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Compounds and methods for analyzing the proteome

  • US 20040209255A1
  • Filed: 03/11/2003
  • Published: 10/21/2004
  • Est. Priority Date: 03/11/2002
  • Status: Abandoned Application
First Claim
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1. A gradient array, comprising:

  • a 2-dimensional array of moieties X and optionally Y; and

    a surface Z for presenting moieties X and Y, wherein;

    the surface Z comprises a solid support;

    the X and Y moieties are arranged in a two dimensional array of continuous gradients of one or more properties of X and Y;

    the properties of moiety X are in a gradient along the X-axis;

    the properties of moiety Y are in a gradient along the Y-axis;

    the X moieties are each independently selected to bind to biomolecules covalently or with sufficiently high affinity so that the resulting complexes of biomolecule/capture compounds are stable under conditions of mass spectrometric analysis; and

    the Y moieties are each independently selected to increase the selectivity of the binding by moiety X.

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