Novel dietary compositions to reduce inflammation
First Claim
1. A nutritional supplement for increasing the ratio of anti-inflammatory eicosanoids to pro-inflammatory eicosanoids derived from omega-6 fatty acids in a mammal, said supplement consisting essentially of, as active ingredients;
- (a) fish oil comprising eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA);
(b) gamma linolenic acid (GLA); and
(c) a specific inhibitor of delta-5 desaturase enzymatic activity, wherein the amount of each of said fish oil, GLA, and inhibitor in said supplement is a function of the ratio of arachidonic acid (AA) to EPA in the plasma phospholipids in said mammal.
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Abstract
The invention relates to the use of combinations of fatty acids and specific inhibitors of delta-5 desaturase activity in a nutritional supplement to modulate the inflammatory state of a mammal. The nutritional supplement is composed of various oils selected in combination to enhance the production of anti-inflammatory eicosanoids derived from omega 6 fatty acids while simultaneously decreasing the production of pro-inflammatory eicosanoids derived from omega 6 fatty acids. In one embodiment, the invention features a combination of a fish oil, an oil containing gamma linolenic acid (GLA), and a sesame oil extract rich in one or more lignans (such as sesamol and sesamin) that are specific inhibitors of delta-5 desaturase activity.
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Citations
35 Claims
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1. A nutritional supplement for increasing the ratio of anti-inflammatory eicosanoids to pro-inflammatory eicosanoids derived from omega-6 fatty acids in a mammal, said supplement consisting essentially of, as active ingredients;
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(a) fish oil comprising eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA);
(b) gamma linolenic acid (GLA); and
(c) a specific inhibitor of delta-5 desaturase enzymatic activity, wherein the amount of each of said fish oil, GLA, and inhibitor in said supplement is a function of the ratio of arachidonic acid (AA) to EPA in the plasma phospholipids in said mammal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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35. The method of claim 36, wherein said crystallization step comprises the step of cystallizing said lignan in acetone solvent.
Specification