Wound and ulcer treatment with super-oxidized water

• US 20040208940A1
• Filed: 04/23/2004
• Published: 10/21/2004
• Est. Priority Date: 08/23/1999
• Status: Active Grant

• Current Assignee: Urgo US, Inc.
• Original Assignee: Sterilox Medical Limited
• Inventors: Selkon, Joe B.
• Granted Patent: US 7,276,255 B2
• Time in Patent Office: Days
• US Class Current: 424/661
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 33/40 Peroxides
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: C02F 1/4674 with halogen or compound of halogens, e.g. chlorine, bromine
• CPC Class Codes: C02F 2103/026 Treating water for medical or cosmetic purposes
• CPC Class Codes: C02F 2209/04 Oxidation reduction potential [ORP]
• CPC Class Codes: C02F 2209/06 pH
• CPC Class Codes: C02F 2303/04 Disinfection

Abstract

Super-oxidized water based on hypochlorous acid, such as is obtained by the electrochemical treatment of a saline solution, may be used in the treatment of leg ulcers or other open wounds. Preferably, the pH of the super-oxidized water is in a range of 4 to 7, and the water has a redox potential of >950 mV. Medicaments based on the super-oxidized water may be in liquid or gel form. The super-oxidized water is able to control the microbial population within the wound and at the same time permit cell proliferation.

Claims

1. A method for treating an open wound in a human or animal body comprising administering to the open wound a super-oxidized water having a pH of 4 to 7 based on hypochlorous acid, wherein the super-oxidized water is administered in an amount effective to act as a biocide and permit cell proliferation for wound healing.

2. The method according to claim 1, wherein the open wound is an ulcer, burn, or surface wound.

3. The method according to claim 1, wherein the super-oxidized water is in a liquid form and is applied to the wound by bathing.

4. The method according to claim 3, wherein the super-oxidized water is applied to the wound by immersing in a hydrobath containing the water.

5. The method according to claim 1, wherein the super-oxidized water is in a liquid form and is applied to the wound by spraying.

6. The method according to claim 1, wherein the super-oxidized water is in a gel form and is topically applied to the wound.

7. The method according to claim 1, wherein the super-oxidized water has a pH of 4.0 to 6.5.

8. The method according to claim 7, wherein the super-oxidized water has a pH of 4.0 to 6.2.

9. The method according to claim 8, wherein the super-oxidized water has a pH of 4.3 to 6.2.

10. The method according to claim 9, wherein the super-oxidized water has a pH of about 5.4.

11. The method according to claim 1, wherein the super-oxidized water has a redox potential of >

950 mV.

12. The method according to claim 11, wherein the super-oxidized water has a redox potential of about 1000 mV.

13. The method according to claim 1, wherein the super-oxidized water or a preparation derived therefrom has a biocide rate (D Value) of approximately 1 log reduction unit of bacillus subtilis spores in less than 1 minute with a 9:

1 super-oxidized water;

innoculum mix.

14. The method according to claim 1, wherein the super-oxidized water is diluted to an extent that it does not inhibit cell proliferation in use.

15. The method according to claim 14, wherein the super-oxidized water is diluted to an extent that it promotes cell proliferation in use.

16. The method according to claim 1, wherein the super-oxidized water comprises an output solution obtained by electrochemical treatment of a saline solution.

17. The method according to claim 16, wherein the super-oxidized water has a pH adjusted to a desired level by using an alkaline solution output from an electrochemical cell in which the saline solution is treated.

18. The method according to claim 16, wherein the output solution further comprises a phosphate buffer to adjust a pH of the solution to a desired level.