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Compositions for RNA interference and methods of use thereof

  • US 20040203145A1
  • Filed: 08/07/2003
  • Published: 10/14/2004
  • Est. Priority Date: 08/07/2002
  • Status: Active Grant
First Claim
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1. An isolated, single-stranded small interfering molecule (ss-siRNA), wherein the sequence of said ss-siRNA molecule is sufficiently complementary to a target mRNA sequence to direct target-specific RNA interference (RNAi) and wherein the 5′

  • nucleotide is 5′

    phosphorylated or is capable of being 5′

    phosphorylated in situ or in vivo.

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