;

3-hydroxypropyl;

1(R) -2-hydroxy-1-methylethyl;

1(S) -2-hydroxy-1-methylethyl;

2(R)-2-hydoxypropyl;

or 2(S)-2-hydoxypropyl.

129. A compound according to claim 126, wherein

R_s is 3-hydroxypropyl, or 4-hydroxybutyl.

130. A compound according to claim 126, wherein

R_s is 2(R)-2-methoxymethylpyrrolidin-1-yl, 2(R)-2-hydroxymethylpyrrolidin-1-yl, 2(S)-2-hydroxymethylpyrrolidin-1-yl, pyrrolidin-1-yl, or 1-piperazinyl,

131. A compound according to claim 126, wherein

R₅, R₆, and the nitrogen to which they are attached form a 2(S)-2-methoxymethyl)pyrrolidin-1-yl.

132. A compound according to claim 131, wherein

R_s is —

NH(tert-butyl), —

N(CH₃) (CH₂CH₃), or 2(S)-2-methoxymethylpyrrolidin-1-yl.

133. A compound of the formula

134. A compound of the formula

135. A compound according to claim 134, wherein X is CH.

136. A compound according to claim 135, wherein R₁ is di(C₁-C₂) alkylamino.

137. A compound according to claim 136, wherein at least one of R₅ and R₆ is propyl.

138. A compound according to claim 134, wherein X is nitrogen.

139. A compound according to claim 138, wherein both of R₅ and R₆ are not methyl.

140. A compound according to claim 135, wherein R₁ is di(C₁-C₂) alkylamino (C₁-C₂) alkyl.

141. A compound of the formula

142. A compound of the formula

143. A compound according to claim 142, wherein R₁ is ethyl, n-propyl, isopropyl, or trifluoromethyl.

144. A compound according to claim 143, wherein R₅ is methyl or ethyl and R₆ is C₃ C₄ alkyl.

145. A compound according to claim 142, wherein R₅ is methyl or propyl.

146. A compound according to claim 145, wherein R_f and R_g are both chloro or fluoro.

147. A compound according to claim 146, wherein both of R₂ and R₃ are hydrogen;

and

R₁ is C₂-C₃ alkynyl.

148. A compound according to claim 1151, wherein R₅ and R₆ are independently propyl or butyl.

149. A compound according to claim 1156, wherein both of R₂ and R₃ are hydrogen.

150. A compound according to claim 1157, wherein R_f and R_g are both chloro or fluoro.

151. A compound according to claim 1157, wherein

R₂ and R₃ together form a 3-membered ring with the carbon atom to which they are attached.

152. A compound of the formula

153. A compound according to claim 152, wherein X is nitrogen;

R₁ is C₂-C₃ alkynyl;

R₂ and R₃ together form a 3-membered ring with the carbon atom to which they are attached; and

R_p is C₁-C₂ alkyl.

154. A compound according to claim 152, wherein X is nitrogen;

and R₁ is C₂ alkynyl.

155. A compound according to claim 152, wherein X is nitrogen;

R₁ is C₁-C₂ alkyl;

R₂ and R₃ are hydrogen; and

R_p is hydrogen, C₁-C₂ alkyl, or oxazol-2-yl.

156. A compound according to claim 152, wherein X is nitrogen;

R₁ is C₁-C₂ alkyl;

R₂ and R₃ are hydrogen; and

R_p is cyano.

157. A compound according to claim 152, wherein X is nitrogen;

R₁ is C₂-C₃ alkyl;

R₂ and R₃ together form a 3-membered ring with the carbon atom to which they are attached; and

R_p is C₁-C₂ alkyl.

158. A compound according to any of claims 153-157, wherein R_f and R_g are both chloro or fluoro.

159. A compound according to any of claims 153-157, wherein R₅ and R₆ are independently propyl or butyl.

160. A compound of the formula

161. A compound according to claim 160, wherein X is nitrogen;

X′

is CH; and

R₅ and R₆ are independently propyl or butyl.

162. A compound according to claim 160, wherein X is CH;

X′

is nitrogen; and

R₅ and R₆ are independently propyl or butyl.

163. A compound according to claim 162, wherein R₁ is —

CH₂N(CH₃)CH₃.

164. A compound of the formula

165. A compound of the formula

166. A compound according to claim 165, wherein R_j is methyl;

and Z₁ is hydrogen.

167. A compound according to claim 165, where Z is CH and R_p is N—

(C₁-C₂ alkylsulfonyl)-N—

((C₁-C₂)alkyl)amino; and

R_j is C₃-C₄ alkyl.

168. A compound according to claims 165, wherein R_p is 2-oxazolyl and Z is CH.

169. A compound according to claims 165, wherein R_p is cyano;

Z is CH; and

R_j is C₃-C₄ (butyl) alkyl.

170. A compound according to claim 167, wherein

R_p is —

N(CH₃)SO₂(C₁-C₂ alkyl); and

R₁ is ethyl.

171. A compound of the formula

172. A compound according to claim 171, wherein R₁ is C₂-C₃ alkyl.

173. A compound according to claim 171, wherein R₁ is di(C₁-C₃)alkylamino and both of R_f and R_g are chloro or fluoro.

174. A compound according to claim 171, wherein R₁ is di(C₁-C₃)alkylamino(C₁-C₂)alkyl, and both of R_f and R_g are chloro or fluoro.

175. A compound according to claim 171, wherein X is nitrogen;

R_f and R_g are both fluoro;

R₁ is C₁-C₃ alkyl; and

R₂ and R₃ together form a 3-membered ring with the carbon atom to which they are attached.

176. A compound according to claim 172, wherein both X and X′

are CH; and

R_f and R_g are both chloro or fluoro.

177. A compound according to claim 176, wherein one of R₅ and R₆ is methyl or ethyl and the other is C₃ or C₄ alkyl.

178. A compound according to claim 176, wherein R₅ and R₆ are independently C_2,3-C₄ alkyl.

179. A compound according to claim 178, wherein R₅ is C₂-C₄ alkyl and R₆ is ethyl.

180. A compound according to claim 176, wherein one of R₅ and R₆ is methyl and the other is C₃ or C₄ alkyl.

181. A compound according to claim 176, wherein R₅ and R₆ are independently propyl or butyl.

182. A compound according to claim 171, wherein R₁ is C₂ alkynyl.

183. A compound according to claim 182, wherein

X is nitrogen and X′

is CH; and

R₂ and R₃ together form a 3-membered ring with the carbon atom to which they are attached.

184. A compound according to claim 182, wherein both X and X′

are CH; and

R_f and R_g are both chloro or fluoro.

185. A compound according to claim 176, wherein R₅ and R₆ are independently propyl or butyl.

186. A compound according to any of claims 176-185, wherein R₂ and R₃ together form a 3-membered ring with the carbon atom to which they are attached.

187. A compound according to claim 171, wherein

R₁ is CF₃, or —

NHSO₂CH₃;

R₂ and R₃ are both H;

R₅ and R₆ are independently C₃ or C₄ alkyl.

188. A compound according to claim 172, wherein

X is CH and X′

is nitrogen.

189. A compound according to claim 188, wherein

R₂, R₃, and the carbon to which they are attached form a cyclopropyl ring.

190. A compound according to claim 186, wherein

R₁ is bromo or chloro.

191. A compound of the formula

192. A compound according to claim 191, wherein R_s is 2-thiazolidinyl or 2-thiazolinyl.

193. A compound of the formula

194. A compound according to claim 193, wherein R_p is 4-pyridyl, 2-pyrimidinyl, 4-pyrazolyl, or 4-imidazolyl.

195. A compound according to claim 193, wherein R_p is diethylamino or dimethylamino.

196. A compound according to claim 193, wherein R_p is amino or C₁-C₆ alkylamino.

197. A compound according to claim 193 where R_p is 1-piperazinyl.

198. A compound according to claim 193 where R_p is amino(C₂-C₄)alkyl where the amino is optionally mono substituted with C₁-C₂ alkyl;

or where R_p is —

N(CH₃)—

SO₂CH₃, —

NH—

SO₂CH₃, —

N(CH₃) —

SO₂-thien-2-yl, or —

N(CH₃) —

SO₂CF₃.

199. A compound according to claim 193 where R_p is 3-(mono(C₁-C₂)alkylamino)propyn-1-yl, 3-(di(C₁-C₂)alkylamino)propyn-1-yl, or 4-(di(C₁-C₂)alkylamino)propyn-1-yl.

200. A compound according to any of claims 194 to 199, wherein R₅ and R₆ are both C₃ alkyl.

201. A compound according to any of claims 194 to 199, wherein R₂ and R₃ are hydrogen.

202. A compound according to any of claims 194 to 199, wherein R₂ and R₃ together form a 3-membered ring with the carbon atom to which they are attached.

203. A compound according to claim 193 where R_p is di(C₁-C₂) alkylamino(C₃-C₅) alkyl;

and

R₅ and R₆ are both C₃ alkyl.

204. A compound according to claim 193 where

R_p is C₂-C₃ alkynyl, C₁-C₂ alkyl, or —

NH(cyclopropyl); and

R₂ and R₃ are both H.

205. A compound according to claim 193 where

R_p is C₂-C₃ alkynyl, C₁-C₂ alkyl, or —

NH(cyclopropyl); and

R₂ and R₃ together form a 3-membered ring with the carbon atom to which they are attached.

206. A compound of the formula

207. A compound according to claim 206, wherein R_p is methyl.

208. A compound of the formula

210. A compound according to claim 208, wherein R₁ is C₁-C₂ alkyl;

R₂ and R₃ are hydrogen; and

R_p is R_sSO₂—

where R_s is C₃-C₄ t-butyl amino.

211. A compound according to claim 208, wherein R₁ is C₁-C₂ alkyl;

R₂ and R₃ are hydrogen;

R_p is C₁-C₂ alkyl; and

R_q is C₂-C₄ alkyl.

212. A compound according to claim 208, wherein R₁ is C₁-C₂ alkyl;

R₂ and R₃ are hydrogen;

R_p is C₁-C₂ alkyl; and

R_q is propoxy(C₁-C₂) alkyl.

213. A compound according to claim 208, wherein R₁ is C₁-C₂ alkyl;

R₂ and R₃ are hydrogen;

R_p is C₁-C₂ alkyl; and

R_q is methoxy(C₁-C₂) alkyl.

214. A compound according to claim 208, wherein R₁ is C₁-C₂ alkyl;

R₂ and R₃ together form a 3-membered ring with the carbon atom to which they are attached;

R_p is C₁-C₂ alkyl; and

R_q is C₁-C₂ alkyl.

215. A compound according to claim 208, wherein R₁ is C₁-C₂ alkyl;

R₂ and R₃ are hydrogen;

R_p is C₁-C₂ alkyl; and

R_q is C₁-C₂ alkyl.

216. A compound according to claim 208, wherein R_q is (R)-methoxymethyl, methyl, propyl, (S)-propyl, (R)-propyl, butyl, (R)-butyl, (S)-butyl, (R)-2-methoxymethyl, (R)-2-methoxyethyl,

209. A compound according to claim 1240, wherein R₁ is C₂ alkynyl;

R₂ and R₃ together form a 3-membered ring with the carbon atom to which they are attached; and

R_p is R_sSO₂—

where R_s is

217. A compound of the formula

218. A compound according to claim 217, wherein R₁ is bromo, and Z is oxygen.

219. A compound according to claim 217, wherein

Z is nitrogen;

and

R₁ is C₁-C₃ alkyl.

220. A compound according to claim 217, wherein

Z is sulfur;

and

R₁ is C₁-C₃ alkyl.

221. A compound of the formula

222. A compound according to claim 221, wherein R₁ is ethyl.

223. A compound of the formula

224. A compound according to claim 223, wherein X is CH and X′

is nitrogen.

225. A compound of the formula

227. A compound according to claim 225, wherein R₁ is 2-formylthien-3-yl.

228. A compound according to claim 225, wherein R₁ is 5-formylthien-3-yl.

229. A compound according to claim 225, wherein R_s21 is cyano.

230. A compound according to claim 225, wherein R₁ is 5-cyanopyrid-3-yl.

231. A compound according to claim 225, wherein R₁ is 6-halopyrid-3-yl.

233. A compound according to claim 225, wherein, R₁ is a substituted or unsubstituted thienyl group.

226. A compound according to claim 226, wherein R₁ is 6-(C₁-C₂) alkoxypyridin-2-yl.

232. A compound according to any one of claims 226 to 1285, wherein the halogen is fluoro or chloro.

234. A compound of the formula

235. A compound according to claim 234, wherein

R₁ is ethyl;

and

Z is

236. A compound of the formula

237. A compound according to claim 236, wherein R₅ is methyl optionally substituted with phenyl and R₆ is phenyl.

238. A compound according to claim 236, wherein R₅ is C₁-C₂ alkyl and R₆ is 4-halophenyl.

239. A compound of the formula

240. A compound according to claim 239, wherein X is nitrogen;

R_p is C₁-C₂ alkyl; and

R₁ is ethyl.

241. A compound of the formula

242. A compound of the formula

243. A compound according to claim 242, wherein R_S is (2-cyanoethyl)(methyl)amino.

244. A compound according to claim 242, wherein R_S is (cyclohexyl)(methyl)amino.

245. A compound according to claim 242, wherein R_S41 is C₁-C₆ alkyl, allyl, cyano(C₁-C₃)alkyl, (C₄-C₇)cycloalkyl, pyridyl(C₁-C₃)alkyl, phenyl, or phenyl(C₁-C₃)alkyl.

246. A compound according to claim 242, wherein R_S41 is phenyl or cyclohexyl.

247. A compound according to claim 242, wherein

R_s is —

N(CH₃)phenyl, or —

N(ethyl) (C₃-C₄ alkyl)

248. A compound of the formula

249. A compound according to claim 248, wherein R₅ and R₆ are C₃ alkyl.

250. A compound according to claim 248, wherein R₅ is methyl and R₆ is C₃ alkyl.

251. A compound of the formula

252. A compound of the formula

253. A compound according to claim 252, where Z is S or S(O).

254. A compound of the formula

255. A compound according to claim 254, wherein R₂ and R₃ together form a 3-membered ring with the carbon atom to which they are attached;

X is N; and

X′

is CH.

256. A compound according to claim 254, wherein R₂ and R₃ are hydrogen;

X′

is N; and

X is CH.

257. A compound according to claim 255, wherein R₁ is C₂ alkynyl.

258. A compound according to claim 256 or 257, wherein R₁ is di(C₁-C₃) alkylamino (C₁-C₃) alkyl.

259. A compound according to claim 256 or 257, wherein R₁ is dimethylamino(C₁-C₂)alkyl.

260. A compound of the formula

261. A compound according to claim 260, wherein R_j is methyl or ethyl and R_p is hydrogen, methyl, or ethyl.

262. A compound according to claim 260, wherein R_j is methyl or butyl;

and R_p is hydrogen.

263. A compound of the formula

264. A compound according to claim 263, wherein X is N.

265. A compound according to claim 264, wherein R_p is cyano.

266. A compound according to claim 265, wherein R₅ is methyl and R₆ is C₂-C₄ alkyl.

267. A compound according to claim 266, wherein R₆ is propyl.

268. A compound according to claim 264, wherein

R₁ is C₂-C₃ alkyl;

R_p is methyl; and

R₅ and R₆ are independently C₃-C₄ alkyl.

269. A compound according to claim 268, wherein

R₂ and R₃ are both hydrogen.

270. A compound according to claim 264, wherein

R₁ is C₂-C₃ alkynyl, or C₂ alkyl;

and

R_p is methyl.

271. A compound according to claims 264, wherein

R₁ is CF₃.

272. A compound of the formula

273. A compound according to claim 272, wherein R₁ is hydrogen and R₂ and R₃ are both hydrogen.

274. A compound according to claim 272, wherein R₁ is hydrogen and R₂ and R₃ together with the carbon atom to which they are attached form a 3-membered ring.

275. A compound according to either claim 273 or 274, wherein R_f and R_g are both chloro or fluoro.

276. A compound according to either claim 273 or 274, wherein R_f and R_g are both fluoro and are in the 3 and 5 positions with respect to the point of attachment of the phenyl group.

277. A compound of the formula:

278. A compound according to claim 277, wherein the hydroxyalkyl group is 2-hydroxy-1,1,dimethylethyl.

279. A compound of the formula:

280. A compound according to claim 279, wherein the hydroxyalkyl group is 2-hydroxy-1,1,dimethylethyl;

or 2-hydroxyethyl.

281. A compound of the formula:

282. A compound according to claim 281, wherein

R_c is isobutyl;

or 1,2,3,4-tetrahydronaphthylen-1-yl, —

CH(CH₂CH₂—

S—

CH₃)C(O)NH(isobutyl), 2-tert butylpyrimidin-4yl.

283. A compound according to claim 281, wherein

R_p is —

SO₂NH(2-hydroxy-1,1-dimethylethyl).

284. A compound according to claim 282 or 283, wherein R₅ and R₆ are both C₃ alkyl.

285. A compound according to claim 281, wherein

R_p is oxazol-2-yl;

and

R_c is —

CH₂-(2-isobutylthiazol-5-yl)

286. A compound of the formula:

287. A compound of the formula:

288. A compound according to claim 287, wherein

R₁ is C₂-C₃ alkyl.

289. A compound according to claim 288, wherein

R₅ and R₆ are simultaneously ethoxyethyl or

R₅ is propyl and R₆ is butyl.

290. A compound according to claim 288, wherein

R₅, R₆, and the nitrogen to which they are attached form a 2-propyl piperidin-1-yl ring.

291. A compound according to claim 287, wherein

R₁ is cyclopentyl, cyclohexyl, propenyl, allyl, or —

(C₃-C₆-alkyl)-CN, C₂-C₅ alkyl, 4-chlorobutyl, 3-pyridyl, methyl 2-methylpropanoate, hex-5-enyl, CN, —

N(CH₃)SO₂CH₃, —

SO₂CH₂CH₃, 3-methylpyrid-2-yl, oxazol-2-yl, 3,5-dimethylisoxazol-4-yl, 3-methylthien-2-yl, 2-pyridyl, 4-carbaldehydefuran-5-yl, and 2-carbaldehydethien-5-yl, 2-carbaldehyde-3-methylthien-5-yl, 2-methoxypyridin-4-yl, —

NH-cyclopropyl, —

NHSO₂CH₃; and

R_p is methyl.

292. A compound according to claim 291, wherein

R₅ and R₆ are both C₃ alkyl.

293. A compound of the formula:

294. A compound according to claim 293, wherein

R₂ and R₃ are both methyl;

and

R₅ and R₆ are independently C₃-C₄ alkyl.

295. A compound according to claim 294, wherein

R_p is oxazol-2-yl or thiazol-2-yl.

296. A compound according to claim 294, wherein

R_p is C₂-C₃ alkynyl;

and

R₅ and R₆ are independently C₃-C₄ alkyl.

297. A compound of the formula:

298. A compound according to claim 297, wherein

R_p is oxazol-2-yl or thiazol-2-yl;

299. A compound according to claim 298, wherein

R_c is 3-isobutylisoxazol-5-yl or N-isobutyl-2-methylpropion-2-yl amide;

and

R_f and R_g are independently Cl or F.

300. A compound according to claim 298, wherein

R_c is 2-isobutylthiazol-2-yl;

and

R_f and R_g are independently Cl or F.

301. A compound according to claim 297, wherein

R_c is 3-isobutylisoxazol-5-yl or N-isobutyl-2-methylpropion-2-yl amide;

R_f and R_g are independently Cl or F; and

R_p is C₂-C₃ alkynyl.

302. A compound of the formula:

303. A compound according to claim 302, wherein

Hal is bromo or chloro.

304. A compound according to claim 303, wherein

R₁ is methyl, ethyl, bromo or iodo.

305. A compound of the formula:

306. A compound according to claim 305, wherein

R₂ is methoxymethyl.

307. A compound of the formula:

308. A compound according to claim 307, wherein R_p is 3-methylisoxazol-4-yl, 5-oxazolyl, 3-oxazolyl, 3-methyloxazol-2-yl, 3-ethyloxazol-2-yl.

309. A compound which is

N-[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(1-isobutylcarbamoyl-3-methylsulfanyl-propylamino)-propyl]-5-methyl-N′

,N′

-dipropyl-isophthalamide;

N⁴-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-6-methyl-N²,N²-dipropylpyridine-2,4-dicarboxamide;

N¹-butyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N¹-methyl-5-(1,3-thiazol-2-yl)isophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-methyl-N³-propyl-5-(1,3-thiazol-2-yl)isophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N³-methyl-5-(1,3-oxazol-2-yl)-N³-propylisophthalamide;

N¹-butyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl) amino]-2-hydroxypropyl}-N¹-methyl-5-(1,3-oxazol-2-yl)isophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-ethyl-5-(1,3-oxazol-2-yl)-N³-propylisophthalamide;

N-[1-(3,5-Difluoro-benzyl)-3-(1-ethylcarbamoylethylamino)-2-hydroxy-propyl]-5-methyl-N′

,N′

-dipropylisophthalamide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-N′

-dimethylcarbamoylmethyl-5,N′

-dimethylisophthalamide;

N-[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(1-methylcarbamoyl-3-methylsulfanyl-propylamino)-propyl]-5-methyl-N′

,N′

-dipropyl-isophthalamide;

N-[3-(1-Benzylcarbamoyl-ethylamino)-1-(3,5-difluorobenzyl)-2-hydroxy-propyl]-5-methyl-N′

,N′

-dipropylisophthalamide;

N-{[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylcarbamoyl]-methyl}-3-trifluoromethyl-benzamide;

N-{[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylcarbamoyl]-methyl}-4-trifluoromethyl-benzamide;

3,4-Dichloro-N-{[1-(3,5-difluoro-benzyl)-3-(3-ethylbenzylamino)-2-hydroxy-propylcarbamoyl]-methyl}-benzamide;

N-[3-(1-Carbamoyl-3-methyl-butylamino)-1-(3,5-difluorobenzyl)-2-hydroxy-propyl]-5-methyl-N′

,N′

-dipropylisophthalamide;

N-{[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylcarbamoyl]-methyl}-4-methoxy-benzamide;

N-{[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylcarbamoyl]-methyl}-2,6-difluoro-benzamide;

N-[3-(1-Carbamoyl-ethylamino)-1-(3,5-difluoro-benzyl)-2-hydroxy-propyl]-5-methyl-N′

,N′

-dipropyl-isophthalamide;

N-{[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylcarbamoyl]-methyl}-2,6-dimethoxy-benzamide;

2-{[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylcarbamoyl]-methylsulfanyl}-N-(4-oxazol-5-yl-phenyl)-acetamide;

2-{[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylcarbamoyl]-methylsulfanyl}-N-(5-methyl-isoxazol-3-yl)-acetamide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-4-methanesulfonyl-benzenesulfonamide;

2-Cyano-N-[1-(3,5-difluoro-benzyl)-3-(3-ethylbenzylamino)-2-hydroxy-propyl]-benzenesulfonamide;

2-Chloro-N-[1-(3,5-difluoro-benzyl)-3-(3-ethylbenzylamino)-2-hydroxy-propyl]-4-trifluoromethoxy-benzenesulfonamide;

2-Chloro-N-[1-(3,5-difluoro-benzyl)-3-(3-ethylbenzylamino)-2-hydroxy-propyl]-6-methyl-benzenesulfonamide;

5-Chloro-N-[1-(3,5-difluoro-benzyl)-3-(3-ethylbenzylamino)-2-hydroxy-propyl]-2-methoxy-benzenesulfonamide;

2-Chloro-4-cyano-N-[1-(3,5-difluoro-benzyl)-3-(3-ethylbenzylamino)-2-hydroxy-propyl]-benzenesulfonamide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-trifluoromethyl-benzenesulfonamide;

4-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylsulfamoyl]-benzoic acid;

6-Chloro-pyridine-3-sulfonic acid [1-(3,5-difluorobenzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2,5-bis-(2,2,2-trifluoro-ethoxy)-benzenesulfonamide;

Pyridine-3-sulfonic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

N-(2-Chloro-4-[1-(3,5-difluoro-benzyl)-3-(3-ethylbenzylamino)-2-hydroxy-propylsulfamoyl]-phenyl}-acetamide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-trifluoromethoxy-benzenesulfonamide;

N-{5-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylsulfamoyl]-thiophen-2-ylmethyl}-benzamide;

5-Chloro-3-methyl-benzo[b]thiophene-2-sulfonic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

N-{5-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylsulfamoyl]-4-methyl-thiazol-2-yl}-acetamide;

4-Chloro-N-[1-(3,5-difluoro-benzyl)-3-(3-ethylbenzylamino)-2-hydroxy-propyl]-benzenesulfonamide;

3-Chloro-N-[1-(3,5-difluoro-benzyl)-3-(3-ethylbenzylamino)-2-hydroxy-propyl]-benzenesulfonamide;

N-[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(3-methoxybenzylamino)-propyl]-2-trifluoromethyl-benzenesulfonamide;

6-Chloro-pyridine-3-sulfonic acid [1-(3,5-difluorobenzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-amide;

Pyridine-3-sulfonic acid [1-(3,5-difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-amide;

N-[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-2-methanesulfonyl-benzenesulfonamide;

3,5-Dichloro-N-[1-(3,5-difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-benzenesulfonamide;

1,2-Dimethyl-1H-imidazole-4-sulfonic acid [1-(3,5-difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-amide;

N-[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-3,4-dimethoxy-benzenesulfonamide;

2-(2,2,2-Trifluoro-acetyl)-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid [1-(3,5-difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-amide;

5-Chloro-3-methyl-benzo[b]thiophene-2-sulfonic acid [1-(3,5-difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-amide;

3-{4-[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propylsulfamoyl]-phenyl}-propionic acid methyl ester;

3-Chloro-N-[1-(3,5-difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-benzenesulfonamide;

3-Cyano-N-[1-(3,5-difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-benzenesulfonamide;

Butane-1-sulfonic acid [1-(3,5-difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-amide;

N-{1-(3,5-Difluoro-benzyl)-2-hydroxy-3-[(1-methanesulfonyl-piperidin-4-ylmethyl)-amino]-propyl}-5-methyl-N′

,N′

-dipropyl-isophthalamide;

N-[3-Benzenesulfonylamino-1-(3,5-difluoro-benzyl)-2-hydroxy-propyl]-5-methyl-N′

,N′

-dipropyl-isophthalamide;

N-[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzoylamino)-propyl]-5-methyl-N′

,N′

-dipropyl-isophthalamide;

4-(3,5-Difluoro-phenyl)-3-(2,5-dimethyl-4-nitro-2H-pyrazol-3-ylamino)-1-(3-methoxy-benzylamino)-butan-2-ol;

3-(2-Amino-7H-purin-6-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;

3-(4-Chloro-pyrimidin-2-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;

3-(2-Amino-6-methyl-pyrimidin-4-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;

3-(2-Chloro-6-methyl-pyrimidin-4-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;

3-(2-Amino-6-chloro-pyrimidin-4-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;

4-(3,5-Difluoro-phenyl)-1-(3-methoxy-benzylamino)-3-(1-phenyl-1H-tetrazol-5-ylamino)-butan-2-ol;

3-(2-Chloro-7H-purin-6-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;

4-(3,5-Difluoro-phenyl)-1-(3-methoxy-benzylamino)-3-[9-(tetrahydro-pyran-2-yl)-9H-purin-6-ylamino]-butan-2-ol;

3-[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propylamino]-pyrazine-2-carbonitrile;

