Delivery of diphenhydramine through an inhalation route
First Claim
1. A composition for delivery of diphenhydramine consisting of a condensation aerosol a) formed by volatilizing a thin layer of diphenhydramine on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of diphenhydramine and condensing the heated vapor of diphenhydramine to form condensation aerosol particles;
- b) wherein said condensation aerosol particles are characterized by less than 5% diphenhydramine degradation products, and c) wherein the aerosol has an MMAD of less than 3 microns.
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Abstract
The present invention relates to the delivery of diphenhydramine through an inhalation route. In a composition aspect of the present invention, a composition of a diphenhydramine condensation aerosol is presented. In a method aspect of the present invention, diphenhydramine aerosol is formed by: a) heating a thin layer of diphenhydramine on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% degradation product and an aerosol having an MMAD less than 3 microns. In a kit aspect of the present invention, a kit for delivering a condensation aerosol is provided which comprises: a) a thin coating of diphenhydramine; and b) a device for dispensing the diphenhydramine as an aerosol.
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Citations
12 Claims
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1. A composition for delivery of diphenhydramine consisting of a condensation aerosol
a) formed by volatilizing a thin layer of diphenhydramine on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of diphenhydramine and condensing the heated vapor of diphenhydramine to form condensation aerosol particles; -
b) wherein said condensation aerosol particles are characterized by less than 5% diphenhydramine degradation products, and c) wherein the aerosol has an MMAD of less than 3 microns. - View Dependent Claims (2, 3, 4, 5)
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6. A method of producing diphenhydramine in an aerosol form comprising:
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a) heating a thin layer of diphenhydramine on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the diphenhydramine to form a heated vapor of the diphenhydramine and b) during said heating, passing air through the heated vapor to produce aerosol particles of the diphenhydramine comprising less than 5% diphenhydramine degradation products and an aerosol having an MMAD less than 3 microns. - View Dependent Claims (7, 8, 9)
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10. A kit for delivering a drug aerosol comprising:
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a) a thin coating consisting essentially of diphenhydramine, and b) a device for dispensing said thin coating as a condensation aerosol. - View Dependent Claims (11, 12)
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Specification