System and method for treating Parkinson's Disease and other movement disorders
First Claim
Patent Images
1. A method for treating movement disorders, comprising:
- providing an image showing a relative position between an external marker on a patient and at least one of the central sulcus, the precentral gyrus and/or the postcentral gyrus of the patient;
identifying a stimulation site proximate to the dura of the patient and over the precentral gyrus relative to the external marker; and
applying neural stimulation directly to the stimulation site.
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Accused Products
Abstract
Systems and methods for treating movement disorders using cortical stimulation. In one embodiment, a method for treating movement disorders comprises determining a site at the cortex of the brain of a patient related to a movement disorder of an afflicted body part. The site can be determined by obtaining a representation of neural activity occurring in the cortex of the patient and correlating an area of neural activity with the afflicted body part. The method can also include applying neural stimulation, such as electrical or magnetic waveforms, directly to the site.
264 Citations
71 Claims
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1. A method for treating movement disorders, comprising:
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providing an image showing a relative position between an external marker on a patient and at least one of the central sulcus, the precentral gyrus and/or the postcentral gyrus of the patient;
identifying a stimulation site proximate to the dura of the patient and over the precentral gyrus relative to the external marker; and
applying neural stimulation directly to the stimulation site. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for treating movement disorders, comprising:
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locating a stimulation site at least proximate to the dura and along the precentral gyrus of a patient by imaging at least one of the precentral gyrus, central sulcus and/or postcentral gyrus of the patient relative to an external marker on the patient; and
applying neural stimulation directly to the stimulation site. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A method for treating movement disorders, comprising:
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implanting an electrode array having a plurality of first electrodes arranged in a first row and a plurality of second electrodes arranged in a second row at a stimulation site over the central sulcus of the patient; and
applying an electrical signal to at least some of the first electrodes and/or the second electrodes. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35)
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36. A method for treating a patient having a movement disorder that is worse on a first side of the patient than on a second side of the patient opposite the first side;
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implanting an electrode at a stimulation site located over at least a portion of the precentral gyrus of the patient on only the second side of the patient; and
applying stimulation to the electrode to treat the movement disorder on both the first side and the second side of the patient. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43, 44, 45, 46)
- comprising;
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47. A method for treating movement disorders, comprising:
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determining a site at the cortex of the brain of a patient related to a movement disorder of an afflicted body part by obtaining a representation of neural activity occurring in the cortex of the patient and correlating an area of neural activity with the afflicted body part; and
applying neural stimulation directly to the site. - View Dependent Claims (48, 49, 50, 51, 52, 53, 54, 55, 56)
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57. A method of treating movement disorders, comprising:
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providing a representation of neural activity in the cortex of the brain of a patient;
identifying an area of neural activation on the representation expected to be related to a body part of the patient affected by a movement disorder;
selecting a stimulation site on the patient by referencing the identified area of neural activation to the anatomy of the brain of the patient; and
applying electrical stimulation to the cortex of the patient at the stimulation site. - View Dependent Claims (58, 59, 60, 61)
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62. A method of treating movement disorders, comprising:
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performing a craniotomy to expose a cortical location for neural activity related to a body part affected by a movement disorder;
applying a test electrical stimulation waveform to a plurality of discrete regions of the cortical location;
mapping the test electrical stimulation waveform applied to the discrete regions to the efficacy in treating the movement disorder of the affected body part;
selecting one or more of the discrete regions that have a desired efficacy for treating the movement disorder; and
applying a therapy electrical stimulation waveform to the one or more selected discrete regions of the cortical location. - View Dependent Claims (63, 64)
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65. A method of treating a movement disorder that affects a body part of a patient, comprising:
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implanting an electrode at a cortical stimulation site other than the precentral gyrus where neural activity related the movement disorder of the affected body part is expected to occur; and
applying electrical stimulation to the cortical stimulation site by electrically biasing the electrode.
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66. A method of selecting a stimulation site for a patient having a movement disorder, comprising:
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providing an image showing a relative position between an external marker on a patient and at least one of the central sulcus, the precentral gyrus and/or the postcentral gyrus of the patient; and
identifying a stimulation site proximate to the dura of the patient and over the precentral gyrus relative to the external marker.
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67. A method of selecting a stimulation site for a patient having a movement disorder, comprising:
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obtaining an image of at least one of the precentral gyrus, central sulcus and/or postcentral gyrus of the patient relative to an external marker on the patient;
locating a stimulation site on the image relative to the external marker that is over at least one of the precentral gyrus, central sulcus and/or postcentral gyrus of the patient and proximate to the dura according to the image; and
correlating the stimulation site on the image with an external site on the patient.
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68. A method of selecting a stimulation site for a patient having a movement disorder that is worse on a first side of the patient than on a second side of the patient opposite the first side;
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ascertaining a homologous region of the cortex of the patient associated with control of the movement disorder; and
identifying a stimulation site relative to the homologous region on only the second side of the patient. - View Dependent Claims (69, 70)
- comprising;
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71. A method of selecting a stimulation site for a patient having a movement disorder, comprising:
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obtaining a representation of neural activity occurring in the cortex of a patient and correlating an area of neural activity with a body part afflicted by the movement disorder; and
correlating the representation of the area of neural activity in the cortex of the patient with an external site on the patient.
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Specification