Raman spectroscopic monitoring of hemodialysis
First Claim
1. A method for monitoring hemodialysis, the method comprising the steps of:
- irradiating a sample of blood undergoing hemodialysis with light;
obtaining a Raman spectrum of chemical constituents from the sample; and
analyzing the Raman spectrum to detect one analyte in the sample, the analyte being indicative of the progress of dialysis.
3 Assignments
0 Petitions
Accused Products
Abstract
Spectroscopic systems and methods are disclosed for determining levels of at least one analyte in blood undergoing hemodialysis. In one aspect, the invention employs Raman spectroscopy to monitor and/or control hemodialysis. In one embodiment, the system uses a laser light directed to circulating blood from a patient undergoing dialysis to make Raman spectral measurements. For example, the laser light can be directed into a segment of the dialysis tubing. The system can utilize unique Raman spectroscopic signature of one or more analytes, e.g., urea, to identify and quantify such analytes against a whole blood background. Based on the spectral response, the concentration of the analytes can be monitored and/or used to control hemodialysis.
64 Citations
20 Claims
-
1. A method for monitoring hemodialysis, the method comprising the steps of:
-
irradiating a sample of blood undergoing hemodialysis with light;
obtaining a Raman spectrum of chemical constituents from the sample; and
analyzing the Raman spectrum to detect one analyte in the sample, the analyte being indicative of the progress of dialysis. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
-
-
14. A method for monitoring a subject'"'"'s urea concentration, the method comprising the steps of:
-
irradiating the blood sample from a subject;
collecting a Raman spectrum of light scattered by the sample;
analyzing the Raman spectrum to detect the concentration of urea in the sample, the concentration of urea being indicative of the progress of dialysis or kidney function. - View Dependent Claims (15, 16, 17)
-
-
18. In a hemodialysis system, the improvement characterized by a Raman spectral analysis system comprising:
-
means for irradiating a sample of blood undergoing hemodialysis;
means for obtaining a Raman spectrum of chemical constituents from the sample; and
means for analyzing the Raman spectrum to detect the concentration of at least one analyte in the sample, the concentration of the analyte being indicative of the progress of hemodialysis.
-
-
19. A hemodialysis system comprising
at least one blood cleaning element for removing toxins from blood; -
a light source to irradiate a sample of blood undergoing hemodialysis;
a Raman spectrometer to detect the concentration of at least one analyte in the sample, the concentration of the analyte being indicative of the progress of hemodialysis. - View Dependent Claims (20)
-
Specification