Filter and concentrator device for treatment of blood
First Claim
1. A method of treating a patient by removing one or more toxins from the patient'"'"'s blood, comprising:
- removing at least a portion of the patient'"'"'s blood;
diluting said at least a portion of the blood with a diluent to provide diluted blood, thereby reducing the hematocrit of said at least a portion of the blood;
transporting the diluted blood to a concentrator with a flow rate of less than 400 ml/min;
concentrating the diluted blood using the concentrator thereby removing at least a portion of the diluent therefrom;
filtering said diluted blood to remove one or more toxins from said diluted blood, thereby producing treated blood; and
returning the treated blood to the patient.
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Accused Products
Abstract
A method and apparatus for preventing and treating septicemia in patient blood is provided. The extracorporeal system includes an antimicrobial device to inactivate at least 99% of bloodbome microorganisms, a hemoconcentrator/filtration unit to remove approximately 50-75% of target molecules from the patient blood and a filter unit to remove target molecules from patient blood from the sieved plasma filtrate. Target molecules are produced by microorganisms, as well as by the patient'"'"'s cells. These molecules include endotoxins from Gram negative bacteria, exotoxins from Gram negative and Gram positive bacteria, as well as RAP protein mediator from Staphylococcus aureus, and cell mediators such as tumor necrosis factor-alpha, and interleukin 1-beta, interleukin 6, complement proteins C3a and C5a, and bradykinin.
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Citations
43 Claims
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1. A method of treating a patient by removing one or more toxins from the patient'"'"'s blood, comprising:
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removing at least a portion of the patient'"'"'s blood;
diluting said at least a portion of the blood with a diluent to provide diluted blood, thereby reducing the hematocrit of said at least a portion of the blood;
transporting the diluted blood to a concentrator with a flow rate of less than 400 ml/min;
concentrating the diluted blood using the concentrator thereby removing at least a portion of the diluent therefrom;
filtering said diluted blood to remove one or more toxins from said diluted blood, thereby producing treated blood; and
returning the treated blood to the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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37. A method for removing toxins from the blood of a patient comprising:
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removing blood from the patient;
diluting the blood, thereby reducing the hematocrit of said blood and producing diluted blood;
transporting the diluted blood to a first filter with a flow rate of less than 400 ml/min;
filtering the diluted blood with the first filter to receive the blood and extract cell mediators and diluent therefrom to produce filtered blood;
re-filtering the filtered blood with a second filter to produce treated blood; and
returning the treated blood to the patient. - View Dependent Claims (38, 39, 40, 41, 42)
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43. A blood treatment system comprising:
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a diluent source for supplying a diluent to reduce the hematocrit of the blood;
a concentrator device to filter the diluted blood and to remove the diluent therefrom, said blood being received at a combined flow rate of less than 400 ml/min;
a pump to regulate flow rate of a fluid; and
a return path connected for returning filtered blood from said concentrator device to a blood source.
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Specification