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Sustained release device and method for ocular delivery of carbonic anhydrase inhibitors

  • US 20040175410A1
  • Filed: 01/22/2004
  • Published: 09/09/2004
  • Est. Priority Date: 04/26/2000
  • Status: Abandoned Application
First Claim
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1. A sustained release drug device adapted for implantation in or adjacent to the eye of a patient, the drug delivery device comprising:

  • (i) an inner drug core comprising a carbonic anhydrase inhibitor;

    (ii) a first coating on the surface of the drug core, that is substantially impermeable to the passage of the carbonic anhydrase inhibitor, having one or more openings therein which permit diffusion of the carbonic anhydrase inhibitor, and which is substantially insoluble and inert in body fluids and compatible with body tissues; and

    (iii) one or more additional coatings that are permeable to the passage of the carbonic anhydrase inhibitor, and which are substantially insoluble and inert in body fluids and compatible with body tissues;

    wherein the first and additional coatings are disposed about the inner drug core so as to produce, when implanted, a substantially constant rate of release of the carbonic anhydrase inhibitor from the device.

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