Transdermal administration of huperzine
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Abstract
The present invention provides a composition of transdermally administered huperzine for improving memory and cognitive function. In one aspect, huperzine is delivered in a sufficient amount to achieve and maintain a blood plasma Huperzine level of about 0.5 ng/mL to about 30 ng/mL. Huperzine may be delivered by itself, or in combination with other elements, such as additional cholinesterase inhibitors, drugs or treatment agents, or positive health promoting substances. Various formulations for the transdermal delivery of huperzine are disclosed, and may include selected penetration enhancers.
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Citations
97 Claims
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1-52. -52. (canceled)
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53. A transdermal formulation for improving memory and cognitive function comprising:
an inert carrier having from about 0.01% w/w to about 20% w/w of huperzine admixed therewith, and including a permeation enhancer selected from the group consisting of;
fatty acids, fatty acid esters, fatty alcohols, amides, pyrrolidones, glycerol triesters, terpenes, their salts, and mixtures thereof, wherein said formulation provides a huperzine blood plasma level of from about 0.1 ng/ml to about 30 ng/ml, upon administration to a subject.- View Dependent Claims (54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 78, 79)
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80. A transdermal formulation for improving memory and cognitive function consisting essentially of:
a mixture of an inert carrier and huperzine in an amount of from about 0.01% w/w to about 20% w/w, which provides a huperzine blood plasma level of from about 0.1 to about 30 ng/ml upon administration to a subject.
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81. A method of improving memory and cognitive function in a subject, comprising:
transdermally administering a huperzine formulation to the subject which provides a huperzine blood plasma level of from about 0.1 to about 30 ng/ml. - View Dependent Claims (82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97)
Specification