Method and apparatus for measuring degree of neuronal impairment in brain cortex

• US 20040171960A1
• Filed: 12/18/2003
• Published: 09/02/2004
• Est. Priority Date: 02/17/2003
• Status: Abandoned Application

• Current Assignee: Brain Functions Laboratory, Inc.
• Original Assignee: Brain Functions Laboratory, Inc.
• Inventors: Mochizuki, Yusuke, Take, Noriyuki, Musha, Toshimitsu
• Application Number:
  US10/737,839
• Publication Number:
  US 20040171960A1
• Time in Patent Office: Days
• US Class Current: 600/544
• CPC Class Codes: A61B 5/165 Evaluating the state of mind, e.g. depression, anxiety
• CPC Class Codes: A61B 5/245 specially adapted for magnetoencephalographic [MEG] signals
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/372 Analysis of electroencephalograms
• CPC Class Codes: A61B 5/4088 Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia

Abstract

In a method and an apparatus for measuring degree of neuronal impairment in brain cortex, scalp potentials or magnetic fields of a subject are measured by mounting a plurality of sensors on a head of the subject, the measured scalp potentials or magnetic fields are converted into numerical data to obtain a dipolarity at each sampling, mean values of squared errors, within a fixed time interval, between a scalp potential or a magnetic field by an equivalent dipole at a dipolarity peak emergence time and the measured scalp potentials or magnetic fields, or variances of the squared errors from the mean values are obtained for the sensors, and a contour concerning a distribution of the mean values or the variances on a scalp or a brain surface corresponding thereto is mapped as an output. Alternatively, the squares of potentials sensed by the sensors are averaged for several seconds, and variances of these mean values are obtained for numerous reference persons. The mean value and the standard deviation of the variances for a group of the reference persons are obtained, so that the variance of an individual subject is ranked depending on which area of the standard deviation of the group of the reference persons the variance is located. By allocating the values to a brain surface corresponding to the sensors, maps are prepared. By these maps, a local impairment degree of a neuronal function is indicated.

Claims

1. A method for measuring degree of neuronal impairment in brain cortex comprising the steps of:

measuring scalp potentials or magnetic fields of a subject by mounting a plurality of sensors on a head of the subject;

converting the measured scalp potentials or magnetic fields into numerical data to obtain a dipolarity at each sampling;

obtaining mean values of squared errors, within a fixed time interval, between a scalp potential or a magnetic field by an equivalent dipole at a dipolarity peak emergence time and the measured scalp potentials or magnetic fields, or variances of the squared errors from the mean values for the sensors; and

mapping a contour concerning a distribution of the mean values or the variances on a scalp or a brain surface corresponding thereto, as an output.

2. The method for measuring degree of neuronal impairment in brain cortex as claimed in claim 1 wherein the mean values or the variances within the fixed time interval are obtained for an overall time interval, and a contour for the mean values or the variances is mapped as an output.

3. The method for measuring degree of neuronal impairment in brain cortex as claimed in claim 1 wherein the head comprises a spherical model.

6. The method for measuring degree of neuronal impairment in brain cortex as claimed in claim 1 wherein the sensors comprise EEG sensors or MEG sensors.

7. The method for measuring degree of neuronal impairment in brain cortex as claimed in any one of claims 1 to 6 wherein the scalp potentials or the magnetic fields are detected by a terminal equipment, the data are transmitted to an operation center through a communication line, and the operation center prepares the map from the data to be returned to the terminal equipment through the communication line.

4. A method for measuring degree of neuronal impairment in brain cortex comprising the steps of:

measuring scalp potentials or magnetic fields by a plurality of sensors mounted on heads of reference persons to be converted into numerical data;

obtaining squared mean values from the numerical data at the sensors for every short time interval within a designated measurement time;

obtaining a normalized standard deviation of the squared mean values within the designated measurement time;

obtaining the normalized standard deviations for a plurality of reference persons;

obtaining a mean value of the normalized standard deviations and an inter-reference person standard deviation for the mean value to be stored; and

determining a distance level of a normalized standard deviation similarly obtained for a subject from the normalized standard deviation mean value of the reference persons based on the inter-reference person standard deviation, made different between a positive side and a negative side of the normalized standard deviation mean value of the reference persons.

5. The method for measuring degree of neuronal impairment in brain cortex as claimed in claim 4 wherein levels are projected to positions, on a brain surface, preliminarily obtained corresponding to sensor positions on a scalp, and by interpolating the levels, a contour concerning a distribution on the brain surface is mapped and colored.