4-(3,5-Difluoro-phenyl)-3-(4,6-dimethoxy-[1,3,5]triazin-2-ylamino)-1-(3-methoxy-benzylamino)-butan-2-ol;

2-[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propylamino]-nicotinonitrile;

4-(3,5-Difluoro-phenyl)-1-(3-methoxy-benzylamino)-3-(7H-purin-6-ylamino)-butan-2-ol;

3-(Benzothiazol-2-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;

4-(3,5-Difluoro-phenyl)-1-(3-methoxy-benzylamino)-3-(2-phenyl-quinolin-4-ylamino)-butan-2-ol;

6-[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propylamino]-nicotinonitrile;

2-[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propylamino]-nicotinic acid ethyl ester;

4-(3,5-Difluoro-phenyl)-1-(3-methoxy-benzylamino)-3-(3-methyl-5-nitro-3H-imidazol-4-ylamino)-butan-2-ol;

3-(Benzooxazol-2-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;

4-(3,5-Difluoro-phenyl)-1-(3-methoxy-benzylamino)-3-(quinolin-4-ylamino)-butan-2-ol;

4-(3,5-Difluoro-phenyl)-3-(5-ethyl-pyrimidin-2-ylamino)-1-(3-methoxy-benzylamino)-butan-2-ol;

4-(3,5-Difluoro-phenyl)-1-(3-methoxy-benzylamino)-3-(4-trifluoromethyl-pyrimidin-2-ylamino)-butan-2-ol;

3-(6-Chloro-2-methylsulfanyl-5-phenyl-pyrimidin-4-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;

3-(3-Chloro-quinoxalin-2-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;

4-(3,5-Difluoro-phenyl)-1-(3-methoxy-benzylamino)-3-(8-trifluoromethyl-quinolin-4-ylamino)-butan-2-ol;

3-(6-Chloro-2,5-diphenyl-pyrimidin-4-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;

3-(3-Chloro-pyrazin-2-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;

4-(3,5-Difluoro-phenyl)-1-(3-methoxy-benzylamino)-3-(5-trifluoromethyl-pyridin-2-ylamino)-butan-2-ol;

4-(3,5-Difluoro-phenyl)-1-(3-methoxy-benzylamino)-3-(quinolin-2-ylamino)-butan-2-ol;

3-(6-Chloro-pyrazin-2-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;

4-(3,5-Difluoro-phenyl)-1-(3-methoxy-benzylamino)-3-(3-nitro-pyridin-2-ylamino)-butan-2-ol;

4-(3,5-Difluoro-phenyl)-1-(3-methoxy-benzylamino)-3-(pyrimidin-2-ylamino)-butan-2-ol;

4-(3,5-Difluoro-phenyl)-1-(3-methoxy-benzylamino)-3-(2-phenyl-quinazolin-4-ylamino)-butan-2-ol;

N-[3-(N′

-Acetyl-N-ethyl-hydrazino)-1-benzyl-2-hydroxy-propyl]-3-hydroxy-4-(pyrrolidine-1-carbonyl)-benzamide;

3-(4,6-Diamino-[1,3,5]triazin-2-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;

5-Acetylamino-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-hydroxy-benzamide;

2-(2,5-Dimethyl-pyrrol-1-yl)-thiophene-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

N-{1-(3,5-Difluoro-benzyl)-2-hydroxy-3-[3-(3-hydroxymethyl-piperidine-1-carbonyl)-phenylamino]-propyl}-5-methyl-N′

,N′

-dipropyl-isophthalamide;

4-Phenyl-[1,2,3]thiadiazole-5-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

N-[3-(3-Cyclohexyl-1-phenyl-propylamino)-1-(3,5-difluoro-benzyl)-2-hydroxy-propyl]-5-methyl-N′

,N′

-dipropyl-isophthalamide;

2-Methanesulfonylamino-oxazole-4-carboxylic acid {1-benzyl-3-[N-ethyl-N′

-(3-ethyl-benzoyl)-hydrazino]-2-hydroxy-propyl}-amide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-(2,6-dimethyl-phenoxy)-propionamide;

2-Methanesulfonylamino-oxazole-4-carboxylic acid {1-benzyl-3-[N-ethyl-N′

-(4-methyl-pentanoyl)-hydrazino]-2-hydroxy-propyl}-amide;

4-Acetylamino-1-methyl-1H-pyrrole-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

2-Ethyl-5-thiophen-2-yl-2H-pyrazole-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

2-Methanesulfonylamino-oxazole-4-carboxylic acid [3-(N′

-acetyl-N-ethyl-hydrazino)-1-benzyl-2-hydroxy-propyl]-amide;

2-Methanesulfonylamino-oxazole-4-carboxylic acid [3-(N′

-benzoyl-N-ethyl-hydrazino)-1-benzyl-2-hydroxy-propyl]-amide;

6-Methyl-4-oxo-1-phenyl-1,4-dihydro-pyridazine-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

2-Methanesulfonylamino-thiazole-4-carboxylic acid {1-benzyl-3-[N-ethyl-N′

-(3-ethyl-benzoyl)-hydrazino]-2-hydroxy-propyl}-amide;

4-Methyl-2-phenyl-oxazole-5-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

2-Methanesulfonylamino-thiazole-4-carboxylic acid [3-(N′

-acetyl-N-ethyl-hydrazino)-1-benzyl-2-hydroxy-propyl]-amide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-pyridin-3-yl-benzamide;

2-p-Tolyl-thiazole-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

N-{1-Benzyl-3-[N-ethyl-N′

-(3-ethyl-benzoyl)-hydrazino]-2-hydroxy-propyl}-2-[4-(2-oxo-pyrrolidin-1-yl)-phenyl]-acetamide;

2-Phenoxymethyl-thiazole-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

N-{1-Benzyl-3-[N-ethyl-N′

-(4-methyl-pentanoyl)-hydrazino]-2-hydroxy-propyl}-2-[4-(2-oxo-pyrrolidin-1-yl)-phenyl]-acetamide;

[1,2,5]Thiadiazole-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

N-[3-(N′

-Acetyl-N-ethyl-hydrazino)-1-benzyl-2-hydroxy-propyl]-2-[4-(2-oxo-pyrrolidin-1-yl)-phenyl]-acetamide;

2-m-Tolyl-thiazole-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

N-[3-(N′

-Benzoyl-N-ethyl-hydrazino)-1-benzyl-2-hydroxy-propyl]-2-[4-(2-oxo-pyrrolidin-1-yl)-phenyl]-acetamide;

2-(2-Chloro-phenyl)-thiazole-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

N-{1-Benzyl-3-[N-ethyl-N′

-(3-ethyl-benzoyl) -hydrazino]-2-hydroxy-propyl}-3-hydroxy-4-(pyrrolidine-1-carbonyl)-benzamide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-3-phenyl-2-tetrazol-1-yl-propionamide;

N-[1-Benzyl-3-[N-ethyl-N′

-(4-methyl-pentanoyl)-hydrazino]-2-hydroxy-propyl}-3-hydroxy-4-(pyrrolidine-1-carbonyl)-benzamide;

4-Chloro-7,7-dimethyl-7,8-dihydro-5H-pyrano[4,3-b]pyridine-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

2-Propyl-tetrahydro-pyran-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

5-p-Tolyl-3,4-dihydro-2H-pyrazole-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

2-Acetylamino-5-chloro-thiophene-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-N′

-(2-fluoro-5-methanesulfonyl-phenyl)-succinamide;

1-(4-Fluoro-phenyl)-5-methyl-1H-[1,2,4]triazole-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

N-(2-Acetyl-thiophen-3-yl)-N′

-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-succinamide;

6-Chloro-4-trifluoromethyl-pyridine-2-carboxy;

ic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-acetamide;

N-(1-Cyclopropyl-ethyl)-N′

-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-N-phenyl-succinamide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-(3,4-dimethoxy-phenylsulfanyl)-acetamide;

1-Methyl-5-oxo-2-pyridin-3-yl-pyrrolidine-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

4-Methoxy-thiophene-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

2,5-Dimethyl-1-pyridin-4-ylmethyl-1H-pyrrole-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

2-Methyl-5-thiophen-2-yl-furan-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

4-(4-Benzyl-[1,4]diazepan-1-yl)-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-4-oxo-butyramide;

2-(Benzo[1,2,5]thiadiazol-4-yloxy)-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-acetamide;

3-Chloro-5-phenyl-isothiazole-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-5-phenylethynyl-nicotinamide;

4,7-Dimethoxy-benzofuran-5-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-3-morpholin-4-ylmethyl-benzamide;

2,2-Dimethyl-4-oxo-chroman-6-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

[1,6]Naphthyridine-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

8-Cyano-4-hydroxy-quinoline-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

2-Pyridin-3-yl-thiazole-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

5-Chloro-benzofuran-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

4-Dibenzofuran-2-yl-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-4-oxo-butyramide;

N-{[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylcarbamoyl]-methyl}-nicotinamide;

4-tert-Butyl-N-{[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylcarbamoyl]-methyl}-benzamide;

4-Chloro-N-{[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylcarbamoyl]-methyl}-benzamide;

4-Chloro-6-methyl-quinoline-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-(2,4-dihydroxy-thiazol-5-yl)-acetamide;

2-Methyl-pyrimidine-5-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-4-piperidin-1-yl-benzamide;

4-Acetylamino-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-benzamide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-4-methoxy-benzamide;

4-Methyl-oxazole-5-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

1H-Indole-5-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

6-Chloro-1H-indole-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

2-(4-Chloro-2-oxo-benzothiazol-3-yl)-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-acetamide;

Thiophene-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

2-Methyl-oxazole-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-(1-oxy-pyridin-3-yl)-acetamide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-hydroxy-2-phenyl-2-thiophen-2-yl-acetamide;

6-Hydroxy-2-methylsulfanyl-pyrimidine-4-carboxylic aci [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

2,5-Dimethyl-furan-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-nicotinamide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-4-(3-methoxy-phenyl)-4-oxo-butyramide;

4-Acetyl-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-benzamide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-4-hydroxy-3,5-dimethoxy-benzamide;

Furan-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-yl)-acetamide;

4-Acetylamino-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2,6-dimethyl-benzamide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-thiophen-2-yl-acetamide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-4-oxo-4-phenyl-butyramide;

1H-Indole-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionamide;

3-Benzo[1,3]dioxol-5-yl-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-propionamide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-4-morpholin-4-yl-4-oxo-butyramide;

[2,3′

]Bithiophenyl-5-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

5-Methoxy-thiophene-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

4-Phenyl-thiophene-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

2-(5-Benzo[1,3]dioxol-5-yl-tetrazol-2-yl)-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-acetamide;

2-(Benzothiazol-2-ylmethoxy)-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-acetamide;

Pyrrolidine-1,2-dicarboxylic acid 1-{[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide}2-phenylamide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-3-(6-ethoxy-1H-benzoimidazol-2-yl)-propionamide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-(3-methyl-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-acetamide;

2-Oxo-2,3-dihydro-benzooxazole-6-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

Thieno[3,2-c]pyridine-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

1-Methyl-1H-indole-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

Benzo[b]thiophene-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

4-Oxy-3-propyl-pyrazine-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

1,1,3-Trioxo-2,3-dihydro-1H-116-benzo[d]isothiazole-6-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-(7-hydroxy-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylsulfanyl)-acetamide;

2-Hydroxy-6-methyl-quinoline-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-(2-methyl-2,3-dihydro-benzofuran-5-yl)-propionamide;

3-(Benzooxazol-2-ylsulfanyl)-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-propionamide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-(5-o-tolyl-tetrazol-2-yl)-acetamide;

2-Chloro-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-4-tetrazol-1-yl-benzamide;

N-(4-tert-Butyl-thiazol-2-yl)-N′

-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-succinamide;

N-(5-Cyclopropyl-[1,3,4]thiadiazol-2-yl)-N′

-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-succinamide;

2-(3-Chloro-phenoxy)-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-propionamide;

N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-3-(pyridin-4-ylmethylsulfanyl)-benzamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxyethyl)amino]sulfonyl}-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(2-isobutyl-1,3-thiazol-5-yl)methyl]amino}propyl)-5-ethynyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-5-ethynyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(4-methyl-1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(2-isobutyl-1,3-thiazol-5-yl)methyl]amino}propyl)-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(3-hydroxypropyl)amino]sulfonyl}-N³,N³-dipropylisophthalamide;

methyl [3-({[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}methyl)phenyl]methylcarbamate;

N′

-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-2,2-dioxido-3,4-dihydro-1H-2,1-benzothiazin-4-yl]amino}-2-hydroxypropyl)-5-methyl-N,N-dipropylisophthalamide

N′

-((1S,2R)-1-(3,5-difluorobenzyl)-3-([(4S)-2,2-dioxido-3,4-dihydro-1H-2,1-benzothiazin-4-yl]amino}-2-hydroxypropyl)-5-methyl-N,N-dipropylisophthalamide

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,3-dimethyl-N²,N²-dipropylcyclopropane-1,2-dicarboxamide

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-(2,2-dimethylpropanoyl)-3-[(1-propylbutyl)sulfonyl]-D-alaninamide

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropyl-5-pyrimidin-2-ylisophthalamide

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-propylbenzyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-5-ethynyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3-isobutylisoxazol-5-yl)methyl]amino}propyl)-5-ethynyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(dimethylamino)sulfonyl]-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(5-formylthien-2-yl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalamide;

5-bromo-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-({[(1R)-2-hydroxy-1-methylethyl]amino}sulfonyl)-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isobutylbenzyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-5-ethynyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-methylbenzamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-({[(1S)-2-hydroxy-1-methylethyl]amino}sulfonyl)-N³,N³-dipropylisophthalamide;

N¹-butyl-N³-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-5-methyl-N¹-propylisophthalamide;

N¹,N¹-dibutyl-N³-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(3-hydroxyprop-1-ynyl)benzyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]sulfonyl}-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-{[3-(cyclopropylamino)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-ethynyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-thien-3-ylbenzyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-([3-(trifluoromethyl)benzyl]amino}propyl)-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(piperazin-1-ylsulfonyl)-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3-iodophenyl)cyclopropyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-[(3-sec-butylbenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R) -1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(3-methylisoxazol-4-yl)-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3-isobutylisoxazol-5-yl)cyclopropyl]amino}propyl)-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methyl-N²,N²-dipropylpyridine-2,4-dicarboxamide;

N¹-(cyclopropylmethyl)-N³-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N¹-propylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

5-(aminosulfonyl)-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[(1Z)-prop-1-enyl]benzyl}amino)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropyl-5-(1H-pyrazol-4-yl)isophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)-1-methylethyl]amino}-2-hydroxypropyl)-5-ethynyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-[(3-allylbenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)-1-methylethyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-ethyl-5-methyl-N³-propylisophthalamide;

N¹-[(1S,2R)-3-{[3-(cyclopropylamino)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-ethynyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3-isobutylisoxazol-5-yl)cyclopropyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(5-formyl-4-methylthien-2-yl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[(methylsulfonyl)amino]benzyl}amino)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopentylbenzyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-[(1,1′

-biphenyl-3-ylmethyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-({[2-(methylamino)ethyl]amino}sulfonyl)-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3-isobutylisoxazol-5-yl)cyclopropyl]amino}propyl)-5-ethynyl-N³,N³-dipropylisophthalamide;

N¹,N¹-diallyl-N³-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(2-isobutyl-1,3-thiazol-5-yl)cyclopropyl]amino}propyl)-5-methyl-N³ N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)-1-methylethyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxyethyl)amino]sulfonyl}-N³-propylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³, 5-dimethyl-N³-propylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-(phenylsulfonyl)-3-[(1-propylbutyl)sulfonyl]alaninamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-diethyl-5-(1,3-oxazol-2-yl)isophthalamide;

N²-[(benzylamino)carbonyl]-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]alaninamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-pyridin-3-ylbenzyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(3-formyl-2-furyl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1-methyl-1H-imidazol-2-yl)-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-diethyl-5-methylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(ethylsulfinyl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalamide;

3-{[butyl(ethyl)amino]sulfonyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}propanamide;

N¹-[(1S,2R)-3-[(3-cyanobenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]propanamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-isobutyl-N³,5-dimethylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-pyridin-2-ylbenzyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[methyl(methylsulfonyl)amino]benzyl}amino)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-(3-phenylpropanoyl)-3-[(1-propylbutyl)sulfonyl]alaninamide trifluoroacetate;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(ethylsulfonyl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N³ N³-dipropylisophthalamide;

N²-[(5-chlorothien-2-yl)sulfonyl]-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]alaninamide;

N¹-[(1S,2R)-3-{[3-(5-acetylthien-2-yl)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-(sec-butyl)-N³-{(1S, 2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1,3-oxazol-2-yl)benzamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,5-dimethyl-N³-(2-phenylethyl)isophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(3,5-dimethylisoxazol-4-yl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,5-dimethyl-N³-prop-2-ynylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-ethyl-N³,5-dimethylisophthalamide;

3-({[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}methyl)phenyl dimethylcarbamate;

N¹-benzyl-N³-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N¹,5-dimethylisophthalamide;

N¹-(sec-butyl)-N³-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N¹-propylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(4-methylthien-2-yl)benzyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

methyl 3-({[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl]amino)-2-hydroxybutyl]amino}methyl)phenyl(methyl)carbamate;

N¹-((1S,2R)-2-hydroxy-1-(2,3,5-trifluorobenzyl)-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-diisobutyl-5-methylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,5-dimethyl-N³-(2-pyridin-2-ylethyl)isophthalamide;

N¹-{(1S,2R)-1-(3-fluoro-5-hydroxybenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3-chloro-5-fluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-4-hydroxy-3-(pyrrolidin-1-ylcarbonyl)benzamide;

5-oxo-D-prolyl-N¹-{(1S, 2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]alaninamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[(trifluoromethyl)sulfonyl]amino}benzamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-pyridin-4-ylbenzyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({3-[(dimethylamino)sulfonyl]benzyl}amino)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-(phenylacetyl)-3-[(1-propylbutyl)sulfonyl]alaninamide;

methyl 3-({[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoylamino)-2-hydroxybutyl]amino}methyl)phenylcarbamate;

5-oxo-L-prolyl-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]alaninamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-isobutyl-5-methylisophthalamide;

4-({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-4-oxo-3-{[(1-propylbutyl)sulfonyl]methyl}butanoic acid trifluoroacetate;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[methyl(methylsulfonyl)amino]benzamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-ethyl-N³-isopropyl-5-methylisophthalamide;

N¹-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(thien-2-ylmethyl)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2-hydroxyethyl)(propyl)amino]sulfonyl}propanamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-isopropyl-N³, 5-dimethylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(methylsulfonyl)amino]-1,3-thiazole-4-carboxamide;

N¹-allyl-N¹-cyclopentyl-N³-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalamide;

N-(3-({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-3-oxo-2-{[(1-propylbutyl)sulfonyl]methyl}propyl)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(isopentylsulfonyl)propanamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(5-methylthien-2-yl)benzyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1-methylhexyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-{[1-(aminocarbonyl)cyclohexyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2E)-hex-2-enylamino]-2-hydroxypropyl}-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxyisoxazole-5-carboxamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({3-[(1E)-hex-1-enyl]benzyl}amino)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-isopropyl-5-methylisophthalamide;

N¹-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(thien-2-ylmethyl)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

2-[3-(2-amino-2-oxoethoxy)phenyl]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}acetamide;

N¹-{(1S,2R)-1-(3-bromobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2-ethylhexyl)amino]-2-hydroxypropyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(6-methoxypyridin-3-yl)benzyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(2,4-dimethoxypyrimidin-5-yl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-ethylbutanoyl)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(4-hydroxypiperidin-1-yl)carbonyl]-5-methylbenzamide;

N¹-{(1S,2R)-1-(3-bromobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

4′

-[4-({(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}amino)-4-oxobutanoyl]-1,1′

-biphenyl-2-carboxamide;

1-{3-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]-5-methylbenzoyl}-L-prolinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(3-hydroxypiperidin-1-yl)carbonyl]-5-methylbenzamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-hydroxy-1-phenylpropyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-[2-(dimethylamino)ethyl]-N³-ethyl-5-methylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methyl-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepine-4-carboxamide;

2-(5-acetylthien-2-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N³,N³-diisopropyl-5-methylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-3-[(methylsulfonyl)amino]benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-2-[4-(2-oxopyrrolidin-1-yl)phenyl]acetamide;

N-{(1S,2R)-1-(3-chloro-5-fluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(dipropylamino)sulfonyl]propanamide;

N¹-[(1S,2R)-1-(3-chloro-5-fluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(1-methyl-1H-imidazol-4-yl)sulfonyl]amino}benzamide tri;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(pentylamino)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(3-chloro-5-fluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-cyclohexyl-N³-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N¹-ethyl-5-methylisophthalamide;

2-{[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}ethyl 2,4-difluorophenylcarbamate;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-methylbenzamide;

N¹-[(1S,2R)-1-(3-bromobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,8-dimethylquinoline-3-carboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(6-hydroxyhexyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(2R)-2-hydroxypropyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(1-propylbutyl)sulfonyl]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}benzamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(4-phenylbutyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-7-(1H-imidazol-1-yl)-5,6-dihydronaphthalene-2-carboxamide;

3-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methylbenzamide;

N¹-[(1S,2R)-3-{[2-(aminosulfonyl)ethyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[2-(ethylthio)ethyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-[benzyl(cyanomethyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(2-hydroxypropyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-[(3-butoxypropyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[2-(2-hydroxyethyl)piperidin-1-yl]carbonyl}-5-methylbenzamide;

methyl N-[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]-beta-alaninate;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1-hydroxy-2-propylpentyl)benzamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(3-chloro-5-fluorobenzyl)-2-hydroxypropyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(methylsulfonyl)amino]butanamide;

N¹-[(1S,2R)-3-{[3-(1-benzothien-2-yl)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

3-(benzyloxy)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isoxazole-5-carboxamide;

2-{[(benzyloxy)carbonyl]amino}-7-[(cyclopropylmethyl)amino]-1,2,4,5,7-pentadeoxy-5-(3,5-difluorobenzyl)-1-[(1-propylbutyl)sulfonyl]-D-threo-hept-3-ulose trifluoroacetate;

1-{3-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]-5-methylbenzoyl}-D-prolinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1H-pyrazol-1-yl)pentanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(2-furylmethyl)-5-oxopyrrolidine-3-carboxamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(5-hydroxypentyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

3-[({(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1-methyl-1-phenylethyl)amino]propyl}amino)sulfonyl]-N,N-dipropylbenzamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N³,N³-dipropylpiperidine-1,3-dicarboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N³,N³-diethylpiperidine-1,3-dicarboxamide;

5-bromo-N¹-(1S,2R)-2-hydroxy-1-(pentafluorobenzyl)-3-{[3-(trifluoromethyl)benzyl]amino}propyl}-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(methylsulfonyl)amino]benzamide;

N-{(1S,2R)-1-(3-bromobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(dipropylamino)sulfonyl]propanamide;

3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(thien-2-ylmethyl)propyl]propanamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethoxypropyl)amino]-2-hydroxypropyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(thien-2-ylmethyl)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-(phenylsulfonyl)butanamide;

N¹-[(1S,2R)-1-(3,5-dichlorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3,3-dimethylbutyl)amino]-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(3-bromobenzyl)-2-hydroxypropyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-[(1S,2R)-1-(3-chloro-5-fluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(1,3-diphenylpropyl)amino]-2-hydroxypropyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-(hydroxymethyl)propyl]amino}propyl)-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3S)-2-oxoazepan-3-yl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-cyclohexyl-N⁵-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}pentanediamide;

N¹-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(3-methylbenzyl)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-[(2-propylpentyl)sulfonyl]-beta-alaninamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1,3-thiazol-2-yl)benzamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[methyl(phenyl)amino]propyl}amino)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(4-methylbenzyl)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-oxo-1-(thien-2-ylmethyl)pyrrolidine-3-carboxamide;

4-[(butylthio)methyl]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-2-furamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2-hydroxyethyl)amino]sulfonyl}benzamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methylcyclohexyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-oxo-1,3-oxazolidin-3-yl)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1H-pyrrol-1-yl)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3,4,5-tetrahydrothiopyrano[4,3-b]indole-8-carboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N⁴-[2-(trifluoromethyl)phenyl]succinamide;

N¹-[(1S,2R)-1-(3-bromobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5-dimethyl-2-(1H-pyrrol-1-yl)thiophene-3-carboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2,3-dihydroxypropyl)amino]-2-hydroxypropyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(2S)-2-hydroxypropyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1R)-1-methylpropyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

2-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(methylsulfonyl)benzamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(2-hydroxyethyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-1-(3-methoxybenzyl)-3-[(3-methoxybenzyl)amino]propyl}propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{methyl[(trifluoromethyl)sulfonyl]amino}benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxy-6-(1-hydroxy-2,2-dimethylpropyl)pyridine-2-carboxamide;

N¹-[(1S,2R)-3-[(1,3-dicyclohexylpropyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2′

-bithiophene-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1H-imidazol-1-yl)butanamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,3-dihydroxy-N⁴-(4-methoxyphenyl)succinamide;

N¹-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-hydroxybenzyl)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-[3-(trifluoromethyl)benzyl]propyl}-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(thien-2-ylmethyl)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-[(1S,2R)-3-{[2-(aminocarbonyl)-1H-indol-6-yl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(3-bromobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide;

3-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(methylsulfonyl)thiophene-2-carboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(1-ethylpropyl)amino]-2-hydroxypropyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({[(5R)-3-ethyl-2-oxo-1,3-oxazolidin-5-yl]methyl}amino)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide;

N¹-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N²-[(methylthio)acetyl]-3-[(1-propylbutyl)sulfonyl]alaninamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2,3-dimethylcyclohexyl)amino]-2-hydroxypropyl}-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5-dimethoxy-1-benzothiophene-2-carboxamide;

N¹-[(1S,2R)-1-[3-fluoro-5-(trifluoromethyl)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({[(5S)-3-ethyl-2-oxo-1,3-oxazolidin-5-yl]methyl}amino)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,5-dioxo-1,2,4-triazolidin-4-yl)benzamide;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-hydroxy-3-[(3-methoxyphenyl)sulfonyl]propanamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(2-methylcyclohexyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-[(2-{4-[(3-chlorobenzyl)oxy]phenyl}ethyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-oxo-4-thien-3-ylbutanamide;

N¹-{(1S,2R)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-oxo-4-[3-(trifluoromethyl)phenyl]butanamide;

N¹-{(1S,2R)-2-hydroxy-3-(isopentylamino)-1-[3-(trifluoromethoxy)benzyl]propyl}-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(hydroxymethyl)-3-(methylthio)propyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

2-(1H-1,2,3-benzotriazol-1-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}hexanamide;

N¹-[(1S,2R)-1-(3-fluoro-4-methylbenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-{[(1-propylbutyl)sulfonyl]methyl}propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[(trifluoromethyl)sulfonyl]amino}butanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(5-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(hydroxymethyl)propyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(3,5-dichlorobenzyl)-2-hydroxypropyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-{[(2-hydroxyethyl)(propyl)amino]sulfonyl}propanamide;

5-(benzylthio)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}nicotinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-pyrazole-5-carboxamide;

6-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-benzimidazole-2-carboxamide;

N¹-{(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-hydroxy-4,7-dimethoxy-1-benzofuran-5-carboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(4-methylcyclohexyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}[1,2,4]triazolo[4,3-a]pyridine-6-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-oxo-4-thien-2-ylbutanamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(3,5-dichlorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-hydroxy-5-methylphenyl)-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-phenoxybenzamide;

