Dispensing method and device for delivering material to an eye

• US 20040204674A1
• Filed: 04/10/2003
• Published: 10/14/2004
• Est. Priority Date: 04/10/2003
• Status: Active Grant

• Current Assignee: Hewlett-Packard Development Company, L.P. (HP Inc.)
• Original Assignee: Hewlett-Packard Development Company, L.P. (HP Inc.)
• Inventors: Van Brocklin, Andrew L., Anderson, Daryl E.
• Granted Patent: US 7,201,732 B2
• Time in Patent Office: Days
• US Class Current: 604/66
• CPC Class Codes: A61B 3/113 for determining or recording eye movement
• CPC Class Codes: A61F 9/0008 Introducing ophthalmic products into the ocular cavity or retaining products therein putting in contact lenses A61F9/0061; introducing or retaining media in cavities of the body in general A61M31/00
• CPC Class Codes: A61F 9/0026 Ophthalmic product dispenser attachments to facilitate positioning near the eye
• CPC Class Codes: A61M 2210/0612 Eyes
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

A method and device for administering material to an eye during an eye-open interval. The device includes, an electronically controllable fluid delivery element and a detector in communication with the electronically controllable fluid delivery element. The detector is capable of discerning at least a portion of an eye-blink event and producing a signal actionable on the electronically controllable fluid delivery element.

Claims

1. A device for administering material to an eye, the administering device comprising:

an electronically controllable fluid delivery element;

a detector in electronic communication with the electronically controllable fluid delivery element, the detector configured to discern at least one portion of an eye-blink event and produce a signal actionable on the electronically controllable fluid delivery element.

2. The device of claim 1 wherein the actionable signal initiates ejection of at least one material from the electronically controllable fluid delivery element during an eye-open portion of the eye-blink event.

3. The device of claim 2 wherein the material ejected is a fluid suitable for contact with the eye.

4. The device of claim 3 wherein the material has at least one of therapeutic capabilities and diagnostic capabilities.

5. The device of claim 1 wherein the detector is capable of ascertaining at least a portion of the eye-open portion of the eye-blink event and wherein the electronically controllable fluid delivery element is a microfluidic jetting device.

6. The device of claim 5 wherein the microfluidic jetting element is at least one of a thermal jetting device and a piezoelectric jetting device.

7. The device of claim 6 wherein the electronically controllable jetting element is positioned to deliver fluid material to a location on the anterior region of the eye.

8. The device of claim 1 wherein the electronically controllable fluid delivery element functions during at least a portion of at least one eye-open portion of the eye-blink event.

9. The device of claim 1 further comprising control electronics having an information storage portion, the control electronics in communication with the electronically controllable fluid delivery element and the detector.

10. The device of claim 9 further comprising a trigger switch, the trigger switch capable of being activated by a user, the trigger actionable on at least one of the control electronics, detector and electronically controllable fluid delivery element.

11. The device of claim 1 wherein the detector includes a sensor capable of detecting at least one characteristic of an eye-blink event.

12. The device of claim 11 wherein the detector further comprises at least one emitter capable of generating at least one analytic waveform.

13. The device of claim 12 wherein the analytic waveform is at least one of an optical waveform and an acoustical waveform.

14. The device of claim 13 wherein the sensor is configured to ascertain analytical waveform reflected from the eye.

15. The device of claim 14 wherein the waveform is reflected from at least one of the anterior optic structure and the eyelid.

16. The device of claim 14 wherein an actionable command is derived from a characteristic difference between waveform reflected from the anterior structure of the eye and the waveform reflected from the eyelid.

17. The device of claim 1 wherein the detector includes an emitter and a sensor, the emitter directing an analytic waveform toward a targeted optic structure and the sensor detecting at least one change in reflected wave based on reflection based on the eye-blink event.

18. The device of claim 17 wherein the emitter produces at least one of an optical waveform and an acoustic waveform.

19. The device of claim 1 wherein the control electronics includes a logic-processing unit.

20. The device of claim 19 wherein the logic processing unit includes at least one of a central processing unit and an application specific integrated circuit.

21. The device of claim 18 further comprising a chronometric device, the chronometric device in electronic communication with the control electronics.

22. The device of claim 1 further comprising a spacer, the spacer configured to maintain a distance between the electronically controllable fluid delivery element and the eye.

23. A device for administering material to an eye, the administering device comprising:

an electronically controllable fluid delivery element, the electronically controllable fluid delivery element in communication with a source of at least one material to be delivered to the eye;

a detector in electronic communication with the electronically controllable fluid delivery element, the detector capable of ascertaining an eye-open state and producing at least one signal actionable on the electronically controllable fluid delivery element; and

control electronics in communication with the electronically controllable fluid delivery element and the detector, the control electronics configured to mediate the signal emitted by the detector and actionable on the electronically controllable fluid delivery element.

