Therapeutic liposome composition and method of preparation
0 Assignments
0 Petitions
Accused Products
Abstract
Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting conjugates composed of a lipid, a hydrophilic polymer and a targeting ligand. The therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.
-
Citations
56 Claims
-
1-32. -32. (Canceled)
-
33. A method of formulating a therapeutic liposome composition having sensitivity to a target cell, comprising
providing a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent; -
providing a plurality of targeting conjugates a targeting conjugate composed of (i) a lipid having a polar head group and a hydrophobic tail, (ii) a hydrophilic polymer having a proximal end and a distal end, said polymer attached at its proximal end to the head group of the lipid, and (iii) a targeting ligand attached to the distal end of the polymer; and
combining the liposome formulation and the plurality of targeting conjugates to form said therapeutic, target-cell sensitive liposome composition. - View Dependent Claims (34, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56)
-
-
35. (Canceled)
Specification