4-[(aminocarbonyl)amino]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-(hydroxymethyl)-3-(methylthio)propyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-7-hydroxy-4-oxochromane-2-carboxamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-(hydroxymethyl)-3-methylbutyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1R)-1-(hydroxymethyl)propyl]amino}propyl)-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1-methyl-3-phenylpropyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2,3-dihydro-1-benzofuran-5-yl)-1,3-thiazole-4-carboxamide;

N¹-{(1S,2R)-1-[3-(benzyloxy)benzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(4-chlorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(dipropylamino)sulfonyl]propanamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-pentylmalonamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(trifluoromethoxy)benzamide;

3-[(dipropylamino)sulfonyl]-N-{(1S,2R)-1-(3-fluoro-4-methylbenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}propanamide;

N-[(1S,2R)-1-(3-chloro-5-fluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-3-[(dipropylamino)sulfonyl]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-{[(1-propylbutyl)sulfonyl]methyl}propanamide;

N¹-[4-(acetylamino)phenyl]-N⁴-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}succinamide;

3-(1-cyanoethyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N⁴-(5-phenyl-1,3,4-thiadiazol-2-yl)succinamide;

N¹-{(1S,2R)-3-(benzylamino)-2-hydroxy-1-[3-(trifluoromethoxy)benzyl]propyl}-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[2-(2-oxo-2-pyrrolidin-1-ylethoxy)phenyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-(4-chlorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(1,1-dioxidotetrahydrothien-2-yl)acetamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(4-chlorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-hex-1-ynylnicotinamide;

N-[(1S,2R)-1-(3-bromobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-3-[(dipropylamino)sulfonyl]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methoxyisoxazole-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,3-dimethyl-1H-indole-7-carboxamide;

4-(3-chlorophenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(1-methyl-1H-indol-3-yl)-2-oxoacetamide;

N¹-[(1S,2R)-1-(3-fluoro-4-methylbenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(4-methylbenzyl)propyl]propanamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(3-fluoro-4-methylbenzyl)-2-hydroxypropyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[5-(4-methylphenyl)-2H-tetraazol-2-yl]acetamide;

N-{(1S,2R)-1-(3,5-dichlorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(dipropylamino)sulfonyl]propanamide;

N¹-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(thien-2-ylmethyl)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-3-phenylisoxazole-4-carboxamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(4-fluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-[(methylsulfonyl)acetyl]-N²-pentylglycinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1H-indol-3-yl)-4-oxobutanamide;

N¹-(5-benzyl-1,3,4-thiadiazol-2-yl)-N⁴-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}succinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3-fluoro-4-methoxyphenyl)-4-oxobutanamide;

ethyl 4-{[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}piperidine-1-carboxylate;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-4-(2-fluorobenzoyl)-1H-pyrrole-2-carboxamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(4-chlorobenzyl)-2-hydroxypropyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-{(1S,2R)-2-hydroxy-3-(isopentylamino)-1-[3-(trifluoromethyl)benzyl]propyl}-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-[(1S,2R)-2-hydroxy-1-(4-hydroxybenzyl)-3-(isopentylamino)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(4-morpholin-4-ylphenyl)acetamide;

3-[(dipropylamino)sulfonyl]-N-{(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-[3-(trifluoromethoxy)benzyl]propyl}propanamide;

N¹-benzyl-N¹-(1-cyclopropylethyl)-N⁴-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}succinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-(2,5-dimethylbenzoyl)-5-methylbenzamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl) amino]-2-hydroxypropyl}-N⁴-(2-methoxy-5-methylphenyl)succinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-hydroxyphenyl)acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[hydroxy(2-methylphenyl)methyl]-5-methylbenzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(ethylthio)nicotinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[4-(2-furoyl)piperazin-1-yl]-4-oxobutanamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(3-fluoro-4-methylbenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-oxoisoindoline-1-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(ethylthio)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thieno[2,3-b]quinoline-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(4-methyl-1,3-oxazol-2-yl)benzamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(4-fluorobenzyl)-2-hydroxypropyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-{2-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]phenyl}-N-methyl-2-furamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-(3-methoxyphenyl)-4-oxobutanamide;

N¹-[(1S,2R)-3-(cycloheptylamino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

3-[(dipropylamino)sulfonyl]-N-{(1S,2R)-1-(3-fluoro-5-hydroxybenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}propanamide;

3-[(dipropylamino)sulfonyl]-N-{(1S,2R)-1-(3-fluoro-5-hydroxybenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-hydroxy-1H-indole-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2-dimethylchromane-8-carboxamide;

6-benzyl-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}pyrazine-2-carboxamide 4-oxide;

2-{[({(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl]amino)carbonyl]amino}-N,N-dipropylethanesulfonamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1R)-1-(hydroxymethyl)-2-methylpropyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N-[(1S,2R)-3-(benzylamino)-1-(3-chloro-5-fluorobenzyl)-2-hydroxypropyl]-3-[(dipropylamino)sulfonyl]propanamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(4-methoxyphenyl)-4-oxobutanamide;

N¹-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-hydroxybenzyl)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-4-oxo-3,4-dihydrophthalazine-1-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dihydro-2H-1,5-benzodioxepine-7-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[4-(2,5-dioxopyrrolidin-1-yl)phenoxy]acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide;

N¹-[(1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-[(1S,2R)-1-(3-chloro-5-fluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N⁵,N⁵-dipropylpentanediamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-fluoro-2-hydroxyquinoline-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxo-4-thien-2-ylbutanamide;

N³-[({(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}amino)carbonyl]-N¹,N¹-dipropyl-beta-alaninamide;

N¹-{(1R,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-[(phenylthio)methyl]propyl}-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1R,2S)-1-(hydroxymethyl)-2-methylbutyl]amino propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(phenoxymethyl)benzamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-N⁵-(2,4-difluorophenyl)pentanediamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N⁵-(4,6-dimethylpyrimidin-2-yl)pentanediamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-(3-methoxybenzoyl)-5-methylbenzamide;

N¹-{(1S,2R)-1-[3-(benzyloxy)benzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

4-(3,4-dichlorophenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-4-oxobutanamide;

methyl 4-{(2R,3R)-2-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-3-hydroxy-4-[(3-methoxybenzyl)amino]butyl}benzoate;

N¹-(4-acetylphenyl)-N⁵-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}pentanediamide;

N¹-{(1R,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-[(phenylthio)methyl]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

2-{[3-({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-3-oxopropyl]thio}-N-methylbenzamide;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(1-propylbutyl)thio]propanamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N⁴-(4-ethoxyphenyl)succinamide;

N¹-[(1S,2R)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxy-3-(isopentylamino)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

2-{[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}ethyl 3-methoxyphenylcarbamate;

3-(benzyloxy)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-2-hydroxy-1-methylethyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-2-hydroxy-1-(pentafluorobenzyl)-3-([3-(trifluoromethyl)benzyl]aminoypropyl)-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(4-hydroxyphenyl)-4-oxobutanamide;

3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-[3-(trifluoromethyl)benzyl]propyl}propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(piperidin-3-ylsulfonyl)benzamide;

6-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxyquinoline-2-carboxamide;

N¹-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(thien-2-ylmethyl)propyl]-N⁵,N⁵-dipropylpentanediamide;

N¹-((1S)-1-{(1R)-1-hydroxy-2-[(3-methoxybenzyl)amino]ethyl}-3-methylbutyl)-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(6-oxo-3-phenylpyridazin-1(6H)-yl)acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{4-[(methylsulfonyl)amino]phenyl}propanamide;

N¹-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methylbenzyl)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

3-(2-chlorophenoxy)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propylipropanamide;

N¹-[(1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-((1S,2R)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(dipropylamino)sulfonyl]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(4-methylphenyl)-4-oxobutanamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N⁴-[3-(trifluoromethyl)phenyl]succinamide;

N¹-{(1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(5-pyridin-2-yl-2H-tetraazol-2-yl)acetamide;

3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(3-methylbenzyl)propyl]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isoxazole-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3,5-dimethoxyphenoxy)acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2,5-dimethyl-1H-pyrrol-1-yl)-3-hydroxybenzamide;

N¹-{(1S,2R)-1-(3-bromobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N⁵,N⁵-dipropylpentanediamide;

N¹-[5-(cyclopentylmethyl)-1,3,4-thiadiazol-2-yl]-N⁴-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}succinamide;

N¹-((1S,2R)-3-(benzylamino)-2-hydroxy-1-[3-(trifluoromethyl)benzyl]propyl}-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-oxo-1,2-benzisothiazol-2(3H)-yl)acetamide;

N′

-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[[-methyl-5-(pyrrolidin-1-ylcarbonyl)-1H-pyrrol-3-yl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,4-difluorophenyl)-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-naphthyl)-4-oxobutanamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,6-diethoxypyridine-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(5-methyl-1H-pyrrol-2-yl)-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-({[2-(methylamino)ethyl]amino}sulfonyl)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-methyl-5-(4-methylbenzoyl)benzamide;

N¹-[(1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-3-(benzylamino)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(piperazin-1-ylsulfonyl)benzamide;

N¹-[(1S,2R)-3-({2-[4-(aminosulfonyl)phenyl]ethyl}amino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[2-hydroxy-1-(hydroxymethyl)ethyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-(4-fluoro-3-methylbenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(3-oxo-2,1-benzisothiazol-1(3H)-yl)propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2,6-dihydroxypyrimidin-4-yl)acetamide;

N¹-{(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-[3-(trifluoromethyl)benzyl]propyl}-N⁵,N⁵-dipropylpentanediamide;

N-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-hydroxybenzyl)propyl]-3-[(dipropylamino)sulfonyl]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,4-difluorophenyl)-2-methyl-4-oxobutanamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl) amino]-2-hydroxypropyl)-N⁵-(2-pyridin-2-ylethyl)pentanediamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[2-(4-fluorophenyl)-1,3-benzoxazol-5-yl]acetamide;

N²-(anilinocarbonyl)-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}glycinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(1,3-dithian-2-yl)-3-furamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[2-oxo-2-(propylamino)ethyl]benzamide;

N-[(1S,2R)-3-(benzylamino)-1-(3-bromobenzyl)-2-hydroxypropyl]-3-[(dipropylamino)sulfonyl]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-3-(2-fluorophenyl)propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylthiophene-2-carboxamide;

2-[4-(benzyloxy)phenyl]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(5,7-dimethyl[1,2,4]triazolo[4,3-a]pyrimidin-3-yl)thio]acetamide;

N¹-(1-acetyl-2,3-dihydro-1H-indol-7-yl)-N⁴-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}succinamide;

N¹-(3-acetylphenyl)-N⁵-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}pentanediamide;

3-(4-chlorophenoxy)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxypropanamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(3-fluoro-4-methoxybenzyl)-2-hydroxypropyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(3-methylbenzyl)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-7-carboxamide;

N¹-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(3-methylbenzyl)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1,2,3-thiadiazol-4-yl)benzamide;

N-{(1S,2R)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(dipropylamino)sulfonyl]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-{[(1-propylbutyl)sulfonyl]methyl}propanamide;

N¹-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-3-(benzylamino)-1-[3-fluoro-5-(trifluoromethyl)benzyl]-2-hydroxypropyl}-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2-[1-methyl-3-(methylthio)-1H-indol-2-yl]acetamide;

N¹-[(1S,2R)-1-(3,5-dichlorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-furyl)-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)propanamide;

2-[2-(acetylamino)-1,3-thiazol-4-yl]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(4-methyl-4H-1,2,4-triazol-3-yl)thio]-2-phenylacetamide;

N¹-[(1S,2R)-1-(4-chlorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

4-(1,3-benzothiazol-2-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}butanamide;

N¹-(3-chloro-4-fluorophenyl)-N⁴-(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]succinamide;

N¹-[(1S,2R)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(2-oxo-2,3-dihydroquinazolin-4-yl)thio]acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-methyl-5-(2-methylbenzoyl)benzamide;

N¹-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methylbenzyl)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-propoxybenzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-1-methyl-1H-indole-2-carboxamide;

5-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-methyl-4H-1,2,4-triazol-4-yl)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,4-difluorophenyl)-2-methoxy-4-oxobutanamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-thien-2-yl-1H-pyrazol-1-yl)acetamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N⁵-phenylpentanediamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-thioxo-1,3-benzothiazol-3(2H)-yl)acetamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(cyclohexylmethyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-2-hydroxy-1-(4-methoxybenzyl)-3-[(3-methoxybenzyl)amino]propyl}-N³ N³-dipropylbenzene-1,3,5-tricarboxamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-hydroxy-4-methylphenyl)acetamide;

N¹-[(1S,2R)-1-[3-fluoro-5-(trifluoromethyl)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-7-fluoro-4H-imidazo[5,1-c][1,4]benzoxazine-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-benzofuran-3-carboxamide;

N′

-(3,4-dichlorophenyl)-N³-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}malonamide;

N¹-{(1S,2R)-3-(benzylamino)-1-[3-fluoro-5-(trifluoromethyl)benzyl]-2-hydroxypropyl}-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1R)-2-hydroxy-1-methylethyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(3-methylbenzyl)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl) amino]-2-hydroxypropyl}-N⁵-pyridin-3-ylpentanediamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2-methyl-4-oxo-4H-chromene-6-carboxamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(1H-imidazol-1-yl)propyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

3-[(dipropylamino)sulfonyl]-N-{(1S,2R)-1-[3-fluoro-5-(trifluoromethyl)benzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}propanamide;

3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-1-(4-hydroxybenzyl)-3-(isopentylamino)propyl]propanamide;

N¹-[(1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(thien-2-ylmethyl)propyl]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(2,2-dimethylpropanoyl)amino]-2-hydroxybenzamide;

N¹-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(3-methoxybenzyl)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N-((1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-3-{[(3-methoxybenzyl)amino]sulfonyl}benzamide;

N¹-{(1S,2R)-2-hydroxy-3-(isopentylamino)-1-[3-(trifluoromethyl)benzyl]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N-[6-({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-6-oxohexyl]-2-furamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(1-phenyl-4,5-dihydro-1H-tetraazol-5-yl)thio]acetamide;

4-acetyl-4-amino-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}cyclohexa-1,5-diene-1-sulfonamide;

N-{(1S,2S)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-3-{[(3-methoxybenzyl)amino]sulfonyl}benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,4-dihydro-2H-chromen-6-yl)-4-oxobutanamide;

N¹-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(3-methoxybenzyl)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-[(1S,2R)-1-(3-fluoro-4-methylbenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N⁵,N⁵-dipropylpentanediamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}indolizine-2-carboxamide;

N¹-{(1S,2R)-3-(benzylamino)-2-hydroxy-1-[3-(trifluoromethoxy)benzyl]propyl}-5-methyl-N³ N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}nicotinamide 1-oxide;

N-[(1S,2R)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxy-3-(isopentylamino)propyl]-3-[(dipropylamino)sulfonyl]propanamide;

2-(((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}amino)-2-oxoethyl carbamate;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,3-dihydro-1H-cyclopenta[b]quinoline-9-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-1H-pyrazole-5-carboxamide;

N-[5-({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-5-oxopentyl]benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(methoxymethyl)thio]benzamide;

3-(1,3-benzothiazol-2-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methoxypropanamide;

N-{(1S,2R) -1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(methylamino)carbonyl]amino}-3-thien-3-ylpropanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-pyridin-2-ylthiophene-2-carboxamide;

N¹-{(1S,2R)-3-(benzylamino)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxypropyl}-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(5,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyridin-3-yl)acetamide;

N¹-[(1S,2R)-1-(3-fluoro-4-methoxybenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-isobutyl-1,3-dioxoisoindoline-5-carboxamide;

3-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)sulfonyl]benzoic acid;

5-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-furamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-[(4-methoxyphenyl)acetyl]glycinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isoquinoline-4-carboxamide;

N¹-[(1S,2R)-1-[3-(benzyloxy)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(4-hydroxy-3-methoxyphenyl)acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(4-phenyl-4H-1,2,4-triazol-3-yl)thio]acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3,5-dimethoxyphenyl)acetamide;

N¹-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(3-methoxybenzyl)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-ethyl-4H-[1,2,4]triazolo[1,5-a]benzimidazol-4-yl)acetamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(2-furylmethyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

7-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-benzofuran-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-oxo-2H-1,3-benzoxazin-3(4H)-yl)propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(pyrimidin-2-ylthio)acetamide;

N¹-[3-(aminocarbonyl)-4,5,6,7-tetrahydro-1-benzothien-2-yl]-N⁴-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}succinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)thio]acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}quinoline-6-carboxamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(2-furylmethyl)-2-hydroxypropyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1H-indol-3-yl)-1H-pyrazole-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-{[(methylamino)carbonothioyl]amino}benzamide;

6-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}nicotinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3-hydroxyphenyl)-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(phthalazin-1-ylthio)acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(1-oxidopyridin-2-yl)thio]acetamide;

3-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-fluoro-1H-indole-2-carboxamide;

N-((1S,2S)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-3-{[(3-chlorobenzyl)amino]sulfonyl}benzamide;

N¹-[(1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-3-(benzylamino)-2-hydroxypropyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

4-(3,4-dichlorophenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-3-methyl-4-oxobutanamide;

3-[(dipropylamino)sulfonyl]-N-{(1S,2R)-2-hydroxy-3-(isopentylamino)-1-[3-(trifluoromethoxy)benzyl]propyl}propanamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N⁴-(5-methyl-1,3,4-thiadiazol-2-yl)succinamide;

N-{(S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-ethyl-1H-benzimidazol-1-yl)acetamide;

N-{(1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(dipropylamino)sulfonyl]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-oxo-1,3-benzoxazol-3(2H)-yl)propanamide;

N-[(1S,2R)-1-(3,5-dichlorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-3-[(dipropylamino)sulfonyl]propanamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N⁴-(6-methylpyridin-2-yl)succinamide;

ethyl (4R)-4-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]-1,3-oxazolidine-3-carboxylate;

N-{(1R,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-glycylbenzamide;

N-{(1S, 2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1-methyl-1H-imidazol-2-yl)benzamide;

4-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}butanamide trifluoroacetate;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-{[(3S)-tetrahydrofuran-3-yloxy]carbonyl}-D-leucinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(pyrrolidin-3-ylsulfonyl)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(dipropylamino)methyl]benzamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1R)-1-(hydroxymethyl)-3-methylbutyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-[tert-butyl(cyclohexyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-(hydroxymethyl)-2,2-dimethylpropyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({[(2R)-1-ethylpyrrolidin-2-yl]methyl}amino)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(dimethylamino)-2,2-dimethylpropyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[2-(diisopropylamino)ethyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(1-ethylpyrrolidin-2-yl)methyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-[(1-benzylpyrrolidin-3-yl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-pyrrolidin-1-ylpropyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(dimethylamino)propyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-{[2-(acetylamino)ethyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[2-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-[7-chloro-1-(2-hydroxy-3-methoxyphenyl)-3,4-dihydroisoquinolin-2(1H)-yl]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-{[4-(1-cyanocyclopentyl)phenyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-({4-[4-(acetylamino)phenoxy]phenyl}amino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³ dipropylisophthalamide;

N¹-[(1S,2R)-3-[(4-benzoyl-2,3-dimethylphenyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-[(2-amino-2-oxo-1-phenylethyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{4-[(1-methyl-1H-imidazol-2-yl)methyl]piperazin-1-yl}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-[3,5-bis(trifluoromethyl)benzyl]-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

(1S,2R)-N¹-[2-(tert-butylthio)ethyl]-N²-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}cyclopropane-1,2-dicarboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5-dihydronaphtho[2,1-d]isoxazole-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1H-benzo[g]indazole-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-1,3-thiazole-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methoxy-1H-pyrrole-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-9-oxo-1,2,3,9-tetrahydrocyclopenta[b]chromene-7-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)acetamide;

2-[2-(1,3-benzoxazol-2-yl)phenoxy]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;

5-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-morpholin-4-ylbenzamide;

3-(3-chloroisoxazol-5-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropylypropanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(6-methoxy-1,1′

-biphenyl-3-yl)-4-oxobutanamide;

4-(1-benzofuran-2-yl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxamide;

2-(1-benzofuran-2-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methylpropanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methoxy-1-benzofuran-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[4-(1H-pyrrol-1-yl)phenyl]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-imidazo[1,2-b]pyrazole-6-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(4-methyl-1,3-thiazol-2-yl)thio]acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methoxy-4-(methylthio)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-(propionylamino)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-{[(4-methylphenyl)sulfonyl]amino}-4-oxohexanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-benzimidazole-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)propanamide;

7-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methylquinoline-5-carboxamide;

N³-(tert-butoxycarbonyl)-N′

-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-b-alaninamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxy-3-propylhexanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenyl-2-(1H-pyrrol-1-yl)acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-5-phenyl-1H-pyrazole-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-oxo-2,3-dihydro-1H-isoindol-1-yl)acetamide;

4-[2-(acetylamino)-4,5-dimethylphenyl]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxobutanamide;

6-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}pyrazine-2-carboxamide 4-oxide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methoxypyrazine-2-carboxamide 4-oxide;

2-(1H,1′

H-2,2′

-biimidazol-1-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;

5-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2,3-dihydro-1-benzofuran-7-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-([1,2,4]triazolo[4,3-b]pyridazin-6-ylthio)acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-1-pyridin-4-yl-1H-1,2,3-triazole-4-carboxamide;

2-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxo-3,4-dihydroquinazoline-6-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(7-methoxy-1-benzofuran-2-yl)-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(2-ethyl-1-oxo-2,3-dihydro-1H-isoindol-5-yl)oxy]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyllpyrazine-2-carboxamide 4-oxide;

7-chloro-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}quinoline-2-carboxamide;

2-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-3-(3,4-dimethoxyphenyl)-2-methylpropanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-5-(propionylamino)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl]propanamide;

5-(4-chlorophenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-furamide;

4-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1H-pyrrol-1-yl)thiophene-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-3,5-bis(methylthio)isothiazole-4-carboxamide;

2-chloro-4-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(methoxyacetyl)amino]-3-phenylpropanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-fluoro-4-morpholin-4-ylbenzamide;

N-{(S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1-oxidothiomorpholin-4-yl)butanamide;

4-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide;

N-{2-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]phenyl}-5-methyl-2-furamide;

1-(cyanomethyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-pyrrole-2-carboxamide;

N¹-(2-chloropyridin-3-yl)-N⁴-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}succinamide;

3-(cyclopentyloxy)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-4-methoxybenzamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(5-pyrrolidin-1-yl-2H-tetraazol-2-yl)acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,5-dimethyl-1-phenyl-1H-pyrrole-3-carboxamide;

1-(4-acetylphenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}piperidine-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-2-(1H-1,2,4-triazol-1-yl)propanamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(piperidin-1-ylmethyl)-2-furamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-2,3-dihydro-1-benzothiophene-2-carboxamide 1,1-dioxide;

2-(2,1,3-benzoxadiazol-5-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-thiazole-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5-dihydrofuro[2,3-g][2,1]benzisoxazole-8-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(4-methyl-1,2,3-thiadiazol-5-yl)thio]acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(2-furoyl)-4-hydroxyprolinamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxo-4,5,6,7-tetrahydro-1-benzofuran-3-carboxamide;

4,5-dichloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isothiazole-3-carboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N⁵-(1,3-thiazol-2-yl)pentanediamide;

N-acetyl-4-chloro-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}phenylalaninamide;

8-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxycinnoline-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,6-dioxohexahydropyrimidine-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(5-methyl-4-phenyl-1,3-oxazol-2-yl)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenylimidazo[1,2-a]pyridine-6-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(4-methyl-1,2,3-thiadiazol-5-yl)-1,3-thiazole-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)butanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-dimethyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;

4-(1,3-benzodioxol-5-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}butanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-(4-methyl-1,2,3-thiadiazol-5-yl)isoxazole-4-carboxamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[2-(dimethylamino)-1-methylethyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(2-methylmorpholin-4-yl)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{2-[hydroxy(phenyl)methyl]-4-methylpiperazin-1-yl}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(2R)-2-methylbutyl]aminopropyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-{[4-(diethylamino)-1-methylbutyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(2-hydroxy-1,1-dimethylethyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(2-methylpiperidin-1-yl)propyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methyl-4,5,6,7-tetrahydro-3H-31ambda4-[1,3]thiazolo[5,4-c]pyridin-2-yl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-[(3-ethylbenzyl)amino]-2-hydroxy-1-(1H-pyrazol-1-ylmethyl)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

3,5-bis(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;

N¹-[4-(aminosulfonyl)phenyl]-N⁴-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}succinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[methyl(methylsulfonyl)amino]benzamide;

1-acetyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}piperidine-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(4-methoxyphenoxy)propanamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N⁴-methylsuccinamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N⁴-(2,6-dimethylphenyl)succinamide;

N-acetyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-D-phenylalaninamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(4-methylphenyl)sulfonyl]acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-{[(ethylamino)carbonyl]amino}benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-phenyl-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxamide;

4-(cyclopentyloxy)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]benzamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N⁴-pyridin-3-ylsuccinamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N⁴-phenylsuccinamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dihydroxybenzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1H-1,2,4-triazol-1-yl)pentanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenyl-1,3-oxazole-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-7-methoxy-4-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{4-[(methylsulfonyl)amino]phenyl}-4-oxobutanamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-4-hydroxy-7-methoxy-1-benzofuran-5-carboxamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-4-hydroxy-7-methoxy-1-benzothiophene-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1-benzofuran-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-thiazole-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-pyridin-2-yl-1,3-thiazol-4-yl)acetamide;

N¹-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]-N⁴-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}succinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxy-6-neopentylpyridine-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(4-fluorophenyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepine-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-3-furamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-furamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-hydroxyethoxy)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thiophene-2-carboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²,N²-dimethylphthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-2-phenyl-1,3-oxazole-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-hydroxybutanamide;

2-(2H-1,2,3-benzotriazol-2-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}butanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indazole-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxyquinoxaline-2-carboxamide;

2-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5-dimethylthiophene-3-carboxamide;

N¹-(2-cyanophenyl)-N⁴-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]succinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-ethyl-1H-indole-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-benzofuran-2-carboxamide;

1-benzyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,5-dimethyl-1H-pyrazole-4-carboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-[(4-methylphenyl)sulfonyl]glycinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,8-dihydroxyquinoline-2-carboxamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(1,1-dioxidotetrahydrothien-3-yl)acetamide;

methyl 5-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]-1H-benzimidazol-2-ylcarbamate;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-methyl-1,3-benzoxazol-5-yl)acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[ethyl(methyl)amino]-4-hydroxypyrimidine-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-pyridin-4-yl-1,3-benzoxazol-5-yl)acetamide;

4-[2-(diethylamino)ethoxy]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;

3-(aminosulfonyl)-4-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;

2-(diethylamino)-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxypyrimidine-5-carboxamide;

N-{(1S,2R) -1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5,6,7,8-tetrahydro-4H-cyclohepta[c]isoxazole-3-carboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N⁴,N⁴-diphenylsuccinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-hydroxy-4-methylpyridine-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenylimidazo[1,2-a]pyridine-7-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}quinoline-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-9H-purin-9-yl)acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methoxy-1H-indole-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,5-dimethyl-1H-pyrazol-1-yl)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisoxazole-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methylisoxazole-5-carboxamide;

2-(1-benzothien-4-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-benzothiophene-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-hydroxynicotinamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-[(4-methylphenyl)sulfonyl]-beta-alaninamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2-hydroxyquinoline-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(5-phenyl-1H-tetraazol-1-yl)acetamide;

