Hybrid organic - inorganic composite film and method for the manufacture thereof

• US 20040197224A1
• Filed: 04/22/2004
• Published: 10/07/2004
• Est. Priority Date: 12/21/2001
• Status: Abandoned Application

• Current Assignee: Council of Scientific & Industrial Research
• Original Assignee: Council of Scientific & Industrial Research
• Inventors: Gole, Anand Mahadeo, Sastry, Murali, Phadtare, Sumant, Kumar, Ashavani
• Application Number:
  US10/829,439
• Publication Number:
  US 20040197224A1
• Time in Patent Office: Days
• US Class Current: 422/400
• CPC Class Codes: G01N 33/66 involving blood sugars, e.g. galactose

Abstract

A hybrid organic-inorganic composite film useful for glucose sensing in aqueous solutions is disclosed along with methods for manufacture thereof and a method of glucose sensing using such novel film.

Claims

1. A hybrid organic-inorganic composite film comprising gold ions diffused in a lipid film deposited on a substrate.

2. A hybrid organic-inorganic composite film as claimed in claim 1 wherein the gold ions are selected from cationic and anionic forms of gold.

3. A hybrid organic-inorganic composite film as claimed in claim 2 wherein the cationic form of gold ion comprises auric chloride.

4. A hybrid organic-inorganic composite film as claimed in claim 2 wherein the anionic form of the gold ion comprises chloroaurate obtained from chloroauric acid.

5. A hybrid organic-inorganic composite film as claimed in claim 1 wherein the substrate is selected from the group consisting of glass, quartz and transparent polymer.

6. A hybrid organic-inorganic composite film as claimed in claim 5 wherein the transparent polymer is selected from plastic, Perspex or fiber material.

7. A hybrid organic-inorganic composite film as claimed in claim 1 wherein the lipid comprising the film layer is selected from the group consisting of fatty acids, fatty amines, fatty alcohols and phospholipids with a hydrocarbon chain length of 12 to 22 carbon atoms.

8. A hybrid organic-inorganic composite film as claimed in claim 7 wherein the fatty amine comprises octadecylamine.

9. A hybrid organic-inorganic composite film as claimed in claim 7 wherein the fatty acid comprises arachidic acid.

10. A hybrid organic-inorganic composite film as claimed in claim 7 wherein the fatty alcohol comprises octadecanol.

11. A hybrid organic-inorganic composite film as claimed in claim 7 wherein the phospholipid comprises 1-phosphatidylethanolamine.

12. A hybrid organic-inorganic composite film as claimed in claim 1 wherein the thickness of the lipid film is in the range of 250 Å

-1000 Å

.

13. A hybrid organic-inorganic composite film as claimed in claim 12 wherein the thickness of the lipid film is about 500 Å

.

14. A method for the manufacture of a hybrid organic-inorganic composite film comprising depositing a lipid film on a substrate and immersing the lipid film deposited substrate in an aqueous solution of gold salt to obtain a hybrid organic-inorganic composite film with gold ion diffused in lipid film.

15. A method as claimed in claim 14 wherein the concentration of the gold solution is in the range of 10⁻

5 to 1 M.

16. A method as claimed in claim 14 wherein the gold ions are selected from cationic and anionic forms of gold.

17. A method as claimed in claim 14 wherein the gold salt is selected from the group consisting of chloroaurate and auric chloride.

18. A method as claimed in claim 14 wherein the lipid film is formed by a method selected from the group consisting of thermal evaporation, spin coating, drop coating and Langmuir-Blodgett method.

19. A method as claimed in claim 14 wherein the substrate is selected from the group consisting of glass, quartz and transparent polymer.

20. A method as claimed in claim 19 wherein the transparent polymer is selected from plastic, Perspex or fiber material.

21. A method as claimed in claim 14 wherein the lipid comprising the film layer is selected from the group consisting of fatty acids, fatty amines, fatty alcohols and phospholipids with a hydrocarbon chain length of 12 to 22 carbon atoms.

22. A method as claimed in claim 21 wherein the fatty amine comprises octadecylamine.

23. A method as claimed in claim 21 wherein the fatty acid comprises arachidic acid.

24. A method as claimed in claim 21 wherein the fatty alcohol comprises octadecanol.

25. A method as claimed in claim 21 wherein the phospholipid comprises 1-phosphatidylethanolamine.

26. A method as claimed in claim 14 wherein the thickness of the lipid film is in the range of 250 Å

-1000 Å

.

27. A method as claimed in claim 26 wherein the thickness of the lipid film is about 500 Å

.

28. A method for glucose sensing comprising using a hybrid organic-inorganic composite film comprising of gold ions diffused in a lipid film deposited on a substrate.

29. A method as claimed in claim 28 wherein said film is immersed in an aqueous solution, the presence of glucose being indicated by colour change in the film.

30. A method as claimed in claim 28 wherein the gold ions are selected from cationic and anionic forms of gold.

31. A method as claimed in claim 28 wherein the gold salt is selected from the group consisting of chloroaurate and auric chloride.

32. A method as claimed in claim 28 wherein the substrate is selected from the group consisting of glass, quartz and transparent polymer.

33. A method as claimed in claim 32 wherein the transparent polymer is selected from plastic, Perspex or fiber material.

34. A method as claimed in claim 28 wherein the lipid comprising the film layer is selected from the group consisting of fatty acids, fatty amines, fatty alcohols and phospholipids with a hydrocarbon chain length of 12 to 22 carbon atoms.

35. A method as claimed in claim 34 wherein the fatty amine comprises octadecylamine.

36. A method as claimed in claim 34 wherein the fatty acid comprises arachidic acid.

37. A method as claimed in claim 34 wherein the fatty alcohol comprises octadecanol.

38. A method as claimed in claim 34 wherein the phospholipid comprises 1-phosphatidylethanolamine.

39. A method as claimed in claim 28 wherein the thickness of the lipid film is in the range of 250 Å

-1000 Å

.

40. A method as claimed in claim 39 wherein the thickness of the lipid film is about 500 Å

.