Antibiotic drug delivery system

• US 20040199145A1
• Filed: 12/31/2003
• Published: 10/07/2004
• Est. Priority Date: 06/02/2001
• Status: Abandoned Application

• Current Assignee: Astrazeneca AB (Astrazeneca PLC)
• Original Assignee: Astrazeneca AB (Astrazeneca PLC)
• Inventors: Ward, Mervyn Simon Andrew
• Application Number:
  US10/482,502
• Publication Number:
  US 20040199145A1
• Time in Patent Office: Days
• US Class Current: 604/890.1
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 5/145 using pressurised reservoirs, e.g. pressurised by means of pistons
• CPC Class Codes: A61M 5/1452 pressurised by means of pistons
• CPC Class Codes: A61M 5/16804 Flow controllers

Abstract

An antibiotic drug delivery system for controlled infusion of an antibiotic drug to a patient, which system comprises delivery device for providing an infusion of the antibiotic at a controlled rate, together with (ii) a control system for varying the infusion rate and time of dosing the antibiotic according to one or more parameters of the drug so as to maintain antibiotic levels in the patient or a desired percentage above the accepted MBC or MPC for that antibiotic.

Claims

1. An antibiotic drug delivery system for controlled infusion of an antibiotic drug to a patient, which system comprises

(i) a delivery device for providing an infusion of the antibiotic at a controlled rate, together with

(ii) a control system for varying the infusion rate and time of dosing of the antibiotic according to one or more parameters of the drug so as to maintain antibiotic levels in the patient of a desired percentage above the accepted MBC or MPC for that antibiotic.

2. An antibiotic drug delivery system as claimed in claim 1, wherein the delivery device comprises a reservoir and pump.

3. An antibiotic drug delivery system as claimed in claim 1, wherein the delivery device comprises a syringe and mechanical means acting on the syringe plunger and/or barrel.

4. An antibiotic drug delivery system as claimed in claim 1, wherein the control system includes instructions provided on a data storage medium.

5. An antibiotic drug delivery system as claimed in claim 4, wherein the data storage medium is a computer chip

6. An antibiotic drug delivery system as claimed in claim 4, wherein the data storage medium is a computer.

7. An antibiotic drug delivery system as claimed in claim 1, wherein the control system includes mechanistic data for one or more antibiotic/bacterium combinations.

8. An antibiotic drug delivery system as claimed in claim 1, wherein the control system includes local mechanistic and/or patient data for one or more antibiotic/bacterium combinations.

9. An antibiotic drug delivery system as claimed in claim 1, wherein the control system includes global mechanistic and/or patient data for one or more antibiotic/bacterium combinations.

10. An antibiotic drug delivery system as claimed in claim 1, wherein the control system is set up to compare local and global mechanistic and/or patient data for one or more antibiotic/bacterium combinations.

11. An antibiotic drug delivery system as claimed in claim 1, further comprising a manual override facility.

12. An antibiotic drug delivery system as claimed in claim 1, further comprising one or more failsafes.

15. An antibiotic drug delivery system as claimed in claim 1, wherein the antibiotic drug is a carbapenem antibiotic.

16. An antibiotic drug delivery system as claimed in claim 1, wherein the antibiotic drug is a penem antibiotic.

17. An antibiotic drug delivery system as claimed in claim 1, wherein the antibiotic drug is an oxazolidinone antibiotic.

13. A computer chip comprising instructions system for varying the infusion rate and time of dosing of an antibiotic according to one or more parameters of the drug so as to maintain antibiotic levels in a patient of a desired percentage above the accepted MBC or MPC for that antibiotic.

14. A control system for varying the infusion rate and time of dosing of an antibiotic according to one or more parameters of the drug so as to maintain antibiotic levels in a patient of a desired percentage above the accepted MBC or MPC for that antibiotic.