Optical-based sensing devices
First Claim
1. An optical-based sensor for determining the presence or concentration of an analyte in a medium, said sensor comprising:
- a substrate, said substrate having a first side and a second side;
a first radiation source mounted on the first side of said substrate;
a second radiation source mounted on the second side of said substrate;
a first detector for detecting radiation incident thereon and generating and electrical signal responsive thereto, said first detector mounted on the first side of said substrate;
a second detector for detecting radiation incident thereon and generating and electrical signal responsive thereto, said second detector mounted on the second side of said substrate;
a first indicator element having an optical characteristic that is affected by the presence or concentration of an analyte, said first indicator element being positioned to receive radiation from said first radiation source;
a second indicator element having an optical characteristic that is affected by the presence or concentration of an analyte, said second indicator element being positioned to receive radiation from said second radiation source; and
wherein said first detector generates an electrical signal responsive to radiation incident thereon emitted by said first indicator element and wherein said second detector generates an electrical signal responsive to radiation incident thereon emitted by said second indicator element.
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Accused Products
Abstract
An optical-based sensor for detecting the presence or amount of an analyte using both indicator and reference channels. The sensor has a sensor body with a source of radiation embedded therein. Radiation emitted by the source interacts with indicator membrane indicator molecules proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For example, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e.g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body. Photosensitive elements within the sensor body generate both indicator channel and reference channel signals to provide an accurate indication of the concentration of the analyte. Preferred embodiments are totally self-contained and are sized and shaped for use in vivo in a human being. Such embodiments preferably include a power source, e.g. an inductor, which powers the source of radiation using external means, as well as a transmitter, e.g. an inductor, to transmit to external pickup means the signal representing the level of analyte.
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Citations
18 Claims
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1. An optical-based sensor for determining the presence or concentration of an analyte in a medium, said sensor comprising:
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a substrate, said substrate having a first side and a second side;
a first radiation source mounted on the first side of said substrate;
a second radiation source mounted on the second side of said substrate;
a first detector for detecting radiation incident thereon and generating and electrical signal responsive thereto, said first detector mounted on the first side of said substrate;
a second detector for detecting radiation incident thereon and generating and electrical signal responsive thereto, said second detector mounted on the second side of said substrate;
a first indicator element having an optical characteristic that is affected by the presence or concentration of an analyte, said first indicator element being positioned to receive radiation from said first radiation source;
a second indicator element having an optical characteristic that is affected by the presence or concentration of an analyte, said second indicator element being positioned to receive radiation from said second radiation source; and
wherein said first detector generates an electrical signal responsive to radiation incident thereon emitted by said first indicator element and wherein said second detector generates an electrical signal responsive to radiation incident thereon emitted by said second indicator element. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. An implantable, biocompatible optical sensor, comprising:
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a fully enclosed polymer housing;
a circuit contained within said housing; and
wherein the polymer housing comprises PMMA. - View Dependent Claims (17, 18)
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Specification