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Therapeutic liposome composition and method of preparation

  • US 20040191307A1
  • Filed: 04/07/2004
  • Published: 09/30/2004
  • Est. Priority Date: 10/11/1996
  • Status: Abandoned Application
First Claim
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1. A composition comprising reagents for use in preparing a therapeutic liposome composition sensitized to a target cell, said reagents comprised of (a) a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent;

  • and (b) a plurality of conjugates, each conjugate composed of (i) a lipid having a polar head group and a hydrophobic tail, (ii) a hydrophilic polymer having a proximal end and a distal end, said polymer attached at its proximal end to the head group of the lipid, and (iii) a targeting ligand attached to the distal end of the polymer;

    wherein said reagents are mixed to form the therapeutic, target-cell sensitized liposome composition.

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