Liposomal vaccine
First Claim
Patent Images
1. An injectable liposomal composition for delivery of a water-soluble substance, the composition comprising:
- a plurality of liposomal vesicles comprising a high weight ratio of a lipid to an encapsulated water-soluble substance so as to achieve a high efficiency of encapsulation.
2 Assignments
0 Petitions
Accused Products
Abstract
The invention provides liposomal vehicles for encapsulating relatively high levels of water-soluble substances including immunogens directed against gastrin and gonadotropin releasing hormone. The liposome encapsulating large amounts of immunogens can be injected parentally to induce effective immune responses without exhibiting significant adverse tissue reactogenicity.
22 Citations
40 Claims
-
1. An injectable liposomal composition for delivery of a water-soluble substance, the composition comprising:
a plurality of liposomal vesicles comprising a high weight ratio of a lipid to an encapsulated water-soluble substance so as to achieve a high efficiency of encapsulation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 37)
-
36. A method for producing a liposomal vaccine comprising the steps of:
- preparing phospholipid multilamellar vesicles and encapsulating water-soluble immunogen and/or immunomodulating substances, whereby the liposomes have a high lipid to protein ratio.
- View Dependent Claims (38)
-
39. A liposomal composition of high lipid to protein weight ratio comprising an immunogenic construct of immunogenic carrier conjugated to peptide selected from the group consisting of SEQ ID NO:
- 17, 18, 19, and 20.
-
40. A method for producing liposomal vaccine containing high doses of immunogen comprising rehydrating a lyophilized lipid complement with water or an aqueous ethanol solution, at which step an immunogen is contained either in the lipid complement or the aqueous ethanol solution.
Specification