4-{[(cyclobutylcarbonyl)amino]methyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-oxo-1,3-benzoxazol-3(2H)-yl)butanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(1,3-dioxooctahydro-2H-isoindol-2-yl)butanamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-(tetrahydrofuran-2-ylmethyl)phthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2,3-dihydro-1H-indol-1-yl)-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]thieno[3,2-b]pyridine-6-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(6-methoxy-1H-benzimidazol-2-yl)thio]acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropylithieno[2,3-c]pyridine-2-carboxamide;

2-(1H-benzimidazol-2-ylthio)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(2,4-difluorobenzyl)oxy]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5,6-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(2-fluorophenyl)-5-oxopyrrolidine-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(5-methyl-1H-tetraazol-1-yl)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)thiophene-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-5-(trifluoromethoxy)-1H-indole-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(pyridin-2-ylthio)methyl]-2-furamide;

5-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-morpholin-4-ylpyrimidine-4-carboxamide;

5-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-1-phenyl-1H-pyrazole-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methyl-1,2,3-thiadiazole-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,1,3-benzoxadiazole-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(imidazo[1,2-a]pyridin-2-ylmethyl)thio]acetamide;

2-(acetylamino)-N-{(1R,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-1,3-oxazole-4-carboxamide;

N-{(1S,2R)-1-[3-(cyclohexylmethyl)benzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}acetamide;

1 2-{[({(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}amino)carbonyl]amino}-N,N-dipropylethanesulfonamide;

2-(3-azabicyclo[3.2.2]non-3-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}acetamide;

2-(4-benzoylphenoxy)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}propanamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-4-(7-methoxy-2,3-dihydro-1-benzofuran-4-yl)-4-oxobutanamide;

N-{(1S,2R)-1-[3-(cyclohexylmethyl)benzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-{[(trifluoromethyl)sulfonyl]amino}benzamide;

N¹-[(1S,2R)-1-[3-(cyclohexylmethyl)benzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-methyl-N³,N³ dipropylisophthalamide;

3-chloro-N-((1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)benzamide;

3-chloro-N-{(1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl benzamide;

3-chloro-N-((1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)benzamide;

3-chloro-N-[(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}benzamide;

N-{(1S,2S)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-3-chlorobenzamide;

N-{(1S,2S)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-chlorobenzamide;

3-{[(3-chlorobenzyl)amino]sulfonyl}-N-((1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)benzamide;

3-{[(3-chlorobenzyl)amino]sulfonyl}-N-{(1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}benzamide;

3-{[(3-chlorobenzyl)amino]sulfonyl}-N-((1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)benzamide;

3-{[(3-chlorobenzyl)amino]sulfonyl}-N-[(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}benzamide;

N-{(1S,2S)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-{[(3-chlorobenzyl)amino]sulfonyl}benzamide;

N-{(1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-{[(3-methoxybenzyl)amino]sulfonyl}benzamide;

N-((1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-3-{[(3-methoxybenzyl)amino]sulfonyl}benzamide;

N-{(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-{[(3-methoxybenzyl)amino]sulfonyl}benzamide;

N-{(1S,2S)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-{[(3-methoxybenzyl)amino]sulfonyl}benzamide;

N′

-[(1R,2S)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(4-methylbenzyl)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-[(1R,2S)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-[(1R,2S)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(4-methylbenzyl)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1R,2S)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1R,2S)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(4-methylbenzyl)propyl]-N⁵,N⁵-dipropylpentanediamide;

N¹-[(1R,2S)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]-N⁵,N⁵-dipropylpentanediamide;

3-[(dipropylamino)sulfonyl]-N-[(1R,2S)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(4-methylbenzyl)propyl]propanamide;

3-[(dipropylamino)sulfonyl]-N-[(1R,2S)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]propanamide;

N¹-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(4-methylbenzyl)propyl]-N⁵,N⁵-dipropylpentanediamide;

N¹-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methylbenzyl)propyl]-N⁵,N⁵-dipropylpentanediamide;

N¹-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]-N⁵,N⁵-dipropylpentanediamide;

N-{(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methylbenzyl)propyl]-3-[(dipropylamino)sulfonyl]propanamide;

3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]propanamide;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-(4,5-dimethyl-2-furoyl)-5-methylbenzamide;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-hydroxy-3-(isopentylsulfonyl)propanamide;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-{[(2-methoxyethyl)(propyl)amino]sulfonyl}propanamide;

N¹-{(1R,2R)-3-(benzylamino)-2-hydroxy-1-[(phenylthio)methyl]propyl}-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-{(1R,2R)-2-hydroxy-3-(isopentylamino)-1-[(phenylthio)methyl]propyl}-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-{(1S,2R)-3-(benzylamino)-1-[4-(benzyloxy)benzyl]-2-hydroxypropyl}-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-[(1S,2R)-1-[4-(benzyloxy)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(1-naphthylmethyl)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(1-naphthylmethyl)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(1-naphthylmethyl)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-[(1S,2R)-1-(2-furylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-{(1S,2R)-3-(benzylamino)-1-[3-(benzyloxy)benzyl]-2-hydroxypropyl}-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-[(1S,2R)-2-hydroxy-1-(4-hydroxybenzyl)-3-(isopentylamino)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-((1S)-1-{(1R)-1-hydroxy-2-[(3-methoxybenzyl)amino]ethyl}but-3-ynyl)-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-{(1S)-1-[(1R)-2-(benzylamino)-1-hydroxyethyl]but-3-ynyl}-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-{((S)-1-[(1R)-1-hydroxy-2-(isopentylamino)ethyl]but-3-ynyl}-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(cyclohexylmethyl)-2-hydroxypropyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-[(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-((1S)-1-{(1R)-1-hydroxy-2-[(3-methoxybenzyl)amino]ethyl}-3-methylbutyl)-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-{(1S)-1-[(1R)-1-hydroxy-2-(isopentylamino)ethyl]-3-methylbutyl}-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-{(1R,2R)-3-(benzylamino)-2-hydroxy-1-[(phenylthio)methyl]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1R,2R)-2-hydroxy-3-(isopentylamino)-1-[(phenylthio)methyl]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-(benzylamino)-1-[4-(benzyloxy)benzyl]-2-hydroxypropyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-[4-(benzyloxy)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(1-naphthylmethyl)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(1-naphthylmethyl)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(1-naphthylmethyl)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-(2-furylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-(benzylamino)-1-[3-(benzyloxy)benzyl]-2-hydroxypropyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-[3-(benzyloxy)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(thien-2-ylmethyl)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S)-1-{(1R)-1-hydroxy-2-[(3-methoxybenzyl)amino]ethylbut-3-ynyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S)-1-[(1R)-2-(benzylamino)-1-hydroxyethyl]but-3-ynyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S)-1-[(1R)-1-hydroxy-2-(isopentylamino)ethyl]but-3-ynyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S)-1-[(1R)-1-hydroxy-2-(isopentylamino)ethyl]-3-methylbutyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1R,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-[(phenylthio)methyl]propyl}-N⁵,N5-dipropylpentanediamide;

N¹-{(1R,2R)-3-(benzylamino)-2-hydroxy-1-[(phenylthio)methyl]propyl}-N5,N⁵-dipropylpentanediamide;

N¹-{(1R,2R)-2-hydroxy-3-(isopentylamino)-1-[(phenylthio)methyl]propyl}-N5, N⁵-dipropylpentanediamide;

N¹-{(1S,2R)-3-(benzylamino)-1-[4-(benzyloxy)benzyl]-2-hydroxypropyl}-N⁵,N5-dipropylpentanediamide;

N¹-[(1S,2R)-1-[4-(benzyloxy)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-N⁵,N⁵-dipropylpentanediamide;

N¹-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(1-naphthylmethyl)propyl]-N⁵,N⁵-dipropylpentanediamide;

N¹-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(1-naphthylmethyl) propyl]-N⁵,N⁵-dipropylpentanediamide;

N¹-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(1-naphthylmethyl) propyl 1-N⁵,N⁵-dipropylpentanediamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(2-furylmethyl)-2-hydroxypropyl]-N⁵,N⁵-dipropylpentanediamide;

N¹-[(1S,2R)-1-(2-furylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-N⁵,N⁵-dipropylpentanediamide;

N¹-{(1S,2R)-1-[3-(benzyloxy)benzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N⁵,N⁵-dipropylpentanediamide;

N¹-{(1S,2R)-3-(benzylamino)-1-[3-(benzyloxy)benzyl]-2-hydroxypropyl}-N⁵,N⁵-dipropylpentanediamide;

N¹-[(1S,2R)-1-[3-(benzyloxy)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-N⁵,N⁵-dipropylpentanediamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(4-fluorobenzyl)-2-hydroxypropyl]-N⁵,N⁵-dipropylpentanediamide;

N¹-[(1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N⁵,N⁵-dipropylpentanediamide;

N′

-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(thien-2-ylmethyl)propyl]-N⁵,N⁵-dipropylpentanediamide;

N¹-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(thien-2-ylmethyl)propyl]-N⁵,N⁵-dipropylpentanediamide;

N¹-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-hydroxybenzyl)propyl]-N⁵,N⁵-dipropylpentanediamide;

N¹-[(1S,2R)-2-hydroxy-1-(4-hydroxybenzyl)-3-(isopentylamino)propyl]-N⁵,N⁵-dipropylpentanediamide;

N¹-((1S)-1-{(1R)-1-hydroxy-2-[(3-methoxybenzyl)amino]ethyl}but-3-ynyl)-N⁵,N⁵-dipropylpentanediamide;

N¹-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-isopropylbenzyl)propyl]-N⁵,N⁵-dipropylpentanediamide;

N¹-{(1S)-1-[(1R)-2-(benzylamino)-1-hydroxyethyl]but-3-ynyl}-N⁵,N⁵-dipropylpentanediamide;

N¹-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-isopropylbenzyl)propyl]-N⁵,N⁵-dipropylpentanediamide;

N¹-{(1S)-1-[(1R)-1-hydroxy-2-(isopentylamino)ethyl]but-3-ynyl}-N⁵,N⁵-dipropylpentanediamide;

N¹-[(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-[(3-methoxybenzyl) amino]propyl}-N⁵,N⁵-dipropylpentanediamide;

N¹-{(1S,2R)-1-[3-fluoro-5-(trifluoromethyl)benzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N⁵,N⁵-dipropylpentanediamide;

N-[(1S,2R)-1-(4-chlorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-3-[(dipropylamino)sulfonyl]propanamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(cyclohexylmethyl)-2-hydroxypropyl]-N⁵,N⁵-dipropylpentanediamide;

N¹-((1S,2R)-3-(benzylamino)-1-[3-fluoro-5-(trifluoromethyl)benzyl]-2-hydroxypropyl}-N⁵,N⁵-dipropylpentanediamide;

N-[(1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-3-(benzylamino)-2-hydroxypropyl]-3-[(dipropylamino)sulfonyl]propanamide;

N¹-[(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-N⁵,N⁵-dipropylpentanediamide;

N¹-[(1S,2R)-1-[3-fluoro-5-(trifluoromethyl)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-N⁵,N⁵-dipropylpentanediamide;

N-[(1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-3-[(dipropylamino)sulfonyl]propanamide;

N¹-{(1S)-1-{(1R)-1-hydroxy-2-[(3-methoxybenzyl)amino]ethyl}-3-methylbutyl)-N⁵,N⁵-dipropylpentanediamide;

N¹-((1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-[3-(trifluoromethoxy)benzyl]propyl}-N⁵,N⁵-dipropylpentanediamide;

3-[(dipropylamino)sulfonyl]-N-{(1S,2R)-1-(4-fluoro-3-methylbenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}propanamide;

N¹-[(1S)-1-[(1R)-2-(benzylamino)-1-hydroxyethyl]-3-methylbutyl}-N⁵,N⁵-dipropylpentanediamide;

N¹-{(1S,2R)-3-(benzylamino)-2-hydroxy-1-[3-(trifluoromethoxy)benzyl]propyl}-N⁵,N⁵-dipropylpentanediamide;

N-[(1S,2R)-3-(benzylamino)-1-(4-fluoro-3-methylbenzyl)-2-hydroxypropyl]-3-[(dipropylamino)sulfonyl]propanamide;

N¹-{(1S)-1-[(11R)-1-hydroxy-2-(isopentylamino)ethyl]-3-methylbutyl}-N⁵,N⁵-dipropylpentanediamide;

N¹-{(1S,2R)-2-hydroxy-3-(isopentylamino)-1-[3-(trifluoromethoxy)benzyl]propyl}-N⁵,N⁵-dipropylpentanediamide;

3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-1-(4-fluoro-3-methylbenzyl)-2-hydroxy-3-(isopentylamino)propyl]propanamide;

3-[(dipropylamino)sulfonyl]-N-{(1R,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-[(phenylthio)methyl]propyl}propanamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(3-fluoro-4-methylbenzyl)-2-hydroxypropyl]-N⁵,N⁵-dipropylpentanediamide;

N-{(1R,2R)-3-(benzylamino)-2-hydroxy-1-[(phenylthio)methyl]propyl}-3-[(dipropylamino)sulfonyl]propanamide;

N-{(1S,2R)-3-(benzylamino)-2-hydroxy-1-[3-(trifluoromethyl)benzyl]propyl}-3-[(dipropylamino)sulfonyl]propanamide;

N¹-[(1S,2R)-1-(3-fluoro-4-methylbenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N⁵,N⁵-dipropylpentanediamide;

3-[(dipropylamino)sulfonyl]-N-{(1R,2R)-2-hydroxy-3-(isopentylamino)-1-[(phenylthio)methyl]propyl}propanamide;

3-[(dipropylamino)sulfonyl]-N-{(1S,2R)-2-hydroxy-3-(isopentylamino)-1-[3-(trifluoromethyl)benzyl]propyl}propanamide;

N¹-{(1S,2R)-2-hydroxy-1-(4-methoxybenzyl)-3-[(3-methoxybenzyl) amino]propyl}-N⁵,N⁵-dipropylpentanediamide;

N-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(3-methylbenzyl)propyl]-3-[(dipropylamino)sulfonyl]propanamide;

N-{(1S,2R)-3-(benzylamino)-1-[4-(benzyloxy)benzyl]-2-hydroxypropyl}-3-[(dipropylamino)sulfonyl]propanamide;

N¹-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methoxybenzyl)propyli-N⁵,N⁵-dipropylpentanediamide;

3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(3-methylbenzyl)propyl]propanamide;

N-[(1S,2R)-1-[4-(benzyloxy)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-3-[(dipropylamino)sulfonyl]propanamide;

N′

-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-methoxybenzyl)propyl]-N⁵,N⁵-dipropylpentanediamide;

N-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(1-naphthylmethyl)propyl]-3-[(dipropylamino)sulfonylipropanamide;

N-{(1S,2R)-3-(benzylamino)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxypropyl}-3-[(dipropylamino)sulfonyl]propanamide;

N¹-{(1S,2R)-1-(4-chlorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl) amino]propyl}-N⁵,N⁵-dipropylpentanediamide;

3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(i-naphthylmethyl)propyl]propanamide;

3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-1-(3-fluoro-4-methoxybenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}propanamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(4-chlorobenzyl)-2-hydroxypropyl]-N⁵,N⁵-dipropylpentanediamide;

N-[(1S,2R)-3-(benzylamino)-1-(2-furylmethyl)-2-hydroxypropyl]-3-[(dipropylamino)sulfonyl]propanamide;

N-[(1S,2R)-3-(benzylamino)-1-(3-fluoro-4-methoxybenzyl)-2-hydroxypropyl]-3-[(dipropylamino)sulfonyl]propanamide;

N′

-[(1S,2R)-1-(4-chlorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N⁵,N⁵-dipropylpentanediamide;

3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-1-(2-furylmethyl)-2-hydroxy-3-(isopentylamino)propyl]propanamide;

3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-1-(3-fluoro-4-methoxybenzyl)-2-hydroxy-3-(isopentylamino)propyl]propanamide;

N¹-{(1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N⁵,N⁵-dipropylpentanediamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenyl-2-(4H-1,2,4-triazol-3-ylthio)acetamide;

N¹-[(1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-3-(benzylamino)-2-hydroxypropyl]-N⁵,N⁵-dipropylpentanediamide;

1-acetyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenylprolinamide;

N-{(1S,2R)-3-(benzylamino)-1-[3-(benzyloxy)benzyl]-2-hydroxypropyl}-3-[(dipropylamino)sulfonyl]propanamide;

N¹-[(1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-N⁵,N⁵-dipropylpentanediamide;

N-[(1S,2R)-1-[3-(benzyloxy)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-3-[(dipropylamino)sulfonyl]propanamide;

N¹-{(1S,2R)-1-(4-fluoro-3-methylbenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N⁵,N⁵-dipropylpentanediamide;

N-[(1S,2R)-3-(benzylamino)-1-(4-fluorobenzyl)-2-hydroxypropyl]-3-[(dipropylamino)sulfonyl]propanamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(4-fluoro-3-methylbenzyl)-2-hydroxypropyl]-N⁵,N⁵-dipropylpentanediamide;

3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]propanamide;

N′

-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3R,4S)-3-(hydroxymethyl)-6-isopropyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;

N¹-[(1S,2R)-1-(4-fluoro-3-methylbenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N⁵,N⁵-dipropylpentanediamide;

N′

-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3R,4S)-6-isopropyl-3-methyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;

N-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(thien-2-ylmethyl)propyl]-3-[(dipropylamino)sulfonyl]propanamide;

N¹-{(1S,2R)-3-(benzylamino)-2-hydroxy-1-[3-(tri fluoromethyl) benzyl] propyl}-N⁵,N⁵-dipropylpentanediamide;

3-[(dipropylamino)sulfonyl]-N-((1S)-1-{(1R)-1-hydroxy-2-[(3-methoxybenzyl)amino]ethyl}but-3-ynyl)propanamide;

N′

-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3R,4S)-6-isopropyl-2,2-dioxido-3-propyl-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;

N¹-{(1S,2R)-2-hydroxy-3-(isopentylamino)-1-[3-(trifluoromethyl)benzyl]propyl}-N⁵,N⁵-dipropylpentanediamide;

N-{(1S)-1-[(1R)-2-(benzylamino)-1-hydroxyethyl]but-3-ynyl}-3-[(dipropylamino)sulfonyl]propanamide;

N¹-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(3-methylbenzyl)propyl]-N⁵,N⁵-dipropylpentanediamide;

3-[(dipropylamino)sulfonyl]-N-((1S)-1-[(1R)-1-hydroxy-2-(isopentylamino)ethyl)but-3-ynyl}propanamide;

N′

-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3S,4R)-3-(hydroxymethyl)-6-isopropyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;

N¹-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(3-methylbenzyl)propyl]-N⁵,N5-dipropylpentanediamide;

N′

-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3S,4R)-3-(2-hydroxyethyl)-6-isopropyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;

N-{(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(dipropylamino)sulfonyl]propanamide;

N¹-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(3-methylbenzyl)propyl]-N⁵,N⁵-dipropylpentanediamide;

N-[(1S,2R)-3-(benzylamino)-1-(cyclohexylmethyl)-2-hydroxypropyl]-3-[(dipropylamino)sulfonyl]propanamide;

N¹-{(1S,2R)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N⁵,N⁵-dipropylpentanediamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3S,4S)-6-isopropyl-2,2-dioxido-3-propyl-3,4-dihydro-1H-isothiochromen-4-yl]amino propyl)-5-methyl-N,N-dipropylisophthalamide;

N-[(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-3-[(dipropylamino)sulfonyl]propanamide;

N¹-{(1S,2R)-3-(benzylamino)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxypropyl}-N⁵,N⁵-dipropylpentanediamide;

3-[(dipropylamino)sulfonyl]-N-((1S)-1-{(1R)-1-hydroxy-2-[(3-methoxybenzyl)amino]ethyl)-3-methylbutyl)propanamide;

N′

-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3S,4S)-6-isopropyl-3-methyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;

N¹-[(1S,2R)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxy-3-(isopentylamino)propyl]-N⁵,N⁵-dipropylpentanediamide;

N′

-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(4R)-6-isopropyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;

N-{(1S)-1-[(1R)-2-(benzylamino)-1-hydroxyethyl]-3-methylbutyl}-3-[(dipropylamino)sulfonyl]propanamide;

N¹-[(1S,2R)-1-(3-fluoro-4-methoxybenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N⁵,N⁵-dipropylpentanediamide;

3-[(dipropylamino)sulfonyl]-N-((1S)-1-[(1R)-1-hydroxy-2-(isopentylamino)ethyl]-3-methylbutyl}propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(3-methoxypropyl)(methylsulfonyl)amino]benzamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(3-fluoro-4-methoxybenzyl)-2-hydroxypropyl]-N⁵,N⁵-dipropylpentanediamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(3-methoxypropyl)(methylsulfonyl)amino]benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1,3-dihydro-2,1-benzisothiazole-5-carboxamide 2,2-dioxide;

N¹-[(1S,2R)-1-(3-fluoro-4-methoxybenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N⁵,N⁵-dipropylpentanediamide;

N¹-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(3-methoxybenzyl)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(2-methoxyethyl)(methylsulfonyl)amino]benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2-dimethylchromane-6-carboxamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(3-bromobenzyl)-2-hydroxypropyl]-N⁵,N⁵-dipropylpentanediamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-[(2-methoxyethyl)(methylsulfonyl)amino]nicotinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2-dimethylchromane-7-carboxamide;

N¹-[(1S,2R)-1-(3-bromobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N⁵,N⁵-dipropylpentanediamide;

N¹-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-isopropylbenzyl)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

benzyl (3R)-4-({(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}amino)-2,2,3-trimethyl-4-oxobutanoate;

N-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(3-methoxybenzyl)propyl]-3-[(dipropylamino)sulfonyl]propanamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-[(3-hydroxypropyl)(methylsulfonyl)amino]nicotinamide;

N¹-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-isopropylbenzyl)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(3-methoxybenzyl)propyl]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-[(2-hydroxyethyl)(methylsulfonyl)amino]nicotinamide;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-4-(phenylsulfonyl)butanamide;

(3S)-tetrahydrofuran-3-yl (1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propylcarbamate;

N-[(1S,2R)-3-(benzylamino)-1-(3,5-dichlorobenzyl)-2-hydroxypropyl]-3-[(dipropylamino)sulfonyl]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-[(2-methoxyethyl)(methylsulfonyl)amino]nicotinamide;

N¹-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methoxybenzyl)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

3-[(dipropylamino)sulfonyl]-N-{(1S,2R)-2-hydroxy-1-(4-isopropylbenzyl)-3-[(3-methoxybenzyl)amino]propyl}propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(2-methoxyethyl)(methylsulfonyl)amino]isonicotinamide;

N¹-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-methoxybenzyl)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N³-(phenylsulfonyl)-beta-alaninamide;

N-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-isopropylbenzyl)propyl]-3-[(dipropylamino)sulfonyl]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(2-methoxyethyl)(methylsulfonyl)amino]nicotinamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(4-fluoro-3-methylbenzyl)-2-hydroxypropyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N³-[(4-methylphenyl)sulfonyl]-beta-alaninamide;

3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-isopropylbenzyl)propyl]propanamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(3-hydroxypropyl)(methylsulfonyl)amino]isonicotinamide;

N¹-[(1S,2R)-1-(3-fluoro-4-methoxybenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N³-[(4-fluorophenyl)sulfonyl]-beta-alaninamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(2-hydroxyethyl)(methylsulfonyl)amino]isonicotinamide;

N-{(1S,2R)-3-(benzylamino)-1-[3-fluoro-5-(trifluoromethyl)benzyl]-2-hydroxypropyl)-3-[(dipropylamino)sulfonyl]propanamide;

N¹-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-isopropylbenzyl)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N³-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide;

3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-1-[3-fluoro-5-(trifluoromethyl)benzyl]-2-hydroxy-3-(isopentylamino)propyl]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(2-hydroxyethyl)(methylsulfonyl)amino]nicotinamide;

N¹-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-isopropylbenzyl)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N²-[(4-methylphenyl)sulfonyl]glycinamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(3-hydroxypropyl)(methylsulfonyl)amino]nicotinamide;

N-{(1S,2R)-3-(benzylamino)-2-hydroxy-1-[3-(trifluoromethoxy)benzyl]propyl}-3-[(dipropylamino)sulfonyl]propanamide;

N¹-((1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N²-[(4-fluorophenyl)sulfonyl]glycinamide;

N¹-{(1S,2R)-2-hydroxy-3-(isopentylamino)-1-[3-(trifluoromethoxy)benzyl]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N-[(1S,2R)-3-(benzylamino)-1-(3-fluoro-4-methylbenzyl)-2-hydroxypropyl]-3-[(dipropylamino)sulfonyl]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(3-methoxypropyl)(methylsulfonyl)amino]isonicotinamide;

N¹-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methoxybenzyl)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N²-[(4-methoxyphenyl)sulfonyl]glycinamide;

3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-1-(3-fluoro-4-methylbenzyl)-2-hydroxy-3-(isopentylamino)propyl]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(3-methoxypropyl)(methylsulfonyl)amino]nicotinamide;

N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(4-chlorophenyl)sulfonyl]propanamide;

N¹-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-methoxybenzyl)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

3-[(dipropylamino)sulfonyl]-N-{(1S,2R)-2-hydroxy-1-(4-methoxybenzyl)-3-[(3-methoxybenzyl)amino]propyl}propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-1-(methylsulfonyl)-1H-indole-5-carboxamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(4-fluoro-3-methylbenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl]-N²-(benzylsulfonyl)glycinamide;

N-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methoxybenzyl)propyl]-3-[(dipropylamino)sulfonyl]propanamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(methylsulfonyl)indoline-5-carboxamide;

N-((1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(4-fluorophenyl)sulfonyl]propanamide;

N¹-[(1S,2R)-1-(4-fluoro-3-methylbenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-methoxybenzyl)propyl]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-1-(methylsulfonyl)indoline-4-carboxamide;

N¹-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl]-N³-[(4-chlorophenyl)sulfonyl]-beta-alaninamide;

N¹-{(1S,2R)-3-(benzylamino)-2-hydroxy-1-[3-(trifluoromethyl)benzyl]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N-[(1S,2R)-3-(benzylamino)-1-(4-chlorobenzyl)-2-hydroxypropyl]-3-[(dipropylamino)sulfonyl]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(methylsulfonyl)indoline-6-carboxamide;

N¹-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(3-methylbenzyl)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N³-(benzylsulfonyl)-beta-alaninamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(methylsulfonyl)-1H-indole-4-carboxamide;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(4-methoxyphenyl)sulfonyl]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[1-methyl-1-(methylsulfonyl)ethyl]benzamide;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(4-methylphenyl)sulfonyl]propanamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(3-fluoro-4-methoxybenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[1-methyl-1-(methylsulfonyl)ethyl]benzamide;

N¹-{(1S,2R)-2-hydroxy-1-(3-methoxybenzyl)-3-[(3-methoxybenzyl)amino]propyl}-N⁵,N⁵-dipropylpentanediamide;

N¹-benzyl-N⁴-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2,2-dimethylsuccinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(ethylsulfonyl)benzamide;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propanamide;

N¹-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(3-methoxybenzyl)propyl]-N⁵,N⁵-dipropylpentanediamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(propylsulfonyl)benzamide;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanamide;

N¹-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(3-methoxybenzyl)propyl]-N⁵,N⁵-dipropylpentanediamide;

(2R)-N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-methyl-3-(phenylsulfonyl)propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(pentylsulfonyl)benzamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(3-chloro-5-fluorobenzyl)-2-hydroxypropyl]-N⁵,N⁵-dipropylpentanediamide;