8. An apparatus for measuring degree of neuronal impairment in brain cortex comprising:

a plurality of sensors mounted on a head of a subject for measuring scalp potentials or magnetic fields of the subject;

a computing unit for converting output signals of the sensors into numerical data to obtain a dipolarity at each sampling, for obtaining mean values of squared errors, within a fixed time interval, between a scalp potential or a magnetic field by an equivalent dipole at a dipolarity peak emergence time and the measured scalp potentials or magnetic fields or variances of the squared errors from the mean values for the sensors, and for mapping a contour concerning a distribution of the mean values or the variances on a scalp or a brain surface corresponding thereto; and

an output unit for outputting a contour map.

9. The apparatus for measuring degree of neuronal impairment in brain cortex as claimed in claim 8 wherein the computing unit obtains the mean values or the variances within the fixed time interval for an overall time interval, and maps a contour for the mean values or the variances.

10. The apparatus for measuring degree of neuronal impairment in brain cortex as claimed in claim 8 wherein the head comprises a spherical model.

13. The apparatus for measuring degree of neuronal impairment in brain cortex as claimed in claim 8 wherein the sensors comprise EEG sensors or MEG sensors.

14. The apparatus for measuring degree of neuronal impairment in brain cortex as claimed in any one of claims 8 to 13 wherein the sensors and the output unit are provided in a terminal equipment, the computing unit is provided in an operation center, and the terminal equipment and the operation center are connected through a communication line.

11. An apparatus for measuring degree of neuronal impairment in brain cortex comprising:

a plurality of sensors mounted on heads of reference persons or a subject for measuring scalp potentials or magnetic fields; and

a computing unit for converting the scalp potentials or magnetic fields of the reference persons into numerical data, for obtaining squared mean values from the numerical data at the sensors for every short time interval within a designated measurement time, for obtaining a normalized standard deviation of the squared mean values within the designated measurement time, for obtaining the normalized standard deviation for a plurality of reference persons, for obtaining a mean value of the normalized standard deviation and an inter-reference person standard deviation for the mean value to be stored, and for determining a distance level of a normalized standard deviation similarly obtained for a subject from the normalized standard deviation mean value of the reference persons based on the inter-reference person standard deviation, made different between a positive side and a negative side of the normalized standard deviation mean value of the reference persons.

12. The apparatus for measuring degree of neuronal impairment in brain cortex as claimed in claim 11 wherein the computing unit projects levels to positions, on a brain surface, preliminarily obtained corresponding to sensor positions on a scalp, and maps and colors a contour concerning a distribution on the brain surface by interpolating the levels.

15. A computer program for measuring degree of neuronal impairment in brain cortex, and making a computer execute the steps of:

obtaining a dipolarity at each sampling based on numerical data of scalp potentials of a subject measured by mounting a plurality of sensors on a head of the subject;

obtaining mean values of squared errors, within a fixed time interval, between a scalp potential by an equivalent dipole at a dipolarity peak emergence time and the measured scalp potentials, or variances of the squared errors from the mean values for the sensors; and

mapping a contour concerning a distribution of the mean values or the variances on a scalp or a brain surface corresponding thereto, as an output.

16. The computer program as claimed in claim 15 wherein the mean values or the variances within the fixed time interval are obtained for an overall time interval, and a contour for the mean values or the variances is mapped as an output.

17. The computer program as claimed in claim 15 wherein the dipolarity indicates an approximate degree, after a predetermined frequency component within the data is extracted, and based on the predetermined frequency component, at a time when one or more equivalent dipoles are determined in which a mean value of a squared error between a potential distribution which one or more current dipoles, supposed in the head, form at positions of the sensors and a measured potential of the sensors indicated by the data becomes least.

18. The computer program as claimed in claim 15 wherein the head comprises a spherical model.

21. A computer readable recording medium for recording the program as claimed in any one of claims 15 to 20.

19. A computer program for measuring degree of neuronal impairment in brain cortex, and making a computer execute the steps of:

measuring scalp potentials by a plurality of sensors mounted on heads of reference persons to be converted into numerical data;

obtaining squared mean values from the numerical data at the sensors for every short time interval within a designated measurement time;

obtaining a normalized standard deviation of the squared mean values within the designated measurement time;

obtaining the normalized standard deviation for a plurality of reference persons;

obtaining a mean value of the normalized standard deviations and an inter-reference person standard deviation for the mean value to be stored; and

determining a distance level of a normalized standard deviation similarly obtained for a subject from the normalized standard deviation mean value of the reference persons based on the inter-reference person standard deviation, made different between a positive side and a negative side of the normalized standard deviation mean value of the reference persons.

20. The computer program as claimed in claim 19 wherein levels are projected to positions, on a brain surface, preliminarily obtained corresponding to sensor positions on a scalp, and by interpolating the levels, a contour concerning a distribution on the brain surface is mapped and colored.