Transdermal delivery system (TDS) with electrode network

• US 20040193089A1
• Filed: 04/08/2004
• Published: 09/30/2004
• Est. Priority Date: 04/09/1998
• Status: Active Grant

• Current Assignee: Luye Pharma AG (Australian Hospital Partners Holdings Pty Limited)
• Original Assignee: Acino AG
• Inventors: Haas, Ruediger, Fischer, Wilfried, Zimmermann, Clifton
• Granted Patent: US 7,383,083 B2
• Time in Patent Office: Days
• US Class Current: 602/48
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0448 Drug reservoir
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428

Abstract

The invention relates to an “intelligent”, electronically controlled transdermal delivery system (TDS) having

a carrier layer (cover layer) impermeable to the substances/active ingredients to be delivered,

a membrane permeable to the substances/active ingredients to be delivered,

a reservoir containing substances/active ingredients to be delivered, the reservoir being provided between the carrier layer and the membrane, and

a removable film, wherein

the carrier layer and the membrane comprise electrodes such that the electrode(s) of the membrane serve(s) as counterelectrode(s) to the electrode (the electrodes) of the carrier layer.

Claims

1. Transdermal delivery system (TDS) having

a carrier layer impermeable to a substance to be delivered,

a membrane permeable to said substance to be delivered,

a reservoir containing said substance to be delivered, the reservoir being provided between the carrier layer and the membrane, and

a removable film,

wherein the carrier layer and the membrane comprise electrodes such that the electrode(s) of the membrane serve(s) as counterelectrode(s) to the electrode(s) of the carrier layer.

2. Delivery system according to claim 1, wherein the electrodes of the carrier layer are arranged in the form of one or more electrode network(s) on the carrier layer, each electrode network having a plurality of individual electrodes.

3. Delivery system according to claim 1 further comprising:

a battery,

a microchip that (i) is fixed to the carrier layer or (ii) is accommodated with the battery in an external housing and is connected to the electrodes of the carrier layer and of the membrane by means of flexible wiring systems, and

a reading and writing device for writing to the microchip.

4. Delivery system according to claim 1, comprising a carrier layer having a thickness in the range from 10 μ

m to 1000 μ

m.

5. Delivery system according to claim 1, wherein the substance reservoir comprises a contact adhesive, a gel or an immobilised solution for the substance to be delivered.

6. Delivery system according to claim 1, wherein the electrodes of the carrier layer and/or of the membrane has/have been applied by printing.

7. Delivery system according to claim 2, wherein there is a plurality of electrode networks, each electrode network is actuatable individually or a plurality of electrode networks are actuatable in groups and/or each individual electrode in a network is actuatable individually or a plurality of individual electrodes in a network are actuatable in groups.

8. Delivery system according to claim 1, wherein the membrane permeable to said substance is electrically conductive and is a metal lattice, or a polymer lattice on which a conductive layer has been vopour-deposited, or a perforated conductive layer.

9. Delivery system according to claim 1, wherein the membrane permeable to said substance is electrically conductive and has uninterrupted conductivity or has conductive areas that are separated by non-conductive areas, so that one or more networks of conductive areas are formed.

10. Delivery system according to claim 9, wherein each electrode of the carrier layer corresponds to a counterelectrode with which it is uniquely associated.

11. Delivery system according to claim 3, wherein the microchip is securely bonded to the carrier layer.

12. Delivery system according to claim 3, wherein the microchip is a chip that is programmable according to a prescription.

13. Delivery system according to claim 3, wherein the battery is a button battery or a sheet battery.

14. Delivery system according to claim 3, wherein the battery is provided in a pocket in the carrier layer.

15. Delivery system according to claim 1, wherein a layer comprising a pressure pressure-sensitive contact adhesive for attaching the delivery system to skin and for improving contact with skin is applied to the side of the membrane remote from the reservoir.