Pharmaceutical use of N-carbamoylazole derivatives

• US 20040186153A1
• Filed: 01/27/2004
• Published: 09/23/2004
• Est. Priority Date: 05/18/2001
• Status: Active Grant

• Current Assignee: Eisai R & D Management Company Limited (Eisai Medical Research Incorporated)
• Original Assignee: Eisai R & D Management Company Limited (Eisai Medical Research Incorporated)
• Inventors: Yoshikawa, Seiji, Koyanagi, Mika, Okada, Toshimi, Nagakura, Tadashi, Ikuta, Hironori, Yasuda, Nobuyuki, Yamazaki, Kazuto
• Granted Patent: US 7,238,720 B2
• Time in Patent Office: Days
• US Class Current: 514/383
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: C07D 249/12 Oxygen or sulfur atoms
• CPC Class Codes: C07D 401/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 403/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 405/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 413/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 451/02 containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
• CPC Class Codes: C07D 471/04 Ortho-condensed systems

Abstract

The present invention relates to use of 1-carbamoylazole derivatives as medicaments and pharmaceutical compositions containing 1-carbamoylazole derivatives as the active ingredient, based on their DPPIV inhibiting effects. The present invention provides a dipeptidyl peptidase IV inhibiting agent comprising a compound represented by the general formula (I):

Claims

1. A dipeptidyl peptidase IV inhibiting agent comprising a compound represented by following general formula (I):

2. The dipeptidyl peptidase IV inhibiting agent according to claim 1, wherein Z is a group represented by following formula Z-3:

3. The dipeptidyl peptidase IV inhibiting agent according to claim 1, wherein R^1a is a phenyl group or a 4-pyrazolyl group.

4. The dipeptidyl peptidase IV inhibiting agent according to claim 1, wherein X¹ is a nitrogen atom, and X² is a methine group.

5. The dipeptidyl peptidase IV inhibiting agent according to claim 1, wherein X¹ and X² are methine group.

6. The dipeptidyl peptidase IV inhibiting agent according to claim 1, wherein n is 1 or 2.

7. The dipeptidyl peptidase IV inhibiting agent according to claim 1, wherein the inhibiting agent is an agent for the treatment and prophylaxis of diabetic diseases.

8. The dipeptidyl peptidase IV inhibiting agent according to claim 1, wherein the inhibiting agent is an agent for the treatment and prophylaxis of obesity.

9. The dipeptidyl peptidase IV inhibiting agent according to claim 1, wherein the inhibiting agent is a hyperlipemia treating agent, an AIDS treating agent, an osteoporosis treating agent, an agent for treating intestinal disorders, a neovascularization treating agent, an infertility treating agent, an anti-inflammatory agent, an anti-allergic agent, an immune-modulating agent, a hormone-modulating agent, an antirheumatic agent, or an agent for treating cancers.