Optimized sensor geometry for an implantable glucose sensor
First Claim
1. An implantable sensor for use in measuring a concentration of an analyte in a bodily fluid, the sensor comprising:
- a body comprising a sensing region adapted for transport of analytes between the sensor and the bodily fluid, wherein the sensing region is located on a curved portion of the body such that when a foreign body capsule forms around the sensor, a contractile force is exerted by the foreign body capsule toward the sensing region.
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Accused Products
Abstract
An implantable sensor for use in measuring a concentration of an analyte such as glucose in a bodily fluid, including a body with a sensing region adapted for transport of analytes between the sensor and the bodily fluid, wherein the sensing region is located on a curved portion of the body such that when a foreign body capsule forms around the sensor, a contractile force is exerted by the foreign body capsule toward the sensing region. The body is partially or entirely curved, partially or entirely covered with an anchoring material for supporting tissue ingrowth, and designed for subcutaneous tissue implantation. The geometric design, including curvature, shape, and other factors minimize chronic inflammatory response at the sensing region and contribute to improved performance of the sensor in vivo.
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Citations
76 Claims
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1. An implantable sensor for use in measuring a concentration of an analyte in a bodily fluid, the sensor comprising:
a body comprising a sensing region adapted for transport of analytes between the sensor and the bodily fluid, wherein the sensing region is located on a curved portion of the body such that when a foreign body capsule forms around the sensor, a contractile force is exerted by the foreign body capsule toward the sensing region. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69)
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47. The sensor of 46, wherein the sensing region is spaced away from the edges by a distance that is at least about 15% of the width of the first major surface.
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70. An implantable sensor for use in measuring a concentration of an analyte in a bodily fluid, the sensor comprising:
a body comprising a sensing region on a major surface of said body, wherein said major surface comprises a continuous curvature substantially across the entire surface such that when a foreign body capsule forms around the sensor, a contractile force is exerted by the foreign body capsule toward the sensing region.
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71. A wholly implantable sensor adapted to measure a concentration of an analyte in a bodily fluid, comprising:
a wholly implantable body comprising a sensing region adapted for transport of analytes between the sensor and the bodily fluid, wherein the sensing region is located on a curved portion of a first surface of said body and wherein said first surface comprises anchoring material thereon for supporting tissue ingrowth.
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72. An implantable sensor adapted to measure a concentration of an analyte in a bodily fluid, comprising:
a body having a first major surface and, opposite thereto, a second major surface, wherein the first major surface is generally planar, slightly convex, and has rounded edges, with a sensor region located on the first major surface that is spaced away from the rounded edges, wherein the first major surface is sufficiently convex that when a foreign body capsule forms around the sensor, contractile forces are exerted thereby generally uniformly towards the sensing region.
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73. An implantable sensor for use in measuring a concentration of an analyte in a bodily fluid, the sensor comprising:
a body, the body comprising a sensing region adapted for transport of analytes between the sensor and the bodily fluid, wherein the sensing region is located on a curved portion of the body, and wherein a thermoset material substantially encapsulates the body outside the sensing region.
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74. An implantable sensor for use in measuring a concentration of an analyte in a bodily fluid, the sensor comprising:
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sensing means for measuring a concentration of analyte in a bodily fluid; and
housing means for supporting said sensing means, wherein said sensing means is located on a curved portion of housing means such that when a foreign body capsule forms around the housing means, a contractile force is exerted by the foreign body capsule toward the sensing means.
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75. An implantable drug delivery device that allows transport of analytes between the device and a bodily fluid, the device comprising:
a body comprising an analyte transport region adapted for transport of analytes between the device and the bodily fluid, wherein the transport region is located on a curved portion of the body such that when a foreign body capsule forms around the device, a contractile force is exerted by the foreign body capsule toward the analyte transport region.
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76. An implantable cell transplantation device that allows transport of analytes between the device and a bodily fluid, the device comprising:
a body comprising an analyte transport region adapted for transport of analytes between the device and the bodily fluid, wherein the transport region is located on a curved portion of the body such that when a foreign body capsule forms around the device, a contractile force is exerted by the foreign body capsule toward the analyte transport region.
Specification