Antiepileptic dosage form and process for protecting antiepileptic drug
First Claim
1. A dosage form for delivering an antiepileptic drug to a gastrointestinal tract, comprising:
- a compartment containing a drug formulation layer, the drug formulation layer comprising an antiepileptic drug;
a semipermeable wall surrounding the compartment, the semipermeable wall having a passageway that allows communication between the compartment and an exterior of the dosage form;
an internal lamina formed on an inner surface of the semipermeable wall, the internal lamina being substantially soluble in water;
wherein the internal lamina in a hydrated state forms a gelatinous layer that lubricates the semipermeable wall, thereby substantially preventing crack formation in the semipermeable wall while the dosage form is dispensing the drug.
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Abstract
A dosage form for delivering an antiepileptic drug to a gastrointestinal tract includes a compartment containing a drug formulation layer which comprises an antiepileptic drug. The dosage form further includes a semipermeable wall surrounding the compartment. The semipermeable wall has a passageway that allows communication between the compartment and an exterior of the dosage form. An internal lamina is formed on an inner surface of the semipermeable wall. The internal lamina is substantially soluble in water. The internal lamina in a hydrated state forms a gelatinous layer that lubricates the semipermeable wall, thereby preventing crack formation in the semipermeable wall while the dosage form is dispensing the drug.
43 Citations
11 Claims
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1. A dosage form for delivering an antiepileptic drug to a gastrointestinal tract, comprising:
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a compartment containing a drug formulation layer, the drug formulation layer comprising an antiepileptic drug;
a semipermeable wall surrounding the compartment, the semipermeable wall having a passageway that allows communication between the compartment and an exterior of the dosage form;
an internal lamina formed on an inner surface of the semipermeable wall, the internal lamina being substantially soluble in water;
wherein the internal lamina in a hydrated state forms a gelatinous layer that lubricates the semipermeable wall, thereby substantially preventing crack formation in the semipermeable wall while the dosage form is dispensing the drug. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A process for maintaining the integrity and performance of a dosage form having a semipermeable wall enclosing an antiepileptic drug formulation, comprising:
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laminating an inner surface of the semipermeable wall with a lamina that is substantially soluble in water;
wherein the lamina when hydrated forms a gelatinous layer that lubricates the semipermeable wall, thereby substantially preventing crack formation in the semipermeable wall as the dosage form dispenses the drug.
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Specification