Colorimetric sensor
First Claim
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1. A colorimetric sensor for measuring one or both of the presence and concentration of an analyte, said calorimetric sensor comprising:
- a substantially continuous reflective layer;
a detection layer over the reflective layer, the detection layer comprising at least one polymer component, said detection layer being capable of a change in optical thickness upon exposure to said analyte; and
a semi-reflective layer over the detection layer, the semi-reflective layer having an index of refraction different from the index of refraction of the detection layer, wherein at least a portion of the semi-reflective layer is permeable to said analyte.
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Abstract
Colorimetric sensor films comprising a reflective layer, a polymeric detection layer, and a semi-reflective layer are disclosed. Devices comprising the colorimetric sensor films and methods of making the films and devices are also disclosed.
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Citations
47 Claims
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1. A colorimetric sensor for measuring one or both of the presence and concentration of an analyte, said calorimetric sensor comprising:
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a substantially continuous reflective layer;
a detection layer over the reflective layer, the detection layer comprising at least one polymer component, said detection layer being capable of a change in optical thickness upon exposure to said analyte; and
a semi-reflective layer over the detection layer, the semi-reflective layer having an index of refraction different from the index of refraction of the detection layer, wherein at least a portion of the semi-reflective layer is permeable to said analyte. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40)
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41. A colorimetric sensor for measuring one or both of the presence and concentration of an analyte, said colorimetric sensor comprising:
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a substantially continuous reflective layer;
a detection layer over the reflective layer, the detection layer comprising (i) at least one polymer component, (ii) at least one inorganic component, or (iii) both (i) and (ii); and
a substantially continuous semi-reflective layer over the detection layer, the semi-reflective layer having an index of refraction different from the index of refraction of the detection layer and being permeable to said analyte, said sensor being capable of a change in color upon exposure to said analyte. - View Dependent Claims (42, 43, 44)
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45. A colorimetric sensor for measuring one or both of the presence and concentration of an analyte, said colorimetric sensor comprising:
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a reflective layer;
a detection layer over the reflective layer; and
a discontinuous semi-reflective layer over the detection layer, the semi-reflective layer having an index of refraction different from the index of refraction of the detection layer, said sensor being capable of a change in color upon exposure to said analyte, wherein the sensor has at least one of the following features;
(a) the discontinuous semi-reflective layer comprises a single layer of semi-reflective islands having at least one dimension greater than 10 μ
m, and exposed areas between the semi-reflective islands, said exposed areas having a width of at least 1.0 μ
m;
(b) the discontinuous semi-reflective layer comprises a single layer of semi-reflective islands and the detection layer contains wells extending a depth into the detection layer;
(c) the discontinuous semi-reflective layer comprises a single layer of semi-reflective islands and the detection layer comprises at least one inorganic component either alone or in combination with at least one polymer component;
(d) the detection layer comprises at least one inorganic component, wherein said at least one inorganic component is (i) blended with at least one polymer component, (ii) within a given layer containing at least one polymer component but not blended with the at least one polymer component, (iii) in a layer separate from a layer containing at least one polymer component, or (iv) any combination of (i) to (iii); and
(e) the detection layer comprises at least two different polymeric components, wherein the polymeric components are (1) blended with one another, (2) within a given layer but not blended with one another, (3) in a layer separate from one another, or (4) any combination of (1) to (3). - View Dependent Claims (46, 47)
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Specification