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Stimuli-responsive systems for controlled drug delivery

  • US 20040202719A1
  • Filed: 12/17/2003
  • Published: 10/14/2004
  • Est. Priority Date: 12/17/2002
  • Status: Active Grant
First Claim
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1. A material for delivery of a therapeutic agent, comprising:

  • a cross-linked polymer including a biodegradable polymer and a polyfunctional cross-linking agent;

    an indicator analog incorporated into one of the biodegradable polymer and the cross-linking agent;

    a cross-link receptor incorporated into the other of the biodegradable polymer and the cross-linking agent, wherein;

    the biodegradable polymer is cross-linked by interactions between the indicator analog and the cross-link receptor;

    the therapeutic agent is contained within the cross-linked polymer, the degradation rate of the cross-linked polymer depends on the local concentration of the indicator whose analog one of the biodegradable polymer and the cross-linking agent is functionalized with, and the interruption of the interaction between the indicator analog and the cross-link receptor causes the material to release the therapeutic agent.

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