Low-cost method and apparatus for non-invasively measuring blood glucose levels
First Claim
1. A method for measuring a blood analyte concentration, comprising the steps of:
- obtaining energy absorption measurement data through a body part of an individual;
calculating a plurality of indicator variables from said energy absorption measurement data;
determining which indicator variable from said plurality of indicator variables has the highest correlation to blood glucose level;
allocating a first optical term based on said indicator variable with said highest correlation to blood glucose level to form a regression analysis equation; and
calculating an estimated value of said blood analyte concentration using said regression analysis equation.
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Abstract
A method and apparatus for measuring a blood analyte concentration using an inexpensive, low precision sensor device is provided. One embodiment of the method includes obtaining energy absorption measurement data through a body part of an individual. A plurality of indicator variables are subsequently calculated from the energy absorption measurement data. An indicator variable from the plurality of indicator variables having the highest correlation to blood glucose level is determined, and a first optical term based on the indicator variable with the highest correlation to blood glucose level is allocated to form a regression analysis equation. An estimated value of the blood analyte concentration using the regression analysis equation is calculated. The inexpensive, non-invasive measurement instrument includes a first light source that introduces near-infrared energy into blood present in a body part of an individual, and a second light source that introduces red light energy into the blood present in the body part. A detector detects the energy emerging from the body part, and produces an electrical signal indicative of the energy emerging from the body part. A processor calculates a plurality of indicator variables from the electrical signal, determines which indicator variable from the plurality of indicator variables has the highest correlation to blood glucose level, and calculates an estimated value of the blood analyte concentration based on the indicator variable having the highest correlation to blood glucose level. The blood analyte concentration is calculated using a regression analysis equation.
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Citations
30 Claims
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1. A method for measuring a blood analyte concentration, comprising the steps of:
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obtaining energy absorption measurement data through a body part of an individual;
calculating a plurality of indicator variables from said energy absorption measurement data;
determining which indicator variable from said plurality of indicator variables has the highest correlation to blood glucose level;
allocating a first optical term based on said indicator variable with said highest correlation to blood glucose level to form a regression analysis equation; and
calculating an estimated value of said blood analyte concentration using said regression analysis equation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 28)
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10. A non-invasive measurement instrument for measuring a blood analyte concentration, comprising:
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a first light source for introducing near-infrared energy into blood present in a body part of an individual;
a second light source for introducing red light energy into said blood present in said body part;
a detector for detecting said energy emerging from said body part, said detector producing an electrical signal indicative of said energy emerging from said body part; and
a processor for calculating a plurality of indicator variables from said electrical signal, determining which indicator variable from said plurality of indicator variables has the highest correlation to blood glucose level, and calculating an estimated value of said blood analyte concentration based on said indicator variable having said highest correlation to blood glucose level, wherein said blood analyte concentration is calculated using a regression analysis equation. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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29. A method for measuring a blood analyte concentration, comprising the steps of:
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obtaining energy absorption measurement data through a body part of an individual;
calculating an indicator variable from said energy absorption measurement data;
allocating a first optical term based on said indicator variable to form a regression analysis equation; and
calculating an estimated value of said blood analyte concentration using said regression analysis equation, wherein said indicator variable is at least one of a pulse rate, LED pulse strength, IRED pulse strength, LED normalized pulse strength, IRED normalized pulse strength, pulse strength ratio, normalized pulse strength ratio, Delta OD, Delta OD divided by average LED Log 1/T, Delta OD divided by average IRED Log 1/T, Delta OD divided by average LED Log 1/T and average IRED Log 1/T, meal data, and occluded measurement data.
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30. A non-invasive measurement instrument for measuring a blood analyte concentration, comprising:
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a first light source for introducing near-infrared (NIR) energy into blood present in a body part of an individual;
a second light source for introducing red light energy into said blood present in said body part;
a first detector for detecting said NIR energy emerging from said body part, said first detector producing a first electrical signal indicative of said NIR energy emerging from said body part;
a second detector for detecting said red light energy emerging from said body part, said second detector producing a second electrical signal indicative of said red light energy emerging from said body part; and
a processor for calculating a plurality of indicator variables from said first electrical signal and said second electrical signal, determining which indicator variable from said plurality of indicator variables has the highest correlation to blood glucose level, and calculating an estimated value of said blood analyte concentration based on said indicator variable having said highest correlation to blood glucose level, wherein said blood analyte concentration is calculated using a regression analysis equation.
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Specification