Hemofiltration systems, methods and devices used to treat inflammatory mediator related disease
First Claim
1. A hemofiltration system to treat an inflammatory mediator related disease in a mammal, comprising:
- a hemofilter operable to remove ultrafiltrate from a blood stream extracted from the mammal and to create a filtered blood stream and an ultrafiltrate stream;
an adsorptive device containing at least one adsorbent material operable to receive the ultrafiltrate stream from the hemofilter and to remove a wide range of inflammatory mediators therefrom to create a post adsorption ultrafiltrate stream;
the adsorbent material selected from a group consisting of coated materials, uncoated materials, a matrix of rods, a matrix configured for convenient presentation of ultrafiltrate to adsorbent material, beads, and particulates and any combination thereof; and
tubing for use in combining the post adsorption ultrafiltrate stream with the filtered blood stream and returning the combined stream to the mammal.
1 Assignment
0 Petitions
Accused Products
Abstract
A hemofiltration system for a mammal is provided with a hemofilter and an adsorbent device. The hemofilter removes ultrafiltrate from a blood stream extracted from the mammal to create a filtered blood stream and an ultrafiltrate stream. The adsorbent device has one or more adsorbent materials and is used to adsorb inflammatory mediators from the ultrafiltrate stream received from the hemofilter removing inflammatory mediators that cause inflammatory mediator related disease, sepsis, and SIRS/MODS/MOSF to create a post adsorption ultrafiltrate stream. The post adsorption ultrafiltrate stream is selectively combined with the filtered blood stream and together with the filtered blood stream is returned to the mammal.
76 Citations
15 Claims
-
1. A hemofiltration system to treat an inflammatory mediator related disease in a mammal, comprising:
-
a hemofilter operable to remove ultrafiltrate from a blood stream extracted from the mammal and to create a filtered blood stream and an ultrafiltrate stream;
an adsorptive device containing at least one adsorbent material operable to receive the ultrafiltrate stream from the hemofilter and to remove a wide range of inflammatory mediators therefrom to create a post adsorption ultrafiltrate stream;
the adsorbent material selected from a group consisting of coated materials, uncoated materials, a matrix of rods, a matrix configured for convenient presentation of ultrafiltrate to adsorbent material, beads, and particulates and any combination thereof; and
tubing for use in combining the post adsorption ultrafiltrate stream with the filtered blood stream and returning the combined stream to the mammal. - View Dependent Claims (2, 3, 4, 5)
-
-
6. A hemofiltration system to treat an inflammatory mediator related disease including sepsis and septic shock in a mammal, comprising:
-
a hemofilter operable to remove ultrafiltrate from a blood stream extracted from the mammal and to create a filtered blood stream and an ultrafiltrate stream;
an adsorptive device containing at least one adsorbent material operable to receive the ultrafiltrate stream from the hemofilter and to remove at least one inflammatory mediator therefrom to create a post adsorption ultrafiltrate stream;
the adsorbent material selected from a group consisting of coated materials, uncoated materials, a matrix of rods, a matrix configured for convenient presentation of ultrafiltrate to adsorbent material, beads, and particulates and any combination thereof; and
means for selectively combining the post adsorption ultrafiltrate stream with the filtered blood stream and returning the combined stream to the mammal. - View Dependent Claims (7, 8, 9, 10)
-
-
11. A hemofiltration system to treat an inflammatory mediator related disease in a mammal, comprising:
-
a hemofilter operable to remove ultrafiltrate from a blood stream extracted from the mammal and to create a filtered blood stream and an ultrafiltrate stream;
an adsorptive device containing at least one adsorbent material operable to receive the ultrafiltrate stream from the hemofilter and to remove a wide range of inflammatory mediators therefrom to create a post adsorption ultrafiltrate stream;
the adsorbent material selected from a group consisting of coated materials, uncoated materials, a matrix of rods, a matrix configured for convenient presentation of ultrafiltrate to adsorbent material, beads, and particulates and any combination thereof;
tubing operable to combine the post adsorption ultrafiltrate stream with the filtered blood stream and return the combined stream to the mammal;
a first pump to transfer the post adsorption ultrafiltrate stream from the adsorptive device; and
a second pump to transfer a portion of the post adsorption ultrafiltrate stream which is not returned to the mammal to the waste reservoir using a second ultrafiltrate pump. - View Dependent Claims (12, 13, 14, 15)
-
Specification