Substituted pyrroline kinase inhibitors
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Abstract
The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
38 Citations
53 Claims
- 1. A compound of Formula (I):
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17. The compound of claim I wherein R2is one substituent attached to a carbon or nitrogen atom selected from the group consisting of hydrogen, —
- C1-4alkyl-R5, —
C2-4alkenyl-R5, —
C2-4alkynyl-R5, —
C(O)H, —
C(O)—
(C1-4)alkyl-R9, —
C(O)—
NH2, —
C(O)—
NH(C1-4alkyl-R9), —
C(O)—
N(C1-4alkyl-R9)2, —
C(O)—
NH(aryl-R8), —
C(O)-cycloalkyl-R8, —
C(O)-heterocyclyl-R8, —
C(O)-aryl-R8, —
C(O)-heteroaryl-R8, —
CO2H, —
C(O)—
O—
(C1-4)alkyl-R9, —
C(O)—
O—
aryl-R8, —
SO2—
(C1-4)alkyl-R9, —
SO2-aryl-R8, -cycloalkyl-R6, -aryl-R6 and —
(C1-4)alkyl-N—
R7;
with the proviso that, when R2 is attached to a carbon atom, R2 is further selected from the group consisting of —
C1-4alkoxy-R5, —
N—
R7, cyano, halogen, hydroxy, nitro, oxo, -heterocyclyl-R6 and -heteroaryl-R6.
- C1-4alkyl-R5, —
Specification