Rapid-detection biosensor
First Claim
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1. A sensor for detecting an analyte, comprising:
- a base member having a conductive electrical property, said base member defining a first conductive element;
a binding agent layer proximate said base member;
a dielectric element proximate said base member; and
, a second conductive element that is physically contacted to said dielectric element and adapted for electrical connection in a circuit with said first conductive element;
wherein said base member and said binding agent layer define a sensor strip.
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Abstract
A sensor for detecting analytes of interest is described. Analyte presence or concentration is determined through measurement of changes in an electrical property in a sensor circuit during analyte exposure to the sensor. The device immobilizes natural or synthetic macromolecules sufficiently close to a capacitor, so that binding of target analyte leads to charging of the capacitor. Current flow resulting from the capacitor charging is measured in an associated detection unit.
173 Citations
20 Claims
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1. A sensor for detecting an analyte, comprising:
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a base member having a conductive electrical property, said base member defining a first conductive element;
a binding agent layer proximate said base member;
a dielectric element proximate said base member; and
,a second conductive element that is physically contacted to said dielectric element and adapted for electrical connection in a circuit with said first conductive element;
wherein said base member and said binding agent layer define a sensor strip. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for detecting a predetermined analyte, comprising the steps of:
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providing an electrically conductive base member, said base member defining a first conductive element;
forming a binding agent layer of macromolecules in proximity to said base member, wherein said macromolecules are capable of interacting at a level of specificity with said predetermined analyte, disposing a dielectric element proximate said base member, wherein said base member, said binding agent layer and said dielectric element define a sensor strip;
exposing said predetermined analyte to said binding agent layer; and
,detecting an electrical current generated in a closed electrical circuit, said electrical current being responsive to a presence of said predetermined analyte, wherein said closed electrical circuit comprises said base member, said dielectric element, and a second conductive element physically contacted to said dielectric element. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15)
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16. A method for detecting a predetermined analyte, comprising the steps of:
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providing an electrically conductive base member;
forming a binding agent layer of macromolecules in proximity to said base member, wherein said macromolecules are capable of interacting at a level of specificity with said predetermined analyte, forming a capacitor on said base member, wherein said base member comprises an element of said capacitor, said capacitor and said base member defining a sensor strip;
exposing said predetermined analyte to said binding agent layer; and
,detecting an electrical current generated in a closed electrical circuit, said electrical current being responsive to a presence of said predetermined analyte, wherein said closed electrical circuit comprises said sensor strip. - View Dependent Claims (17, 18, 19, 20)
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Specification