Method and apparatus for the repigmentation of human skin

• US 20040176824A1
• Filed: 03/03/2004
• Published: 09/09/2004
• Est. Priority Date: 03/04/2003
• Status: Abandoned Application

• Current Assignee: SpectraGenics, Inc. (Channel Investments, LLC)
• Original Assignee: SpectraGenics, Inc. (Channel Investments, LLC)
• Inventors: Island, Tobin C., Grove, Robert E., Weckwerth, Mark V.
• Application Number:
  US10/794,676
• Publication Number:
  US 20040176824A1
• Time in Patent Office: Days
• US Class Current: 607/88
• CPC Class Codes: A61B 18/203 applying laser energy to the outside of the body
• CPC Class Codes: A61B 2017/00057 Light
• CPC Class Codes: A61B 2017/00061 spectrum
• CPC Class Codes: A61B 2017/00066 intensity
• CPC Class Codes: A61B 2017/00172 Pulse trains, bursts, intermittent continuous operation
• CPC Class Codes: A61B 2017/00734 battery operated
• CPC Class Codes: A61B 2018/00005 Cooling or heating of the probe or tissue immediately surrounding the probe
• CPC Class Codes: A61B 2018/00452 Skin
• CPC Class Codes: A61B 2018/00476 Hair follicles
• CPC Class Codes: A61B 2018/2261 with scattering, diffusion or dispersion of light
• CPC Class Codes: A61B 2090/065 for measuring contact or contact pressure

Abstract

Disclosed is a handheld, cordless, self-contained dermatological device for localized repigmentation of skin which includes a housing configured for gripping by a person'"'"'s hand, a battery in the housing, a source in the housing and which is capable of emitting electromagnetic radiation in a band from 320 nm to 400 mn, a control circuit in the housing, and an aperture in the housing. The aperture is configured, and the control circuit controls the coupling of the battery to the source, so that a fluence of electromagnetic radiation of one-tenth of a minimum erythemic dose (MED) of skin is delivered at the aperture in less than about 10 seconds. Methods for configuring and for using the disclosed apparatus are described.

Claims

1. A handheld, cordless, self-contained dermatological device for localized repigmentation of skin comprising,

a. a housing configured for gripping by a person'"'"'s hand;

b. a battery in the housing;

c. a source in the housing and which is capable of emitting electromagnetic radiation in a band from 320 nm to 400 nm;

d. a control circuit in the housing;

e. an aperture in the housing;

f. wherein the aperture is configured, and the control circuit controls the

coupling of the battery to the source, so that a fluence of electromagnetic

radiation of one-tenth of a minimum erythemic dose (MED) of skin is

delivered at the aperture in less than about 10 seconds.

2. The device of claim 1, wherein the device has a weight less than about 1 kg.

3. The device of claim 1, wherein the device has a volume less than about 500 cm³.

4. The device of claim 1, further comprising a contact sensor configured to detect substantial contact between the aperture and a surface, and coupled to inhibit emission of radiation through the aperture in the absence of the substantial contact.

5. The device of claim 1;

wherein the aperture has a size between about 1 mm² and about 50 mm².

6. The device of claim 5, wherein the device weighs less than about 1 kg, and occupies a volume less than about 500 cm³.

7. The device of claim 6, further comprising a contact sensor configured to detect substantial contact between the aperture and a surface, and coupled to inhibit emission of radiation through the aperture in the absence of the substantial contact.

8. The device of claim 1, wherein the source includes one or more laser diodes.

9. The device of claim 1, wherein the source includes one or more LED'"'"'s.

10. The device of claim 9, wherein the device weighs less than about 1 kg.

11. The device of claim 9, wherein the device has a volume less than about 500 cm³.

12. The device of claim 9, further comprising a contact sensor configured to detect substantial contact between the aperture and a surface, and coupled to inhibit emission of radiation through the aperture in the absence of the substantial contact.

13. The device of claim 9, wherein the aperture has a size between about 1 mm² and about 50 mm².

14. The device of claim 13, wherein the device weighs less than about 1 kg, and occupies a volume less than about 500 cm³.

15. The device of claim 14, further comprising a contact sensor configured to detect substantial contact between the aperture and a surface, and coupled to inhibit emission of radiation through the aperture in the absence of the substantial contact.

