Systems and methods for providing diagnostic services
First Claim
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1. A method for diagnosing an oral disease in a patient, comprising:
- a. obtaining a biological sample from a patient at the point of care;
b. determining the expression level of a plurality of genes associated with an oral disease in the biological sample, thereby producing a test expression profile;
c. comparing the test expression profile with at least one signature expression profile of the plurality of genes indicative of an oral disease;
wherein if the test expression profile substantially matches a signature expression profile indicative of an oral disease, the patient has the oral disease.
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Abstract
Disclosed are diagnostic methods for oral diseases such as oral cancer. In the methods, expression data of a plurality of genes associated with an oral disease is examined and compared to signature expression profile indicative of an oral disease. Also disclosed are systems, methods and kits for allowing a dentist to provide for detection of oral disease at the point of patient care.
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Citations
32 Claims
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1. A method for diagnosing an oral disease in a patient, comprising:
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a. obtaining a biological sample from a patient at the point of care;
b. determining the expression level of a plurality of genes associated with an oral disease in the biological sample, thereby producing a test expression profile;
c. comparing the test expression profile with at least one signature expression profile of the plurality of genes indicative of an oral disease;
wherein if the test expression profile substantially matches a signature expression profile indicative of an oral disease, the patient has the oral disease. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of allowing a dentist to provide for detection of oral disease at the point of patient care, comprising:
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a. obtaining a biological sample from a dental patient at the point of care;
b. determining the expression level of a plurality of genes associated with an oral disease in the biological sample, thereby producing a test expression profile;
c. comparing the test expression profile with at least one signature expression profile of the plurality of genes indicative of an oral disease; and
d. notifying the patient the results of the test. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A system for allowing a dentist to test for an oral disease at the point of care, comprising:
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a. a sample collection device for collecting a sample from a dental patient at the point of care;
b. a diagnostic system for generating a test expression profile by determining the expression level of a plurality of genes associated with an oral disease in the sample, and comparing the test expression profile with at least one signature expression signatures profile representative of an oral disease; and
c. a notification system for notifying the patient the results of the test. - View Dependent Claims (28, 29, 30, 31, 32)
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Specification