(2S)-N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-methyl-3-(phenylsulfonyl)propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(2-hydroxyethyl)sulfonyl]benzamide;

N¹-[(1S,2R)-1-(3-chloro-5-fluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N⁵,N⁵-dipropylpentanediamide;

N-{(1S,2R) -1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(2-methoxyethyl)sulfonyl]benzamide;

N¹-{(1S,2R)-1-(3,5-dichlorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N⁵,N⁵-dipropylpentanediamide;

N¹-benzyl-N⁵-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}pentanediamide;

N-[(1S,2R) -1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(2-ethoxyethyl)sulfonyl]benzamide;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-[(phenylsulfonyl)methyl]acrylamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(3,5-dichlorobenzyl)-2-hydroxypropyl]-N⁵,N⁵-dipropylpentanediamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(3-hydroxypropyl)sulfonyl]benzamide;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-[(isopentylsulfonyl)methyl]acrylamide;

N¹-[(1S,2R)-1-(3,5-dichlorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N⁵,N⁵-dipropylpentanediamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,3-dihydro-1-benzothiophene-5-carboxamide 1,1-dioxide;

N¹-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N³-[(dipropylamino)carbonyl]-beta-alaninamide;

N¹-{(1S,2R)-2-hydroxy-1-(4-isopropylbenzyl)-3-[(3-methoxybenzyl)amino]propyl}-N⁵,N⁵-dipropylpentanediamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-benzothiophene-5-carboxamide 1,1-dioxide;

N¹-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N²-[(dipropylamino)carbonyl]glycinamide;

benzyl (4R)-4-{[((1S,2R)-1-benzyl-3-([3-(dimethylamino)-2,2-dimethylpropyl]amino}-2-hydroxypropyl)amino]carbonyl}-1,3-oxazolidine-3-carboxylate compound with methyl hydroperoxide (1;

2);

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,3-dihydro-1-benzothiophene-6-carboxamide 1,1-dioxide;

tert-butyl (2R,3S)-2-hydroxy-3-({2-hydroxy-3-[(3-methoxyphenyl)sulfonyl]propanoyl}amino)-4-phenylbutyl(3-methoxybenzyl)carbamate;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-benzothiophene-6-carboxamide 1,1-dioxide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-2,3-dihydro-1,2-benzisothiazole-6-carboxamide 1,1-dioxide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-2,3-dihydro-1,2-benzisothiazole-5-carboxamide 1,1-dioxide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1,3-dihydro-2,1-benzisothiazole-6-carboxamide 2,2-dioxide;

N¹-[(1S,2R)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-3-(benzylamino)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxypropyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxy-3-(isopentylamino)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-{(1S,2R)-1-[3-(benzyloxy)benzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(dipropylamino)sulfonyl]propanamide;

N¹-[(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-[4-(benzyloxy)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-[(1S,2R)-3-(benzylamino)-1-(cyclohexylmethyl)-2-hydroxypropyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-{(1S,2R)-3-(benzylamino)-1-[3-(benzyloxy)benzyl]-2-hydroxypropyl}-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-[(1S,2R)-1-[4-(benzyloxy)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl)-3-[hydroxy(2-methylphenyl)methyl]-5-methylbenzamide;

N¹-[(1R,2S)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1R,2S)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(4-methylbenzyl)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1R,2S)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-[(1R,2S)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(4-methylbenzyl)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

3-chloro-N-{(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}benzamide;

3-chloro-N-((1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)benzamide;

benzyl (2R,3S)-4-(3,5-difluorophenyl)-3-[(3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-{[(1-propylbutyl)sulfonyl]methyl}propanoyl)amino]-2-hydroxybutyl(3-ethylbenzyl)carbamate;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-7-(1H-imidazol-1-yl)-5,6-dihydronaphthalene-2-carboxamide;

2-{[({(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}amino)carbonyl]amino}-N,N-dipropylethanesulfonamide;

benzyl (2R,3S)-4-(3,5-difluorophenyl)-2-hydroxy-3-({N-(3-phenylpropanoyl)-3-[(1-propylbutyl)sulfonyl]alanyl}amino)butyl(3-ethylbenzyl)carbamate;

N¹-[(1S,2R)-3-{[(benzyloxy)carbonyl](3-ethylbenzyl)amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-N²-{[(3S)-tetrahydrofuran-3-yloxy]carbonyl}-D-leucinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-([1,3]oxazolo[4,5-b]pyridin-2-ylthio)acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(imidazo[1,2-a]pyridin-2-ylmethyl)thio]acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(5,7-dimethyl[1,2,4]triazolo[4,3-a]pyrimidin-3-yl)thio]acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,3-dihydro-1H-cyclopenta[b]quinoline-9-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxy-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-dioxoisoindoline-5-carboxamide;

1-benzyl-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-imidazole-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)thiophene-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-isobutyl-1,3-dioxoisoindoline-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-oxo-2-phenylpyrazolidine-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5,6-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(2,4-difluorobenzyl)oxy]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropylthieno[2,3-c]pyridine-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-methyl-1H-benzimidazol-1-yl)-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2,5-dioxopyrrolidin-1-yl)-4-methylbenzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thieno[3,2-b]pyridine-6-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2,3-dihydro-1H-indol-1-yl)-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(1,3-dioxooctahydro-2H-isoindol-2-yl)butanamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-[(4-methylphenyl)sulfonyl]-beta-alaninamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1H-indol-3-yl)-4-oxobutanamide;

N²-(anilinocarbonothioyl)-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}glycinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5,6,7,8-tetrahydro-4H-cyclohepta[c]isoxazole-3-carboxamide;

4-[2-(diethylamino)ethoxy]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-[(4-methylphenyl)sulfonyl]glycinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,5-dioxo-1,2,4-triazolidin-4-yl)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-hydroxyethoxy)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(1,3-dithian-2-yl)-3-furamide;

4-(3-chlorophenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-oxobutanamide or 2479;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-5,6,7, 8-tetrahydro-4H-pyrazolo[1,5-a]azepine-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(4-fluorophenyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1-benzofuran-2-carboxamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-7-methoxy-4-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5,6,7-tetrahydro-2H-indazole-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-7-fluoro-4H-imidazo[5,1-c][1,4]benzoxazine-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3-fluoro-4-methoxyphenyl)-4-oxobutanamide;

methyl 4-({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-4-oxobutyl-(dithiocarbamate);

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}[1,2,4]triazolo[4,3-a]pyridine-6-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-phenyl-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(4-methylphenyl)sulfonyl]acetamide;

3-(2-chlorophenyl)-2-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(4-methylphenyl)-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-hydroxy-5-methylphenyl)-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxo-4-thien-2-ylbutanamide or 2379;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-2-hydroxybenzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2,5-dioxopyrrolidin-1-yl)benzamide;

4-[(aminocarbonyl)amino]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(trifluoroacetyl)amino]butanamide;

5-bromo-N¹-((1S,2R)-2-hydroxy-1-(pentafluorobenzyl)-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-N³,N³-dipropylisophthalamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(1-hydroxycyclopentyl)thio]acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-oxocyclohexyl)propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-naphthyl)-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-oxo-2,3-dihydro-1H-indazole-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-dimethyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-[(dimethylamino)sulfonyl]valinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-furyl)-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(5-methyl-4-phenyl-1,3-oxazol-2-yl)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,6-dioxohexahydropyrimidine-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-5,7-dimethoxy-1-oxoindane-2-carboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N⁵-(2-pyridin-2-ylethyl)pentanediamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[4-(2-furoyl)piperazin-1-yl]-4-oxobutanamide;

N′

-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-([3-[(1Z)-prop-1-en-1-yl]benzyl}amino)propyl]-5-methyl-N,N-dipropylisophthalamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxo-4,5,6,7-tetrahydro-1-benzofuran-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-oxo-1-(thien-2-ylmethyl)pyrrolidine-3-carboxamide;

2-[(cyanomethyl)thio]-N-((1S,2R) -1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyllnicotinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(2-furoyl)-4-hydroxyprolinamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5-dihydrofuro[2,3-g][2,1]benzisoxazole-8-carboxamide;

methyl 3-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]-5-methylthiophene-2-sulfenate;

2-(acetylamino)-2-(1H-1,2,3-benzotriazol-1-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;

1-([(cyclohexylamino)carbonyl]amino}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}cyclopropanecarboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-ethyl-4H-[1,2,4]triazolo[1,5-a]benzimidazol-4-yl)acetamide;

(2E)-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N⁴-[4-(1,3-oxazol-5-yl)phenyl]but-2-enediamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3,4,5-tetrahydrothiopyrano[4,3-b]indole-8-carboxamide;

4-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1-oxidothiomorpholin-4-yl)butanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxo-4-(2-thioxo-1,3-benzothiazol-3(2H)-yl)butanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-8H-thieno[2,3-b]indole-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dihydro-2H-1,5-benzodioxepine-7-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4H-chromeno[3,4-d]isoxazole-4-carboxamide;

4-(3,4-dichlorophenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxobutanamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,4-difluorophenyl)-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,4-difluorophenyl)-2-methyl-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,4-difluorophenyl)-2-methoxy-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-oxo-4-[3-(trifluoromethyl)phenyl]butanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-oxo-4-thien-2-ylbutanamide;

4-(3,4-dichlorophenyl)-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-3-methyl-4-oxobutanamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(2-ethyl-1-oxo-2,3-dihydro-1H-isoindol-5-yl)oxy]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-oxoisoindoline-1-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(7-methoxy-1-benzofuran-2-yl)-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-4H-chromeno[3,4-d]isoxazole-8-carboxamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2-methyl-4-oxo-4H-chromene-6-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-([1,2,4]triazolo[4,3-b]pyridazin-6-ylthio)acetamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2-(1,1-dioxidotetrahydrothien-2-yl)acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,4-dihydro-2H-chromen-6-yl)-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-ethyl-3-oxoisoindoline-1-carboxamide;

4-[2-(acetylamino)-4,5-dimethylphenyl]-N-J(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxobutanamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(4-hydroxyphenyl)-4-oxobutanamide;

2-[(6-chloro[1,2,4]triazolo[4,3-b]pyridazin-3-yl)oxy]-N-{(1S,2R) -1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-(3-methoxyphenyl)-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-2-hydroxy-4-oxo-4-thien-3-ylbutanamide;

3-chlorophenyl 4-({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-4-oxobutanoate;

4-(4-chloro-2-hydroxyphenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-{[(4-methylphenyl)sulfonyl]amino}-4-oxohexanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-2-(6-hydroxy-3-oxo-2,3-dihydroimidazo[2,1-b][1,3]thiazol-2-yl)acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(4,5-dihydro-1,3-thiazol-2-ylthio)acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-imidazo[1,2-b]pyrazole-6-carboxamide;

4-(1-benzofuran-2-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxobutanamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(6-methoxy-1,1′

-biphenyl-3-yl)-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-4-(4-methoxyphenyl)-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-9-oxo-1,2,3,9-tetrahydrocyclopenta[b]chromene-7-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1H-benzo[g]indazole-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5-dihydronaphtho[2,1-d]isoxazole-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(tetraazolo[1,5-b]pyridazin-6-ylthio)acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(5-methyl-1H-pyrrol-2-yl)-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[(trifluoromethyl)sulfonyl]amino}butanamide;

N-[(1S,2R)-3-(2-acetyl-1-ethylhydrazino)-1-benzyl-2-hydroxypropyl]-2-[(methylsulfonyl)amino]-1,3-thiazole-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1-hydroxy-2-propylpentyl)benzamide;

N¹-[(1S,2R)-3-[(2-[4-[(3-chlorobenzyl)oxy]phenyl}ethyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-morpholin-4-ylpropyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

ethyl 4-{[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}piperidine-1-carboxylate;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-N-[(methylsulfonyl)acetyl]-N²-pentylglycinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl}propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl}propanamide;

ethyl 4-([(2R,3S)-3-([3-[(dipropylamino)carbonyl]benzoyl}amino)-2-hydroxy-4-phenylbutyl]amino}piperidine-1-carboxylate;

N¹-((1S,2R)-1-benzyl-3-([(3R)-1-benzylpyrrolidin-3-yl]amino}-2-hydroxypropyl)-N³,N³-dipropylisophthalamide;

methyl (2E)-2-[2-({(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}amino)-2-oxoethyl]-4-methylpent-2-enoate;

N¹-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N⁴-(4-methoxybenzyl)succinamide;

N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-{[(4-fluorophenyl)sulfonyl]amino}-3-methylbutanamide;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-9,10-dioxo-9,10-dihydroanthracene-2-carboxamide;

N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-4-(benzyloxy)benzamide;

N′

-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N-methyl-N-phenylurea

N′

-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N,N-diisopropylurea

N′

-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N,N-diphenylurea

N′

-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N,N-dimethylurea

methyl 2-{[([(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}amino)carbonyl]amino}benzoate;

phenyl (1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propylcarbamate;

2-methoxyethyl (1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propylcarbamate;

2-(benzyloxy)ethyl (1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propylcarbamate;

prop-2-ynyl (1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propylcarbamate;

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propylcarbamate;

pentyl (1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propylcarbamate;

neopentyl (1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propylcarbamate;

N¹-[(1S,2R)-3-{[(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)methyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(4-oxo-4H-chromen-3-yl)methyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1,7,7-trimethylbicyclo[2.2.1]hept-2-yl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-4-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzamide;

N¹-[(1S,2R)-3-[(1-acetylpiperidin-3-yl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-ethoxy-5-methylisophthalamide;

N¹-(allyloxy)-N³-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-isobutoxy-5-methylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N³-(2,2,3,3,3-pentafluoropropyl)isophthalamide;

ethyl 4-({3-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]-5-methylbenzoyl}amino)butanoate;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N³,N³-bis (2,2,2-trifluoroethyl)isophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-ethyl-N³-[(1-ethylpiperidin-4-yl)carbonyl]-5-methylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-(2,2,3,3,4,4,4-heptafluorobutyl)-5-methylisophthalamide;

N¹-(1-benzylpyrrolidin-3-yl)-N³-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N¹-ethyl-5-methylisophthalamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N³-(tetrahydrofuran-2-ylmethyl)isophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3R)-2-oxoazepan-3-yl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(1,1-dioxido-3,4-dihydro-2H-1,2-benzothiazin-4-yl)amino]-2-hydroxypropyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[2-(4-methylpentanoyl)hydrazino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(3-ethylphenyl)sulfonyl]propanamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2,3,3,4,4-hexafluoro-N⁵,N⁵-dipropylpentanediamide;

N⁵-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2-phenyl-N¹,N¹-dipropylpentanediamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(3-hydroxypropyl)(methylsulfonyl)amino]benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(2-hydroxyethyl)(methylsulfonyl)amino]benzamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl}-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(3-hydroxypropyl)(methylsulfonyl)amino]benzamide;

5-bromo-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(trifluoromethyl)sulfonyl]amino}benzamide;

N¹-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(thien-2-ylmethyl)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(4-methyl-1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropyl-5-(1,3-thiazol-2-yl)isophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(methylsulfonyl)amino]benzamide;

4-({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-4-oxo-3-{[(1-propylbutyl)sulfonyl]methyl}butanoic acid trifluoroacetate;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-[(methylsulfonyl)amino]-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]propanamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-2-[(methylsulfonyl)amino]-1,3-thiazole-4-carboxamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N³,N³-dipropyl-5-{[(trifluoromethyl)sulfonyl]amino}isophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(isopentylsulfonyl)propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(1-methyl-1H-imidazol-4-yl)sulfonyl]amino}benzamide tri;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[(trifluoromethyl)sulfonyl]amino}benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2-hydroxyethyl)(propyl)amino]sulfonyl}propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1,3-oxazol-2-yl)benzamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}benzamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(3-hydroxypropyl)amino]sulfonyl}-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2-[(methylsulfonyl)amino]-1,3-thiazole-4-carboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-(phenylacetyl)-3-[(1-propylbutyl)sulfonyl]alaninamide;

N¹-{(1R,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-N²-benzyloxycarbonyl-3-[(1-propylbutyl)sulfonyl]alaninamide trifluoroacetate;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(3-methylisoxazol-4-yl)-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-({[2-(methylamino)ethyl]aminosulfonyl)-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxyethyl)amino]sulfonyl}-N³,N³-dipropylisophthala;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(methylsulfonyl)amino]butanamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(piperazin-1-ylsulfonyl)-N³,N³-dipropylisophthalamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[methyl(methylsulfonyl)amino]benzamide;

5-([bis (2-hydroxyethyl) amino]sulfonyl}-N¹-{(1S, 2R) -1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropylisophthalamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,8-dimethylquinoline-3-carboxamide;

2-{[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}ethyl 2,4-difluorophenylcarbamate;

5-(aminosulfonyl)-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropyl-5-(1H-pyrazol-4-yl)isophthala;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxyisoxazole-5-carboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1-methyl-1H-imidazol-2-yl)-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl)-5-methylbenzamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxyethyl)amino]sulfonyl}-N³-propylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-({[(1S)-2-hydroxy-1-methylethyl]amino}sulfonyl)-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-diethyl-5-(1,3-oxazol-2-yl)isophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2s)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-methylbenzamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]sulfonyl}-N³,N³-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-({[(1R)-2-hydroxy-1-methylethyl]amino}sulfonyl)-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-2-hydroxy-1-(2,3,5-trifluorobenzyl)-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalammide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-ethyl-1-hydroxybutyl)benzammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(dimethylamino)sulfonyl]-N³,N³-dipropylisophthalammide;

N¹-[(1S,2R)-3-{[1-(aminocarbonyl)cyclohexyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalammide;

N¹-[(1S,2R)-3-{[2-(aminosulfonyl)ethyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1-methylhexyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(2-hydroxypropyl)amino]propyl}-5-methyl-N³,N 3-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2-ethylhexyl)amino]-2-hydroxypropyl}-5-methyl-N³,N³-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(4-phenylbutyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalammide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(pentylamino)propyl]-5-methyl-N³,N³-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(5-hydroxypentyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(6-hydroxyhexyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalammide;

N¹-[(1S,2R)-3-[(3-butoxypropyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(2R)-2-hydroxypropyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl) amino]-2-hydroxypropyl}-N³-ethyl-N³-methyl-5-(1,3-oxazol-2-yl)isophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-methyl-5-(1,3-oxazol-2-yl)-N³-propylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropyl-5-(pyrrolidin-1-ylsulfonyl)isophthalamide hydrochlormide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}-N³,N³-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1,3-oxazol-5-yl)-N³,N³-dipropylisophthalamide hydrochlormide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide hydrochlormide;

N¹-butyl-N³-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N¹-methyl-5-(1,3-oxazol-2-yl)isophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dimethyl-5-(1,3-oxazol-2-yl)isophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-ethyl-5-(1,3-oxazol-2-yl)-N³-propylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropyl-5-(1,3-thiazol-2-yl)isophthalamide hydrochlormide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(1-propylbutyl)amino]sulfonyl}propanammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]sulfonyl}-N³,N³-dipropylisophthalammide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}-N³,N³-dipropylisophthalammide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(isobutylamino)propyl]-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide hydrochlormide;

5-bromo-N¹-((1S,2R)-1-[3-fluoro-4-(trifluoromethyl)benzyl]-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-N³,N³-dipropylisophthalammide;

5-bromo-N¹-((1S,2R)-2-hydroxy-1-(2,3,4-trifluorobenzyl)-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-N³,N³-dipropylisophthalammide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-ethylbutanoyl)-5-methylbenzamide hydrochlormide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-[(2-propylpiperidin-1-yl)carbonyl]benzamide hydrochlormide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-[(2-methylpyrrolidin-1-yl)carbonyl]benzamide hydrochlormide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(2,6-dimethylpiperidin-1-yl)carbonyl]-5-methylbenzamide hydrochlormide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-methoxyethyl)amino]sulfonyl)-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-N³,N³-dipropyl-5-(1,3-thiazol-2-yl)isophthalamide dihydrochlormide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-5-([(2-hydroxyethyl)amino]sulfonyl}-N³,N³-dipropylisophthalammide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-(2-propylpentanoyl)benzamide hydrochlormide;

N¹-(sec-butyl)-N³-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-5-methyl-N¹-propylisophthalammide;

N¹-butyl-N³-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-5-methyl-N¹-propylisophthalammide;

N¹-allyl-N¹-cyclopentyl-N³-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalammide;

N¹,N¹-dibutyl-N³-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-diisobutyl-5-methylisophthalammide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[(1Z)-prop-1-enyl]benzyl}amino)propyl]-5-methyl-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(ethylsulfonyl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3-iodophenyl)cyclopropyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalammide;

N¹-(1-(3,5-difluorobenzyl)-3-{[2-(ethylamino)-1-methyl-2-oxoethyl]amino}-2-hydroxypropyl)-5-methyl-N,N-dipropylisophthalammide;

N¹-[(1S,2R)-3-[(1,1′

-biphenyl-3-ylmethyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-hydroxy-1-phenylpropyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalammide;

N¹-cyclohexyl-N³-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N¹,5-dimethylisophthalammide;

N¹-cyclohexyl-N³-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl) amino]-2-hydroxypropyl}-N¹-ethyl-5-methylisophthalammide;

N¹-[(1S,2R)-3-{[3-(1-benzothien-2-yl)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³ N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-5-ethynyl-N³,N³-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-thien-3-ylbenzyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(5-methylthien-2-yl)benzyl]amino}propyl)-5-methyl-N³,N³ dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-pyridin-4-ylbenzyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(4-methylthien-2-yl)benzyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(2,4-dimethoxypyrimidin-5-yl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(3,5-dimethylisoxazol-4-yl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalammide;

N⁴-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methyl-N²,N²-dipropylpyridine-2,4-dicarboxammide;

N¹-[(1S,2R)-3-{[3-(cyclopropylamino)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N ,N 3-dipropylisophthalammide;

N¹-[(1S,2R)-3-{[3-(cyclopropylamino)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-ethynyl-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(2-isobutyl-1,3-thiazol-5-yl)cyclopropyl]amino}propyl)-5-methyl-N³, N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-([1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalammide;

methyl 3-({[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}methyl)phenyl(methyl)carbamate;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[methyl(methylsulfonyl)amino]benzyl}amino)propyl]-5-methyl-N³,N³-dipropylisophthalammmide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({3-[(dimethylamino)sulfonyl]benzyl}amino)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(2-isobutyl-1,3-thiazol-5-yl)methyl]amino}propyl)-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)-1-methylethyl]amino}-2-hydroxypropyl)-5-ethynyl-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)-1-methylethyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)-1-methylethyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3-isobutylisoxazol-5-yl)cyclopropyl]amino}propyl)-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3-isobutylisoxazol-5-yl)cyclopropyl]amino}propyl)-5-ethynyl-N³,N³-dipropylisophthalammide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[(methylsulfonyl)amino]benzyl}amino)propyl]-5-methyl-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3-isobutylisoxazol-5-yl)cyclopropyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalammide;

N¹-[(1S,2R)-3-[(3-cyanobenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-[(isobutylamino)(oxo)methyl]-3-(methylthio)propyl]amino}propyl)-5-methyl-N,N-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalammide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({3-[(1E)-hex-1-enyl]benzyl}amino)-2-hydroxypropyl]-5-methyl-N3, N3-dipropylisophthalammide;

N¹-[(1S,2R)-3-{[3-(5-acetylthien-2-yl)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalammide;

N¹-[(1S,2R)-3-[(3-allylbenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(6-methoxypyridin-3-yl)benzyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalammide;

N-[(1S,2R)-3-{[(2-tert-butylpyrimidin-4-yl)methyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalammide;

N⁴-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-6-methyl-N²,N²-dipropylpyridine-2,4-dicarboxammide;

N¹-[(1S,2R)-3-[(3-butylbenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-pentylbenzyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-pent-4-enylbenzyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-[(3-cyclopentylbenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-[(3-cyclohexylbenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-{[3-(cyclohexylmethyl)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-hex-5-enylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N³,N³-dipropylisophthalammide;

methyl (2S)-3-[3-({[(2R,3S)-4-(3,5-difluorophenyl)-3-([3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}methyl)phenyl]-2-methylpropanoate;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-([3-(3-methylthien-2-yl)benzyl]amino}propyl)-5-methyl-N³,N³ dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(3-methylpyridin-2-yl)benzyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(4-methylpyridin-2-yl)benzyl]amino propyl)-5-methyl-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(5-methylpyridin-2-yl)benzyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalammide;

N¹-[(1S,2R)-3-([3-(4-chlorobutyl)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalammide;

N¹-[(1S,2R)-3-{[3-(3-cyanopropyl)benzyl]amino-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalammide;

N¹-[(1S,2R)-3-{[3-(4-cyanobutyl)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalammide;

N¹-[(1S,2R)-3-{[3-(6-cyanohexyl)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-([3-(6-methylpyridin-2-yl)benzyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(1,3-oxazol-2-yl)benzyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalammide;

methyl 3-{[((2R,3S)-4-(3,5-difluorophenyl)-3-{[3-[(dipropylamino)carbonyl]-5-(1,3-oxazol-2-yl)benzoyl]amino}-2-hydroxybutyl)amino]methyl}phenyl(methyl)carbamate;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-[(isobutylamino)carbonyl]-3-(methylsulfonyl)propyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalammide;

N¹-butyl-N³-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl) amino]propyl}-N¹,5-dimethylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)-1-methylethyl]amino}-2-hydroxypropyl)-5-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}-N³,N³-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{methyl[(trifluoromethyl)sulfonyl]amino}-N³,N³-dipropylisophthalammide;

N¹-[(1S,2R)-3-(cyclopropylamino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)-1-methylethyl]amino}-2-hydroxypropyl)-N³,N³-dipropyl-5-(1,3-thiazol-2-yl)isophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[methyl(methylsulfonyl)amino]-N³,N³-dipropylisophthalammide;

N¹-butyl-N³-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)-1-methylethyl]amino}-2-hydroxypropyl)-N¹,5-dimethylisophthalammide;

N¹-((1S,2R)-1-(2,4-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalammide;

5-bromo-N¹-((1S,2R)-1-(2,4-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-N³,N³-dipropylisophthalammide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(2-ethylpiperidin-1-yl)sulfonyl]propanammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-ethynyl-N³,N³-dipropylisophthalammide;

N¹-cyclobutyl-N³-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalammide;

N¹-cyclopentyl-N³-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N³-pentylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-isopentyl-5-methylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-ethyl-N³-(2-hydroxyethyl)-5-methylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl) amino]-2-hydroxypropyl}-N³-(2-ethoxyethyl) -5-methylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-(2-methoxyethyl)-N³,5-dimethylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-(2-furylmethyl)-N³,5-dimethylisophthalammide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{(2R,5R)-2,5-dimethylpyrrolidin-1-yl]carbonyl}-5-methylbenzammide;

N¹-cyclopentyl-N³-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N¹,5-dimethylisophthalammide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,5-dimethyl-N³-pentylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-(2-hydroxyethyl)-5-methyl-N³-propylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-ethyl-N³-(2-methoxyethyl)-5-methylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N³-(2-methylcyclohexyl)isophthalammide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-(2-methoxyethyl)-5-methyl-N³-propylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-bis(2-methoxyethyl)-5-methylisophthalammide;

N¹-allyl-N¹-cyclohexyl-N³-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N³,N³-dipentylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-bis(2-ethoxyethyl)-5-methylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(2-naphthylmethyl)amino]propyl}-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalammide;

