Modulation of HIV replication by RNA interference
First Claim
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1. A small interfering RNA (siRNA) comprising a sequence sufficiently complementary to a portion of the HIV genome to mediate RNA interference (RNAi).
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Abstract
Disclosed herein are small interfering RNAs (siRNAs), and vectors encoding one or more siRNAs (including short hairpin siRNAs), that are sufficiently homologous to a portion of the HIV genome to mediate RNA interference in vivo. Also disclosed are methods wherein siRNAs, or vectors encoding siRNAs, are administered to prevent or inhibit HIV infection in a subject, cell or tissue. Knockout and/or knockdown cells or organisms are also disclosed that utilize the siRNAs or vectors of the present invention.
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Citations
74 Claims
- 1. A small interfering RNA (siRNA) comprising a sequence sufficiently complementary to a portion of the HIV genome to mediate RNA interference (RNAi).
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23. A method of treating a subject infected with HIV, the method comprising the steps of:
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providing an siRNA comprising a sequence sufficiently complementary to a portion of the HIV genome to mediate RNA interference (RNAi); and
initiating RNAi by administering the siRNA to said subject. - View Dependent Claims (24, 25, 26, 27)
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28. A method of inhibiting or preventing HIV replication or infection in a subject, the method comprising the steps of:
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providing a siRNA comprising a sequence sufficiently complementary to a portion of the HIV genome to mediate RNA interference (RNAi); and
administering the siRNA to the subject the siRNA such that HIV replication or infection is inhibited or prevented. - View Dependent Claims (29, 30, 31, 32, 33)
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34. A method of inhibiting or preventing HIV replication or infection in a cell, the method comprising the steps of:
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providing a siRNA comprising a sequence sufficiently complementary to a portion of the HIV genome to mediate RNA interference (RNAi); and
inhibiting or preventing HIV replication or infection by contacting a cell with the siRNA. - View Dependent Claims (35, 36, 37, 38, 39, 40, 41, 42, 43, 44)
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- 45. A vector that expresses an siRNA comprising a sequence sufficiently complementary to a portion of the HIV genome to mediate RNA interference (RNAi).
Specification