16. Device of claim 14, further comprising a skin sensor configured to detect the presence of skin at the aperture, and coupled to inhibit emission of radiation through the aperture in the absence of skin at the aperture.

17. A dermatological device for localized repigmentation of skin, wherein the device is handheld, cordless, and self-contained, comprising

a. a housing shaped for gripping by a person'"'"'s hand;

b. a battery in the housing;

c. a source in the housing which is capable of emitting electromagnetic radiation;

d. control circuitry in the housing;

e. an aperture;

f. wherein the control circuitry controllably couples the battery to the source so that

electromagnetic radiation emitted from the aperture satisfies the equation,

$\frac{1}{0.017<br><br>\frac{W}{{\mathrm{cm}}^2}}<br><br>{\int <br><br>}_{\mathrm{\lambda <br><br>}=295<br><br>\mathrm{nm}}^{\mathrm{\lambda <br><br>}=400<br><br>\mathrm{nm}}<br><br>\frac{I<br><br>\left(\mathrm{\lambda <br><br>}\right)}{R<br><br>\left(\mathrm{\lambda <br><br>}\right)}<br><br>\text{\hspace{1em}<br><br>}<br><br><br><br>\mathrm{\lambda <br><br>}><br><br>0.01$

where I(λ

) is the irradiance versus wavelength (units of W/cm²/nm) and R(λ

) is the relative erythemicity of the radiation as a function of wavelength relative to the erythemicity of radiation at 295 nm.

18. The device of claim 17, wherein the device has a weight less than about 1 kg.

19. The device of claim 17, wherein the device has a volume less than about 500 cm³.

20. The device of claim 17, further comprising a contact sensor configured to detect substantial contact between the aperture and a surface, and coupled to inhibit emission of radiation through the aperture in the absence of the substantial contact.

21. The device of claim 17, wherein the aperture has a size between about 1 mm² and about 50 mm².

22. The device of claim 21, wherein the device weighs less than about 1 kg, and occupies volume less than about 500 cm³.

23. The device of claim 22, further comprising a contact sensor configured to detect substantial contact between the aperture and a surface, and coupled to inhibit emission of radiation through the aperture in the absence of the substantial contact.

24. The device of claim 17, wherein the source includes one or more laser diodes.

25. The device of claim 17, wherein the source includes one or more LED'"'"'s.

26. The device of claim 25, wherein the device weighs less than about 1 kg.

27. The device of claim 25, wherein the device has a volume less than about 500 cm³.

28. The device of claim 25, further comprising a contact sensor configured to detect substantial contact between the aperture and a surface, and coupled to inhibit emission of radiation through the aperture in the absence of the substantial contact.

29. The device of claim 25, wherein the aperture has a size between about 1 mm² and about 50 mm².

30. The device of claim 29, wherein the device weighs less than about 1 kg, and occupies a volume less than about 500 cm³.

31. The device of claim 30, further comprising a contact sensor configured to detect substantial contact between the aperture and a surface, and coupled to inhibit emission of radiation through the aperture in the absence of the substantial contact.

32. The device of claim 30, further comprising a skin sensor configured to detect the presence of skin at the aperture, and coupled to inhibit emission of radiation through the aperture in the absence of skin at the aperture.

33. A handheld, cordless, self-contained dermatological device for targeted repigmentation of skin comprising,

a. a housing configured for gripping by a person'"'"'s hand;

g. a battery in the housing;

h. a source of electromagnetic radiation in the housing;

i. an aperture through which the electromagnetic radiation is emitted;

j. wherein the radiation emitted from the aperture is controlled to satisfy the

equation,

$\frac{1}{0.017<br><br>\frac{W}{{\mathrm{cm}}^2}}<br><br>{\int <br><br>}_{\mathrm{\lambda <br><br>}=295<br><br>\mathrm{nm}}^{\mathrm{\lambda <br><br>}=400<br><br>\mathrm{nm}}<br><br>\frac{I<br><br>\left(\mathrm{\lambda <br><br>}\right)}{R<br><br>\left(\mathrm{\lambda <br><br>}\right)}<br><br>\text{\hspace{1em}<br><br>}<br><br><br><br>\mathrm{\lambda <br><br>}><br><br>0.01$

where I(λ

) is the irradiance versus wavelength (units of W/cm²/nm) and R(λ

) is a function having the characteristics of

R(λ

)=2.04×

10²⁴×

exp(−

λ

/5.27), for 295 nm>

λ

>

330 nm; and

R(λ

)=67.35×

exp(−

λ

/30.40), for 330 nm>

λ

>

400 nm.

