Devices for collecting analytes of interest in tears

• US 20040181172A1
• Filed: 03/10/2004
• Published: 09/16/2004
• Est. Priority Date: 03/12/2003
• Status: Abandoned Application

• Current Assignee: Novartis Ag
• Original Assignee: Novartis Ag
• Inventors: Qiu, Yongxing, Carney, Fiona Patricia, Morris, Carol Ann
• Application Number:
  US10/797,707
• Publication Number:
  US 20040181172A1
• Time in Patent Office: Days
• US Class Current: 600/573
• CPC Class Codes: A61B 10/0045 Devices for taking samples of body liquids devices for taking blood samples A61B5/15
• CPC Class Codes: A61B 2010/0067 Tear or lachrymal fluid
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61B 5/42 Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems A61B1/00, A61B5/4857, A61B5/486, A61B5/4866, A61B5/4869 take precedence
• CPC Class Codes: A61B 5/4306 for evaluating the female reproductive systems, e.g. gynaecological evaluations

Abstract

The present invention provides a contact lens, preferably a daily disposable contact lens, which can be used to collect one or more analytes of interest in a tear fluid, and in turn, determine the physiological state or health of an individual.

Claims

1. A contact lens for collecting an analyte of interest in a tear fluid, comprising:

(1) surface charges present in a density sufficient to impart to the contact lens an increased adsorption of the analyte of interest;

(2) a coating comprising a receptor which binds specifically the analyte of interest;

(3) molecular imprints for the analyte of interest;

or (4) a core material that is prepared from a composition containing a receptor which binds specifically the analyte of interest.

2. A contact lens of claim 1, wherein the contact lens has surface charges which are introduced by:

(1) preparing the contact lens from a composition comprising a positively or negatively charged monomer or macromer;

(2) altering the chemical nature of chemical groups on the surface of the contact lens;

(3) applying an LbL coating composed of at least one layer of a polyionic material onto the contact lens;

or (4) combinations of (1), (2) and (3).

3. A contact lens of claim 2, wherein the contact lens has surface charges which are introduced by applying an LbL coating composed of at least one layer of a polyionic material onto the contact lens.

4. A contact lens of claim 1, wherein the contact lens has a coating comprising a receptor which binds specifically the analyte of interest.

5. A contact lens of claim 4, wherein the receptor is selected from the group consisting of antibodies, lectins, hormone receptors, drug receptors, enzymes, aptamers, nucleic acids, nucleic acid analogs, and fragments thereof.

6. A contact lens of claim 1, wherein the contact lens has molecular imprints for the analyte of interest.

7. A contact lens of claim 1, wherein the contact lens has a core material that is prepared from a composition containing a receptor which binds specifically the analyte of interest.

8. A contact lens of claim 1, wherein the contact lens is a soft contact lens.

9. A contact lens of claim 8, wherein the soft contact lens is a daily disposable hydrogel lens.

10. A method for collecting an analyte of interest in a body fluid, comprising the steps of:

providing a contact lens capable of binding the analyte of interest;

wearing the contact lens on an eye of an individual for a period of time sufficient to absorb an amount of the analyte of interest; and

removing the contact lens containing the amount of the analyte of interest from the eye.

11. A method of claim 10, wherein the contact lens comprises:

(1) surface charges present in a density sufficient to impart to the contact lens an increased adsorption of the analyte of interest;

(2) a coating comprising a receptor which binds specifically the analyte of interest;

(3) molecular imprints for the analyte of interest;

or (4) a core material that is prepared from a composition containing a receptor which binds specifically the analyte of interest.

12. A method for assaying an analyte of interest in a body fluid, comprising the steps of:

providing a contact lens capable of binding the analyte of interest;

wearing the contact lens on an eye of an individual for a period of time sufficient long to absorb an amount of the analyte of interest;

removing the contact lens containing the amount of the analyte of interest from the eye;

determining the presence or the amount of the analyte of interest.

13. A method of claim 12, wherein the contact lens comprises:

(1) surface charges present in a density sufficient to impart to the contact lens an increased adsorption of the analyte of interest;

(2) a coating comprising a receptor which binds specifically the analyte of interest;

(3) molecular imprints for the analyte of interest;

or (4) a core material that is prepared from a composition containing a receptor which binds specifically the analyte of interest.

14. A kit for collecting an analyte of interest in a body fluid, comprising:

a contact lens capable of binding the analyte of interest in a tear fluid, wherein said contact lens has surface charges that can impart to the contact lens an increased adsorption of the analyte of interest, a coating comprising a receptor which can bind specifically the analyte of interest, molecular imprints for the analyte of interest, or a core material that is prepared from a composition containing a receptor which binds specifically the analyte of interest; and

an instruction.

15. A kit of claim 14, wherein the contact lens has surface charges which are introduced by:

(1) preparing the contact lens from a composition comprising a positively or negatively charged monomer or macromer;

(2) altering the chemical nature of chemical groups on the surface of the contact lens;

(3) applying an LbL coating composed of at least one layer of a polyionic material onto the contact lens;

or (4) combinations of (1), (2) and (3).

16. A kit of claim 15, wherein the contact lens has surface charges which are introduced by applying an LbL coating composed of at least one layer of a polyionic material onto the contact lens.

17. A kit of claim 14, wherein the contact lens has a coating comprising a receptor which binds specifically the analyte of interest.

18. A kit of claim 17, wherein the receptor is selected from the group consisting of antibodies, lectins, hormone receptors, drug receptors, enzymes, aptamers, nucleic acids, nucleic acid analogs, and fragments thereof.

19. A kit of claim 14, wherein the contact lens has molecular imprints for the analyte of interest.

20. A kit of claim 14, wherein the contact lens has a core material that is prepared from a composition containing a receptor which binds specifically the analyte of interest.

21. A kit for assaying an analyte of interest in a body fluid, comprising:

a contact lens capable of binding the analyte of interest, wherein said contact lens has surface charges that can impart to the contact lens an increased adsorption of the analyte of interest, a coating comprising a receptor which can bind specifically the analyte of interest, molecular imprints for the analyte of interest, or a core material that is prepared from a composition containing a receptor which binds specifically the analyte of interest; and

a testing agent composition which specifically reacts or interacts with the analyte of interest to form a detectable signal.

22. A kit of claim 21, wherein the contact lens has surface charges which are introduced by:

(1) preparing the contact lens from a composition comprising a positively or negatively charged monomer or macromer;

(2) altering the chemical nature of chemical groups on the surface of the contact lens;

(3) applying an LbL coating composed of at least one layer of a polyionic material onto the contact lens;

or (4) combinations of (1), (2) and (3).

23. A kit of claim 22, wherein the contact lens has surface charges which are introduced by applying an LbL coating composed of at least one layer of a polyionic material onto the contact lens.

24. A kit of claim 21, wherein the contact lens has a coating comprising a receptor which binds specifically the analyte of interest.

25. A kit of claim 24, wherein the receptor is selected from the group consisting of antibodies, lectins, hormone receptors, drug receptors, enzymes, aptamers, nucleic acids, nucleic acid analogs, and fragments thereof.

26. A kit of claim 21, wherein the contact lens has molecular imprints for the analyte of interest.

27. A kit of claim 21, wherein the contact lens has a core material that is prepared from a composition containing a receptor which binds specifically the analyte of interest.

28. A contact lens of claim 21, wherein the contact lens is a soft hydrogel contact lens.