Biodegradable macromers for the controlled release of biologically active substances

• US 20040197369A1
• Filed: 11/17/2003
• Published: 10/07/2004
• Est. Priority Date: 07/18/1997
• Status: Abandoned Application

• Current Assignee: Eyal S. Ron, Jeffrey A. Hubbell, Mark T. Kieras, Stephen C. Rowe
• Original Assignee: Eyal S. Ron, Jeffrey A. Hubbell, Mark T. Kieras, Stephen C. Rowe
• Inventors: Kieras, Mark T., Ron, Eyal S., Hubbell, Jeffrey A., Rowe, Stephen C.
• Application Number:
  US10/715,867
• Publication Number:
  US 20040197369A1
• Time in Patent Office: Days
• US Class Current: 424/423
• CPC Class Codes: A61K 9/1635 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61K 9/1641 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
• CPC Class Codes: A61K 9/1647 Polyesters, e.g. poly(lactide-co-glycolide)
• CPC Class Codes: B01J 13/02 Making microcapsules or microballoons for medical preparations A61K9/50

Abstract

A method for delivering a biologically active substance including the steps of: (a) combining said biologically active substance with a macromer; (b) forming a mixture of the combination formed in step (a); (c) polymerizing said mixture to form articles; and (d) administering said articles, or a portion thereof, to a mammal, where step (c) takes place in the absence of a polymerizable monovinyl monomer, is disclosed.

Claims

1-58. -58. (Canceled)

59. A composition comprising a protein within a biodegradable polymerized macromer, said macromer comprising at least one water soluble region, at least one degradable region which is hydrolyzable under in vivoconditions, and polymerized end groups, wherein said polymerized end groups are separated by at least one degradable region and wherein said composition contains at least 5% by weight of said protein.

60. The composition of claim 59, wherein said water soluble region comprises poly(ethylene glycol).

61. The composition of claim 59, wherein said said degradable region comprises a polyester.

62. The composition of claim 59, wherein said protein is bovine somatotropin, human growth hormone, granulocyte macrophage colony stimulating factor, insulin-like growth factor-I, insulin-like growth factor-II, an interferon, an antibody, or an immunoglobulin.

63. The composition of claim 62, wherein said antibody is selected from anti-HER, anti-VEGF, and anti-Tac antibodies.

64. The composition of claim 62, wherein said immunoglobulin is selected from immunoglobulin A, immunoglobulin D, immunoglobulin E, immunoglobulin G, and immunoglobulin M.

65. The composition of claim 62, wherein said interferon is selected from interferon alpha and interferon beta.

66. A composition comprising a peptide within a biodegradable polymerized macromer, said macromer comprising at least one water soluble region, at least one degradable region which is hydrolyzable under in vivoconditions, and polymerized end groups, wherein said polymerized end groups are separated by at least one degradable region and wherein said composition contains at least 5% by weight of said peptide.

67. The composition of claim 66, wherein said water soluble region comprises poly(ethylene glycol).

68. The composition of claim 66, wherein said degradable region comprises a polyester.

69. The composition of claim 66, wherein said peptide is LHRH, glucagon like peptide-1, insulin, calcitonin, somatostatin, or GLP-1 amylin.