N¹-butyl-N³-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-N¹,5-dimethylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}-N³,N³-dipropylisophthalammide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1S)-1,2,3,4-tetrahydronaphthalen-1-ylamino]propyl}-5-methyl-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(2S)-tetrahydrofuran-2-ylmethyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(3-hydroxypropyl)sulfonyl]-N³,N³-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1H-imidazol-4-yl)-N³,N³-dipropylisophthalamide trifluoroacetate;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-isoxazol-3-yl-N³,N³-dipropylisophthalammide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-(1,3-oxazol-2-yl)benzammide;

N⁴-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-6-methyl-N², N²-dipropylpyridine-2,4-dicarboxammide;

N⁴-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-6-methyl-N²,N²-dipropylpyridine-2,4-dicarboxammide;

N⁴-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-6-methyl-N ,N 2-dipropylpyridine-2,4-dicarboxammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino)-2-hydroxypropyl)-N³,N³-dipropyl-5-(1,3-thiazol-2-yl)isophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[methyl(thien-2-ylsulfonyl)amino]-N³,N³-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-({[(2R)-2-hydroxypropyl]amino)sulfonyl)-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(2-isobutyl-1,3-thiazol-5-yl)cyclopropyl]amino}propyl)-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxy-N5,N5-dipropylpentanediammide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-dipropylamine-2-oxoethoxy)acetammide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(2-dipropylamine-2-oxoethyl)thio]acetammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[2-(isobutylamino)-1,1-dimethyl-2-oxoethyl]amino}propyl)-5-(1,3-oxazol-2-yl)-N,N-dipropylisophthalammide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(methylsulfonyl)methyl]benzammide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-3-methyl-5-(2-methylpentanoyl)benzamide hydrochlormide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-5-[(methylsulfonyl)amino]-N³,N³-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-3-[(1-propylbutyl)sulfonyl]-D-alaninamide dihydrochlormide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-propionyl-3-[(1-propylbutyl)sulfonyl]-D-alaninammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-2-(isobutylamino)-1-methyl-2-oxoethyl]amino)propyl)-N,N-dipropyl-5-(1,3-thiazol-2-yl)isophthalammide;

N′

-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-2-(isobutylamino)-1-methyl-2-oxoethyl]amino}propyl)-N-methyl-N-propyl-5-(1,3-thiazol-2-yl)isophthalammide;

N¹-butyl-N³-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N¹-methyl-5-(1,3-thiazol-2-yl)isophthalammide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(3-hydroxypropyl)(methylsulfonyl)amino]benzammide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(methylsulfonyl)benzammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-(1-oxobutyl)-3-[(1-propylbutyl)sulfonyl]-D-alaninamide hydrochlormide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropyl-5-pyrimidin-2-ylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-({[(2S)-2-hydroxypropyl]amino}sulfonyl)-N³,N³-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-methyl-N³-propyl-5-(1,3-thiazol-2-yl)isophthalammide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-methylpentanoyl)-5-(1,3-oxazol-2-yl)benzammide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[(methylsulfonyl)amino]benzyl}amino)propyl]-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-(2,2-dimethylpropanoyl)-3-[(1-propylbutyl)sulfonyl]-D-alaninamide hydrochlormide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl}-N³,N³-dipropylisophthalammide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(3-hydroxypropyl)(methylsulfonyl)amino]benzammide;

N²-acetyl-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]-D-alaninamide hydrochlormide;

2-[allyl(methylsulfonyl)amino]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-thiazole-5-carboxammide;

3-(butylsulfonyl)-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-D-alaninamide bis(trifluoroacetate);

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-3-[(1-propylbutyl)sulfonyl]-D-alaninam;

bis(trifluoroacetate);

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-isobutyryl-3-[(1-propylbutyl)sulfonyl]-D-alaninamide hydrochlormide;

N-[(1S,2R)-3-(butylamino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-4-(ethylthio)benzammide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(2-fluorophenyl)-5-oxopyrrolidine-3-carboxammide;

N¹-(4-tert-butyl-1,3-thiazol-2-yl)-N⁴-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}succinammide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxy-6-(1-hydroxy-2,2-dimethylpropyl)pyridine-2-carboxammide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-{[(ethylamino)carbonyl]amino}benzammide;

3-(1-cyanoethyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzammide;

1-(cyanomethyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-pyrrole-2-carboxammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(1H-imidazol-1-yl)propyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalammide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({[(2R)-1-ethylpyrrolidin-2-yl]methyl}amino)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalammide;

3-acetyl-N-[(1S,2R)-3-(benzylamino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]benzammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]propyl}-5-methyl-N³,N 3-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2E)-hex-2-enylamino]-2-hydroxypropyl}-5-methyl-N³,N³-dipropylisophthalammide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({[(5R)-3-ethyl-2-oxo-1,3-oxazolidin-5-yl]methyl}amino)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalammide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({[(5S)-3-ethyl-2-oxo-1,3-oxazolidin-5-yl]methyl}amino)-2-hydroxypropyl]-5-methyl-N 3, N³-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2,2-dioxido-3,4-dihydro-1,2-benzoxathiin-4-yl)amino]-2-hydroxypropyl}-5-methyl-N³,N³-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(1,1-dioxido-3,4-dihydro-2H-1,2-benzothiazin-4-yl)amino]-2-hydroxypropyl}-5-methyl-N³,N³-dipropylisophthalammide;

N⁵-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenyl-N¹,N¹-dipropylpentanediammide;

N¹-{(1S,2R)-1-{[5-(cyanomethyl)-1H-imidazol-1-yl]methyl}-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N³,N³-dipropylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropyl-5-pyrimidin-2-ylisophthalammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(2-ethylpyrimidin-4-yl)methyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-(2,2-dimethylpropanoyl)-3-[(1-propylbutyl)sulfonyl]-D-alaninamide hydrochlormide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-5-{[ethyl(methyl)amino]sulfonyl}-N³,N³-dipropylisophthalammide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(2-hydroxyethyl)(methylsulfonyl)amino]benzammide;

5-bromo-N¹-{(1S,2R)-1-(2,4-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropylisophthalammide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(2-methoxyethyl)(methylsulfonyl)amino]benzamide hydrochlormide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(methylsulfonyl)methyl]benzammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(4-hydroxybutyl)sulfonyl]-N³,N³-dipropylisophthalamide hydrochlormide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(dipropylamino)isoquinoline-7-carboxammide;

N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxyethyl)(methyl)amino]sulfonyl}-N³,N³-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(ethylamino)sulfonyl]-N³,N³-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(5-methyl-1,2,4-oxadiazol-3-yl)-N³,N³-dipropylisophthalamide hydrochlormide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[methyl(methylsulfonyl)amino]-1,3-oxazole-4-carboxammide;

3-(butylsulfonyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}propanammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropylmalonammide;

N²-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropylbieyclo[2.2.1]hept-5-ene-2,3-dicarboxammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropylcyclopentane-1,3-dicarboxammide;

N²-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dimethyl-N⁵,N⁵-dipropylthieno[2,3-b]thiophene-2,5-dicarboxammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2-phenyl-N⁵,N⁵-dipropylpentanediammide;

N²-benzyl-N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-[2-(dipropylamino)-2-oxoethyl]glycinammide;

3-(4-chlorophenyl)-N′

-{(1S, 2R) -1-(3,5-difluorobenzyl) -3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N⁵,N⁵-dipropylpentanediammide;

(2E)-N⁵-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(methoxyimino)-N¹,N¹-dipropylpentanediammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl})N²,N²-(dipropylamino)-2-oxoethyl]-N²-phenylglycinammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)}N²,N²-dipropylcyclohexane-1,2-dicarboxammide;

N¹-[(1S,2R)-3-[(benzyloxy)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalammide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-phenylpropanammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(1,1-dioxido-3,4-dihydro-2H-1,2-benzothiazin-4-yl)amino]-2-hydroxypropyl}-5-methyl-N³,N³-dipropylisophthalammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1H-imidazol-2-yl)-N³,N³-dipropylisophthalammide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1-hydroxy-2-propylpentyl)benzammide;

N-[(1R,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-isobutyrylbenzammide;

hydrochlormide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-propylpentanoyl)benzammide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-ethylbutanoyl)benzamide hydrochlormide;

N³-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-ylamino)propyl]-N⁵,N⁵-diisopropylpyridine-3,5-dicarboxammide;

N′

-((1S,2R)-1-(3,5-difluorobenzyl)-3-t[(1S)-2-(ethylamino)-1-methyl-2-oxoethyl]amino}-2-hydroxypropyl)-5-methyl-N,N-dipropylisophthalammide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-hydroxy-1-phenylpropyl)amino]propyl}-5-methyl-N³ N³-dipropylisophthalammide;

N¹-[(1S,2R)-3-{[(1S)-2-(benzylamino)-1-methyl-2-oxoethyl]amino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N,N-dipropylisophthalammide;

N′

-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,3-dimethyl-N²,N²-dipropylcyclopropane-1,2-dicarboxammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,3-dimethyl-N²,N²-dipropylcyclopropane-1,2-dicarboxammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-N⁵,N⁵-dipropylpentanediammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,3-dimethyl-N⁵,N⁵-dipropylpentanediammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-3-ethyl-3-methyl-N⁵,N⁵-dipropylpentanediammide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxy-3-methyl-N⁵,N⁵-dipropylpentanediammide;

2-[allyl(methylsulfonyl)amino]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-oxazole-4-carboxammide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[2-(dimethylamino)ethyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalammide;

N¹-[(1S,2R)-3-({2-[bis(2-hydroxyethyl)amino]ethyl}amino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalammide;

N¹-[(1S,2R)-3-(cyclopropylamino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-3-[(1-propylbutyl)sulfonyl]-D-alaninamide dihydrochlormide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[4-(hydroxymethyl)-1,3-oxazol-2-yl]benzamide hydrochlormide;

or a pharmaceutically acceptable salt thereof.

310. A compound of the formula:

311. A compound according to claim 310, wherein R_a is methyl and R_d is ethyl.

312. A compound according to claim 311, wherein X is O.

313. A compound according to claim 312, wherein R_b and R_c are F.

314. A compound according to claim 312, wherein R_b and R_c are hydrogen.

315. A compound according to claim 314, wherein R_e is meta-substituted ethyl phenyl group.

316. A compound according to claim 314, wherein R_e is —

CH₂CH₂CH(CH₃)₂.

317. A compound according to claim 314, wherein R_e is methyl.

318. A compound according to claim 314, wherein R_e is phenyl.

319. A compound according to claim 311, wherein X is S.

320. A compound according to claim 319, wherein R_b and R_c are F.

321. A compound according to claim 319, wherein R_b and R_c are hydrogen.

322. A compound according to claim 321, wherein R_e is meta-substituted ethyl phenyl group.

323. A compound according to claim 321, wherein R_e is methyl.

324. A compound of the formula:

325. A compound according to claim 324, wherein R_f and R_g, taken together with the carbon to which they are attached, are a carbonyl.

336. A compound according to claim 324, wherein R_f and R_g are hydrogen.

337. A compound according to claim 336, wherein X_a is a carbonyl.

338. A compound according to claim 337, wherein R_h is hydroxyl.

339. A compound according to claim 338, wherein R_i and R_j are F.

340. A compound according to claim 338, wherein R_i and R_j are hydrogen.

341. A compound according to claim 338, wherein R_k is ethyl.

342. A compound according to claim 338, wherein R_e is meta-substituted ethyl phenyl group.

343. A compound according to claim 338, wherein R_e is —

CH₂CH₂CH(CH₃)₂.

344. A compound according to claim 338, wherein R_e is methyl.

326. A compound according to claim 4325, wherein X_a is a covalent bond.

327. A compound according to claim 326, wherein R_h is hydrogen.

328. A compound according to claim 327, wherein m is 1.

329. A compound according to claim 328, wherein R_i and R_j are F.

330. A compound according to claim 328, wherein R_i and R_j are hydrogen.

331. A compound according to claim 330, wherein R_k is ethyl.

332. A compound according to claim 330, wherein R_e is meta-substituted ethyl phenyl group.

333. A compound according to claim 330, wherein R_e is —

CH₂CH₂CH(CH₃)₂.

334. A compound according to claim 330, wherein R_e is methyl.

335. A compound according to claim 330, wherein R_e is phenyl.

345. A compound which is:

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(2-hydroxyethyl)(methylsulfonyl)amino]benzamide;

5-bromo-N¹-{(1S,2R)-1-(2,4-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(2-methoxyethyl)(methylsulfonyl)amino]benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(methylsulfonyl)methyl]benzamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(4-hydroxybutyl)sulfonyl]-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(dipropylamino)isoquinoline-7-carboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxyethyl)(methyl)amino]sulfonyl}-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(ethylamino)sulfonyl]-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(5-methyl-1,2,4-oxadiazol-3-yl)-N³,N³-dipropylisophthalamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[methyl(methylsulfonyl)amino]-1,3-oxazole-4-carboxamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl) amino]-2-hydroxypropyl}-N³,N³-dipropylmalonamide;

N²-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropylbicyclo[2.2.1]hept-5-ene-2,3-dicarboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropylcyclopentane-1,3-dicarboxamide;

N²-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dimethyl-N⁵,N⁵-dipropylthieno[2,3-b]thiophene-2,5-dicarboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenyl-N⁵,N⁵-dipropylpentanediamide;

N²-benzyl-N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-[2-(dipropylamino)-2-oxoethyl]glycinamide;

3-(4-chlorophenyl)-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N⁵,N⁵-dipropylpentanediamide;

(2E)-N⁵-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2-(methoxyimino)-N¹,N¹-dipropylpentanediamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-[2-(dipropylamino)-2-oxoethyl]-N²-phenylglycinamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N²,N²-dipropylcyclohexane-1,2-dicarboxamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-phenylpropanamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(2,2-dioxido-3,4-dihydro-1,2-benzoxathiin-4-yl)amino]-2-hydroxypropyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(2,2-dioxido-3,4-dihydro-1,2-benzoxathiin-4-yl)amino]-2-hydroxypropyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1H-imidazol-2-yl)-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-propyl-1,3-benzoxazole-6-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-1,3-benzoxazole-6-carboxamide;

5-[(tert-butylamino) sulfonyl]-N¹-{(1S, 2R) -1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

N⁴-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino)-2-hydroxypropyl)-6-methyl-N²,N²-dipropylpyridine-2,4-dicarboxamide;

N⁴-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-6-methyl-N²,N²-dipropylpyridine-2,4-dicarboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-ethynyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-5-ethynyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropyl-5-(1,3-thiazol-2-yl)isophthalamide;

N¹-butyl-N³-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N¹-methyl-5-(1,3-thiazol-2-yl)isophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-methyl-N³-propyl-5-(1,3-thiazol-2-yl)isophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(4-methyl-1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-methyl-5-(1,3-oxazol-2-yl)-N³-propylisophthalamide;

N¹-butyl-N³-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N¹-methyl-5-(1,3-oxazol-2-yl)isophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-ethyl-5-(1,3-oxazol-2-yl)-N³-propylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-N³,N³-dipropyl-5-(1,3-thiazol-2-yl)isophthalamide; and

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

5-{[tert-butyl(methyl)amino]sulfonyl}-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-isopropyl-1,3-benzoxazole-6-carboxamide;

(2S)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-2-(1-naphthyl)ethanamide;

(2R)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-2-(1-naphthyl)ethanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]isonicotinamide;

N¹-{(1S,2R)-1-benzyl-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-methyl-5-(1,3-oxazol-2-yl)-N³-propylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[1-(ethoxymethyl)-1H-imidazol-2-yl]-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-propyl-1,3-benzoxazole-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-isopropyl-1,3-benzoxazole-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[ethyl(methyl)amino]sulfonyl}benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2-methyl-1,3-benzoxazole-5-carboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(methylsulfonyl)-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(methylsulfonyl)-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-1,3-benzoxazole-7-carboxamide;

methyl 3-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]benzoate;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-2-hydroxypropyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N²,N²-dipropylcyclohexane-1,2-dicarboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl}benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[ethyl(methyl)amino]sulfonyl}benzamide;

formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[ethyl(methyl)amino]sulfonyl}benzamide (1;

1);

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,5-dimethylbenzamide;

N¹-butyl-N³-((1S, 2R) -1-(3,5-difluorobenzyl) -3-{[1-(3-ethynylphenyl) cyclopropyl]amino]-2-hydroxypropyl)-N¹-methyl-5-(1,3-thiazol-2-yl)isophthalamide;

N¹-butyl-N⁵-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl) amino]-2-hydroxypropyl}-N¹-methylpentanediamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl) amino]-2-hydroxypropyl}-N⁵,N⁵-dipropylpentanediamide;

(2R)-N⁵-{((S, 2R) -1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-2-methyl-N¹,N¹-dipropylpentanediamide;

(2S)-N⁵-{(1S, 2R) -1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-N¹,N¹-dipropylpentanediamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N⁴,N⁴-dipropylsuccinamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-[2-(dipropylamino)-2-oxoethyl]-N²-methylglycinamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-[2-(dipropylamino)-2-oxoethyl]glycinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[2-(methoxymethyl)pyrrolidin-1-yl]-5-oxopentanamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N⁵-(2-furylmethyl)-N⁵-methylpentanediamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4-ethylpyridin-2-yl)methyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalamide;

N⁴-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-6-methyl-N²,N²-dipropylpyridine-2,4-dicarboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2-dimethylchromane-7-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2-dimethylchromane-6-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-1,3-benzoxazole-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-propyl-1,3-benzoxazole-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl}benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{dihydroxy[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-lambda⁴-sulfanyl]benzamide;

1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-6-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-propyl-1H-indole-6-carboxamide;

1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[4-(2-hydroxyethyl)-1,3-oxazol-2-yl]benzamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-N³,N³-dipropyl-5-(1,3-thiazol-2-yl)isophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl) amino]propyl}-N³,N³-dipropyl-5-(1,3-thiazol-2-yl)isophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-([(4-ethylpyridin-2-yl)methyl]amino)-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-4-(ethoxymethyl)benzamide;

1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}indoline-6-carboxamide;

3-[(tert-butylamino)sulfonyl]-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,3-dihydro-1,4-benzodioxine-6-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]sulfonyl}benzamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropyl-5-pyridin-4-ylisophthalamide;

N¹-butyl-N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-N¹,5-dimethylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-3-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-methylbenzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-3-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-methylbenzamide;

3-(1-butyl-1H-pyrazol-4-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}propanamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-3-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-methylbenzamide;

1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-1H-indazole-6-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-thien-2-yl-1,3-thiazole-4-carboxamide;

5-(aminosulfonyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1H-pyrrole-2-carboxamide;

N-[(1S,2R) -1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-{[(2-furylmethyl)sulfonyl]methyl}-1,3-thiazole-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-{[(4-fluorobenzyl)sulfonyl]methyl}-1,3-thiazole-4-carboxamide;

1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[methyl(methylsulfonyl)amino]-1H-indole-6-carboxamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-4-(2-methoxyethyl)benzamide;

N¹-butyl-N³-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1-phenylcyclopropyl)amino]propyl}-N¹-methyl-5-(1,3-thiazol-2-yl)isophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1-phenylcyclopropyl)amino]propyl}-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(ethylamino)sulfonyl]benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(methylamino)sulfonyl]benzamide;

(2E)-3-(1-butyl-1H-pyrazol-4-yl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}prop-2-enamide or (2E)-3-(1-butyl-1H-pyrazol-4-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}prop-2-enamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isoquinoline-7-carboxamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(propylamino)isoquinoline-7-carboxamide or N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(propylamino)isoquinoline-7-carboxamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-5-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}-N³,N³-dipropylisophthalamide;

methyl 3-(2-{3-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]phenyl}-1,3-oxazol-5-yl)propanoate;

3-(2-(3-[(((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]phenyl}-1,3-oxazol-5-yl)propanoic acid;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(3-hydroxypropyl)-1H-indole-6-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-ethoxybenzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-6-(pyrrolidin-1-ylcarbonyl)isonicotinamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(6-ethylpyridin-2-yl)methyl]amino}-2-hydroxypropyl)-5-methyl-N , N3-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(dipropylamino)sulfonyl]benzamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(6-ethylpyridin-2-yl)methyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

tert-butyl (1R)-1-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]-3-(methylsulfinyl)propylcarbamate;

N-{(1S,2R) -1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(dipropylamino)isonicotinamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(dipropylamino)isonicotinamide;

(2R)-2-amino-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(methylsulfinyl)butanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[ethyl(methyl)amino]sulfonyl}-5-{[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-[methyl(propyl)amino]isoquinoline-7-carboxamide or N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-1-[methyl(propyl)amino]isoquinoline-7-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1,3-oxazol-2-yl)benzamide;

N¹-[(1S,2R)-3-{[1-(3-bromophenyl)cyclopropyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-{[1-(3-bromophenyl)cyclopropyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

N⁵-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N³,N³-dipropyl-1H-pyrazole-3,5-dicarboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-N²,N²-dipropylcyclobutane-1,2-dicarboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(dipropylamino)carbonothioyl]benzamide;

3-[(E)-(cyanoimino)(dipropylamino)methyl]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(6-isopropyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1-propylbutoxy)benzamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(5-ethylpyridin-3-yl)methyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(6-isopropyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(2-methoxyethyl)-1H-indole-6-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-{(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl}benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1,3-thiazol-2-yl)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,8-diethoxyquinoline-2-carboxamide;

2-(4-butyl-3-oxopiperazin-1-yl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-[2-(dimethylamino)ethyl]-N³, 5-dimethylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methylbutanoyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(4-methylpentanoyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

isobutyl (2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutylcarbamate;

ethyl (2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutylcarbamate;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(pyrimidin-2-ylamino)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-5-methyl-N³-[(1S)-1-methylpropyl]isophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N³-[(1R)-1-methylpropyl]isophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(dipropylamino)-6-methylpyrimidine-4-carboxamide;

1-[butyl(methyl)amino]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]isoquinoline-7-carboxamide or 1-[butyl(methyl)amino]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]isoquinoline-7-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-dihydro-2-benzothiophene-5-carboxamide 2,2-dioxide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-3-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-methylbenzamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-({[-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-3-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-methylbenzamide trifluoroacetate;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-isobutyl-1H-indole-6-carboxamide;

1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2,5-dimethyl-1H-pyrrol-1-yl)-1H-indole-6-carboxamide;

1-butyl-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methyl-1H-indole-6-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-oxo-2-propyl-2,3-dihydro-1,2-benzisothiazole-6-carboxamide 1,1-dioxide;

1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1,3-oxazol-2-yl)-1H-indole-6-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(dipropylamino)-6-methylisonicotinamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(methylsulfonyl)methyl]-1,3-thiazole-4-carboxamide;

4-amino-1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-6-carboxamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-ethyl-3-oxo-2,3-dihydro-1,2-benzisothiazole-6-carboxamide 1,1-dioxide;

3-[(tert-butylamino)sulfonyl]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}benzamide;

3-{[(2S)-2-butylpyrrolidin-1-yl]carbonyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylbenzamide;

4-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-{[(2R)-2-(propoxymethyl)pyrrolidin-1-yl]carbonyl}benzamide;

2-(1-butyl-2-oxopiperidin-4-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-pentylbenzamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-ethylhexyl)benzamide;

ethyl 5-{3-[([(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropylamino)carbonyl]phenyl}-2-furoate;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,1′

-biphenyl-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-21-(methylthio)-1,11-biphenyl-3-carboxamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-fluorobenzyl)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(4-fluorobenzyl)benzamide;

ethyl 3′

-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]-1,1′

-biphenyl-2-carboxylate;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-3′

,5′

-difluoro-1,1′

-biphenyl-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenylacetamide;

tert-butyl 4-[([(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]amino)carbonyl]benzylcarbamate;

(2R)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-2-phenylethanamide;

(2S)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-2-phenylethanamide;

3-(5-chloropentyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1-phenylethyl)benzamide trifluoroacetate;

3-(cyclohexylmethyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;

3-cyclopentyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hex-5-enylbenzamide;

3-(6-cyanohexyl)-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(2-formylthien-3-yl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(5-formylthien-3-yl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(6-methoxypyridin-2-yl)benzyl]amino}propyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-{[3-(5-cyanopyridin-3-yl)benzyl]amino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(6-fluoropyridin-3-yl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-pyrimidin-4-ylbenzyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(5-ethylpyrimidin-2-yl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-pyrimidin-2-ylbenzyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

methyl 2-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]amino)carbonyl]-6-methylisonicotinate;

N⁴-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-6-methyl-N²,N²-dipropylpyridine-2,4-dicarboxamide 1-oxide;

1-butyl-4-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-6-carboxamide;

1-butyl-4-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-6-carboxamide;

5-(diethylamino)-N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-{[3-(diethylamino)benzyl]amino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-(1,3-oxazol-2-yl)-N³,N³ dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(dimethylamino)-N³,N³-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(2-ethylpyridin-4-yl)methyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

N²-(tert-butoxycarbonyl)-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-L-norleucinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)methyl]benzamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-3-{[(2-hydroxyethyl)(propyl)amino]methyl}-5-methylbenzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-3-{[ethyl(propyl)amino]methyl}-5-methylbenzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1,3-dihydro-2,1-benzisothiazole-5-carboxamide 2,2-dioxide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-L-norleucinamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(dimethylamino)benzyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

2-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methylisonicotinamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-3-{[(2-hydroxyethyl)(propyl)amino]methyl}benzamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-fluoro-4-propoxyphenyl)acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-2-(3-methoxy-4-propoxyphenyl)acetamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-3-methyl-5-{[methyl(propyl)amino]methyl}benzamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-3-[(dipropylamino)methyl]-5-methylbenzamide;

3-{[butyl(methyl)amino]methyl}-N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-5-methylbenzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(piperidin-1-ylsulfonyl)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(6-isopropyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl)amino]propyl}-3-methylbenzamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-([1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-4-(3-methoxypropyl)benzamide;

5-amino-N¹-{(1S, 2R) -1-(3,5-difluorobenzyl) -3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({3-[(dimethylamino)methyl]benzylamino)-2-hydroxypropyl]-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

N-(tert-butoxycarbonyl)-3-butyl-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-L-histidinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-isopentyl-1H-indole-6-carboxamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-propyl-2,3-dihydro-1,2-benzisothiazole-6-carboxamide 1,1-dioxide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-ethyl-2,3-dihydro-1,2-benzisothiazole-6-carboxamide 1,1-dioxide;

6-bromo-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2-dimethylchromane-8-carboxamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(methylsulfonyl)methyl]cyclohexanecarboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-piperidin-4-yl-N³,N³-dipropylisophthalamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-(1,3-oxazol-2-yl)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(methylsulfonyl)methyl]thiophene-2-carboxamide;

3-[(cyclohexylamino)methyl]-N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-5-methylbenzamide;

2-(2-chlorophenoxy)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}pyrazine-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(phenylsulfonyl)propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]-6-methylisonicotinamide;

3-[({(1S,2R) -1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]amino)carbonyl]-5-methylbenzoic acid;

6-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2-dimethylchromane-8-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-(1,3-thiazol-2-yl)benzamide;

formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(4-ethoxyphenyl)acetamide (1;

1);

formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-{[(2S)-2-propylpyrrolidin-1-yl]carbonyl}benzamide (1;

1);

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2R)-2-(2-methoxyethyl)pyrrolidin-1-yl]carbonyl)-5-methylbenzamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(methylsulfonyl)methyl]cyclohexanecarboxamide;

3-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1H-indole-5-carboxamide;

formic acid compound with 2-(1-butyl-2-oxo-1,2-dihydropyridin-4-yl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide (1;

