Delivery of compounds for the treatment of migraine through an inhalation route
First Claim
1. A composition for delivery of rizatriptan consisting of a condensation aerosol a) formed by volatilizing a thin layer of rizatriptan on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of rizatriptan and condensing the heated vapor of rizatriptan to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% rizatriptan degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
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Abstract
The present invention relates to the delivery of a migraine headache drug through an inhalation route. Specifically, it relates to aerosols containing a migraine headache drug that are used in inhalation therapy. In a method aspect of the present invention, a migraine headache drug is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of a migraine headache drug, on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering a migraine headache drug through an inhalation route is provided which comprises: a) a thin coating of an a migraine drug composition and b) a device for dispensing said thin coating as a condensation aerosol.
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Citations
30 Claims
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1. A composition for delivery of rizatriptan consisting of a condensation aerosol
a) formed by volatilizing a thin layer of rizatriptan on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of rizatriptan and condensing the heated vapor of rizatriptan to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% rizatriptan degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
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4. A composition for delivery of zolmitriptan consisting of a condensation aerosol
a) formed by volatilizing a thin layer of zolmitriptan on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of zolmitriptan and condensing the heated vapor of zolmitriptan to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% zolmitriptan degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
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7. A composition for delivery of sumatriptan consisting of a condensation aerosol
a) formed by volatilizing a thin layer of sumatriptan on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of sumatriptan and condensing the heated vapor of sumatriptan to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% sumatriptan degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
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10. A composition for delivery of frovatriptan consisting of a condensation aerosol
a) formed by volatilizing a thin layer of frovatriptan on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of frovatriptan and condensing the heated vapor of frovatriptan to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% frovatriptan degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
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13. A composition for delivery of naratriptan consisting of a condensation aerosol
a) formed by volatilizing a thin layer of naratriptan on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of naratriptan and condensing the heated vapor of naratriptan to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% naratriptan degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
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16. A method of producing rizatriptan in an aerosol form comprising:
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a. heating a thin layer of rizatriptan on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the rizatriptan to form a heated vapor of the rizatriptan, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the rizatriptan comprising less than 5% rizatriptan degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (17, 18)
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19. A method of producing zolmitriptan in an aerosol form comprising:
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a. heating a thin layer of zolmitriptan on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the zolmitriptan to form a heated vapor of the zolmitriptan, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the zolmitriptan comprising less than 5% zolmitriptan degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (20, 21)
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22. A method of producing sumatriptan in an aerosol form comprising:
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a. heating a thin layer of sumatriptan on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the sumatriptan to form a heated vapor of the sumatriptan, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the sumatriptan comprising less than 5% sumatriptan degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (23, 24)
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25. A method of producing frovatriptan in an aerosol form comprising:
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a. heating a thin layer of frovatriptan on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the frovatriptan to form a heated vapor of the frovatriptan, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the frovatriptan comprising less than 5% frovatriptan degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (26, 27)
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28. A method of producing naratriptan in an aerosol form comprising:
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a. heating a thin layer of naratriptan on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the naratriptan to form a heated vapor of the naratriptan, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the naratriptan comprising less than 5% naratriptan degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (29, 30)
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Specification