34. The device of claim 33, wherein the device has a weight less than about 1 kg.

35. The device of claim 33, wherein the device has a volume less than about 500 cm³.

36. The device of claim 33, further comprising a contact sensor configured to detect substantial contact between the aperture and a surface, and coupled to inhibit emission of radiation through the aperture in the absence of the substantial contact.

37. The device of claim 33, wherein the aperture has a size between about 1 mm² and about 50 mm^2.

38. The device of claim 37, wherein the device weighs less than about 1 kg, and occupies a volume less than about 500 cm³.

39. The device of claim 38, further comprising a contact sensor configured to detect substantial contact between the aperture and a surface, and coupled to inhibit emission of radiation through the aperture in the absence of the substantial contact.

40. The device of claim 33, wherein the source includes one or more laser diodes.

41. The device of claim 33, wherein the source includes one or more LED'"'"'s.

42. The device of claim 41, wherein the device weighs less than about 1 kg.

43. The device of claim 41, wherein the device has a volume less than about 500 cm³.

44. The device of claim 41, further comprising a contact sensor configured to detect substantial contact between the aperture and a surface, and coupled to inhibit emission of radiation through the aperture in the absence of the substantial contact.

45. The device of claim 41, wherein the aperture has a size between about 1 mm² and about 50 mm².

46. The device of claim 45, wherein the device weighs less than about 1 kg, and occupies a volume less than about 500 cm³.

47. The device of claim 46, further comprising a contact sensor configured to detect substantial contact between the aperture and a surface, and coupled to inhibit emission of radiation through the aperture in the absence of the substantial contact.

48. The device of claim 46, further comprising a skin sensor configured to detect the presence of skin at the aperture, and coupled to inhibit emission of radiation through the aperture in the absence of skin at the aperture.

49. A dermatological device for localized repigmentation of skin comprising

a. one or more LED'"'"'s capable of emitting electromagnetic radiation in a band from

nm to400 nm;

b. an aperture;

c. a control circuit;

d. wherein the aperture is configured, and the control circuit activates the one or

more LED'"'"'s, so that a fluence of electromagnetic radiation one-tenth the

minimum erythemic dose (MED) of skin is delivered at the aperture in less than

about 10 seconds.

50. The device of claim 49, further comprising a contact sensor configured to detect substantial contact between the aperture and a surface, and coupled to inhibit emission of radiation through the aperture in the absence of the substantial contact.

51. The device of claim 49, wherein the aperture has a size between about 1 mm² and about 50 mm².

52. The device of claim 51 further comprising a contact sensor configured to detect substantial contact between the aperture and a surface, and coupled to inhibit emission of radiation through the aperture in the absence of the substantial contact.

53. The device of claim 51 further comprising a skin sensor configured to detect the presence of skin at the aperture, and coupled to inhibit emission of radiation through the aperture in the absence of skin at the aperture.

54. A dermatological device for localized repigmentation of skin that,

a. one or more LED'"'"'s capable of emitting electromagnetic radiation in a band from 320 mn to 400 nm;

b. an aperture;

c. a control circuit;

d. wherein the aperture is configured, and the control circuit activates the one or

more LED'"'"'s, so that a fluence of electromagnetic radiation emitted from the

aperture satisfies the equation,

$\frac{1}{0.017<br><br>\frac{W}{{\mathrm{cm}}^2}}<br><br>{\int <br><br>}_{\mathrm{\lambda <br><br>}=295<br><br>\mathrm{nm}}^{\mathrm{\lambda <br><br>}=400<br><br>\mathrm{nm}}<br><br>\frac{I<br><br>\left(\mathrm{\lambda <br><br>}\right)}{R<br><br>\left(\mathrm{\lambda <br><br>}\right)}<br><br>\text{\hspace{1em}<br><br>}<br><br><br><br>\mathrm{\lambda <br><br>}><br><br>0.01$

where I(λ

) is the irradiance versus wavelength (units of W/cm²/nm) and R(λ

) is the relative erythemicity of the radiation as a function of wavelength relative to the erythemicity of radiation at 295 nm.