1);

3-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-L-histidinamide;

5-[(diethylamino)methyl]-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(dimethylamino)methyl]-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-3-[(3-ethylbenzyl)amino]-1-[3-(hexyloxy)benzyl]-2-hydroxypropyl}-3-(1,3-oxazol-2-yl)benzamide;

formic acid compound with N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-hydroxy-4-methoxyphenyl)acetamide (1;

1);

formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1,3-thiazolidin-3-ylsulfonyl)benzamide (1;

1);

formic acid compound with N-((1S,2R)-1-(3,5-idifluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-4-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)benzamide (1;

1);

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(4-phenylpiperazin-1-yl)sulfonyl]benzamide;

3-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-5-carboxamide;

N-{(1S,2R)-3-[(3-ethylbenzyl)amino]-1-[3-(hexyloxy)benzyl]-2-hydroxypropyl}acetamide;

1-butyl-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-1H-benzimidazole-6-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(methylsulfonyl)methyl]nicotinamide;

N¹-[(1S,2R)-3-({3-[(diethylamino)methyl]benzylamino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(dipropylamino)-6-(1,3-oxazol-2-yl)isonicotinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-6-(1,3-oxazol-2-yl)isonicotinamide;

1-butyl-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-1H-benzimidazole-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(6-isopropyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl)amino]propyl}-3-methylbenzamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-piperidin-3-yl-N³,N³-dipropylisophthalamide;

3-{[benzyl(methyl)amino]methyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-5-methylbenzamide;

formic acid compound with N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-([4-(4-fluorophenyl)piperazin-1-yl]sulfonyl}benzamide (2;

1);

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(pyrrolidin-1-ylsulfonyl)benzamide;

formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(pyrrolidin-1-ylsulfonyl)benzamide (1;

1);

formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-([4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}sulfonyl)benzamide (2;

1);

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(dimethylamino)sulfonyl]benzamide;

formic acid compound with N-[((S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(dimethylamino)sulfonyl]benzamide (1;

1);

N-{(1S,2R)-3-[(3-ethylbenzyl)amino]-1-[3-(hexyloxy)benzyl]-2-hydroxypropyl}-2-[(methylsulfonyl)amino]-1,3-oxazole-4-carboxamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-[(methylsulfonyl)methyl]nicotinamide;

N-[(1S,2R)-3-[(3-bromobenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-4-methylpentanamide;

1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-1H-pyrrole-2-carboxamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1H-pyrrol-2-ylmethyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-piperazin-1-yl-N³,N³-dipropylisophthalamide;

N-[(1S,2R)-3-[(3-bromobenzyl)amino]-1(3,5-difluorobenzyl)-2-hydroxypropyl]acetamide;

N²-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methyl-N⁴,N⁴-dipropylpyridine-2,4-dicarboxamide;

N²-(tert-butoxycarbonyl)-N¹-{(S, 2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-D-norleucinamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-D-norleucinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(4R)-6-isopropyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)acetamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-t[(4S)-6-isopropyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)acetamide;

formic acid compound with 4-{[(4-chlorophenyl)(methyl)amino]sulfonyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (1;

1);

formic acid compound with 4-{[benzyl(phenyl)amino]sulfonyl}-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (1;

1);

formic acid compound with N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(morpholin-4-ylsulfonyl)benzamide (1;

1);

N-[(1S,2R)-3-[(3-bromobenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]propanamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-oxo-4-propylcyclohexyl)acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-oxocyclohexyl)acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,1-dipropyl-3,4-dihydro-1H-isochromene-7-carboxamide;

formic acid compound with 4-{[(2-cyanoethyl)(methyl)amino]sulfonyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (1;

1);

formic acid compound with 4-{[cyclohexyl(methyl)amino]sulfonyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (1;

1);

formic acid compound with N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[methyl(2-pyridin-2-ylethyl)amino]sulfonylbenzamide (2;

1);

formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[methyl(phenyl)amino]sulfonyl}benzamide (1;

1);

formic acid compound with 4-{[benzyl(methyl)amino]sulfonyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (1;

1);

formic acid compound with N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[methyl(2-phenylethyl)amino]sulfonylbenzamide (1;

1);

formic acid compound with 4-{[allyl(methyl)amino]sulfonyl}-N-{(1S*,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (1;

1);

formic acid compound with 4-{[[2-(diethylamino)ethyl](methyl)amino]sulfonyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (2;

1);

formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[methyl(propyl)amino]sulfonyl}benzamide (1;

1);

formic acid compound with 4-{[butyl(methyl)amino]sulfonyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (1;

1);

formic acid compound with N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[methyl(pentyl)amino]sulfonyl}benzamide (1;

1);

formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[isopentyl(methyl)amino]sulfonyl}benzamide (1;

1);

2-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,2,3,4-tetrahydroisoquinoline-7-carboxamide;

formic acid compound with N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[methyl(1-methylpyrrolidin-3-yl)amino]sulfonyl}benzamide (2;

1);

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(4-ethylpyridin-2-yl)cyclopropyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-3-(2-methoxyethyl)benzamide;

1-butyl-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-2-(2-methoxyethyl)-1H-benzimidazole-6-carboxamide;

L-alpha-glutamyl-L-valyl-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-L-methioninamide;

3-([cyclohexyl(methyl)amino]methyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-5-methylbenzamide;

N-{(1S,2R)-1-(3-butoxybenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;

formic acid compound with 2-(4-butyl-2,5-dioxopiperazin-1-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide (1;

1);

3-bicyclo[2.2.1]hept-2-yl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;

3-(butylamino)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-4-(2-methoxyethyl)benzamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-2-(dipropylamino)-6-(1,3-oxazol-2-yl)isonicotinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1S)-1,2,3,4-tetrahydronaphthalen-1-ylamino]propyl}-3-methylbenzamide;

formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(dipropylamino)sulfonyl]benzamide (1;

1);

formic acid compound with 4-[(diethylamino)sulfonyl]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (1;

1);

4-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(methylsulfonyl)-1,2,3,4-tetrahydroquinoxaline-6-carboxamide;

1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isoquinoline-7-carboxamide;

5-{[butyl(methyl)amino]methyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thiophene-2-carboxamide;

3-{[butyl(methyl)amino]methyl}-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-methylbenzamide;

3-{[butyl(methyl)amino]methyl}-N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-5-methylbenzamide;

3-bromo-5-([butyl(methyl)amino]methyl}-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)benzamide;

3-{[butyl(methyl)amino]methyl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-methylbenzamide;

(2R)-2-(4-butyl-3-oxopiperazin-1-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}propanamide;

3-{[butyl(methyl)amino]methyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylbenzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(dipropylamino)-6-(1,3-thiazol-2-yl)isonicotinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-3-{[isopentyl(methyl)amino]methyl}-5-methylbenzamide;

N-{(1S,2R)-1-(3-butoxybenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(methylsulfonyl)amino]-1,3-oxazole-4-carboxamide;

3-butyl-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}imidazo[1,2-a]pyridine-6-carboxamide;

2-[butyl(methyl)amino]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-(1,3-oxazol-2-yl)isonicotinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-benzodioxole-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl)amino]-2-hydroxypropyl}acetamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl)amino]-2-hydroxypropyl]acetamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[methyl(propyl)amino]-6-(1,3-oxazol-2-yl)isonicotinamide;

3-{[butyl(methyl)amino]methyl}-N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1-phenylcyclopropyl)amino]propyl}-5-methylbenzamide;

3-{[butyl(methyl)amino]methyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-5-methylbenzamide;

N-[(1S,2R)-3-{[1-(3-bromophenyl)cyclopropyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]acetamide;

3-([butyl(methyl)amino]methyl}-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)benzamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[2-(methylsulfonyl)-1-phenylethyl]amino}propyl)acetamide;

3-{[butyl(methyl)amino]methyl}-5-cyano-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({2-[(methylsulfonyl)methyl]benzyl}amino)propyl]acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2-furylmethyl)(methyl)amino]methyl}-5-methylbenzamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2-methoxyethyl)(methyl)amino]methyl}-5-methylbenzamide;

3-{[[2-(diethylamino)ethyl](methyl)amino]methyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylbenzamide;

N-[(1S,2R)-3-[(3-bromobenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-2-methoxyacetamide;

formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[4-(ethoxymethyl)piperidin-1-yl]pentanamide (2;

1);

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-oxoindane-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxyindane-5-carboxamide;

formic acid compound with N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(4-propoxypiperidin-1-yl)acetamide (2;

1);

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[isobutyl(methyl)amino]methyl}-5-methylbenzamide;

formic acid compound with 2-(1-butyl-2-oxopiperidin-4-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide (1;

1);

formic acid compound with 2-(4-butylpiperazin-1-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide (3;

1);

4-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dihydro-2H-1,4-benzothiazine-6-carboxamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-([(1R,2s)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}propyl)acetamide;

2-[(2S)-4-butyl-2-methyl-3-oxopiperazin-1-yl]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]acetamide;

2-[(2R)-4-butyl-2-methyl-3-oxopiperazin-1-yl]-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2,3-dioxo-4-propylpiperazin-1-yl)acetamide;

4-butyl-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,2,3,4-tetrahydroquinoxaline-6-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-{[methyl(pentyl)amino]methyl}benzamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-([(2R)-2-(methoxymethyl)pyrrolidin-1-yl]methyl)-5-methylbenzamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-2-(dipropylamino)isonicotinamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(1-{4-[(dimethylamino)methyl]pyridin-2-yl}cyclopropyl)amino]-2-hydroxypropyl}-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(dipropylamino)-4-methyl-1,3-thiazole-5-carboxamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({2-[(4-ethylbenzyl)sulfonyl]ethyl}amino)-2-hydroxypropyl]acetamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-3-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)-3,5-dimethylbenzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1S)-1,2,3,4-tetrahydronaphthalen-1-ylamino]propyl}acetamide;

3-bromo-5-{[butyl(methyl)amino]methyl}-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;

1-butyl-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[[-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-1H-indole-6-carboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[({4-[(dimethylamino)methyl]pyridin-2-ylmethyl)amino]-2-hydroxypropyl}-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

3-[(butylamino)methyl]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylbenzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]methyl}-5-methylbenzamide;

formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[4-(2-methoxyethyl)piperidin-1-yl]acetamide (2;

1);

1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,2,3,4-tetrahydroisoquinoline-7-carboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N¹,5-dimethyl-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[3-(dimethylamino)prop-1-ynyl]-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-phenoxyphenyl)acetamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2,5-dimethylphenyl)acetamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[2-(trifluoromethoxy)phenyl]acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-ethoxyphenyl)acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[2-(trifluoromethyl)phenyl]acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-methoxyphenyl)acetamide;

2-[2-(benzyloxy)phenyl]-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenylbutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-mesitylacetamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2,4-dimethoxyphenyl)acetamide;

2-(2-chlorophenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;

2-cyclohexyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;

2-cyclopent-2-en-1-yl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(1-methyl-5-oxo-2-thioxoimidazolidin-4-yl)acetamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-fluorophenyl)acetamide;

2-cyclopropyl-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]acetamide;

2-cyclohex-1-en-1-yl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropylacetamide;

2-(1-adamantyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]acetamide;

(2S)-N-[,(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenylpropanamide;

(2R)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenylpropanamide;

2-(2,4-dichlorophenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropylacetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2,3-dimethoxyphenyl)acetamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[3-(dimethylamino)propyl]-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl)amino]-2-hydroxypropyl}acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl)amino]-2-hydroxypropyl}acetamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(4-ethynylpyridin-2-yl)cyclopropyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

4-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dihydro-2H-1,4-benzothiazine-6-carboxamide 1-oxide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-heptyl-4-hydroxy-L-prolinamide;

2-[butyl(methyl)amino]-6-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isonicotinamide;

2-[butyl(methyl)amino]-6-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isonicotinamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[({2-[(dimethylamino)methyl]pyridin-4-yl}methyl)amino]-2-hydroxypropyl}-5-(1,3-oxazol-2-yl)-N,AN-dipropylisophthalamide;

4-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-8-(1,3-oxazol-2-yl)-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide or 4-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-8-(1,3-oxazol-2-yl)-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(4-ethyl-1,3-oxazol-2-yl)-5-(1,3-oxazol-2-yl)benzamide;

3-benzyl-4-(4-butylphenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxobutanamide;

2-(4-butyl-2-oxopiperazin-1-yl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[4-(ethoxymethyl)piperidin-1-yl]acetamide;

2-(4-butyl-2,3-dioxopiperazin-1-yl)-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}hexanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}acetamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(4-ethynylpyridin-2-yl)cyclopropyl]amino)-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N³,N³-dipropylisophthalamide;

5-[((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)amino]-5-oxopentanoic acid;

1-butyl-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,2,3,4-tetrahydroquinoline-7-carboxamide or 1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,2,3,4-tetrahydroquinoline-7-carboxamide;

4-(((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)amino]-4-oxobutanoic acid;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-propyl-1,2-benzisoxazole-5-carboxamide;

2-[allyl(methyl)amino]-N-{(1S,2R)-1-[3-(allyloxy)-5-fluorobenzyl]-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isonicotinamide;

1-allyl-N-{(1S,2R)-1-[4-(allyloxy)-3-fluorobenzyl]-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-6-carboxamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-4-phenyl-2-(1H-pyrrol-1-yl)-1,3-thiazole-5-carboxamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-2-(dipropylamino)-4-(trifluoromethyl)-1,3-thiazole-5-carboxamide;

(2S)-2-{[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-N-isobutyl-4-(methylsulfonyl)butanamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(3-hydroxyprop-1-ynyl)benzyl]amino}propyl)acetamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-([1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-2,6-dimorpholin-4-ylpyrimidine-4-carboxamide;

N-J(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2S)-2-ethylpyrrolidin-1-yl]carbonyl}-5-methylbenzamide;

(2S)-2-(4-butyl-3-oxopiperazin-1-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}propanamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-([(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)tetrahydrofuran-3-carboxamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)propanamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)-2-(1H-imidazol-4-yl)acetamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)-N²,2-dimethylalaninamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)cyclopentanecarboxamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-([(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)cyclopropanecarboxamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)-2-phenylacetamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)tetrahydrofuran-2-carboxamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-t[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)-1,3-thiazolidine-4-carboxamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)-3-hydroxybutanamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)-3-hydroxypropanamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-([(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)-3-hydroxy-2,2-dimethylpropanamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)-3-methylbutanamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)glycinamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)-N²-methylglycinamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-1-methyl-3-(trifluoromethyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

2-[allyl(methyl)amino]-N-((1S,2R)-1-[4-(allyloxy)-3-fluorobenzyl]-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isonicotinamide;

3-butyl-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,2-benzisoxazole-5-carboxamide;

5-(3-aminopropyl)-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[3-(methylamino)propyl]-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[3-(methylamino)prop-1-ynyl]-N³,N³-dipropylisophthalamide;

5-(3-aminoprop-1-ynyl)-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropylisophthalamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-pyrrolidin-1-ylpyrazine-2-carboxamide;

4-butoxy-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}quinoline-2-carboxamide;

2-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-[methyl(propyl)amino]isonicotinamide;

3-acetyl-1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-1H-indole-6-carboxamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1H-indol-6-ylmethyl)amino]propyl}-5-methyl-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-isobutyl-1,2-benzisoxazole-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyli-2-[(2S)-pyrrolidin-2-yl]acetamide;

2-[2-([(1S,2R)-1-(3,5-.difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-2-oxoethyl]-N-(6-methoxypyridin-3-yl)benzamide;

2-[2-([(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-2-oxoethyl]-N-(2,4-difluorophenyl)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-pyridin-3-ylacetamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(1H-imidazol-5-yl)acetamide;

2-cyclopentyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-hydroxyphenyl)acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-methylphenyl)acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-iodophenyl)acetamide;

1-(4-chlorophenyl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-oxopyrrolidine-3-carboxamide;

4-(2,4-dichlorophenoxy)-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}butanamide;

4,5-dibromo-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thiophene-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)acetamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-2,6-bis(dimethylamino)pyrimidine-4-carboxamide;

4-butyl-8-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide;

3-(allylsulfonyl)-N-((1S,2R) -1(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)benzamide;

3-(allylthio)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]propyl}acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]propyl}acetamide;

formic acid compound with N¹-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-N⁵-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)pentanediamide (1;

1);

formic acid compound with N¹-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-N⁵-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)pentanediamide (1;

1);

formic acid compound with N¹-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-N⁴-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)succinamide (1;

1);

formic acid compound with N¹-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-N⁴-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)succinamide (1;

1);

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)pentanamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)-3-phenylpropanamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[4-(dimethylamino)but-1-ynyl]-N³,N³-dipropylisophthalamide;

1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(trifluoroacetyl)-1H-indole-6-carboxamide;

N-((1S,2R) -1(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-3-{[isopentyl(methyl)amino]methyl}-5-methylbenzamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-([1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-3-{[isopentyl(methyl)amino]methyl}-5-methylbenzamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-4-(dipropylamino)-1-methyl-1H-pyrrole-2-carboxamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)-4-(2-methoxyethyl)benzamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[4-(dimethylamino)butyl]-N³,N³-dipropylisophthalamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[6-ethyl-2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-4-yl]amino}-2-hydroxypropyl)acetamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[6-ethyl-2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-4-yl]amino}-2-hydroxypropyl)acetamide;

2,6-dichloro-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)pyrimidine-4-carboxamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(1S)-7-ethyl-1,2,3,4-tetrahydronaphthalen-1-yl]amino}-2-hydroxypropyl)acetamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(1R)-7-ethyl-1,2,3,4-tetrahydronaphthalen-1-yl]amino}-2-hydroxypropyl)acetamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-([1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-2-morpholin-4-yl-4-(trifluoromethyl)-1,3-thiazole-5-carboxamide;

N-((1S,2R)-1-benzyl-3-[(6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl)amino]-2-hydroxypropylacetamide;

N-[(1S,2R)-3-([1-(3-bromophenyl)cyclopropyl]amino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]acetamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-(([1-(3-ethylphenyl)-1H-tetraazol-5-yl]methyl}amino)-2-hydroxypropyl]-5-methyl-N³,N³-dipropylisophthalamide;

3-(allylsulfinyl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)benzamide;

methyl 3-[3′

-(acetylamino)-1,1′

-biphenyl-3-yl]-3-{[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}propanoate;

methyl 3-{[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-3-[3-(5-formylthien-2-yl)phenyl]propanoate;

methyl 3-{[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-3-(2′

-acetyl-1,1′

-biphenyl-3-yl)propanoate;

methyl 3-([(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino)-3-[3′

-(hydroxymethyl)-1,1′

-biphenyl-3-yl]propanoate;

N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3′

-methoxy-1,1′

-biphenyl-3-yl)cyclopropyl]amino}propyl)acetamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3′

-(hydroxymethyl)-1,1′

-biphenyl-3-yl]cyclopropyl}amino)propyl]acetamide;

N-[(1S,2R)-3-{[1-(2′

-acetyl-1,1′

-biphenyl-3-yl)cyclopropyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]acetamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({1-[3-(5-formylthien-2-yl)phenyl]cyclopropyl}amino)-2-hydroxypropyl]acetamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-(9H-fluoren-9-ylamino)-2-hydroxypropyl]acetamide;

methyl 3-([(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-3-[3-(trifluoromethyl)phenyl]propanoate;

methyl 3-{[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-3-(3-cyanophenyl)propanoate;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[3-(dimethylamino)propyl]-N³,N³-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3′

-(hydroxymethyl)-5-(1,3-thiazol-2-yl)-1,1′

-biphenyl-3-carboxamide;

3′

-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-5-(1,3-thiazol-2-yl)-1,1′

-biphenyl-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2′

-ethoxy-5-(1,3-thiazol-2-yl)-1,1′

-biphenyl-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1,3-thiazol-2-yl)-3′

-(trifluoromethoxy)-1,1′

-biphenyl-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4′

-propoxy-5-(1,3-thiazol-2-yl)-1,1′

-biphenyl-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4′

-(dimethylamino)-5-(1,3-thiazol-2-yl)-1,1′

-biphenyl-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2′

-propoxy-5-(1,3-thiazol-2-yl)-1,1′

-biphenyl-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3′

-propoxy-5-(1,3-thiazol-2-yl)-1,1′

-biphenyl-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3′

-ethoxy-5-(1,3-thiazol-2-yl)-1,1′

-biphenyl-3-carboxamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4′

-ethoxy-5-(1,3-thiazol-2-yl)-1,1′

-biphenyl-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4′

-isopropoxy-5-(1,3-thiazol-2-yl)-1,1′

-biphenyl-3-carboxamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4′

-(hydroxymethyl)-5-(1,3-thiazol-2-yl)-1,1′

-biphenyl-3-carboxamide;

4′

-butoxy-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1,3-thiazol-2-yl)-1,1′

-biphenyl-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4′

-methoxy-5-(1,3-thiazol-2-yl)-1,1′

-biphenyl-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1,3-thiazol-2-yl)-4′

-(trifluoromethoxy)-1,1′

-biphenyl-3-carboxamide;

4′

-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-5-(1,3-thiazol-2-yl)-1,1′

-biphenyl-3-carboxamide;

3′

-butoxy-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-5-(1,3-thiazol-2-yl)-1,1′

-biphenyl-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-3′

-isopropyl-5-(1,3-thiazol-2-yl)-1,1′

-biphenyl-3-carboxamide;

3′

-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1,3-thiazol-2-yl)-1,1′

-biphenyl-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2′

-methyl-5-(1,3-thiazol-2-yl)-1,1′

-biphenyl-3-carboxamide;

2′

-acetyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1,3-thiazol-2-yl)-1,1′

-biphenyl-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-4′

-hydroxy-5-(1,3-thiazol-2-yl)-1,1′

-biphenyl-3-carboxamide;

4′

-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-5-(1,3-thiazol-2-yl)-1,1′

-biphenyl-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1H-pyrrol-2-yl)-5-(1,3-thiazol-2-yl)benzamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(E)-2-(4-fluorophenyl)ethenyl]-5-(1,3-thiazol-2-yl)benzamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino)-2-hydroxypropyl)pyrimidine-4-carboxamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-([1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)acetamide;

methyl 3-{[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-3-(3-bromophenyl)propanoate;

2-chloro-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{11-(3-ethynylphenyl)cyclopropyl]amino)-2-hydroxypropyl)-6-morpholin-4-ylpyrimidine-4-carboxamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-2-(dipropylamino)-6-morpholin-4-ylpyrimidine-4-carboxamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-([1-(3-ethynylphenyl)cyclopropyl]amino)-2-hydroxypropyl)-2,6-bis(dipropylamino)pyrimidine-4-carboxamide;

methyl 3-{[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-3-(3-bromophenyl)propanoate;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)acetamide;

or pharmaceutically acceptable salts thereof.

346. A compound which is:

N¹-[(1S,2S)-3-(benzylamino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N,N-dipropylisophthalamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-ethynyl-N,N-dipropylisophthalamide;

N-(1-cyclopropylethyl)-N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N-phenylsuccinamide;

N¹-[(1S,2R) -1(3,5-difluorobenzyl)-2-hydroxy-3-({3-[(1E)-prop-1-en-1-yl]benzyl}amino)propyl]-5-methyl-N,N-dipropylisophthalamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-5-(1,3-oxazol-2-yl)-N,N-dipropylisophthalamide;

methyl (3-{[((2R,3S)-4-(3,5-difluorophenyl)-3-{[3-[(dipropylamino)carbonyl]-5-(1,3-oxazol-2-yl)benzoyl]amino}-2-hydroxybutyl)amino]methyl}phenyl)methylcarbamate;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[(methylsulfonyl)amino]benzyl}amino)propyl]-5-(1,3-oxazol-2-yl)-N,N-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-N,N-dipropylpyridine-3,5-dicarboxamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N,N-dipropylpyridine-3,5-dicarboxamide 1-oxide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-5-ethynyl-N,N-dipropylisophthalamide;

N⁴-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-6-methyl-N²,N²-dipropylpyridine-2,4-dicarboxamide;

N¹-[(1S,2R)-3-{[(2-tert-butylpyrimidin-4-yl)methyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N,N-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(2-ethylpyrimidin-4-yl)methyl]amino}-2-hydroxypropyl)-5-methyl-N,N-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-[(isobutylamino)carbonyl]-3-(methylsulfonyl)propyl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-hydroxy-1-phenylpropyl)amino]propyl}-5-methyl-N,N-dipropylisophthalamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ylamino)propyl]-5-methyl-N,N-dipropylisophthalamide;

N¹-((1S,2S)-1-(3,5-difluorobenzyl)-2-hydroxy-3-([(1R)-6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1R)-6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl]aminopropyl)-5-methyl-N,N-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-2-oxo-1-methyl-2-(methylamino)ethyl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;

N¹-[(1S,2R)-3-{[(1S)-1-benzyl-2-oxo-2-(methylamino)ethyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N,N-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-[oxo [3-(trifluoromethyl)phenyl]methyl}glycinamide;

2-{[2-({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-2-oxoethyl]thio}-N-(5-methylisoxazol-3-yl)acetamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-[oxo(methylamino)methyl]-3-(methylthio)propyl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1R)-1-(hydroxymethyl)-2-oxo-2-(methylamino)ethyl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;

N¹-[(1S,2R)-3-({(1S)-1-[amino(oxo)methyl]-3-methylbutyl}amino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N,N-dipropylisophthalamide;

N¹-[(1S,2R)-3-[(2-amino-2-oxo-1-methylethyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N,N-dipropylisophthalamide;

tert-butyl (1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropylcarbamate;

tert-butyl (1S,2R)-3-(cyclopropylamino)-1-(3,5-difluorobenzyl)-2-hydroxypropylcarbamate;

tert-butyl (1S,2R)-3-[(cyclopropylmethyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropylcarbamate;

tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-([2-oxo-2-(isobutylamino)-1-methylethyl]amino}propyl)carbamate;

benzyl (1S,2R)-1-benzyl-3-[(3-ethylbenzyl)amino]-2-hydroxypropylcarbamate;

(2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-([1-(3-ethynylphenyl)cyclopropyl]aminobutan-2-ol;

tert-butyl [(1S,2R)-3-{[(1S)-2-(benzylamino)-2-oxo-1-methylethyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]carbamate;

N²-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-hydroxybutyl]-N¹-benzyl-L-alaninamide bis(trifluoroacetate) (salt);

tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(2-isobutyl-1,3-thiazol-5-yl)cyclopropyl]amino propyl)carbamate;

(2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-{[1-(2-isobutyl-1,3-thiazol-5-yl)cyclopropyl]amino}butan-2-ol bis(trifluoroacetate) (salt);

tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3-isobutylisoxazol-5-yl)cyclopropyl]amino}propyl)carbamate;

(2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-{[1-(3-isobutylisoxazol-5-yl)cyclopropyl]amino}butan-2-ol bis(trifluoroacetate) (salt);

tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(2-ethylpyrimidin-4-yl)methyl]amino}-2-hydroxypropyl)carbamate;

