Materials and methods for intracellular transport and their uses
First Claim
1. :
- Coupled polypeptides and fusion polypeptides comprising (i) an aminoacid sequence with the transport function of herpesviral VP22 protein and (ii) another protein sequence selected from (a) proteins for cell cycle control;
(b) suicide proteins (proteins that are conditionally cytotoxic or lethal upon administration, to a cell containing them, of a corresponding (pro)drug or activator compound);
(c) antigenic sequences or antigenic proteins (e.g. of greater than 12 aminoacid residues in length) from microbial and viral antigens and tumour antigens;
(d) immunomodulating proteins; and
(e) therapeutic proteins.
1 Assignment
0 Petitions
Accused Products
Abstract
Coupled polypeptides and fusion polypeptides for intracellular transport, and their preparation and use, include (i) an aminoacid sequence with the transport function of herpesviral VP22 protein (or a homologue, e.g. from VZV, BHV or MDV) and (ii) another protein sequence selected from (a) proteins for cell cycle control; (b) suicide proteins; (c) antigenic sequences or antigenic proteins from microbial and viral antigens and tumour antigens; (d) immunomodulating proteins; and (e) therapeutic proteins. The coupled proteins can be used for intracellular delivery of protein sequences (ii), to exert the corresponding effector function in the target cell, and the fusion polypeptides can be expressed from corresponding polynucleotides, vectors and host cells.
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Citations
12 Claims
-
1. :
- Coupled polypeptides and fusion polypeptides comprising (i) an aminoacid sequence with the transport function of herpesviral VP22 protein and (ii) another protein sequence selected from (a) proteins for cell cycle control;
(b) suicide proteins (proteins that are conditionally cytotoxic or lethal upon administration, to a cell containing them, of a corresponding (pro)drug or activator compound);
(c) antigenic sequences or antigenic proteins (e.g. of greater than 12 aminoacid residues in length) from microbial and viral antigens and tumour antigens;
(d) immunomodulating proteins; and
(e) therapeutic proteins. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
- Coupled polypeptides and fusion polypeptides comprising (i) an aminoacid sequence with the transport function of herpesviral VP22 protein and (ii) another protein sequence selected from (a) proteins for cell cycle control;
Specification