Electrode apparatus and method for the delivery of drugs and genes into tissue
First Claim
1. An electrode assembly for electroporation of a tissue surface, comprising:
- a non-conductive carrier having a proximal surface, a distal surface, and a plurality of through holes from the proximal surface to the distal surface;
a plurality of first electrodes disposed on the proximal surface;
a first conductor disposed on at least a first portion of the distal surface and extending through at least a first portion of the plurality of through holes and connected to the first electrodes on the proximal surface;
a plurality of second electrodes disposed on the proximal surface; and
a second conductor disposed on at least a second portion of the distal surface and extending through at least a second portion of the plurality of through holes and connected to the second electrodes on the proximal surface;
wherein the first electrodes are in closely spaced relation with the second electrodes on the proximal surface for engaging the tissue surface and applying an electric field.
1 Assignment
0 Petitions
Accused Products
Abstract
An electrode assembly for an apparatus for trans-surface molecular includes a non-conductive carrier having a proximal surface, a distal surface, and a plurality of through holes from the proximal surface to the distal surface, a plurality of first electrodes disposed on the proximal surface, a first conductor disposed on at least a first portion of the distal surface and extending through at least a first portion of the plurality of through holes and connected to the first electrodes on the proximal surface, a plurality of second electrodes disposed on the proximal surface, and a second conductor disposed on at least a second portion of the distal surface and extending through at least a second portion of the plurality of through holes and connected to the second electrodes on the proximal surface, wherein the first electrodes and the second electrodes are configured and disposed in closely spaced relation on the proximal surface for engaging the tissue surface and applying an electric field.
-
Citations
23 Claims
-
1. An electrode assembly for electroporation of a tissue surface, comprising:
-
a non-conductive carrier having a proximal surface, a distal surface, and a plurality of through holes from the proximal surface to the distal surface;
a plurality of first electrodes disposed on the proximal surface;
a first conductor disposed on at least a first portion of the distal surface and extending through at least a first portion of the plurality of through holes and connected to the first electrodes on the proximal surface;
a plurality of second electrodes disposed on the proximal surface; and
a second conductor disposed on at least a second portion of the distal surface and extending through at least a second portion of the plurality of through holes and connected to the second electrodes on the proximal surface;
wherein the first electrodes are in closely spaced relation with the second electrodes on the proximal surface for engaging the tissue surface and applying an electric field. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
-
-
12. An apparatus for trans-surface molecular delivery, comprising:
-
a first electrode assembly, comprising;
a non-conductive carrier having a proximal surface, a distal surface, and a plurality of through holes from the proximal surface to the distal surface;
a plurality of first electrodes disposed on at least a first portion of the proximal surface;
a first conductor disposed on said distal surface and extending through at least a first portion of the plurality of through holes and connected to the plurality of first electrodes; and
a plurality of second electrodes disposed on at least a second portion of the of the proximal surface;
a second conductor disposed on said distal surface and extending through at least a second portion of the plurality of through holes and connected to the plurality of second electrodes;
wherein the first electrodes are in closely spaced relation with the second electrodes on the proximal surface for engaging the tissue surface and applying an electric field;
a first power supply connected to the first electrode assembly for applying a pulsed electric field of sufficient amplitude to induce pores in the tissue surface; and
means for driving molecules through pores in the tissue surface. - View Dependent Claims (13, 14, 15, 16, 17)
-
-
18. A method of trans-surface molecular delivery, comprising:
-
providing a first electrode assembly, comprising;
a non-conductive carrier having a proximal surface, a distal surface, and a plurality of through holes from the proximal surface to the distal surface;
a first electrode disposed on at least a portion of the distal surface and extending through at least a portion of the plurality of through holes and onto at least a portion of the proximal surface; and
a second electrode disposed on at least a portion of the proximal surface and in closely spaced relation with the first electrode;
engaging a tissue surface with the first electrode assembly;
providing a first power supply connected to the first electrode assembly;
applying a pulsed electric field via the first electrode assembly of sufficient amplitude to induce pores in the tissue surface;
providing means for driving molecules through pores in the tissue surface; and
applying means for driving to induce migration of molecules through pores in the tissue surface. - View Dependent Claims (19, 20, 21, 22)
-
-
23. An apparatus for trans-surface molecular delivery, comprising:
-
an electroporation power supply having a first contact and a second contact wherein a pulsed electric field of sufficient amplitude to induce pores in the tissue surface is applied;
an iontophoresis power supply having a first contact and a second contact wherein a low voltage continuous electric field of a preselected polarity and sufficient amplitude to induce migration of molecules through pores in the tissue surface is applied;
a first electrode assembly having a first contact and a second contact;
a second electrode assembly having a first contact and a second contact;
a first diode having an input connected to the first contact of the electroporation power supply and an output connected to the first contact of the first electrode assembly;
a second diode having an input connected to the first contact of the electroporation power supply and an output connected to the first contact of the second electrode assembly;
a third diode having an input connected to the second contact of the first electrode assembly and an output connected to the second contact of the electroporation power supply;
a fourth diode having an input connected to the second contact of the second electrode assembly and an output connected to the second contact of the electroporation power supply;
a fifth diode having an input connected to the first contact of the iontophoresis power supply and an output connected to the first contact of the first electrode assembly;
a sixth diode having an input connected to the first contact of the iontophoresis power supply and an output connected to the second contact of the first electrode assembly; and
a seventh diode having an input connected to the second contact of the second electrode assembly and an output connected to the second contact of the iontophoresis power supply.
-
Specification