(2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-{[(2-ethylpyrimidin-4-yl)methyl]amino}butan-2-ol bis(trifluoroacetate) (salt);

tert-butyl {(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]propyl}carbamate;

tert-butyl [(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ylamino)propyl]carbamate;

tert-butyl {(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-hydroxy-1-phenylpropyl)amino]propyl}carbamate;

tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-[oxo(isobutylamino)methyl]-3-(methylthio)propyl]aminopropyl)carbamate;

tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-[(isobutylamino)carbonyl]-3-(methylsulfonyl)propyl]amino}propyl)carbamate;

tert-butyl {(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2,2-dioxido-3,4-dihydro-1,2-benzoxathiin-4-yl)amino]-2-hydroxypropyl}carbamate;

tert-butyl f(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2,2-dioxido-3,4-dihydro-1H-2,1-benzothiazin-4-yl)amino]-2-hydroxypropyl}carbamate;

tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)carbamate;

tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)carbamate;

tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3-methylphenyl)cyclopropyl]amino}propyl)carbamate;

tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3-iodophenyl)cyclopropyl]amino}propyl)carbamate;

tert-butyl [(1S,2R)-3-{[3-(cyclopropylamino)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]carbamate;

methyl 3-({[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}methyl)benzoate;

methyl [3-({[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}methyl)phenyl]carbamate;

methyl [3-({[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}methyl)phenyl]methylcarbamate;

tert-butyl [(1S,2R)-1-(3,5-difluorobenzyl)-3-([3-[(dimethylamino)sulfonyl]benzyl}amino)-2-hydroxypropyl]carbamate;

tert-butyl [(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[(methylsulfonyl)amino]benzyl}amino)propyl]carbamate;

tert-butyl [(1S,2R)-3-[(3-cyanobenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]carbamate;

3-(([(2R,3S)-3-[(tert-butoxycarbonyl)amino]-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}methyl)phenyl dimethylcarbamate;

tert-butyl [(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl][3-(ethylthio)benzyl]carbamate;

tert-butyl [(1S,2R)-1-(3,5-difluorobenzyl)-3-[(1R)-2,3-dihydro-1H-inden-1-ylamino]-2-hydroxypropyl}carbamate;

tert-butyl {(1S,2R)-1-(3,5-difluorobenzyl)-3-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-2-hydroxypropyl}carbamate;

tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}propyl)carbamate;

tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}propyl)carbamate;

tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3S)-2-oxoazepan-3-yl]amino}propyl)carbamate;

tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3R)-2-oxoazepan-3-yl]amino}propyl)carbamate;

tert-butyl [(1S,2R)-1-(3,5-difluorobenzyl)-3-({[(5S)-3-ethyl-2-oxo-1,3-oxazolidin-5-yl]methyl}amino)-2-hydroxypropyl]carbamate;

tert-butyl [(1S,2R)-1-(3,5-difluorobenzyl)-3-({[(5R)-3-ethyl-2-oxo-1,3-oxazolidin-5-yl]methyl]amino)-2-hydroxypropyl]carbamate;

tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-3-([1-(3-ethylphenyl)-1-methylethyl]amino}-2-hydroxypropyl)carbamate;

tert-butyl [(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(2-naphthylmethyl)amino]propyl}carbamate;

tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-([2-oxo-2-(isobutylamino)-1,1-dimethylethyl]amino}propyl)carbamate;

tert-butyl [(1S,2R)-3-[(benzyloxy)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]carbamate;

tert-butyl 4-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]piperidine-1-carboxylate trifluoroacetate;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-fluoro-1-naphthamide;

N-[(1S,2R)-1-benzyl-3-(2-butyryl-1-ethylhydrazino)-2-hydroxypropyl]-2-(3-methylisoxazol-5-yl)acetamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N-hexyl-N,5-dimethylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzoyl)amino]propyl}-5-methyl-N,N-dipropylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1H-imidazole-2-carboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-3,3-dimethyl-N²,N²-dipropylcyclopropane-1,2-dicarboxamide;

tert-butyl 2-[(((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]-1-methyl-1H-imidazol-4-ylcarbamate;

N⁵-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2-dimethyl-N′

,N¹-dipropylpentanediamide;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(2-morpholin-4-ylethyl)amino]propyl}-2-(4-chlorophenoxy)-2-methylpropanamide compound with methyl hydroperoxide (1;

2);

N-[(1S,2R)-3-(benzylamino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-4-fluoro-1-naphthamide;

3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-isopropylbenzyl)propyl]propanamide;

3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(3-methoxybenzyl)propyl]propanamide;

N¹-[(1S,2R)-1-(3,5-dichlorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N⁵,N⁵-dipropylpentanediamide;

N¹-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methoxybenzyl)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methoxybenzyl)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-[(1S,2R)-2-hydroxy-1-(4-isopropylbenzyl)-3-[(3-methoxybenzyl)amino]propyl}-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

3-[(dipropylamino)sulfonyl]-N-((1S)-1-{(1R)-1-hydroxy-2-[(3-methoxybenzyl)amino]ethyl}but-3-ynyl)propanamide;

N¹-[(1S,2R)-1-(2-furylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-N⁵,N⁵-dipropylpentanediamide;

N¹-[(1S,2R)-1-(2-furylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(1-naphthylmethyl)propyl]-5-methyl-N³,N³-dipropylisophthalamide;

N¹-((1S)-1-[(1R)-1-hydroxy-2-[(3-methoxybenzyl)amino]ethyl}-3-methylbutyl)-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-[(1S,2R)-1-(2-furylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N¹-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(1-naphthylmethyl)propyl]-N³,N³-dipropylbenzene-1,3,5-tricarboxamide;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-{[(2-methoxyethyl)(propyl)amino]sulfonylpropanamide;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-(4,5-dimethyl-2-furoyl)-5-methylbenzamide;

3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]propanamide;

3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-1-(3-fluoro-5-hydroxybenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-1,3-benzothiazole-2-carboxamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide;

N-[(1S,2R)-3-amino-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-3-(isopentylsulfonyl)propanamide trifluoroacetate;

N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-hydroxy-5-methylbenzamide;

4-amino-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]butanamide bis(trifluoroacetate);

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(pyridin-4-ylmethyl)thio]benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,1,3-benzoxadiazole-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methyl-1,2,3-thiadiazole-5-carboxamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(pyridin-2-ylthio)methyl]-2-furamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-5-(trifluoromethoxy)-1H-indole-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(5-methyl-1H-tetraazol-1-yl)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,8-dimethylquinoline-3-carboxamide;

2-(3-chlorophenoxy)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}propanamide;

2-chloro-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1H-tetraazol-1-yl)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[5-(2-methylphenyl)-2H-tetraazol-2-yl]acetamide;

3-(1,3-benzoxazol-2-ylthio)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-6-methylquinoline-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-propylpyrazine-2-carboxamide 4-oxide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-benzothiophene-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1H-indole-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methoxy-1,3-benzothiazole-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2-[(6-methoxy-1H-benzimidazol-2-yl)thio]acetamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-phenylthiophene-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methoxythiophene-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,3′

-bithiophene-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-morpholin-4-yl-4-oxobutanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-3-carboxamide;

4-(acetylamino)-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,6-dimethylbenzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-furamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxy-3,5-dimethoxybenzamide;

4-acetyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropylinicotinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxyquinoline-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-hydroxynicotinamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-benzothiophene-2-carboxamide;

7-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxyquinoline-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methylisoxazole-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisoxazole-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,5-dimethyl-1H-pyrazol-1-yl)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methoxy-1H-indole-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,5-dimethyl-3-furamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-hydroxy-2-(methylthio)pyrimidine-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-1,3-oxazole-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-1H-pyrazole-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thiophene-3-carboxamide;

6-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methyl-1,3-oxazole-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methoxybenzamide;

4-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-piperidin-1-ylbenzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methylpyrimidine-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}quinoline-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenylimidazo[1,2-a]pyridine-7-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-hydroxy-4-methylpyridine-2-carboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N⁴,N⁴-diphenylsuccinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[ethyl(methyl)amino]-4-hydroxypyrimidine-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,8-dihydroxyquinoline-2-carboxamide;

N-{(1S,2R) -1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-1-benzofuran-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-ethyl-1H-indole-2-carboxamide;

2-(acetylamino)-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5-dimethylthiophene-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxyquinoxaline-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indazole-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-2-phenyl-1,3-oxazole-4-carboxamide;

4-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methylquinoline-2-carboxamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyli-N²,N²-dimethylphthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]thiophene-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-furamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-3-furamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxy-6-neopentylpyridine-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-thiazole-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-4-hydroxy-7-methoxy-1-benzothiophene-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxy-7-methoxy-1-benzofuran-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenyl-1,3-oxazole-4-carboxamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dihydroxybenzamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N⁴-phenylsuccinamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl) amino]-2-hydroxypropyl}-N⁴-pyridin-3-ylsuccinamide;

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N⁴-(2,6-dimethylphenyl)succinamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N⁴-methylsuccinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(4-methoxyphenoxy)propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxy-7-methoxyquinoline-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[methyl(methylsulfonyl)amino]benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(pyrrolidin-3-ylsulfonyl)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-(4-methyl-1,2,3-thiadiazol-5-yl)isoxazole-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(4-methyl-1,2,3-thiadiazol-5-yl)-1,3-thiazole-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenylimidazo[1,2-a]pyridine-6-carboxamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-N⁵-(1,3-thiazol-2-yl)pentanediamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(4-methyl-1,2,3-thiadiazol-5-yl)thio]acetamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(piperidin-1-ylmethyl)-2-furamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,5-dimethyl-1-phenyl-1H-pyrrole-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-1-phenyl-1H-pyrazole-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-fluoro-4-morpholin-4-ylbenzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,5-bis(methylthio)isothiazole-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-(trifluoromethyl)isoxazole-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-5-(propionylamino)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-phenyl-1H-pyrrole-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}pyrazine-2-carboxamide 4-oxide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-1-pyridin-4-yl-1H-1,2,3-triazole-4-carboxamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methoxypyrazine-2-carboxamide 4-oxide;

N-{(1S,2R)-1-(3′

,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-5-phenyl-1H-pyrazole-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxy-3-propylhexanamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-benzimidazole-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-(propionylamino)benzamide;

5-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-1-benzofuran-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-pyridin-3-yl-1,3-thiazole-4-carboxamide;

8-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxyquinoline-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,6-naphthyridine-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2-dimethyl-4-oxochromane-6-carboxamide;

N-{(1S,2R) -1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(morpholin-4-ylmethyl)benzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,7-dimethoxy-1-benzofuran-5-carboxamide;

3-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-phenylisothiazole-4-carboxamide;

2-(2,1,3-benzothiadiazol-4-yloxy)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methoxy-4-(methylthio)benzamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(4-methyl-1,3-thiazol-2-yl)thio]acetamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methoxy-1-benzofuran-2-carboxamide;

5-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-morpholin-4-ylbenzamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methoxy-1H-pyrrole-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-1,3-thiazole-4-carboxamide;

N-{(1S,2R) -1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-5-(2-thienyl)-3-furamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methoxythiophene-3-carboxamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-N¹-(3,5-dimethylpyrazin-2-yl)succinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(3,4-dimethoxyphenyl)thio]acetamide;

6-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(trifluoromethyl)pyridine-2-carboxamide;

N-(2-acetyl-3-thienyl)-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropylysuccinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(4-fluorophenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N¹-[2-fluoro-5-(methylsulfonyl)phenyl]succinamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(4-methoxyphenyl)thiophene-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[5-(methylsulfinyl)-2,3-dihydro-1H-indol-1-yl]-4-oxobutanamide;

2-(acetylamino)-5-chloro-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thiophene-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-propyltetrahydro-2H-pyran-4-carboxamide;

4-chloro-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-7,7-dimethyl-7,8-dihydro-5H-pyrano[4,3-b]pyridine-2-carboxamide;

2-(2-chlorophenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-thiazole-4-carboxamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2-(3-methylphenyl)-1,3-thiazole-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,2,5-thiadiazole-3-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(phenoxymethyl)-1,3-thiazole-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(4-methylphenyl)-1,3-thiazole-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-pyridin-3-ylbenzamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methyl-2-phenyl-1,3-oxazole-5-carboxamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-ethyl-3-(2-thienyl)-1H-pyrazole-5-carboxamide;

4-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1H-pyrrole-2-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2,6-dimethylphenoxy)propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-phenyl-1,2,3-thiadiazole-5-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2,5-dimethyl-1H-pyrrol-1-yl)thiophene-3-carboxamide;

5-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxybenzamide;

4-(acetylamino)-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}butanamide trifluoroacetate;

N-{(1S,2R)-1-benzyl-3-[1-ethyl-2-(4-methylpentanoyl)hydrazino]-2-hydroxypropyl}-2-[(methylsulfonyl)amino]-1,3-oxazole-4-carboxamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1-methyl-1H-imidazol-2-yl)benzamide;

N¹-[(1S,2R)-3-{[(1R)-3-cyclohexyl-1-phenylpropyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N,N-dipropylisophthalamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³,N³-dipropyl-5-pyridin-3-ylisophthalamide;

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-fluoro-1-naphthamide;

N-cyclohexyl-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N,5-dimethylisophthalamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1H-imidazole-2-carboxamide;

N¹-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N³-[oxo(phenyl)methyl]-beta-alaninamide

N¹-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N²-[imino(phenyl)methyl]glycinamide

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-(2-propylpentanimidoyl)-beta-alaninamide

6-(4-benzylpiperazin-1-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}nicotinamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(3-methoxyphenyl)sulfonyl]propanamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N¹-(5-phenyl-1,3,4-thiadiazol-2-yl)succinamide

N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}succinamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzamide

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thieno[2,3-b]quinoline-2-carboxamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-1-methyl-5-oxo-2-phenylprolinamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methyl-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepine-4-carboxamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(7-hydroxy-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)thio]acetamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-oxo-2,3-dihydro-1,2-benzisothiazole-6-carboxamide 1,1-dioxide

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thieno[3,2-c]pyridine-2-carboxamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-oxo-2,3-dihydro-1,3-benzoxazole-6-carboxamide

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-[oxo(phenoxy)methyl]prolinamide

6-chloro-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-5-carboxamide

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[4-(2,5-dioxopyrrolidin-1-yl)phenoxy]acetamide

N²-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl) amino]-2-hydroxypropyl}-N¹-phenylpyrrolidine-1,2-dicarboxamide

2-(1,3-benzothiazol-2-ylmethoxy)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-4-oxo-3,4-dihydrophthalazine-1-carboxamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}indolizine-2-carboxamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxo-4-phenylbutanamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)acetamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3-hydroxyphenyl)-4-oxobutanamide

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-4-(3-methoxyphenyl)-4-oxobutanamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3′

,4′

-dihydro-1′

H-spiro[1,3-dioxolane-2,2′

-naphthalene]-8′

-carboxamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-31,4‘

-dihydro-l’

H-spiro[1,3-dioxolane-2,2′

-naphthalene]-7′

-carboxamide

N¹-{[(S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-N²-[mercapto(methylthio)methyl]-D-alaninamide

N²-[(4-chlorophenyl) (oxo)methyl]-N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}glycinamide

N²-[(4-tert-butylphenyl) (oxo)methyl]-N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}glycinamide

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-[oxo(pyridin-3-yl)methyl]glycinamide

2-{[2-({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-2-oxoethyl]thio]-N-[4-(1,3-oxazol-5-yl)phenyl]acetamide

N²-[(4-chlorophenyl) (oxo)methyl]-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-D-alaninamide

N²-[(3,4-dichlorophenyl) (oxo)methyl]-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}glycinamide

N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(5a,9a-dihydrodibenzo[b,d]furan-2-yl)-4-oxobutanamide

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-[oxo [4-(trifluoromethyl)phenyl]methyl]glycinamide

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-N²-[(2,6-difluorophenyl)(oxo)methyl]glycinamide

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-[oxo(4-methoxyphenyl)methyl]glycinamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-oxo-1,3-oxazolidin-3-yl)benzamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(phenylethynyl)nicotinamide

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N³-[oxo(1H-1,2,4-triazol-5-yl)methyl]-o-alaninamide

2-{[2-({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-2-oxoethyl]thio}-N-(pyridin-4-ylmethyl)acetamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(methoxymethyl)thio]benzamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4-oxobutanamide

4-(4-benzyl-1,4-diazepan-1-yl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxobutanamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,5-dimethyl-1-(pyridin-4-ylmethyl)-1H-pyrrole-3-carboxamide

N-[(dimethylamino)sulfonyl]glycyl-N¹-(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]glycinamide

N-((S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxy-1-[(1R,2R)-2-hydroxycyclohexyl]prolinamide

(2S,3S)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-1-methyl-5-oxo-2-pyridin-3-ylpyrrolidine-3-carboxamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2,5-dioxopyrrolidin-1-yl)benzamide

N-(2-cyano-4,5,6,7-tetrahydro-1-benzothien-3-yl)-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]succinamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2-(2,5-dioxoimidazolidin-4-yl)acetamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)acetamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(2-furylmethyl)-5-oxopyrrolidine-3-carboxamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-4-oxo-4-(5-oxo-1,4-diazepan-1-yl)butanamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-5-carboxamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,1,3-benzoxadiazole-5-carboxamide 1-oxide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-pyridin-3-ylpiperidin-1-yl)propanamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxo-4-(2-propyl-1H-imidazol-1-yl)butanamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4a,9a-dihydro-9H-carbazole-9-carboxamide

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methyl-4-oxo-1-phenyl-1,4-dihydropyridazine-3-carboxamide

N′

-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-methyl-5-(pyrrolidin-1-ylcarbonyl)-1H-pyrrol-3-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide

N′

-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[2-(2-oxo-2-pyrrolidin-1-ylethoxy)phenyl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-{[3-(hydroxymethyl)piperidin-1-yl]carbonyl}phenyl)amino]propyl}-5-methyl-N,N-dipropylisophthalamide

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-[3-(methylthio)-1-oxopropyl]-N²-pentylglycinamide

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N²-[3-(methylsulfonyl)-1-oxopropyl]-N²-pentylglycinamide

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-(phenylsulfonyl)propanamide

N′

-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(7-oxabicyclo[2.2.1]hept-2-ylmethyl)amino]propyl}-5-methyl-N,N-dipropylisophthalamide

N′

-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3R)-2-oxo-1-propylazepan-3-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide

N′

-[(1S,2R)-3-[(1-acetylpiperidin-4-yl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N,N-dipropylisophthalamide

N′

-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N-[2-(dimethylamino)-2-oxoethyl]-N,5-dimethylisophthalamide

N′

-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N-[2-(dimethylamino)ethyl]-N-ethyl-5-methylisophthalamide

N-benzyl-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N,5-dimethylisophthalamide

N′

-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-t[2-(2-hydroxyethyl)piperidin-1-yl]carbonyl}-5-methylbenzamide

N′

-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N,5-dimethyl-N-(2-phenylethyl)isophthalamide

N′

-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(3-formyl-2-furyl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N,N-dipropylisophthalamide

N′

-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(5-formyl-2-thienyl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N,N-dipropylisophthalamide

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N,5-dimethyl-N-(2-pyridin-2-ylethyl)isophthalamide

N¹-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({[1-(methylsulfonyl)piperidin-4-yl]methyl}amino)propyl]-5-methyl-N,N-dipropylisophthalamide

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N³,N³-diethylpiperidine-1,3-dicarboxamide

N′

-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N³,N3-dipropylpiperidine-1,3-dicarboxamide

N′

-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(5-formyl-4-methyl-2-thienyl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N,N-dipropylisophthalamide

N′

-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(1-phenylvinyl)benzyl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide

N′

-[(1S,2R)-3-[(3-bicyclo[2.2.1]hept-2-ylbenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N,N-dipropylisophthalamide

ethyl 3-[3-({[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}methyl)phenyl]propanoate

ethyl 4-[3-({[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]aminoYmethyl)phenyl]butanoate

methyl (2R)-3-[3-({[(2R,3S)-4-(3,5-difluorophenyl)-3-([3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}methyl)phenyl]-2-methylpropanoate

ethyl 3′

-({[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}methyl)biphenyl-2-carboxylate

2-{1-[2-({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-2-oxoethyl]cyclopentyl}-N,N-dipropylacetamide

N²-(benzyloxy) carbonyl]-N¹-{(1S, 2R) -1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;

N²-[(benzyloxy)carbonyl]-N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-methylbutyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;

N²-[(benzyloxy)carbonyl]-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-(cyclopropylamino)-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;

N²-[(benzyloxy)carbonyl]-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(cyclopropylmethyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N²-{[(3S)-tetrahydrofuran-3-yloxy]carbonyl}-3-[(1-propylbutyl)sulfonyl]-L-alaninamide trifluoroacetate;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-{[(3S)-tetrahydrofuran-3-yloxy]carbonyl}-3-[(1-propylbutyl)sulfonyl]-D-alaninamide trifluoroacetate;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-{[(3S)-tetrahydrofuran-3-yloxy]carbonyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N²-([(3R)-tetrahydrofuran-3-yloxy]carbonyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;

N¹-{(1S,2R)-1-benzyl-3-[(3-methoxybenzyl)amino]-2-hydroxypropyl}-N²-{[(3S)-tetrahydrofuran-3-yloxy]carbonyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;

N¹-((1S,2R)-1-(3,5diflurobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-[(3S)-1,1-dioxidotetrahydrothien-3-yloxy]carbonyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-[(3S)-tetrahydrothiophen-3-yloxy]carbonyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N²-([tetrahydropyran-4-yloxy]carbonyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;

N¹-{(1S,2R)-1-(3,5-diflourobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N²-{[1-(methylsulfonyl)piperidin-4-yloxy]carbonyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;

N²-{[1-acetylpiperidin-4-yloxy]carbonyl]-N¹-{((S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-{[[(3R)-5-oxopyrrolidin-3-yl]methyl]carbonyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;

N¹-{(1S,2R)-1-benzyl-3-[(3-methoxybenzyl)amino]-2-hydroxypropyl]-N²-[(benzyloxy)carbonyl]-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;

N²-(benzyloxy) carbonyl]-N¹-((1S, 2R) -1-(3,5-difluorobenzyl)-2-hydroxy-3-{[2-(3-methoxyphenyl)ethyl]amino}propyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-N²-{[(3S)-tetrahydrofuran-3-yloxy]carbonyl}-D-leucinamide trifluoracetate;

N¹-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N²-[(benzyloxy)carbonyl]-L-leucinamide;

N²-[(benzyloxy) carbonyl]-Nl-((1S) -1-{(1R) -2-[ethyl(isobutylsulfonyl)amino]-1-hydroxyethyl}-3-methylbutyl)-3-[(1-propylbutyl)sulfonyl]-D.L-alaninamide;

N²-[(benzyloxy)carbonyl]-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N⁵,N⁵-dipropyl-L-glutamamide trifluoroacetate;

N²-[(benzyloxy) carbonyl]-N¹-{(1S,2R) -1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N⁵,N⁵-dipropyl-D-glutamamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N²-[(1H-pyrazol-4-yl)carbonyl]-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;

N²-[(6-chloropyridin-3-yl)carbonyl]-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N²-[(pyridin-2-yl)carbonyl]-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-(2-methylbenzoyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N²-(3-methylbenzoyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N²-(4-methylbenzoyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;

N²-(3-chlorobenzoyl)-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-(4-methoxybenzoyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;

N¹-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-(4-triflluoromethylbenzoyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;

N²-(cyclohexylcarbonyl)-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;

N²(benzoyl)-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-(phenylacetyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N²-(3-phenylpropanoyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;

N¹-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N²-(cyclopropylacetyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;

N¹-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N²-[(methylsulfonyl)acetyl]-3-L(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;

N¹-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl)-N²-[(methylthio)acetyl]-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;

N¹-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl)-N²-(4-hydroxy-4-oxobutanoyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;

N¹-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N²-[4-(methylamino)-4-oxobutanoyl]-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;

N¹-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl)-N²-(4-methoxy-4-oxobutanoyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;

N-(methylsulfonyl)glycyl-N¹-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;

N²-acetyl-N¹-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl)-3-(phenylsulfonyl)-D,L-alaninamide;

(2S)-2-(4-methoxy-4-oxobutanoyl)amino-N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-oxo-5-piperidin-1-ylpentanamide;

(2R)-2-{[(benzyloxy)carbonyl]amino}-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-oxo-5-piperidin-1-ylpentanamide;

(2R)-2-(3-ethoxy-3-oxopropanoyl)amino-N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-oxo-5-piperidin-1-ylpentanamide;

N¹-{[(S,2R)-1-benzyl-3-[(3-methoxybenzyl)amino]-2-hydroxypropyl}-N²-(4-methoxy-4-oxobutanoyl)-N⁵,N⁵-dipropyl-D-glutamamide;

(2R)-2-(4-methoxy-4-oxobutanoyl)amino-N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-oxo-5-piperidin-1-ylpentanamide;

(2R)-2-(5-methoxy-5-oxopentanoyl)amino-N-((S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-oxo-5-piperidin-1-ylpentanamide;

N²-[(5-chlorothien-2-yl)sulfonyl]-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;

N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N²-(phenylsulfonyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;

N²-[(benzylamino)carbonyl]-N¹-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;

4-({(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}amino)-3-[(isopentylsulfonyl)methyl]-4-oxobutanoic acid;

methyl 4-({(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl]amino)-3-[(isopentylsulfonyl)methyl]-4-oxobutanoate;

N¹-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-[(isopentylsulfonyl)methyl]succinamide;

N¹-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-[(isopentylsulfonyl)methyl]-N⁴-methylsuccinamide;

N¹-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-[(isopentylsulfonyl)methyl]-N⁴,N⁴-dimethylsuccinamide;

N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-{[(1-propylbutyl)sulfonyl]methyl}propanamide;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-(ethylsulfonyl)-2-{[(isobutylsulfonyl)amino]methyl}propanamide;

N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-(ethylthio)-2-{[(isobutylsulfonyl)amino]methyl}propanamide;

(2S)-N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-[(isopentylsulfonyl)amino]-4-(methylsulfonyl)butanamide;

N¹-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N²-(isopentylsulfonyl)-L-methioninamide;

S-[3-({(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl]amino)-2-[(isopentylsulfonyl)methyl]-3-oxopropyl}ethanethioate;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-hydroxy-3-[(1-propylbutyl)sulfonyl]propanamide;

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-(phenylsulfonyl)butanamide;

N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-hydroxy-4-(isopentylsulfonyl)butanamide;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-4-(isopentylsulfonyl)-2-phenoxybutanamide;

N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-4-(isopentylsulfonyl)-2-(3-methoxyphenoxy)butanamide;

3-[1-[({(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}amino)carbonyl]-3-(isopentylsulfonyl)propoxy]benzoic acid trifluoroacetate;

methyl 3-[1-[([(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}amino)carbonyl]-3-(isopentylsulfonyl)propoxy]benzoate;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-hydroxy-4-(phenylsulfonyl)butanamide;

N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-hydroxy-4-(phenylthio)butanamide;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-methoxy-4-(phenylsulfonyl)butanamide;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-methoxy-4-(phenylthio)butanamide;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-4-(phenylsulfonyl)-2-propoxybutanamide;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-(benzyloxy)-4-(phenylsulfonyl)butanamide;

N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N²-[(benzyloxy)carbonyl]-D,L-methioninamide;

(2S)-2-amino-N-((1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-oxo-5-piperidin-1-ylpentanamide;

(2S)-2-(2-ethoxy-2-oxoethanyl)amino-N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-oxo-5-piperidin-1-ylpentanamide;

(2R)-2-amino-N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-oxo-5-piperidin-1-ylpentanamide;

(2R)-2-(2-ethoxy-2-oxoethanyl)amino-N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-oxo-5-piperidin-1-ylpentanamide;

(2R)-2-(4-ethoxy-4-oxobutanyl)amino-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-oxo-5-piperidin-1-ylpentanamide ditrifluoroacetate;

N¹-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N²-[(benzyloxy)carbonyl]-L-aspartamide;

N¹-((1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N²-[(tertbutyloxy)carbonyl]-L-aspartamide;

or a pharmacuetically acceptable salt thereof.