Aneurysm treatment device and method of use

• US 20040186562A1
• Filed: 01/22/2004
• Published: 09/23/2004
• Est. Priority Date: 07/20/2001
• Status: Active Grant

• Current Assignee: Microvention Incorporated (Terumo Corporation)
• Original Assignee: Microvention Incorporated (Terumo Corporation)
• Inventors: Cox, Brian J.
• Granted Patent: US 8,252,040 B2
• Time in Patent Office: Days
• US Class Current: 623/1.42
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12113 within an aneurysm
• CPC Class Codes: A61B 17/12118 for positioning in conjunction with a stent
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/12186 liquid materials adapted to be injected
• CPC Class Codes: A61B 17/1219 expandable in contact with liquids
• CPC Class Codes: A61B 2017/00526 Methods of manufacturing
• CPC Class Codes: A61B 2017/00867 shape memory effect
• CPC Class Codes: A61B 2017/00898 expandable upon contact with fluid
• CPC Class Codes: A61B 2017/1205 Introduction devices
• CPC Class Codes: A61F 2/856 Single tubular stent with a side portal passage
• CPC Class Codes: A61F 2/88 the wire-like elements formed as helical or spiral coils forming a net-like or mesh-like structure A61F2/90
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2002/065 Y-shaped blood vessels
• CPC Class Codes: A61F 2002/823 Stents, different from stent-grafts, adapted to cover an aneurysm
• CPC Class Codes: A61F 2230/0054 V-shaped
• CPC Class Codes: A61L 2300/414 Growth factors
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 2300/418 Agents promoting blood coagulation, blood-clotting agents, embolising agents
• CPC Class Codes: A61L 31/145 : Hydrogels or hydrocolloids
• CPC Class Codes: A61L 31/16 : Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: B65H 54/00 : Winding, coiling, or depositing filamentary material cores, formers, holders, cans or receptacles B65H75/02

Abstract

The present application discloses an apparatus for treating vascular aneurysms and includes a radially expandable substantially cylindrical structure formed from a plurality of support members and defining a plurality of openings, and at least one reactive material strand selectively integrated into the substantially cylindrical structure. The reactive material is configured to assume a non-reacted state and a reacted state. The reactive material in the reacted state is configured to restrict a flow of blood to an aneurysm.

Claims

1. An apparatus for treating vascular aneurysms, comprising:

a radially expandable substantially cylindrical structure formed from a plurality of support members and defining a plurality of openings; and

at least one reactive material strand selectively integrated into the substantially cylindrical structure, the reactive material strand having a non-reacted state and a reacted state, wherein the reactive material strand in the reacted state is configured to restrict a flow of blood to an aneurysm.

2. The apparatus of claim 1, wherein the reactive material strand is an expandable polymer.

3. The apparatus of claim 1, wherein the reactive material strand is a hydrogel.

4. The apparatus of claim 1, wherein the reactive material strand is responsive to pH.

5. The apparatus of claim 1 wherein the reactive material strand applied to the support members defines the plurality of openings, wherein each opening has an area A when the reactive material strand is in a non-reacted state and has an area A′

when the reactive material strand is in a reacted state, and wherein area A′

is less than area A.

6. The apparatus of claim 5, wherein the area A′

is at least about 20% less than the area A.

7. The apparatus of claim 1, wherein the reactive material strand is interwoven into the substantially cylindrical structure.

8. The apparatus of claim 1, wherein the reactive material strand is selectively positioned on one or more of the support members.

9. The apparatus of claim 8, wherein the reactive material strand is positioned on one or more of the support members in a radial orientation.

10. The apparatus of claim 8, wherein the reactive material strand is positioned on one or more of the support members in an axial orientation.

11. The apparatus of claim 8, wherein the reactive material strand is positioned on one or more of the support members in a radial and axial orientation.

12. The apparatus of claim 8, wherein the reactive material strand is wrapped around one or more of the support members.

13. The apparatus of claim 8, wherein the reactive material strand is adhesively bonded to one or more of the support members.

14. The apparatus of claim 8, wherein the reactive material strand has a variable diameter.

15. The apparatus of claim 8, wherein the reactive material strand has a variable tangential width.

16. The apparatus of claim 8, wherein the reactive material strand is intermittently applied to one or more of the support members.

17. The apparatus of claim 1, wherein each support member has a diameter D when the reactive material strand is in a non-reacted state and a diameter D′

when the reactive material strand is in a reacted state, and wherein diameter D′

is larger than diameter D.

18. The apparatus of claim 1 further comprising at least one therapeutic agent applied to at least one of the support members and the reactive material strand.

19. The apparatus of claim 18 wherein the therpeutic agent is selected from the group consisting of embolizing factors, anti-embolizing factors, anti-restenotic compounds, endothelial cell assays, compounds to promote endothelial cellular adhesion, and growth factors.

20. An apparatus for treating vascular aneurysms, comprising:

a radially expandable structure formed from a plurality of support members interwoven to form an interwoven structure and defining a plurality of openings; and

at least one reactive material strand interwoven into the interwoven structure, the reactive material strand having a non-reacted state and a reacted state, wherein the reactive material strand in the reacted state is configured to restrict a flow of blood to an aneurysm.

21. An apparatus for treating vascular aneurysms, comprising:

a radially expandable structure formed from a plurality of support members interwoven to form an interwoven structure and defining a plurality of openings; and

at least one reactive material strand wrapped around one or more support members, the reactive material strand having a non-reacted state and a reacted state, wherein the reactive material strand in the reacted state is configured to restrict a flow of blood to an aneurysm.

22. An apparatus for treating vascular aneurysms, comprising:

a radially expandable substantially cylindrical structure formed from a plurality of support members and defining a plurality of openings; and

at least one reactive material strand selectively interwoven into the substantially cylindrical structure, the reactive material having a non-reacted state and a reacted state, wherein the reactive material strand in the reacted state is configured to restrict a flow of blood to an aneurysm.