Device for regeneration of articular cartilage and other tissue
First Claim
1. A bioresorbable device for facilitating healing and repair of tissue comprising, in combination:
- a macrostructure made from a polymer providing an internal three-dimensional architecture defining a network of void spaces;
at least one material for enhancing the attachment of cells to the three-dimensional architecture, said at least one material carried by the macrostructure within the void spaces of the three-dimensional architecture; and
a plurality of cells attached to the device, wherein said plurality of cells are arranged to be transported to a repair site.
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Accused Products
Abstract
An implantable device for facilitating the healing of voids in bone, cartilage and soft tissue is disclosed. A preferred embodiment includes a cartilage region comprising a polyelectrolytic complex joined with a subchondral bone region. The cartilage region, of this embodiment, enhances the environment for chondrocytes to grow articular cartilage; while the subchondral bone region enhances the environment for cells which migrate into that region'"'"'s macrostructure and which differentiate into osteoblasts. A hydrophobic barrier exists between the regions, of this embodiment. In one embodiment, the polyelectrolytic complex transforms to hydrogel, following the implant procedure.
86 Citations
30 Claims
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1. A bioresorbable device for facilitating healing and repair of tissue comprising, in combination:
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a macrostructure made from a polymer providing an internal three-dimensional architecture defining a network of void spaces;
at least one material for enhancing the attachment of cells to the three-dimensional architecture, said at least one material carried by the macrostructure within the void spaces of the three-dimensional architecture; and
a plurality of cells attached to the device, wherein said plurality of cells are arranged to be transported to a repair site. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A bioresorbable device for facilitating healing and repair of tissue comprising, in combination:
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a macrostructure made from a polymer providing an internal three-dimensional architecture defining a network of void spaces;
at least one material for enhancing the attachment of cells to the three-dimensional architecture, said at least one material carried by the macrostructure within the void spaces of the three-dimensional architecture; and
a plurality of cells attached to the device, wherein said plurality of cells are arranged to proliferate and migrate into internal void spaces of the internal three-dimensional architecture. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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Specification