55. The device of claim 54, further comprising a contact sensor configured to detect substantial contact between the aperture and a surface, and coupled to inhibit emission of radiation through the aperture in the absence of the substantial contact.

56. The device of claim 54, wherein the aperture has a size between about 1 mm² and about 50 mm².

57. The device of claim 56, further comprising a contact sensor configured to detect substantial contact between the aperture and a surface, and coupled to inhibit emission of radiation through the aperture in the absence of the substantial contact.

58. The device of claim 56, further comprising a skin sensor configured to detect the presence of skin at the aperture, and coupled to inhibit emission of radiation through the aperture in the absence of skin at the aperture.

59. A dermatological device for localized repigmentation of skin that,

a. one or more LED'"'"'s capable of emitting electromagnetic radiation in a band from

nm to 400 nm;

b. an aperture;

c. a control circuit;

d. wherein the aperture is configured, and the control circuit activates the one or

more LED'"'"'s, so that a fluence of electromagnetic radiation emitted from the

aperture satisfies the equation,

$\frac{1}{0.017<br><br>\frac{W}{{\mathrm{cm}}^2}}<br><br>{\int <br><br>}_{\mathrm{\lambda <br><br>}=295<br><br>\mathrm{nm}}^{\mathrm{\lambda <br><br>}=400<br><br>\mathrm{nm}}<br><br>\frac{I<br><br>\left(\mathrm{\lambda <br><br>}\right)}{R<br><br>\left(\mathrm{\lambda <br><br>}\right)}<br><br>\text{\hspace{1em}<br><br>}<br><br><br><br>\mathrm{\lambda <br><br>}><br><br>0.01$

where I(λ

) is the irradiance versus wavelength (units of W/cm²/nm) and R(λ

) is a function having the characteristics of

R(λ

)=2.04×

10²⁴×

exp(−

λ

/5.27), for 295 nm>

λ

>

330 mn; and

R(λ

)=67.35×

exp(−

λ

/30.40), for 330 nm>

λ

>

400 mn.

60. The device of claim 59, further comprising a contact sensor configured to detect substantial contact between the aperture and a surface, and coupled to inhibit emission of radiation through the aperture in the absence of the substantial contact.

61. The device of claim 59, wherein the aperture has a size between about 1 mm² and about 50 mm².

62. The device of claim 61, further comprising a contact sensor configured to detect substantial contact between the aperture and a surface, and coupled to inhibit emission of radiation through the aperture in the absence of the substantial contact.

63. The device of claim 61, further comprising a skin sensor configured to detect the presence of skin at the aperture, and coupled to inhibit emission of radiation through the aperture in the absence of skin at the aperture.

64. A method for configuring a dermatological device for localized repigmentation of skin comprising

a. shaping a housing for gripping by a person'"'"'s hand;

b. positioning a battery in the housing;

c. providing a source in the housing which is capable of emitting electromagnetic

radiation in a band from 320 nm to 400 nm;

d. locating a control circuit in the housing;

e. providing an aperture in the housing;

f. sizing the aperture, and configuring the control circuit to control the coupling of

the battery to the source, so that a fluence of electromagnetic radiation of one-tenth

of a minimum erythemic dose (MED) of skin is delivered at the aperture in

less than about 10 seconds.

65. A method for localized repigmentation of skin using a self-contained, handheld, cordless dermatological device having a battery, a source which is capable of emitting electromagnetic radiation in a band from 320 nm to 400 nm, an aperture, and a control circuit that controls the coupling of the battery to the source, comprising the steps of

a. sizing the aperture to have a size of between about 1 mm² and 50 mm²;

b. configuring the control circuit so that a fluence of electromagnetic radiation of

one-tenth of a minimum erythemic dose (MED) of skin is delivered at the

aperture in less than about 10 seconds;

c. tracing the device along a portion of skin to be treated; and

d. repeating step c a predetermined number of times;

e. repeating step d for a predetermined number of days.