24. The device of claim 23 wherein the control electronics include an information storage potion, the information storage portion containing information pertaining to at least one of the eye-open state, material dosage administration and optic condition.

25. The device of claim 24 wherein the control electronics are capable of receiving data derived from the detector and generating at least one command actionable on the electronically controllable fluid delivery element.

26. The device of claim 23 wherein the detector is capable of discerning at least one characteristic correlative with the eye-open state.

27. The device of claim 26 wherein the correlative characteristic is at least one of change in light reflectance, change in thermal radiation, and change in sound reflectance.

28. The device of claim 26 wherein the detector includes an emitter capable of producing an analytic wave form, the analytic waveform including at least one of an optic waveform and an acoustical waveform.

29. The device of claim 28 wherein the emitter directs the analytic waveform to a region on the anterior potion of the eye.

30. The device of claim 23 wherein the material to be administered is a therapeutic liquid.

31. The device of claim 23 further comprising at least one alignment mechanism confirming alignment of the electronically controllable fluid delivery element and detector relative to the eye.

32. The device of claim 24 wherein the control electronics and information storage portion are configured to ascertain multiple eye-blink events and develop an activation command operable on the electronically controllable fluid delivery element based on at least one of eye-open state, optic surface fluid content, and optic tissue response.

33. A device for administering material to an eye, the administering device comprising:

means for ejecting a quantity of material into contact with the eye; and

means for ascertaining at least one eye-open state of the eye, the ascertaining means capable of interacting with the ejecting means to deliver material to the eye during the eye-open state.

34. The device of claim 33 wherein the material ejecting means is an electronically controllable fluid delivery element.

35. The device of claim 33 further comprising interactive with the material ejecting means and the means for ascertaining at least one eye-open state.

36. The device of claim 33 wherein the means for ascertaining at least one eye-blink event includes means for directing at least one analytical waveform to a targeted location on the eye, the analytical waveform being at least one of an acoustic waveform and an optical waveform.

37. The device of claim 36 wherein the ascertaining means is capable of determining an eye-open state over multiple eye-open intervals.

38. The device of claim 37 wherein the eye-open state is determined as a function of difference in reflected analytical waveform between the eye-open state and an eye-closed state.

39. A method for administering material to an eye, the method steps of:

positioning a device in proximate alignment to the eye, the device including an electronically controllable fluid delivery element, a detector capable of ascertaining an eye-open state of the eye, the detector device generating at least one command actionable on the electronic fluid delivery element; and

dispensing material from the electronically controllable fluid delivery element into contact with the eye during the eye-open state.

40. The method of claim 39 further comprising the step of recording a plurality of eye-blink events to ascertain eye-open state, the recording step occurring prior to the material dispensing step.

41. The method of claim 40 wherein the recording step comprises the steps of:

emitting an analytical waveform directed toward the eye region; and

analyzing a waveform reflected from the eye region, the reflected waveform occurring during an eye-blink cycle including at least one eye-open interval and at least one interval where an eyelid covers the eye.

42. The method of claim 41 wherein the dispensing step occurs during at least one eye-open interval.

43. The device of claim 41 wherein the analytic waveform is at least one of an optical waveform and an acoustic waveform.

44. The method of claim 39 wherein the dispensed material is a therapeutic liquid.

45. The method of claim 39 wherein the electronically controllable fluid delivery element is at least one of a piezoelectric jetting device and a thermal jetting device.

46. The method of claim 41 further comprising the steps of:

analyzing a portion of the eye for response to material dispensed into contact with the eye; and

based on the response analyzing step, implementing one of a) discontinuing the dispensing step, or b) dispensing additional material from the electronically controllable fluid delivery element into contact with the eye.

47. The method of claim 46 whereby the analyzing step includes analyzing at least one characteristic observable during the eye-open interval of the eye-blink cycle.

49. The device of claim 45 wherein the material transfer means is an electronically controllable jetting device.

50. The device of claim 45 wherein the material transferred is a therapeutic liquid.

48. A device for administering material to an eye, the device comprising:

means for transferring material from a storage reservoir to the eye;

means for electronically controlling operation of the material transferring means; and

means for detecting an eye-blink event, the detecting means in communication with the electronic control means to generate at least one command operable to actuate the material transfer means during at least one eye-open state.

51. A cartridge for use with an ophthalmic delivery system, the ophthalmic delivery system including a detector capable of discerning at least one eye-blink event, the cartridge comprising:

a housing adapted to be removably connected to the device;

an electronically controllable fluid delivery element contained on the housing;

a reservoir containing at least one ophthalmologically compatible material, the reservoir in fluid communication with the electronically controllable fluid delivery element; and

a control circuit in removable communication with the detector of the ophthalmic delivery system, the control circuit actionable on the electronically controllable fluid delivery element.