Solid solution perforator for drug delivery and other applications
3 Assignments
0 Petitions
Accused Products
Abstract
A solid drug perforator (SSP) system and an associated drug reservoir are provided for delivering theraputic, prophylactic and/or cosmetic compounds, for nutrient delivery and for drug targeting. For drug delivery, the SSP system includes an active drug ingredient and a matrix of perforator material that biodegrades or dissolves quickly upon contact with a patient'"'"'s body. The SSP system provides a skin barrier perforator and a controller for prompt initiation and cut-off of drug delivery. In a preferred method of transdermal drug delivery, an SSP system containing a selected drug penetrates into an epidermis or dermis, and the drug is promptly released from the (dissolving) SSP system perforator. An additional drug is optionally delivered from a patch reservoir through skin pores created by insertion of the perforator. Formulation and fabrication procedures for the SSP and associated reservoir are also provided. An SSP system can be fabricated with variety of shapes and dimensions.
113 Citations
45 Claims
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1-25. -25. (canceled)
- 26. A system comprising a source of solvent, and an array having a plurality of micro-perforators that dissolves upon contact with the solvent.
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30. A system for delivering a substance into tissue comprising:
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a patch including a basal layer having a first side and a second side, and a plurality of micro-perforators projecting from the first side of the basal layer and formed from a matrix material that can be dissolved in the tissue; and
a reservoir, including a solvent effective to dissolve the matrix material, that can be attached to the second side of the basal layer. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38)
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39. A method for delivering a substance into tissue comprising:
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forming a plurality of channels into the tissue by inserting a plurality of micro-perforators formed of a matrix material into the tissue, and dissolving the matrix material to form the plurality of channels; and
delivering the substance through the plurality of channels. - View Dependent Claims (40, 41, 42, 43, 44, 45)
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Specification